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UniProtKB - P11124 (RDRP_BPPH6)
Protein
RNA-directed RNA polymerase
Gene
P2
Organism
Pseudomonas phage phi6 (Bacteriophage phi-6)
Status
Functioni
Rna-dependent RNA polymerase part of the packaging complex that packages the viral RNA segments, replicate them into a double-stranded form and transcribe them.
Caution
Was originally thought to be a capsid protein.1 Publication
Catalytic activityi
- EC:2.7.7.48PROSITE-ProRule annotation
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 454 | Magnesium | 1 | |
Metal bindingi | 491 | Magnesium | 1 | |
Metal bindingi | 495 | Magnesium; via carbonyl oxygen | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- nucleotide binding Source: UniProtKB-KW
- RNA binding Source: InterPro
- RNA-directed 5'-3' RNA polymerase activity Source: CACAO
- RNA uridylyltransferase activity Source: CACAO
GO - Biological processi
- transcription, DNA-templated Source: InterPro
- viral RNA genome replication Source: InterPro
Keywordsi
Molecular function | Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase |
Biological process | Viral RNA replication |
Ligand | Magnesium, Manganese, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.7.48, 718 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:P2 |
Organismi | Pseudomonas phage phi6 (Bacteriophage phi-6) |
Taxonomic identifieri | 10879 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Duplornaviricota › Vidaverviricetes › Mindivirales › Cystoviridae › Cystovirus |
Virus hosti | Pseudomonas savastanoi pv. phaseolicola (Pseudomonas syringae pv. phaseolicola) [TaxID: 319] |
Proteomesi |
|
Subcellular locationi
- Virion Note: Found in the capsid (12 copies). Prior to RNA packaging, localizes on the inner procapsid surface near the three-fold axis of symmetry.
Keywords - Cellular componenti
VirionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed; by host | |||
ChainiPRO_0000164635 | 2 – 665 | RNA-directed RNA polymeraseAdd BLAST | 664 |
Interactioni
Subunit structurei
Part of the packaging complex composed of RDRP, P4 and P7.
Interacts with P7 (Probable).
1 PublicationStructurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P11124 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P11124 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 310 – 485 | RdRp catalyticPROSITE-ProRule annotationAdd BLAST | 176 |
Family and domain databases
Gene3Di | 1.10.490.60, 2 hits |
InterProi | View protein in InterPro IPR016406, Cystovir_RNA-dir_pol IPR043110, Cystovir_RNA-dir_pol_N IPR043502, DNA/RNA_pol_sf IPR001205, RNA-dir_pol_C IPR007096, RNA-dir_Rpol_phage_catalytic |
Pfami | View protein in Pfam PF00680, RdRP_1, 1 hit |
PIRSFi | PIRSF004131, RNA_pol_phage_P2, 1 hit |
SUPFAMi | SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS50522, RDRP_PHAGE, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P11124-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPRRAPAFPL SDIKAQMLFA NNIKAQQASK RSFKEGAIET YEGLLSVDPR
60 70 80 90 100
FLSFKNELSR YLTDHFPANV DEYGRVYGNG VRTNFFGMRH MNGFPMIPAT
110 120 130 140 150
WPLASNLKKR ADADLADGPV SERDNLLFRA AVRLMFSDLE PVPLKIRKGS
160 170 180 190 200
STCIPYFSND MGTKIEIAER ALEKAEEAGN LMLQGKFDDA YQLHQMGGAY
210 220 230 240 250
YVVYRAQSTD AITLDPKTGK FVSKDRMVAD FEYAVTGGEQ GSLFAASKDA
260 270 280 290 300
SRLKEQYGID VPDGFFCERR RTAMGGPFAL NAPIMAVAQP VRNKIYSKYA
310 320 330 340 350
YTFHHTTRLN KEEKVKEWSL CVATDVSDHD TFWPGWLRDL ICDELLNMGY
360 370 380 390 400
APWWVKLFET SLKLPVYVGA PAPEQGHTLL GDPSNPDLEV GLSSGQGATD
410 420 430 440 450
LMGTLLMSIT YLVMQLDHTA PHLNSRIKDM PSACRFLDSY WQGHEEIRQI
460 470 480 490 500
SKSDDAILGW TKGRALVGGH RLFEMLKEGK VNPSPYMKIS YEHGGAFLGD
510 520 530 540 550
ILLYDSRREP GSAIFVGNIN SMLNNQFSPE YGVQSGVRDR SKRKRPFPGL
560 570 580 590 600
AWASMKDTYG ACPIYSDVLE AIERCWWNAF GESYRAYRED MLKRDTLELS
610 620 630 640 650
RYVASMARQA GLAELTPIDL EVLADPNKLQ YKWTEADVSA NIHEVLMHGV
660
SVEKTERFLR SVMPR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M17461 Genomic RNA Translation: AAA32355.1 |
PIRi | B29885, P2BPF6 |
RefSeqi | NP_620346.1, NC_003715.1 |
Genome annotation databases
GeneIDi | 956436 |
KEGGi | vg:956436 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M17461 Genomic RNA Translation: AAA32355.1 |
PIRi | B29885, P2BPF6 |
RefSeqi | NP_620346.1, NC_003715.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1HHS | X-ray | 2.00 | A/B/C | 2-665 | [»] | |
1HHT | X-ray | 2.90 | P/Q/R | 2-665 | [»] | |
1HI0 | X-ray | 3.00 | P/Q/R | 2-665 | [»] | |
1HI1 | X-ray | 3.00 | A/B/C | 2-665 | [»] | |
1HI8 | X-ray | 2.50 | A/B | 2-665 | [»] | |
1UVI | X-ray | 2.15 | A/B/C | 2-665 | [»] | |
1UVJ | X-ray | 1.90 | A/B/C | 2-665 | [»] | |
1UVK | X-ray | 2.45 | A/C/E | 2-665 | [»] | |
1UVL | X-ray | 2.00 | A/C/E | 2-665 | [»] | |
1UVM | X-ray | 2.00 | A/B/C | 2-665 | [»] | |
1UVN | X-ray | 3.00 | A/C/E | 2-665 | [»] | |
1WAC | X-ray | 3.00 | A/B/C | 2-665 | [»] | |
2JL9 | X-ray | 3.20 | A/B/C | 1-665 | [»] | |
2JLF | X-ray | 3.20 | A/B/C | 2-665 | [»] | |
2JLG | X-ray | 2.80 | A/B/C | 2-665 | [»] | |
4A8F | X-ray | 3.30 | A/B/C | 1-665 | [»] | |
4A8K | X-ray | 3.50 | A/B/C | 1-665 | [»] | |
4A8M | X-ray | 2.92 | P/Q/R | 1-665 | [»] | |
4A8O | X-ray | 2.67 | A/B/C | 1-665 | [»] | |
4A8Q | X-ray | 3.06 | A/B/C | 1-665 | [»] | |
4A8S | X-ray | 2.90 | A/B/C | 1-665 | [»] | |
4A8W | X-ray | 3.04 | A/B/C | 1-665 | [»] | |
4A8Y | X-ray | 3.41 | A/B/C | 1-665 | [»] | |
4B02 | X-ray | 3.30 | A/B/C | 2-665 | [»] | |
5FJ6 | electron microscopy | 7.90 | A | 2-665 | [»] | |
5FJ7 | electron microscopy | 7.90 | C | 2-665 | [»] | |
SMRi | P11124 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Chemistry databases
DrugBanki | DB04137, Guanosine-5'-Triphosphate |
Genome annotation databases
GeneIDi | 956436 |
KEGGi | vg:956436 |
Enzyme and pathway databases
BRENDAi | 2.7.7.48, 718 |
Miscellaneous databases
EvolutionaryTracei | P11124 |
Family and domain databases
Gene3Di | 1.10.490.60, 2 hits |
InterProi | View protein in InterPro IPR016406, Cystovir_RNA-dir_pol IPR043110, Cystovir_RNA-dir_pol_N IPR043502, DNA/RNA_pol_sf IPR001205, RNA-dir_pol_C IPR007096, RNA-dir_Rpol_phage_catalytic |
Pfami | View protein in Pfam PF00680, RdRP_1, 1 hit |
PIRSFi | PIRSF004131, RNA_pol_phage_P2, 1 hit |
SUPFAMi | SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS50522, RDRP_PHAGE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RDRP_BPPH6 | |
Accessioni | P11124Primary (citable) accession number: P11124 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | January 23, 2007 | |
Last modified: | September 29, 2021 | |
This is version 109 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references