Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein transport protein SEC7

Gene

SEC7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in vesicular budding and traffic between compartments of the Golgi apparatus.

Miscellaneous

Present with 3670 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • ARF guanyl-nucleotide exchange factor activity Source: SGD

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29759-MONOMER
ReactomeiR-SCE-6811438 Intra-Golgi traffic

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein SEC7
Gene namesi
Name:SEC7
Ordered Locus Names:YDR170C
ORF Names:YD9395.01C, YD9489.05C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR170C
SGDiS000002577 SEC7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001202141 – 2009Protein transport protein SEC7Add BLAST2009

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei212PhosphoserineCombined sources1
Modified residuei215PhosphoserineCombined sources1
Modified residuei334PhosphothreonineCombined sources1
Modified residuei447PhosphoserineCombined sources1
Modified residuei452PhosphoserineCombined sources1
Modified residuei455PhosphoserineCombined sources1
Cross-linki797Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Modified residuei807PhosphoserineCombined sources1
Modified residuei1226PhosphoserineCombined sources1
Modified residuei1240PhosphothreonineCombined sources1
Modified residuei1741PhosphoserineCombined sources1
Modified residuei1752PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP11075
PaxDbiP11075
PRIDEiP11075

PTM databases

CarbonylDBiP11075
iPTMnetiP11075

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi32221, 279 interactors
DIPiDIP-830N
IntActiP11075, 59 interactors
MINTiP11075
STRINGi4932.YDR170C

Structurei

Secondary structure

12009
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP11075
SMRiP11075
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini824 – 1010SEC7PROSITE-ProRule annotationAdd BLAST187

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi89 – 213Asp/Glu-rich (highly acidic)Add BLAST125

Domaini

The highly charged acidic domain may serve a structural role to interact with lipids or proteins on the cytoplasmic surface of the Golgi apparatus.

Phylogenomic databases

GeneTreeiENSGT00760000119036
HOGENOMiHOG000181045
InParanoidiP11075
KOiK18442
OMAiLLWNMEM
OrthoDBiEOG092C066Z

Family and domain databases

CDDicd00171 Sec7, 1 hit
Gene3Di1.10.1000.11, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR032629 DCB_dom
IPR015403 Sec7_C
IPR023394 Sec7_C_sf
IPR000904 Sec7_dom
IPR035999 Sec7_dom_sf
IPR032691 Sec7_N
PfamiView protein in Pfam
PF16213 DCB, 1 hit
PF09324 DUF1981, 1 hit
PF01369 Sec7, 1 hit
PF12783 Sec7_N, 1 hit
SMARTiView protein in SMART
SM00222 Sec7, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits
SSF48425 SSF48425, 1 hit
PROSITEiView protein in PROSITE
PS50190 SEC7, 1 hit

Sequencei

Sequence statusi: Complete.

P11075-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEQNSVVNA EKGDGEISSN VETASSVNPS VKPQNAIKEE AKETNGEDQK
60 70 80 90 100
CKGPENAGST AETKETSNDA TNGMKTPEET EDTNDKRHDD EGEDGDEDED
110 120 130 140 150
EDEDEDEDNG DEDDEDVDSS SSETSSEDGE DSESVSGEST ESSSGEDEES
160 170 180 190 200
DESDGNTSNS SSGDESGSEE EEEEEEEEEE EENAGEPAIA HQDSVPTNDS
210 220 230 240 250
TAPRSTHTRN ISLSSNGSNT NSTIILVKTT LETILNDKDI KKNSNAQKAI
260 270 280 290 300
ERTLQKFKEF DPQTTNNPHY VDSILVFEAL RASCRTKSSK VQSLALDCLS
310 320 330 340 350
KLFSFRSLDE TLLVNPPDSL ASNDQRQDAA DGITPPPKQK IIDAAIDTIS
360 370 380 390 400
DCFQGEGTDD RVELQIVRAL SSCILEEDSS SLCHGASLLK AIRTIYNVFV
410 420 430 440 450
FSLNPSNQGI AQATLTQIIS SVYDKIDLKQ STSSAVSLST KNHQQQSAIE
460 470 480 490 500
LSEASENAET PAPLTLENMD KLNDDEERLM DAQQPDSIAI TNQDLAVKDA
510 520 530 540 550
FLVFRVMAKI CAKPLETELD MRSHAVRSKL LSLHIIYSII KDHIDVFLSH
560 570 580 590 600
NIFLPGKERV CFIDSIRQYL RLVLSRNAAS PLAPVFEVTL EIMWLLIANL
610 620 630 640 650
RADFVKEIPV FLTEIYFPIS ELTTSTSQQK RYFLSVIQRI CNDPRTLVEF
660 670 680 690 700
YLNYDCNPGM PNVMEITVDY LTRLALTRVE ITQTQRSYYD EQISKSLSTY
710 720 730 740 750
NFSQLPLLTS SNLSSSPDVG QVNLLFPLDF ALKMVSLNCI VSVLRSLSSW
760 770 780 790 800
AHKALNPNTH TANKVLLNTT SSARQESRSS LSNDVRSSIM TSNDDFKPTY
810 820 830 840 850
EDEESRSLSS QNIDADDPTQ FENLKLRKTA LSECIAIFNN KPKKAIPVLI
860 870 880 890 900
KKGFLKDDSP ISIAKWLLET EGLDMAAVGD YLGEGDDKNI AIMHAFVDEF
910 920 930 940 950
DFTGMSIVDA LRSFLQSFRL PGEGQKIDRF MLKFAERFVD QNPGVFSKAD
960 970 980 990 1000
TAYVLSYSLI MLNTDLHSSQ IKNKMSLQEF LENNEGIDNG RDLPRDFLEG
1010 1020 1030 1040 1050
LFNEIANNEI KLISEQHQAM LSGDTNLVQQ QQSAFNFFNS RDLTREAYNQ
1060 1070 1080 1090 1100
VSKEISSKTE LVFKNLNKNK GGPDVYYAAS HVEHVKSIFE TLWMSFLAAL
1110 1120 1130 1140 1150
TPPFKDYDDI DTTNKCLEGL KISIKIASTF RINDARTSFV GALVQFCNLQ
1160 1170 1180 1190 1200
NLEEIKVKNV NAMVILLEVA LSEGNYLEGS WKDILLVVSQ MERLQLISKG
1210 1220 1230 1240 1250
IDRDTVPDVA QARVANPRVS YESSRSNNTS FFDVWGKKAT PTELAQEKHH
1260 1270 1280 1290 1300
NQTLSPEISK FISSSELVVL MDNIFTKSSE LSGNAIVDFI KALTAVSLEE
1310 1320 1330 1340 1350
IESSENASTP RMFSLQKMVD VCYYNMDRIK LEWTPLWAVM GKAFNKIATN
1360 1370 1380 1390 1400
SNLAVVFFAI DSLRQLSMRF LDIEELSGFE FQHDFLKPFE YTVQNSGNTE
1410 1420 1430 1440 1450
VQEMIIECFR NFILTKSESI KSGWKPILES LQYTARSSTE SIVLKTQLLV
1460 1470 1480 1490 1500
SNDIVTNHFE NVFSQEDAFS ELVGVFREIT KNKRFQKLSL HALESLRKMT
1510 1520 1530 1540 1550
QNVADICFYN ENKTEEERKH NDALLRGKDI FQDVWFPMLF CFNDTIMTAE
1560 1570 1580 1590 1600
DLEVRSRALN YMFDALVAYG GKFNDDFWEK ICKKLLFPIF GVLSKHWEVN
1610 1620 1630 1640 1650
QFNSHDDLSV WLSTTLIQAL RNLIALFTHY FESLNRMLDG FLGLLVSCIC
1660 1670 1680 1690 1700
QENDTIARIG RSCLQQLILQ NVSKFNEYHW NQIGDVFDKL FDLTTANELF
1710 1720 1730 1740 1750
DYDPLQQGRK SSVSHHQTTN DTSQHSDDDS NDRRENDSNI SETVERAHQE
1760 1770 1780 1790 1800
ESSEDVGGDM VETLNGQTKL NNGNSVPTVK DELNPKPASL SIPKKTKHMK
1810 1820 1830 1840 1850
RNESNEDIRR RINIKNSIVV KCVLQLLMIE LLNELFENED FAHCIPYKEA
1860 1870 1880 1890 1900
IRITRLLEKS YEFSRDFNED YGLRTRLVEA RVVDKIPNLL KQETSAAAVL
1910 1920 1930 1940 1950
LDIMFQLYLN DDEKKADLIT RLITICIQVV EGYVSLDDRT MERSINAWRS
1960 1970 1980 1990 2000
VIVEILQGYY EFDDEDFRLY CPAMYALVIQ ILDKSVPTEL RHAIKQFLSR

VGELYLSTD
Length:2,009
Mass (Da):226,886
Last modified:November 1, 1997 - v2
Checksum:i02B2D370DD2E4661
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti188A → S in AAB04031 (PubMed:3042778).Curated1
Sequence conflicti399 – 400FV → LL (PubMed:3042778).Curated2
Sequence conflicti402S → C (PubMed:3042778).Curated1
Sequence conflicti1031 – 1034QQSA → PAIC (PubMed:3042778).Curated4
Sequence conflicti1036 – 1037NF → QL (PubMed:3042778).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03918 Genomic DNA Translation: AAB04031.1
Z46727 Genomic DNA Translation: CAA86696.1
Z47813 Genomic DNA Translation: CAA87801.1
BK006938 Genomic DNA Translation: DAA12011.1
PIRiS49764
RefSeqiNP_010454.3, NM_001180477.3

Genome annotation databases

EnsemblFungiiYDR170C; YDR170C; YDR170C
GeneIDi851748
KEGGisce:YDR170C

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03918 Genomic DNA Translation: AAB04031.1
Z46727 Genomic DNA Translation: CAA86696.1
Z47813 Genomic DNA Translation: CAA87801.1
BK006938 Genomic DNA Translation: DAA12011.1
PIRiS49764
RefSeqiNP_010454.3, NM_001180477.3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4OIYX-ray1.50A/B824-1010[»]
ProteinModelPortaliP11075
SMRiP11075
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32221, 279 interactors
DIPiDIP-830N
IntActiP11075, 59 interactors
MINTiP11075
STRINGi4932.YDR170C

PTM databases

CarbonylDBiP11075
iPTMnetiP11075

Proteomic databases

MaxQBiP11075
PaxDbiP11075
PRIDEiP11075

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR170C; YDR170C; YDR170C
GeneIDi851748
KEGGisce:YDR170C

Organism-specific databases

EuPathDBiFungiDB:YDR170C
SGDiS000002577 SEC7

Phylogenomic databases

GeneTreeiENSGT00760000119036
HOGENOMiHOG000181045
InParanoidiP11075
KOiK18442
OMAiLLWNMEM
OrthoDBiEOG092C066Z

Enzyme and pathway databases

BioCyciYEAST:G3O-29759-MONOMER
ReactomeiR-SCE-6811438 Intra-Golgi traffic

Miscellaneous databases

PROiPR:P11075

Family and domain databases

CDDicd00171 Sec7, 1 hit
Gene3Di1.10.1000.11, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR032629 DCB_dom
IPR015403 Sec7_C
IPR023394 Sec7_C_sf
IPR000904 Sec7_dom
IPR035999 Sec7_dom_sf
IPR032691 Sec7_N
PfamiView protein in Pfam
PF16213 DCB, 1 hit
PF09324 DUF1981, 1 hit
PF01369 Sec7, 1 hit
PF12783 Sec7_N, 1 hit
SMARTiView protein in SMART
SM00222 Sec7, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits
SSF48425 SSF48425, 1 hit
PROSITEiView protein in PROSITE
PS50190 SEC7, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSEC7_YEAST
AccessioniPrimary (citable) accession number: P11075
Secondary accession number(s): D6VSF1, Q03960, Q04139
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1997
Last modified: September 12, 2018
This is version 175 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again