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Protein

Microtubule-associated protein 2

Gene

MAP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calmodulin binding Source: UniProtKB-KW
  • dystroglycan binding Source: UniProtKB
  • microtubule binding Source: GO_Central
  • structural molecule activity Source: ProtInc
  • tau protein binding Source: ARUK-UCL

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P11137

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Microtubule-associated protein 2
Short name:
MAP-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MAP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000078018.19

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6839 MAP2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
157130 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P11137

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
4133

Open Targets

More...
OpenTargetsi
ENSG00000078018

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30583

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2390810

Drug and drug target database

More...
DrugBanki
DB01248 Docetaxel
DB01196 Estramustine
DB01229 Paclitaxel

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MAP2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
215274255

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000727471 – 1827Microtubule-associated protein 2Add BLAST1827

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei136PhosphoserineBy similarity1
Modified residuei140PhosphoserineBy similarity1
Modified residuei143PhosphoserineBy similarity1
Modified residuei285PhosphoserineBy similarity1
Modified residuei498PhosphoserineBy similarity1
Modified residuei601PhosphoserineBy similarity1
Modified residuei605PhosphoserineBy similarity1
Modified residuei610PhosphoserineBy similarity1
Modified residuei629PhosphoserineBy similarity1
Modified residuei725PhosphoserineBy similarity1
Modified residuei729PhosphoserineBy similarity1
Modified residuei733PhosphothreonineBy similarity1
Modified residuei736PhosphoserineBy similarity1
Modified residuei738PhosphoserineBy similarity1
Modified residuei745PhosphotyrosineBy similarity1
Modified residuei821PhosphoserineBy similarity1
Modified residuei881PhosphoserineBy similarity1
Modified residuei890PhosphoserineBy similarity1
Modified residuei936PhosphoserineBy similarity1
Modified residuei1133PhosphoserineBy similarity1
Modified residuei1134PhosphoserineBy similarity1
Modified residuei1139PhosphoserineBy similarity1
Modified residuei1154PhosphothreonineBy similarity1
Modified residuei1155PhosphoserineBy similarity1
Modified residuei1159PhosphoserineBy similarity1
Modified residuei1347PhosphoserineCombined sources1
Modified residuei1353PhosphoserineCombined sources1
Modified residuei1534PhosphoserineBy similarity1
Modified residuei1555PhosphoserineBy similarity1
Modified residuei1588PhosphoserineBy similarity1
Modified residuei1602PhosphothreonineBy similarity1
Modified residuei1605PhosphothreonineBy similarity1
Modified residuei1616PhosphothreonineBy similarity1
Modified residuei1619PhosphothreonineBy similarity1
Modified residuei1649PhosphothreonineBy similarity1
Modified residuei1653PhosphoserineBy similarity1
Modified residuei1679Phosphoserine; by MARK1By similarity1
Modified residuei1782PhosphoserineCombined sources1
Modified residuei1787PhosphoserineBy similarity1
Modified residuei1790PhosphoserineBy similarity1
Modified residuei1795PhosphoserineBy similarity1
Modified residuei1808PhosphoserineBy similarity1
Isoform 2 (identifier: P11137-2)
Modified residuei67PhosphotyrosineBy similarity1 Publication1
Modified residuei323PhosphoserineBy similarity1 Publication1
Modified residuei354PhosphoserineBy similarity1 Publication1
Modified residuei386PhosphoserineBy similarity1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly (By similarity). Isoform 2 is probably phosphorylated by PKA at Ser-323, Ser-354 and Ser-386 and by FYN at Tyr-67. The interaction with KNDC1 enhances MAP2 threonine phosphorylation (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P11137

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P11137

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P11137

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P11137

PeptideAtlas

More...
PeptideAtlasi
P11137

PRoteomics IDEntifications database

More...
PRIDEi
P11137

ProteomicsDB human proteome resource

More...
ProteomicsDBi
52694
52695 [P11137-2]
52696 [P11137-3]
52697 [P11137-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P11137

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P11137

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000078018 Expressed in 213 organ(s), highest expression level in dorsolateral prefrontal cortex

CleanEx database of gene expression profiles

More...
CleanExi
HS_MAP2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P11137 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P11137 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB001984
HPA008273
HPA012828

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with KNDC1 (via KIND2); the interaction enhances MAP2 phosphorylation and localizes KNDC1 to dendrites.By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
CBFBQ139512EBI-2682460,EBI-718750

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110305, 48 interactors

Database of interacting proteins

More...
DIPi
DIP-577N

Protein interaction database and analysis system

More...
IntActi
P11137, 9 interactors

Molecular INTeraction database

More...
MINTi
P11137

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000353508

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P11137

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P11137

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P11137

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1661 – 1691Tau/MAP 1Add BLAST31
Repeati1692 – 1722Tau/MAP 2Add BLAST31
Repeati1723 – 1754Tau/MAP 3Add BLAST32

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni701 – 744Interaction with KNDC1By similarityAdd BLAST44
Regioni1447 – 1467Calmodulin-bindingSequence analysisAdd BLAST21

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2418 Eukaryota
ENOG4111J07 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156597

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113477

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG000991

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P11137

KEGG Orthology (KO)

More...
KOi
K10430

Identification of Orthologs from Complete Genome Data

More...
OMAi
KTETYDD

Database of Orthologous Groups

More...
OrthoDBi
716848at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P11137

TreeFam database of animal gene trees

More...
TreeFami
TF316358

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR030797 MAP2
IPR013588 MAP2_projctn
IPR001084 MAP_tubulin-bd_rpt

The PANTHER Classification System

More...
PANTHERi
PTHR11501:SF15 PTHR11501:SF15, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08377 MAP2_projctn, 1 hit
PF00418 Tubulin-binding, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00229 TAU_MAP_1, 2 hits
PS51491 TAU_MAP_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P11137-1) [UniParc]FASTAAdd to basket
Also known as: MAP2b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADERKDEAK APHWTSAPLT EASAHSHPPE IKDQGGAGEG LVRSANGFPY
60 70 80 90 100
REDEEGAFGE HGSQGTYSNT KENGINGELT SADRETAEEV SARIVQVVTA
110 120 130 140 150
EAVAVLKGEQ EKEAQHKDQT AALPLAAEET ANLPPSPPPS PASEQTVTVE
160 170 180 190 200
EDLLTASKME FHDQQELTPS TAEPSDQKEK ESEKQSKPGE DLKHAALVSQ
210 220 230 240 250
PETTKTYPDK KDMQGTEEEK APLALFGHTL VASLEDMKQK TEPSLVVPGI
260 270 280 290 300
DLPKEPPTPK EQKDWFIEMP TEAKKDEWGL VAPISPGPLT PMREKDVFDD
310 320 330 340 350
IPKWEGKQFD SPMPSPFQGG SFTLPLDVMK NEIVTETSPF APAFLQPDDK
360 370 380 390 400
KSLQQTSGPA TAKDSFKIEE PHEAKPDKMA EAPPSEAMTL PKDAHIPVVE
410 420 430 440 450
EHVMGKVLEE EKEAINQETV QQRDTFTPSG QEPILTEKET ELKLEEKTTI
460 470 480 490 500
SDKEAVPKES KPPKPADEEI GIIQTSTEHT FSEQKDQEPT TDMLKQDSFP
510 520 530 540 550
VSLEQAVTDS AMTSKTLEKA MTEPSALIEK SSIQELFEMR VDDKDKIEGV
560 570 580 590 600
GAATSAELDM PFYEDKSGMS KYFETSALKE EATKSIEPGS DYYELSDTRE
610 620 630 640 650
SVHESIDTMS PMHKNGDKEF QTGKESQPSP PAQEAGYSTL AQSYPSDLPE
660 670 680 690 700
EPSSPQERMF TIDPKVYGEK RDLHSKNKDD LTLSRSLGLG GRSAIEQRSM
710 720 730 740 750
SINLPMSCLD SIALGFNFGR GHDLSPLASD ILTNTSGSMD EGDDYLPATT
760 770 780 790 800
PALEKAPCFP VESKEEEQIE KVKATGEEST QAEISCESPF LAKDFYKNGT
810 820 830 840 850
VMAPDLPEML DLAGTRSRLA SVSADAEVAR RKSVPSETVV EDSRTGLPPV
860 870 880 890 900
TDENHVIVKT DSQLEDLGYC VFNKYTVPLP SPVQDSENLS GESGTFYEGT
910 920 930 940 950
DDKVRRDLAT DLSLIEVKLA AAGRVKDEFS VDKEASAHIS GDKSGLSKEF
960 970 980 990 1000
DQEKKANDRL DTVLEKSEEH ADSKEHAKKT EEAGDEIETF GLGVTYEQAL
1010 1020 1030 1040 1050
AKDLSIPTDA SSEKAEKGLS SVPEIAEVEP SKKVEQGLDF AVQGQLDVKI
1060 1070 1080 1090 1100
SDFGQMASGL NIDDRRATEL KLEATQDMTP SSKAPQEADA FMGVESGHMK
1110 1120 1130 1140 1150
EGTKVSETEV KEKVAKPDLV HQEAVDKEES YESSGEHESL TMESLKADEG
1160 1170 1180 1190 1200
KKETSPESSL IQDEIAVKLS VEIPCPPAVS EADLATDERA DVQMEFIQGP
1210 1220 1230 1240 1250
KEESKETPDI SITPSDVAEP LHETIVSEPA EIQSEEEEIE AQGEYDKLLF
1260 1270 1280 1290 1300
RSDTLQITDL GVSGAREEFV ETCPSEHKGV IESVVTIEDD FITVVQTTTD
1310 1320 1330 1340 1350
EGESGSHSVR FAALEQPEVE RRPSPHDEEE FEVEEAAEAQ AEPKDGSPEA
1360 1370 1380 1390 1400
PASPEREEVA LSEYKTETYD DYKDETTIDD SIMDADSLWV DTQDDDRSIM
1410 1420 1430 1440 1450
TEQLETIPKE EKAEKEARRS SLEKHRKEKP FKTGRGRIST PERKVAKKEP
1460 1470 1480 1490 1500
STVSRDEVRR KKAVYKKAEL AKKTEVQAHS PSRKFILKPA IKYTRPTHLS
1510 1520 1530 1540 1550
CVKRKTTAAG GESALAPSVF KQAKDKVSDG VTKSPEKRSS LPRPSSILPP
1560 1570 1580 1590 1600
RRGVSGDRDE NSFSLNSSIS SSARRTTRSE PIRRAGKSGT STPTTPGSTA
1610 1620 1630 1640 1650
ITPGTPPSYS SRTPGTPGTP SYPRTPHTPG TPKSAILVPS EKKVAIIRTP
1660 1670 1680 1690 1700
PKSPATPKQL RLINQPLPDL KNVKSKIGST DNIKYQPKGG QVQIVTKKID
1710 1720 1730 1740 1750
LSHVTSKCGS LKNIRHRPGG GRVKIESVKL DFKEKAQAKV GSLDNAHHVP
1760 1770 1780 1790 1800
GGGNVKIDSQ KLNFREHAKA RVDHGAEIIT QSPGRSSVAS PRRLSNVSSS
1810 1820
GSINLLESPQ LATLAEDVTA ALAKQGL
Length:1,827
Mass (Da):199,526
Last modified:November 25, 2008 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2C4801C589086603
GO
Isoform 2 (identifier: P11137-2) [UniParc]FASTAAdd to basket
Also known as: MAP2c

The sequence of this isoform differs from the canonical sequence as follows:
     152-1507: Missing.

Show »
Length:471
Mass (Da):49,640
Checksum:iCE8BB23BCD16A159
GO
Isoform 3 (identifier: P11137-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     152-155: Missing.

Show »
Length:1,823
Mass (Da):199,084
Checksum:i7E474A0F3B691188
GO
Isoform 4 (identifier: P11137-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     152-229: DLLTASKMEF...KAPLALFGHT → AAGGESALAP...RLPYSKSGNK
     230-1528: Missing.
     1691-1691: Q → QVRILNKKIDFSKVQSRCGSKDNIKHSAGGGN

Note: No experimental confirmation available.
Show »
Length:559
Mass (Da):58,954
Checksum:i2A4E43681AE8C196
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EV03E7EV03_HUMAN
Microtubule-associated protein 2
MAP2
567Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8MZ31A8MZ31_HUMAN
Microtubule-associated protein 2
MAP2
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZB9H7BZB9_HUMAN
Microtubule-associated protein 2
MAP2
208Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti9A → G in AAB48098 (PubMed:8294038).Curated1
Sequence conflicti9A → G in AAB48097 (PubMed:8294038).Curated1
Sequence conflicti37A → R in AAA03354 (Ref. 1) Curated1
Sequence conflicti108G → A in AAA03354 (Ref. 1) Curated1
Sequence conflicti187K → S in AAA03354 (Ref. 1) Curated1
Sequence conflicti1112E → Q in AAA03354 (Ref. 1) Curated1
Sequence conflicti1112E → Q in AAB48098 (PubMed:8294038).Curated1
Sequence conflicti1112E → Q in AAA59552 (PubMed:15489334).Curated1
Sequence conflicti1655A → GL in AAB48098 (PubMed:8294038).Curated1
Sequence conflicti1655A → GL in AAB48097 (PubMed:8294038).Curated1
Sequence conflicti1715 – 1716RH → D in AAA03354 (Ref. 1) Curated2
Sequence conflicti1736A → V in AAA03354 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01961282A → G. Corresponds to variant dbSNP:rs2271251Ensembl.1
Natural variantiVAR_050019179E → G. Corresponds to variant dbSNP:rs6749066Ensembl.1
Natural variantiVAR_036014277E → D in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_019613423R → K. Corresponds to variant dbSNP:rs741006Ensembl.1
Natural variantiVAR_036015705P → L in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs146432517Ensembl.1
Natural variantiVAR_050020976H → L. Corresponds to variant dbSNP:rs13425372Ensembl.1
Natural variantiVAR_050021991G → R. Corresponds to variant dbSNP:rs35927101Ensembl.1
Natural variantiVAR_0500221099M → V. Corresponds to variant dbSNP:rs17745550Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_003197152 – 1507Missing in isoform 2. 2 PublicationsAdd BLAST1356
Alternative sequenceiVSP_043596152 – 229DLLTA…LFGHT → AAGGESALAPSVFKQAKDKV SNSTLSKIPALQGSTKSPRY SSACPSTTKRATFSDSLLIQ PTSAGSTDRLPYSKSGNK in isoform 4. 1 PublicationAdd BLAST78
Alternative sequenceiVSP_011302152 – 155Missing in isoform 3. 1 Publication4
Alternative sequenceiVSP_043597230 – 1528Missing in isoform 4. 1 PublicationAdd BLAST1299
Alternative sequenceiVSP_0435981691Q → QVRILNKKIDFSKVQSRCGS KDNIKHSAGGGN in isoform 4. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U01828 mRNA Translation: AAA03354.1
U89330 mRNA Translation: AAB48098.1
U89329 mRNA Translation: AAB48097.1
AC006385 Genomic DNA No translation available.
AC019106 Genomic DNA No translation available.
AC079833 Genomic DNA No translation available.
AC108072 Genomic DNA No translation available.
CH471063 Genomic DNA Translation: EAW70459.1
BC038857 mRNA Translation: AAH38857.1
BC110423 mRNA Translation: AAI10424.1
BC117123 mRNA Translation: AAI17124.1
BC143245 mRNA Translation: AAI43246.1
M25668 mRNA Translation: AAA59552.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2384.1 [P11137-1]
CCDS2385.1 [P11137-2]
CCDS33369.1 [P11137-4]
CCDS86916.1 [P11137-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
I53693 QRHUMT
I67793

NCBI Reference Sequences

More...
RefSeqi
NP_001034627.1, NM_001039538.1 [P11137-4]
NP_002365.3, NM_002374.3 [P11137-1]
NP_114033.2, NM_031845.2 [P11137-2]
NP_114035.2, NM_031847.2
XP_016859607.1, XM_017004118.1 [P11137-1]
XP_016859612.1, XM_017004123.1
XP_016859613.1, XM_017004124.1 [P11137-3]
XP_016859627.1, XM_017004138.1 [P11137-4]
XP_016859628.1, XM_017004139.1
XP_016859629.1, XM_017004140.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.368281

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000199940; ENSP00000199940; ENSG00000078018 [P11137-4]
ENST00000360351; ENSP00000353508; ENSG00000078018 [P11137-1]
ENST00000361559; ENSP00000355290; ENSG00000078018 [P11137-2]
ENST00000392194; ENSP00000376032; ENSG00000078018 [P11137-2]
ENST00000447185; ENSP00000392164; ENSG00000078018 [P11137-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4133

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4133

UCSC genome browser

More...
UCSCi
uc002vdd.2 human [P11137-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01828 mRNA Translation: AAA03354.1
U89330 mRNA Translation: AAB48098.1
U89329 mRNA Translation: AAB48097.1
AC006385 Genomic DNA No translation available.
AC019106 Genomic DNA No translation available.
AC079833 Genomic DNA No translation available.
AC108072 Genomic DNA No translation available.
CH471063 Genomic DNA Translation: EAW70459.1
BC038857 mRNA Translation: AAH38857.1
BC110423 mRNA Translation: AAI10424.1
BC117123 mRNA Translation: AAI17124.1
BC143245 mRNA Translation: AAI43246.1
M25668 mRNA Translation: AAA59552.1
CCDSiCCDS2384.1 [P11137-1]
CCDS2385.1 [P11137-2]
CCDS33369.1 [P11137-4]
CCDS86916.1 [P11137-3]
PIRiI53693 QRHUMT
I67793
RefSeqiNP_001034627.1, NM_001039538.1 [P11137-4]
NP_002365.3, NM_002374.3 [P11137-1]
NP_114033.2, NM_031845.2 [P11137-2]
NP_114035.2, NM_031847.2
XP_016859607.1, XM_017004118.1 [P11137-1]
XP_016859612.1, XM_017004123.1
XP_016859613.1, XM_017004124.1 [P11137-3]
XP_016859627.1, XM_017004138.1 [P11137-4]
XP_016859628.1, XM_017004139.1
XP_016859629.1, XM_017004140.1
UniGeneiHs.368281

3D structure databases

ProteinModelPortaliP11137
SMRiP11137
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110305, 48 interactors
DIPiDIP-577N
IntActiP11137, 9 interactors
MINTiP11137
STRINGi9606.ENSP00000353508

Chemistry databases

BindingDBiP11137
ChEMBLiCHEMBL2390810
DrugBankiDB01248 Docetaxel
DB01196 Estramustine
DB01229 Paclitaxel

PTM databases

iPTMnetiP11137
PhosphoSitePlusiP11137

Polymorphism and mutation databases

BioMutaiMAP2
DMDMi215274255

Proteomic databases

EPDiP11137
jPOSTiP11137
MaxQBiP11137
PaxDbiP11137
PeptideAtlasiP11137
PRIDEiP11137
ProteomicsDBi52694
52695 [P11137-2]
52696 [P11137-3]
52697 [P11137-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
4133
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000199940; ENSP00000199940; ENSG00000078018 [P11137-4]
ENST00000360351; ENSP00000353508; ENSG00000078018 [P11137-1]
ENST00000361559; ENSP00000355290; ENSG00000078018 [P11137-2]
ENST00000392194; ENSP00000376032; ENSG00000078018 [P11137-2]
ENST00000447185; ENSP00000392164; ENSG00000078018 [P11137-3]
GeneIDi4133
KEGGihsa:4133
UCSCiuc002vdd.2 human [P11137-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4133
DisGeNETi4133
EuPathDBiHostDB:ENSG00000078018.19

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MAP2
HGNCiHGNC:6839 MAP2
HPAiCAB001984
HPA008273
HPA012828
MIMi157130 gene
neXtProtiNX_P11137
OpenTargetsiENSG00000078018
PharmGKBiPA30583

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2418 Eukaryota
ENOG4111J07 LUCA
GeneTreeiENSGT00940000156597
HOGENOMiHOG000113477
HOVERGENiHBG000991
InParanoidiP11137
KOiK10430
OMAiKTETYDD
OrthoDBi716848at2759
PhylomeDBiP11137
TreeFamiTF316358

Enzyme and pathway databases

SIGNORiP11137

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MAP2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MAP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4133

Protein Ontology

More...
PROi
PR:P11137

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000078018 Expressed in 213 organ(s), highest expression level in dorsolateral prefrontal cortex
CleanExiHS_MAP2
ExpressionAtlasiP11137 baseline and differential
GenevisibleiP11137 HS

Family and domain databases

InterProiView protein in InterPro
IPR030797 MAP2
IPR013588 MAP2_projctn
IPR001084 MAP_tubulin-bd_rpt
PANTHERiPTHR11501:SF15 PTHR11501:SF15, 1 hit
PfamiView protein in Pfam
PF08377 MAP2_projctn, 1 hit
PF00418 Tubulin-binding, 3 hits
PROSITEiView protein in PROSITE
PS00229 TAU_MAP_1, 2 hits
PS51491 TAU_MAP_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMTAP2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P11137
Secondary accession number(s): Q17S04
, Q8IUX2, Q99975, Q99976
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 25, 2008
Last modified: January 16, 2019
This is version 187 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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