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Entry version 181 (16 Oct 2019)
Sequence version 1 (01 Jul 1989)
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Protein

Phenylethanolamine N-methyltransferase

Gene

PNMT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Converts noradrenaline to adrenaline.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=99 µM for phenylethanolamine1 Publication
  2. KM=3.4 µM for S-adenosyl-L-methionine1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: (R)-adrenaline biosynthesis

    This protein is involved in step 1 of the subpathway that synthesizes (R)-adrenaline from (R)-noradrenaline.
    Proteins known to be involved in this subpathway in this organism are:
    1. Phenylethanolamine N-methyltransferase (PNMT)
    This subpathway is part of the pathway (R)-adrenaline biosynthesis, which is itself part of Catecholamine biosynthesis.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-adrenaline from (R)-noradrenaline, the pathway (R)-adrenaline biosynthesis and in Catecholamine biosynthesis.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei35S-adenosyl-L-methionine1
    Binding sitei40S-adenosyl-L-methionine1
    Binding sitei85S-adenosyl-L-methionine1
    Binding sitei101S-adenosyl-L-methionine1
    Binding sitei106S-adenosyl-L-methionine1
    Binding sitei181S-adenosyl-L-methionine; via carbonyl oxygen1
    Binding sitei219Substrate1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionMethyltransferase, Transferase
    Biological processCatecholamine biosynthesis
    LigandS-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:HS06868-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    2.1.1.28 2681

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-209905 Catecholamine biosynthesis

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00749;UER00736

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Phenylethanolamine N-methyltransferase (EC:2.1.1.28)
    Short name:
    PNMTase
    Alternative name(s):
    Noradrenaline N-methyltransferase
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:PNMT
    Synonyms:PENT
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:9160 PNMT

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    171190 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_P11086

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi35Y → F: Strongly increases KM for substrate and S-adenosyl-L-methionine. 1 Publication1
    Mutagenesisi185E → A or Q: Strongly reduced enzyme activity. Increases affinity for S-adenosyl-L-methionine. 1 Publication1
    Mutagenesisi185E → D: Strongly reduced enzyme activity. Decreases affinity for substrate and S-adenosyl-L-methionine 3-fold. 1 Publication1
    Mutagenesisi219E → A: Reduced enzyme activity. Decreases affinity for substrate 6-fold. Decreases affinity for S-adenosyl-L-methionine 2-fold. 1 Publication1
    Mutagenesisi267D → A or N: Strongly reduced enzyme activity. Decreases affinity for substrate 200-fold. Decreases affinity for S-adenosyl-L-methionine 3-fold. 1 Publication1

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    5409

    Open Targets

    More...
    OpenTargetsi
    ENSG00000141744

    Orphanet; a database dedicated to information on rare diseases and orphan drugs

    More...
    Orphaneti
    243761 NON RARE IN EUROPE: Essential hypertension

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA274

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    P11086

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL4617

    Drug and drug target database

    More...
    DrugBanki
    DB08129 (1R)-2-amino-1-[3-(trifluoromethyl)phenyl]ethanol
    DB08128 (1S,4R,9S)-5-(trifluoromethyl)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-9-amine
    DB07739 (3R)-3-(FLUOROMETHYL)-7-(THIOMORPHOLIN-4-YLSULFONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE
    DB07798 (3R)-3-(FLUOROMETHYL)-N-(3,3,3-TRIFLUOROPROPYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDE
    DB07747 (3R)-N-(4-CHLOROPHENYL)-3-(HYDROXYMETHYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDE
    DB03468 1,2,3,4-Tetrahydro-Isoquinoline-7-Sulfonic Acid Amide
    DB08550 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline
    DB03824 7-Iodo-1,2,3,4-Tetrahydro-Isoquinoline
    DB04273 8,9-Dichloro-2,3,4,5-Tetrahydro-1h-Benzo[C]Azepine
    DB07906 [(3R)-7-NITRO-1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL]METHANOL
    DB07597 CIS-(1R,2S)-2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALEN-1-OL
    DB08631 N-(4-CHLOROPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDE
    DB01752 S-adenosyl-L-homocysteine
    DB08654 TRANS-(1S,2S)-2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALEN-1-OL

    DrugCentral

    More...
    DrugCentrali
    P11086

    IUPHAR/BPS Guide to PHARMACOLOGY

    More...
    GuidetoPHARMACOLOGYi
    2496

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    PNMT

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    130375

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001597091 – 282Phenylethanolamine N-methyltransferaseAdd BLAST282

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei7PhosphoserineCombined sources1

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    The CPTAC Assay portal

    More...
    CPTACi
    CPTAC-150
    CPTAC-151

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    P11086

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    P11086

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P11086

    PeptideAtlas

    More...
    PeptideAtlasi
    P11086

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P11086

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    52692

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    P11086

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    P11086

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000141744 Expressed in 153 organ(s), highest expression level in right adrenal gland

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    P11086 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    P11086 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    CAB017029
    HPA043412
    HPA051005

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    111410, 10 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    P11086, 5 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000269582

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    P11086

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1282
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P11086

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    P11086

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni79 – 80S-adenosyl-L-methionine binding2
    Regioni158 – 159S-adenosyl-L-methionine binding2

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    ENOG410IJGY Eukaryota
    ENOG4111F9R LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00390000011708

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000013229

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P11086

    KEGG Orthology (KO)

    More...
    KOi
    K00553

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    AFDWSVY

    Database of Orthologous Groups

    More...
    OrthoDBi
    1318335at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P11086

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF313114

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR025820 NNMT/PNMT/TEMT_CS
    IPR000940 NNMT_TEMT_trans
    IPR029063 SAM-dependent_MTases

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR10867 PTHR10867, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01234 NNMT_PNMT_TEMT, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF000384 PNMTase, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF53335 SSF53335, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS01100 NNMT_PNMT_TEMT, 1 hit
    PS51681 SAM_MT_NNMT_PNMT_TEMT, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

    P11086-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MSGADRSPNA GAAPDSAPGQ AAVASAYQRF EPRAYLRNNY APPRGDLCNP
    60 70 80 90 100
    NGVGPWKLRC LAQTFATGEV SGRTLIDIGS GPTVYQLLSA CSHFEDITMT
    110 120 130 140 150
    DFLEVNRQEL GRWLQEEPGA FNWSMYSQHA CLIEGKGECW QDKERQLRAR
    160 170 180 190 200
    VKRVLPIDVH QPQPLGAGSP APLPADALVS AFCLEAVSPD LASFQRALDH
    210 220 230 240 250
    ITTLLRPGGH LLLIGALEES WYLAGEARLT VVPVSEEEVR EALVRSGYKV
    260 270 280
    RDLRTYIMPA HLQTGVDDVK GVFFAWAQKV GL
    Length:282
    Mass (Da):30,855
    Last modified:July 1, 1989 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i56F3A9981D9ABF4C
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A8MT87A8MT87_HUMAN
    Phenylethanolamine N-methyltransfer...
    PNMT
    184Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    J3QRI3J3QRI3_HUMAN
    Phenylethanolamine N-methyltransfer...
    PNMT
    137Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti169 – 170SP → AQ in AAA60131 (PubMed:2835776).Curated2

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0293519N → S1 PublicationCorresponds to variant dbSNP:rs11569781Ensembl.1
    Natural variantiVAR_03682998T → A Lower activity levels than wild-type. 1 PublicationCorresponds to variant dbSNP:rs36060376Ensembl.1
    Natural variantiVAR_036830112R → C1 PublicationCorresponds to variant dbSNP:rs34530498Ensembl.1
    Natural variantiVAR_036831175A → T1 PublicationCorresponds to variant dbSNP:rs34341496Ensembl.1
    Natural variantiVAR_037611188S → C. Corresponds to variant dbSNP:rs5639Ensembl.1
    Natural variantiVAR_037612211L → H. Corresponds to variant dbSNP:rs5640Ensembl.1
    Natural variantiVAR_037613217L → Q. Corresponds to variant dbSNP:rs5641Ensembl.1
    Natural variantiVAR_037614254R → H. Corresponds to variant dbSNP:rs5642Ensembl.1
    Natural variantiVAR_024547276W → R. Corresponds to variant dbSNP:rs5643Ensembl.1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    J03727 mRNA Translation: AAA60130.1
    X52730 Genomic DNA Translation: CAA36944.1
    J03280 Genomic DNA Translation: AAA60131.1
    BC037246 mRNA Translation: AAH37246.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS11343.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    A28171

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_002677.1, NM_002686.4

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000269582; ENSP00000269582; ENSG00000141744

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    5409

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:5409

    UCSC genome browser

    More...
    UCSCi
    uc002hsi.3 human

    Keywords - Coding sequence diversityi

    Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    J03727 mRNA Translation: AAA60130.1
    X52730 Genomic DNA Translation: CAA36944.1
    J03280 Genomic DNA Translation: AAA60131.1
    BC037246 mRNA Translation: AAH37246.1
    CCDSiCCDS11343.1
    PIRiA28171
    RefSeqiNP_002677.1, NM_002686.4

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1HNNX-ray2.40A/B1-282[»]
    1N7IX-ray2.80A/B1-282[»]
    1N7JX-ray2.70A/B1-282[»]
    1YZ3X-ray2.40A/B1-282[»]
    2AN3X-ray2.20A/B1-282[»]
    2AN4X-ray2.20A/B1-282[»]
    2AN5X-ray2.50A/B1-282[»]
    2G70X-ray2.40A/B1-282[»]
    2G71X-ray2.20A/B1-282[»]
    2G72X-ray2.00A/B1-282[»]
    2G8NX-ray2.15A/B1-282[»]
    2OBFX-ray2.30A/B1-282[»]
    2ONYX-ray2.60A/B1-282[»]
    2ONZX-ray2.80A/B1-282[»]
    2OPBX-ray2.80A/B1-282[»]
    3HCAX-ray2.40A/B1-282[»]
    3HCBX-ray2.40A/B1-282[»]
    3HCCX-ray2.30A/B1-282[»]
    3HCDX-ray2.39A/B1-282[»]
    3HCEX-ray2.85A/B1-282[»]
    3HCFX-ray2.70A/B1-282[»]
    3KPJX-ray2.50A/B1-282[»]
    3KPUX-ray2.40A/B1-282[»]
    3KPVX-ray2.40A/B1-282[»]
    3KPWX-ray2.40A/B1-282[»]
    3KPYX-ray2.40A/B1-282[»]
    3KQMX-ray2.40A/B1-282[»]
    3KQOX-ray2.40A/B1-282[»]
    3KQPX-ray2.40A/B1-282[»]
    3KQQX-ray2.50A/B1-282[»]
    3KQSX-ray2.00A/B1-282[»]
    3KQTX-ray2.40A/B1-282[»]
    3KQVX-ray2.30A/B1-282[»]
    3KQWX-ray2.49A/B1-282[»]
    3KQYX-ray2.20A/B1-282[»]
    3KR0X-ray2.60A/B1-282[»]
    3KR1X-ray2.30A/B1-282[»]
    3KR2X-ray2.30A/B1-282[»]
    4DM3X-ray2.40A/B1-282[»]
    4MIKX-ray1.95A/B1-282[»]
    4MQ4X-ray2.20A/B1-282[»]
    SMRiP11086
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGridi111410, 10 interactors
    IntActiP11086, 5 interactors
    STRINGi9606.ENSP00000269582

    Chemistry databases

    BindingDBiP11086
    ChEMBLiCHEMBL4617
    DrugBankiDB08129 (1R)-2-amino-1-[3-(trifluoromethyl)phenyl]ethanol
    DB08128 (1S,4R,9S)-5-(trifluoromethyl)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-9-amine
    DB07739 (3R)-3-(FLUOROMETHYL)-7-(THIOMORPHOLIN-4-YLSULFONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE
    DB07798 (3R)-3-(FLUOROMETHYL)-N-(3,3,3-TRIFLUOROPROPYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDE
    DB07747 (3R)-N-(4-CHLOROPHENYL)-3-(HYDROXYMETHYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDE
    DB03468 1,2,3,4-Tetrahydro-Isoquinoline-7-Sulfonic Acid Amide
    DB08550 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline
    DB03824 7-Iodo-1,2,3,4-Tetrahydro-Isoquinoline
    DB04273 8,9-Dichloro-2,3,4,5-Tetrahydro-1h-Benzo[C]Azepine
    DB07906 [(3R)-7-NITRO-1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL]METHANOL
    DB07597 CIS-(1R,2S)-2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALEN-1-OL
    DB08631 N-(4-CHLOROPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDE
    DB01752 S-adenosyl-L-homocysteine
    DB08654 TRANS-(1S,2S)-2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALEN-1-OL
    DrugCentraliP11086
    GuidetoPHARMACOLOGYi2496

    PTM databases

    iPTMnetiP11086
    PhosphoSitePlusiP11086

    Polymorphism and mutation databases

    BioMutaiPNMT
    DMDMi130375

    Proteomic databases

    CPTACiCPTAC-150
    CPTAC-151
    jPOSTiP11086
    MassIVEiP11086
    PaxDbiP11086
    PeptideAtlasiP11086
    PRIDEiP11086
    ProteomicsDBi52692

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    5409

    Genome annotation databases

    EnsembliENST00000269582; ENSP00000269582; ENSG00000141744
    GeneIDi5409
    KEGGihsa:5409
    UCSCiuc002hsi.3 human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    5409
    DisGeNETi5409

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    PNMT
    HGNCiHGNC:9160 PNMT
    HPAiCAB017029
    HPA043412
    HPA051005
    MIMi171190 gene
    neXtProtiNX_P11086
    OpenTargetsiENSG00000141744
    Orphaneti243761 NON RARE IN EUROPE: Essential hypertension
    PharmGKBiPA274

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiENOG410IJGY Eukaryota
    ENOG4111F9R LUCA
    GeneTreeiENSGT00390000011708
    HOGENOMiHOG000013229
    InParanoidiP11086
    KOiK00553
    OMAiAFDWSVY
    OrthoDBi1318335at2759
    PhylomeDBiP11086
    TreeFamiTF313114

    Enzyme and pathway databases

    UniPathwayiUPA00749;UER00736
    BioCyciMetaCyc:HS06868-MONOMER
    BRENDAi2.1.1.28 2681
    ReactomeiR-HSA-209905 Catecholamine biosynthesis

    Miscellaneous databases

    EvolutionaryTraceiP11086

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    5409
    PharosiP11086

    Protein Ontology

    More...
    PROi
    PR:P11086

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000141744 Expressed in 153 organ(s), highest expression level in right adrenal gland
    ExpressionAtlasiP11086 baseline and differential
    GenevisibleiP11086 HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR025820 NNMT/PNMT/TEMT_CS
    IPR000940 NNMT_TEMT_trans
    IPR029063 SAM-dependent_MTases
    PANTHERiPTHR10867 PTHR10867, 1 hit
    PfamiView protein in Pfam
    PF01234 NNMT_PNMT_TEMT, 1 hit
    PIRSFiPIRSF000384 PNMTase, 1 hit
    SUPFAMiSSF53335 SSF53335, 1 hit
    PROSITEiView protein in PROSITE
    PS01100 NNMT_PNMT_TEMT, 1 hit
    PS51681 SAM_MT_NNMT_PNMT_TEMT, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPNMT_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P11086
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
    Last sequence update: July 1, 1989
    Last modified: October 16, 2019
    This is version 181 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    7. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
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