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UniProtKB - P11125 (P4_BPPH6)
Protein
Packaging enzyme P4
Gene
P4
Organism
Pseudomonas phage phi6 (Bacteriophage phi-6)
Status
Functioni
Packaging motor with helicase and translocase activities. Part of the packaging complex that packages the viral RNA segments, replicate them into a double-stranded form and transcribe them. is one of the structural proteins of the polyhedral procapsid, which is responsible for genomic replication and transcription. Displays single-stranded RNA-stimulated NTPase activity.
1 PublicationCatalytic activityi
- EC:3.6.1.15
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 126 – 133 | ATPBy similarity | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- nucleoside-triphosphatase activity Source: CACAO
GO - Biological processi
- viral genome packaging Source: InterPro
Keywordsi
Molecular function | Hydrolase |
Biological process | Transcription, Viral genome packaging, Viral release from host cell |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
SABIO-RKi | P11125 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:P4 |
Organismi | Pseudomonas phage phi6 (Bacteriophage phi-6) |
Taxonomic identifieri | 10879 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Duplornaviricota › Vidaverviricetes › Mindivirales › Cystoviridae › Cystovirus |
Virus hosti | Pseudomonas savastanoi pv. phaseolicola (Pseudomonas syringae pv. phaseolicola) [TaxID: 319] |
Proteomesi |
|
Subcellular locationi
- Virion Note: Capsid protein found in 72 copies. Prior to RNA packaging, localizes on the outer procapsid surface at the 12 potential RNA portal sites.
Keywords - Cellular componenti
Capsid protein, VirionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed; by host | |||
ChainiPRO_0000164639 | 2 – 332 | Packaging enzyme P4Add BLAST | 331 |
Interactioni
Subunit structurei
Homohexamer. Part of the packaging complex composed of RDRP, P4 and P7.
2 PublicationsStructurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P11125 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 111 – 138 | Involved in the regulation and mechanisms of transcription, replication and genome packagingBy similarityAdd BLAST | 28 | |
Regioni | 310 – 332 | DisorderedSequence analysisAdd BLAST | 23 |
Family and domain databases
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR020973, Packaging_enz_P4 |
Pfami | View protein in Pfam PF11602, NTPase_P4, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P11125-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPIVVTQAHI DRVGIAADLL DASPVSLQVL GRPTAINTVV IKTYIAAVME
60 70 80 90 100
LASKQGGSLA GVDIRPSVLL KDTAIFTKPK AKSADVESDV DVLDTGIYSV
110 120 130 140 150
PGLARKPVTH RWPSEGIYSG VTALMGATGS GKSITLNEKL RPDVLIRWGE
160 170 180 190 200
VAEAYDELDT AVHISTLDEM LIVCIGLGAL GFNVAVDSVR PLLFRLKGAA
210 220 230 240 250
SAGGIVAVFY SLLTDISNLF TQYDCSVVMV VNPMVDAEKI EYVFGQVMAS
260 270 280 290 300
TVGAILCADG NVSRTMFRTN KGRIFNGAAP LAADTHMPSM DRPTSMKALD
310 320 330
HTSIASVAPL ERGSVDTDDR NSAPRRGANF SL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M17461 Genomic RNA Translation: AAA32356.1 |
PIRi | C29885, P4BPF6 |
RefSeqi | NP_620347.1, NC_003715.1 |
Genome annotation databases
GeneIDi | 956437 |
KEGGi | vg:956437 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M17461 Genomic RNA Translation: AAA32356.1 |
PIRi | C29885, P4BPF6 |
RefSeqi | NP_620347.1, NC_003715.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4BLO | X-ray | 2.80 | A/B/C/D/E/F/G/H/I/J/K/L | 1-309 | [»] | |
5MUU | electron microscopy | 4.00 | C | 1-332 | [»] | |
5MUV | electron microscopy | 9.10 | A/B/I/J/K/L | 1-309 | [»] | |
5MUW | electron microscopy | 2.80 | A/B/I/J/K/L | 1-309 | [»] | |
6HY0 | electron microscopy | 3.50 | C | 1-332 | [»] | |
SMRi | P11125 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Genome annotation databases
GeneIDi | 956437 |
KEGGi | vg:956437 |
Enzyme and pathway databases
SABIO-RKi | P11125 |
Family and domain databases
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR020973, Packaging_enz_P4 |
Pfami | View protein in Pfam PF11602, NTPase_P4, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | P4_BPPH6 | |
Accessioni | P11125Primary (citable) accession number: P11125 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | January 23, 2007 | |
Last modified: | September 29, 2021 | |
This is version 85 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references