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Protein

Filaggrin

Gene

Flg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis.

GO - Molecular functioni

  • keratin filament binding Source: MGI
  • structural constituent of epidermis Source: MGI

GO - Biological processi

  • epidermis development Source: MGI
  • establishment of skin barrier Source: MGI
  • intermediate filament organization Source: MGI

Keywordsi

Molecular functionDevelopmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Filaggrin
Gene namesi
Name:Flg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:95553 Flg

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000144037‹1 – 336FilaggrinAdd BLAST›336

Post-translational modificationi

Filaggrin is initially synthesized as a large, insoluble, highly phosphorylated precursor containing many tandem copies of 248 AA, which are not separated by large linker sequences. During terminal differentiation it is dephosphorylated and proteolytically cleaved.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP11088
PaxDbiP11088
PRIDEiP11088

PTM databases

PhosphoSitePlusiP11088

Expressioni

Tissue specificityi

Expressed in the granular layer of the epidermis.2 Publications

Gene expression databases

CleanExiMM_FLG

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054773

Family & Domainsi

Sequence similaritiesi

Belongs to the S100-fused protein family.Curated

Phylogenomic databases

eggNOGiENOG410IX7U Eukaryota
ENOG410ZH9F LUCA
InParanoidiP11088

Family and domain databases

InterProiView protein in InterPro
IPR003303 Filaggrin
PfamiView protein in Pfam
PF03516 Filaggrin, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

P11088-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
PDGSGRSSNR RDRPRQLSPS QSSDSQVHSG VQVEGRRGHS SSANRRAGSS
60 70 80 90 100
SGSGVQGASA GGLAADASRR SGARQGQASA QGRAGSQGQA QGRVSSSADR
110 120 130 140 150
QGRRGVSESR ASDSEGHSDF SEGQAVGAHR QSGAGQRHEQ RSSRGQHGSG
160 170 180 190 200
YYYEQEHSEE ESDSQHQHGH QHEQQRGHQH QHQHQHEHEQ PESGHRQQQS
210 220 230 240 250
SGRGHQGAHQ EQGRDSARPR GSNQGHSSSR HQADSPRVSA RSGSGGRGQS
260 270 280 290 300
PDASGRSSNR RDRPRQPSPS QSSDSQVHSG VQVEAQRGQS SSANRRAGSS
310 320 330
SGSGVQGAAA SGQGGYESIF TAKHLDFNQS HSYYYY
Length:336
Mass (Da):35,678
Last modified:July 1, 1989 - v1
Checksum:i259F124D3AC0DB2D
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A6YXI5A0A0A6YXI5_MOUSE
Filaggrin
Flg mCG_146973
357Annotation score:
A0A0A6YWE2A0A0A6YWE2_MOUSE
Filaggrin
Flg
255Annotation score:
A0A0A6YX57A0A0A6YX57_MOUSE
Filaggrin
Flg
256Annotation score:
A0A0A6YXH0A0A0A6YXH0_MOUSE
Filaggrin
Flg
256Annotation score:
A0A0A6YVU7A0A0A6YVU7_MOUSE
Filaggrin
Flg
252Annotation score:
A0A0A6YW46A0A0A6YW46_MOUSE
Filaggrin
Flg
259Annotation score:
A0A0A6YXG4A0A0A6YXG4_MOUSE
Filaggrin
Flg
256Annotation score:
A0A0A6YY62A0A0A6YY62_MOUSE
Filaggrin
Flg
336Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03458 mRNA Translation: AAA75559.1
PIRiA28444
UniGeneiMm.162684
Mm.439710

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03458 mRNA Translation: AAA75559.1
PIRiA28444
UniGeneiMm.162684
Mm.439710

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054773

PTM databases

PhosphoSitePlusiP11088

Proteomic databases

MaxQBiP11088
PaxDbiP11088
PRIDEiP11088

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:95553 Flg

Phylogenomic databases

eggNOGiENOG410IX7U Eukaryota
ENOG410ZH9F LUCA
InParanoidiP11088

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

CleanExiMM_FLG

Family and domain databases

InterProiView protein in InterPro
IPR003303 Filaggrin
PfamiView protein in Pfam
PF03516 Filaggrin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFILA_MOUSE
AccessioniPrimary (citable) accession number: P11088
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: May 10, 2017
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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