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Entry version 192 (29 Sep 2021)
Sequence version 1 (01 Jul 1989)
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Protein

Phenylethanolamine N-methyltransferase

Gene

PNMT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Converts noradrenaline to adrenaline.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=99 µM for phenylethanolamine1 Publication
  2. KM=3.4 µM for S-adenosyl-L-methionine1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: (R)-adrenaline biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (R)-adrenaline from (R)-noradrenaline. This subpathway is part of the pathway (R)-adrenaline biosynthesis, which is itself part of Catecholamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-adrenaline from (R)-noradrenaline, the pathway (R)-adrenaline biosynthesis and in Catecholamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei35S-adenosyl-L-methionine1
Binding sitei40S-adenosyl-L-methionine1
Binding sitei85S-adenosyl-L-methionine1
Binding sitei101S-adenosyl-L-methionine1
Binding sitei106S-adenosyl-L-methionine1
Binding sitei181S-adenosyl-L-methionine; via carbonyl oxygen1
Binding sitei219Substrate1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processCatecholamine biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS06868-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.1.1.28, 2681

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P11086

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-209905, Catecholamine biosynthesis

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P11086

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00749;UER00736

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phenylethanolamine N-methyltransferase (EC:2.1.1.28)
Short name:
PNMTase
Alternative name(s):
Noradrenaline N-methyltransferase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PNMT
Synonyms:PENT
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9160, PNMT

Online Mendelian Inheritance in Man (OMIM)

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MIMi
171190, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P11086

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000141744

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi35Y → F: Strongly increases KM for substrate and S-adenosyl-L-methionine. 1 Publication1
Mutagenesisi185E → A or Q: Strongly reduced enzyme activity. Increases affinity for S-adenosyl-L-methionine. 1 Publication1
Mutagenesisi185E → D: Strongly reduced enzyme activity. Decreases affinity for substrate and S-adenosyl-L-methionine 3-fold. 1 Publication1
Mutagenesisi219E → A: Reduced enzyme activity. Decreases affinity for substrate 6-fold. Decreases affinity for S-adenosyl-L-methionine 2-fold. 1 Publication1
Mutagenesisi267D → A or N: Strongly reduced enzyme activity. Decreases affinity for substrate 200-fold. Decreases affinity for S-adenosyl-L-methionine 3-fold. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
5409

Open Targets

More...
OpenTargetsi
ENSG00000141744

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
243761, NON RARE IN EUROPE: Essential hypertension

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA274

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P11086, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4617

Drug and drug target database

More...
DrugBanki
DB08129, (1R)-2-amino-1-[3-(trifluoromethyl)phenyl]ethanol
DB08128, (1S,4R,9S)-5-(trifluoromethyl)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-9-amine
DB07739, (3R)-3-(FLUOROMETHYL)-7-(THIOMORPHOLIN-4-YLSULFONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE
DB07798, (3R)-3-(FLUOROMETHYL)-N-(3,3,3-TRIFLUOROPROPYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDE
DB07747, (3R)-N-(4-CHLOROPHENYL)-3-(HYDROXYMETHYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDE
DB03468, 1,2,3,4-Tetrahydro-Isoquinoline-7-Sulfonic Acid Amide
DB08550, 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline
DB03824, 7-Iodo-1,2,3,4-Tetrahydro-Isoquinoline
DB04273, 8,9-Dichloro-2,3,4,5-Tetrahydro-1h-Benzo[C]Azepine
DB07906, [(3R)-7-NITRO-1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL]METHANOL
DB07597, CIS-(1R,2S)-2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALEN-1-OL
DB09571, Levmetamfetamine
DB08631, N-(4-CHLOROPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDE
DB01752, S-adenosyl-L-homocysteine
DB08654, TRANS-(1S,2S)-2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALEN-1-OL

DrugCentral

More...
DrugCentrali
P11086

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2496

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
PNMT

Domain mapping of disease mutations (DMDM)

More...
DMDMi
130375

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001597091 – 282Phenylethanolamine N-methyltransferaseAdd BLAST282

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei7PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
CPTAC-150
CPTAC-151

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P11086

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P11086

PeptideAtlas

More...
PeptideAtlasi
P11086

PRoteomics IDEntifications database

More...
PRIDEi
P11086

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
52692

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P11086

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P11086

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000141744, Expressed in adrenal gland and 172 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P11086, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P11086, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000141744, Group enriched (adrenal gland, ductus deferens, seminal vesicle)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
111410, 12 interactors

Protein interaction database and analysis system

More...
IntActi
P11086, 5 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000269582

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P11086

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P11086, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1282
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

The Protein Circular Dichroism Data Bank

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PCDDBi
P11086

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P11086

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P11086

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni79 – 80S-adenosyl-L-methionine binding2
Regioni158 – 159S-adenosyl-L-methionine binding2

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QT44, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000011708

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_082526_2_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P11086

Identification of Orthologs from Complete Genome Data

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OMAi
TFCLEAV

Database of Orthologous Groups

More...
OrthoDBi
1054662at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P11086

TreeFam database of animal gene trees

More...
TreeFami
TF313114

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025820, NNMT/PNMT/TEMT_CS
IPR000940, NNMT_TEMT_trans
IPR029063, SAM-dependent_MTases

The PANTHER Classification System

More...
PANTHERi
PTHR10867, PTHR10867, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01234, NNMT_PNMT_TEMT, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000384, PNMTase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53335, SSF53335, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01100, NNMT_PNMT_TEMT, 1 hit
PS51681, SAM_MT_NNMT_PNMT_TEMT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P11086-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGADRSPNA GAAPDSAPGQ AAVASAYQRF EPRAYLRNNY APPRGDLCNP
60 70 80 90 100
NGVGPWKLRC LAQTFATGEV SGRTLIDIGS GPTVYQLLSA CSHFEDITMT
110 120 130 140 150
DFLEVNRQEL GRWLQEEPGA FNWSMYSQHA CLIEGKGECW QDKERQLRAR
160 170 180 190 200
VKRVLPIDVH QPQPLGAGSP APLPADALVS AFCLEAVSPD LASFQRALDH
210 220 230 240 250
ITTLLRPGGH LLLIGALEES WYLAGEARLT VVPVSEEEVR EALVRSGYKV
260 270 280
RDLRTYIMPA HLQTGVDDVK GVFFAWAQKV GL
Length:282
Mass (Da):30,855
Last modified:July 1, 1989 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i56F3A9981D9ABF4C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MT87A8MT87_HUMAN
Phenylethanolamine N-methyltransfer...
PNMT
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QRI3J3QRI3_HUMAN
Phenylethanolamine N-methyltransfer...
PNMT
137Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti169 – 170SP → AQ in AAA60131 (PubMed:2835776).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0293519N → S1 PublicationCorresponds to variant dbSNP:rs11569781Ensembl.1
Natural variantiVAR_03682998T → A Lower activity levels than wild-type. 1 PublicationCorresponds to variant dbSNP:rs36060376Ensembl.1
Natural variantiVAR_036830112R → C1 PublicationCorresponds to variant dbSNP:rs34530498Ensembl.1
Natural variantiVAR_036831175A → T1 PublicationCorresponds to variant dbSNP:rs34341496EnsemblClinVar.1
Natural variantiVAR_037611188S → C. Corresponds to variant dbSNP:rs5639Ensembl.1
Natural variantiVAR_037612211L → H. Corresponds to variant dbSNP:rs5640Ensembl.1
Natural variantiVAR_037613217L → Q. Corresponds to variant dbSNP:rs5641Ensembl.1
Natural variantiVAR_037614254R → H. Corresponds to variant dbSNP:rs5642Ensembl.1
Natural variantiVAR_024547276W → R. Corresponds to variant dbSNP:rs5643Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J03727 mRNA Translation: AAA60130.1
X52730 Genomic DNA Translation: CAA36944.1
J03280 Genomic DNA Translation: AAA60131.1
BC037246 mRNA Translation: AAH37246.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11343.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A28171

NCBI Reference Sequences

More...
RefSeqi
NP_002677.1, NM_002686.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000269582; ENSP00000269582; ENSG00000141744

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5409

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5409

UCSC genome browser

More...
UCSCi
uc002hsi.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03727 mRNA Translation: AAA60130.1
X52730 Genomic DNA Translation: CAA36944.1
J03280 Genomic DNA Translation: AAA60131.1
BC037246 mRNA Translation: AAH37246.1
CCDSiCCDS11343.1
PIRiA28171
RefSeqiNP_002677.1, NM_002686.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HNNX-ray2.40A/B1-282[»]
1N7IX-ray2.80A/B1-282[»]
1N7JX-ray2.70A/B1-282[»]
1YZ3X-ray2.40A/B1-282[»]
2AN3X-ray2.20A/B1-282[»]
2AN4X-ray2.20A/B1-282[»]
2AN5X-ray2.50A/B1-282[»]
2G70X-ray2.40A/B1-282[»]
2G71X-ray2.20A/B1-282[»]
2G72X-ray2.00A/B1-282[»]
2G8NX-ray2.15A/B1-282[»]
2OBFX-ray2.30A/B1-282[»]
2ONYX-ray2.60A/B1-282[»]
2ONZX-ray2.80A/B1-282[»]
2OPBX-ray2.80A/B1-282[»]
3HCAX-ray2.40A/B1-282[»]
3HCBX-ray2.40A/B1-282[»]
3HCCX-ray2.30A/B1-282[»]
3HCDX-ray2.39A/B1-282[»]
3HCEX-ray2.85A/B1-282[»]
3HCFX-ray2.70A/B1-282[»]
3KPJX-ray2.50A/B1-282[»]
3KPUX-ray2.40A/B1-282[»]
3KPVX-ray2.40A/B1-282[»]
3KPWX-ray2.40A/B1-282[»]
3KPYX-ray2.40A/B1-282[»]
3KQMX-ray2.40A/B1-282[»]
3KQOX-ray2.40A/B1-282[»]
3KQPX-ray2.40A/B1-282[»]
3KQQX-ray2.50A/B1-282[»]
3KQSX-ray2.00A/B1-282[»]
3KQTX-ray2.40A/B1-282[»]
3KQVX-ray2.30A/B1-282[»]
3KQWX-ray2.49A/B1-282[»]
3KQYX-ray2.20A/B1-282[»]
3KR0X-ray2.60A/B1-282[»]
3KR1X-ray2.30A/B1-282[»]
3KR2X-ray2.30A/B1-282[»]
4DM3X-ray2.40A/B1-282[»]
4MIKX-ray1.95A/B1-282[»]
4MQ4X-ray2.20A/B1-282[»]
6WS1X-ray2.76A/B1-282[»]
PCDDBiP11086
SMRiP11086
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111410, 12 interactors
IntActiP11086, 5 interactors
STRINGi9606.ENSP00000269582

Chemistry databases

BindingDBiP11086
ChEMBLiCHEMBL4617
DrugBankiDB08129, (1R)-2-amino-1-[3-(trifluoromethyl)phenyl]ethanol
DB08128, (1S,4R,9S)-5-(trifluoromethyl)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-9-amine
DB07739, (3R)-3-(FLUOROMETHYL)-7-(THIOMORPHOLIN-4-YLSULFONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE
DB07798, (3R)-3-(FLUOROMETHYL)-N-(3,3,3-TRIFLUOROPROPYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDE
DB07747, (3R)-N-(4-CHLOROPHENYL)-3-(HYDROXYMETHYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDE
DB03468, 1,2,3,4-Tetrahydro-Isoquinoline-7-Sulfonic Acid Amide
DB08550, 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline
DB03824, 7-Iodo-1,2,3,4-Tetrahydro-Isoquinoline
DB04273, 8,9-Dichloro-2,3,4,5-Tetrahydro-1h-Benzo[C]Azepine
DB07906, [(3R)-7-NITRO-1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL]METHANOL
DB07597, CIS-(1R,2S)-2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALEN-1-OL
DB09571, Levmetamfetamine
DB08631, N-(4-CHLOROPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDE
DB01752, S-adenosyl-L-homocysteine
DB08654, TRANS-(1S,2S)-2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALEN-1-OL
DrugCentraliP11086
GuidetoPHARMACOLOGYi2496

PTM databases

iPTMnetiP11086
PhosphoSitePlusiP11086

Genetic variation databases

BioMutaiPNMT
DMDMi130375

Proteomic databases

CPTACiCPTAC-150
CPTAC-151
MassIVEiP11086
PaxDbiP11086
PeptideAtlasiP11086
PRIDEiP11086
ProteomicsDBi52692

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
28325, 497 antibodies

The CPTC Antibody Portal

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CPTCi
P11086, 3 antibodies

The DNASU plasmid repository

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DNASUi
5409

Genome annotation databases

EnsembliENST00000269582; ENSP00000269582; ENSG00000141744
GeneIDi5409
KEGGihsa:5409
UCSCiuc002hsi.3, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
5409
DisGeNETi5409

GeneCards: human genes, protein and diseases

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GeneCardsi
PNMT
HGNCiHGNC:9160, PNMT
HPAiENSG00000141744, Group enriched (adrenal gland, ductus deferens, seminal vesicle)
MIMi171190, gene
neXtProtiNX_P11086
OpenTargetsiENSG00000141744
Orphaneti243761, NON RARE IN EUROPE: Essential hypertension
PharmGKBiPA274
VEuPathDBiHostDB:ENSG00000141744

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG502QT44, Eukaryota
GeneTreeiENSGT00390000011708
HOGENOMiCLU_082526_2_0_1
InParanoidiP11086
OMAiTFCLEAV
OrthoDBi1054662at2759
PhylomeDBiP11086
TreeFamiTF313114

Enzyme and pathway databases

UniPathwayiUPA00749;UER00736
BioCyciMetaCyc:HS06868-MONOMER
BRENDAi2.1.1.28, 2681
PathwayCommonsiP11086
ReactomeiR-HSA-209905, Catecholamine biosynthesis
SIGNORiP11086

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
5409, 10 hits in 1014 CRISPR screens
EvolutionaryTraceiP11086

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
5409
PharosiP11086, Tchem

Protein Ontology

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PROi
PR:P11086
RNActiP11086, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000141744, Expressed in adrenal gland and 172 other tissues
ExpressionAtlasiP11086, baseline and differential
GenevisibleiP11086, HS

Family and domain databases

InterProiView protein in InterPro
IPR025820, NNMT/PNMT/TEMT_CS
IPR000940, NNMT_TEMT_trans
IPR029063, SAM-dependent_MTases
PANTHERiPTHR10867, PTHR10867, 1 hit
PfamiView protein in Pfam
PF01234, NNMT_PNMT_TEMT, 1 hit
PIRSFiPIRSF000384, PNMTase, 1 hit
SUPFAMiSSF53335, SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS01100, NNMT_PNMT_TEMT, 1 hit
PS51681, SAM_MT_NNMT_PNMT_TEMT, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPNMT_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P11086
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: September 29, 2021
This is version 192 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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