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UniProtKB - P11075 (SEC7_YEAST)
Protein
Protein transport protein SEC7
Gene
SEC7
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
May play a role in vesicular budding and traffic between compartments of the Golgi apparatus.
Miscellaneous
Present with 3670 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- guanyl-nucleotide exchange factor activity Source: SGD
GO - Biological processi
- autophagosome assembly Source: SGD
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: SGD
- intra-Golgi vesicle-mediated transport Source: SGD
- protein transport Source: UniProtKB-KW
- regulation of ARF protein signal transduction Source: InterPro
Keywordsi
Biological process | Protein transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Protein transport protein SEC7 |
Gene namesi | Name:SEC7 Ordered Locus Names:YDR170C ORF Names:YD9395.01C, YD9489.05C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000002577, SEC7 |
VEuPathDBi | FungiDB:YDR170C |
Subcellular locationi
Golgi apparatus
Cytoplasm and Cytosol
Note: Associated with the peripheral Golgi membrane.
Cytosol
- cytosol Source: SGD
Endosome
- late endosome Source: SGD
Golgi apparatus
- trans-Golgi network Source: SGD
Other locations
- Golgi-associated vesicle Source: SGD
Keywords - Cellular componenti
Cytoplasm, Golgi apparatusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000120214 | 1 – 2009 | Protein transport protein SEC7Add BLAST | 2009 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 212 | PhosphoserineCombined sources | 1 | |
Modified residuei | 215 | PhosphoserineCombined sources | 1 | |
Modified residuei | 334 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 447 | PhosphoserineCombined sources | 1 | |
Modified residuei | 452 | PhosphoserineCombined sources | 1 | |
Modified residuei | 455 | PhosphoserineCombined sources | 1 | |
Cross-linki | 797 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources | ||
Modified residuei | 807 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1226 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1240 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1741 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1752 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
MaxQBi | P11075 |
PaxDbi | P11075 |
PRIDEi | P11075 |
PTM databases
CarbonylDBi | P11075 |
iPTMneti | P11075 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 32221, 294 interactors |
DIPi | DIP-830N |
IntActi | P11075, 59 interactors |
MINTi | P11075 |
STRINGi | 4932.YDR170C |
Miscellaneous databases
RNActi | P11075, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P11075 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 824 – 1010 | SEC7PROSITE-ProRule annotationAdd BLAST | 187 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 220 | DisorderedSequence analysisAdd BLAST | 220 | |
Regioni | 771 – 814 | DisorderedSequence analysisAdd BLAST | 44 | |
Regioni | 1708 – 1803 | DisorderedSequence analysisAdd BLAST | 96 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 33 | Polar residuesSequence analysisAdd BLAST | 33 | |
Compositional biasi | 36 – 50 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 59 – 74 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 75 – 90 | Basic and acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 91 – 135 | Acidic residuesSequence analysisAdd BLAST | 45 | |
Compositional biasi | 165 – 184 | Acidic residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 193 – 220 | Polar residuesSequence analysisAdd BLAST | 28 | |
Compositional biasi | 771 – 795 | Polar residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 796 – 810 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1721 – 1755 | Basic and acidic residuesSequence analysisAdd BLAST | 35 | |
Compositional biasi | 1764 – 1779 | Polar residuesSequence analysisAdd BLAST | 16 |
Domaini
The highly charged acidic domain may serve a structural role to interact with lipids or proteins on the cytoplasmic surface of the Golgi apparatus.
Phylogenomic databases
eggNOGi | KOG0929, Eukaryota |
HOGENOMi | CLU_000691_1_1_1 |
InParanoidi | P11075 |
OMAi | LLWNMEM |
Family and domain databases
CDDi | cd00171, Sec7, 1 hit |
Gene3Di | 1.10.1000.11, 1 hit |
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR032629, DCB_dom IPR015403, Sec7_C IPR023394, Sec7_C_sf IPR000904, Sec7_dom IPR035999, Sec7_dom_sf IPR032691, Sec7_N |
Pfami | View protein in Pfam PF16213, DCB, 1 hit PF09324, DUF1981, 1 hit PF01369, Sec7, 1 hit PF12783, Sec7_N, 1 hit |
SMARTi | View protein in SMART SM00222, Sec7, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit SSF48425, SSF48425, 1 hit |
PROSITEi | View protein in PROSITE PS50190, SEC7, 1 hit |
i Sequence
Sequence statusi: Complete.
P11075-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSEQNSVVNA EKGDGEISSN VETASSVNPS VKPQNAIKEE AKETNGEDQK
60 70 80 90 100
CKGPENAGST AETKETSNDA TNGMKTPEET EDTNDKRHDD EGEDGDEDED
110 120 130 140 150
EDEDEDEDNG DEDDEDVDSS SSETSSEDGE DSESVSGEST ESSSGEDEES
160 170 180 190 200
DESDGNTSNS SSGDESGSEE EEEEEEEEEE EENAGEPAIA HQDSVPTNDS
210 220 230 240 250
TAPRSTHTRN ISLSSNGSNT NSTIILVKTT LETILNDKDI KKNSNAQKAI
260 270 280 290 300
ERTLQKFKEF DPQTTNNPHY VDSILVFEAL RASCRTKSSK VQSLALDCLS
310 320 330 340 350
KLFSFRSLDE TLLVNPPDSL ASNDQRQDAA DGITPPPKQK IIDAAIDTIS
360 370 380 390 400
DCFQGEGTDD RVELQIVRAL SSCILEEDSS SLCHGASLLK AIRTIYNVFV
410 420 430 440 450
FSLNPSNQGI AQATLTQIIS SVYDKIDLKQ STSSAVSLST KNHQQQSAIE
460 470 480 490 500
LSEASENAET PAPLTLENMD KLNDDEERLM DAQQPDSIAI TNQDLAVKDA
510 520 530 540 550
FLVFRVMAKI CAKPLETELD MRSHAVRSKL LSLHIIYSII KDHIDVFLSH
560 570 580 590 600
NIFLPGKERV CFIDSIRQYL RLVLSRNAAS PLAPVFEVTL EIMWLLIANL
610 620 630 640 650
RADFVKEIPV FLTEIYFPIS ELTTSTSQQK RYFLSVIQRI CNDPRTLVEF
660 670 680 690 700
YLNYDCNPGM PNVMEITVDY LTRLALTRVE ITQTQRSYYD EQISKSLSTY
710 720 730 740 750
NFSQLPLLTS SNLSSSPDVG QVNLLFPLDF ALKMVSLNCI VSVLRSLSSW
760 770 780 790 800
AHKALNPNTH TANKVLLNTT SSARQESRSS LSNDVRSSIM TSNDDFKPTY
810 820 830 840 850
EDEESRSLSS QNIDADDPTQ FENLKLRKTA LSECIAIFNN KPKKAIPVLI
860 870 880 890 900
KKGFLKDDSP ISIAKWLLET EGLDMAAVGD YLGEGDDKNI AIMHAFVDEF
910 920 930 940 950
DFTGMSIVDA LRSFLQSFRL PGEGQKIDRF MLKFAERFVD QNPGVFSKAD
960 970 980 990 1000
TAYVLSYSLI MLNTDLHSSQ IKNKMSLQEF LENNEGIDNG RDLPRDFLEG
1010 1020 1030 1040 1050
LFNEIANNEI KLISEQHQAM LSGDTNLVQQ QQSAFNFFNS RDLTREAYNQ
1060 1070 1080 1090 1100
VSKEISSKTE LVFKNLNKNK GGPDVYYAAS HVEHVKSIFE TLWMSFLAAL
1110 1120 1130 1140 1150
TPPFKDYDDI DTTNKCLEGL KISIKIASTF RINDARTSFV GALVQFCNLQ
1160 1170 1180 1190 1200
NLEEIKVKNV NAMVILLEVA LSEGNYLEGS WKDILLVVSQ MERLQLISKG
1210 1220 1230 1240 1250
IDRDTVPDVA QARVANPRVS YESSRSNNTS FFDVWGKKAT PTELAQEKHH
1260 1270 1280 1290 1300
NQTLSPEISK FISSSELVVL MDNIFTKSSE LSGNAIVDFI KALTAVSLEE
1310 1320 1330 1340 1350
IESSENASTP RMFSLQKMVD VCYYNMDRIK LEWTPLWAVM GKAFNKIATN
1360 1370 1380 1390 1400
SNLAVVFFAI DSLRQLSMRF LDIEELSGFE FQHDFLKPFE YTVQNSGNTE
1410 1420 1430 1440 1450
VQEMIIECFR NFILTKSESI KSGWKPILES LQYTARSSTE SIVLKTQLLV
1460 1470 1480 1490 1500
SNDIVTNHFE NVFSQEDAFS ELVGVFREIT KNKRFQKLSL HALESLRKMT
1510 1520 1530 1540 1550
QNVADICFYN ENKTEEERKH NDALLRGKDI FQDVWFPMLF CFNDTIMTAE
1560 1570 1580 1590 1600
DLEVRSRALN YMFDALVAYG GKFNDDFWEK ICKKLLFPIF GVLSKHWEVN
1610 1620 1630 1640 1650
QFNSHDDLSV WLSTTLIQAL RNLIALFTHY FESLNRMLDG FLGLLVSCIC
1660 1670 1680 1690 1700
QENDTIARIG RSCLQQLILQ NVSKFNEYHW NQIGDVFDKL FDLTTANELF
1710 1720 1730 1740 1750
DYDPLQQGRK SSVSHHQTTN DTSQHSDDDS NDRRENDSNI SETVERAHQE
1760 1770 1780 1790 1800
ESSEDVGGDM VETLNGQTKL NNGNSVPTVK DELNPKPASL SIPKKTKHMK
1810 1820 1830 1840 1850
RNESNEDIRR RINIKNSIVV KCVLQLLMIE LLNELFENED FAHCIPYKEA
1860 1870 1880 1890 1900
IRITRLLEKS YEFSRDFNED YGLRTRLVEA RVVDKIPNLL KQETSAAAVL
1910 1920 1930 1940 1950
LDIMFQLYLN DDEKKADLIT RLITICIQVV EGYVSLDDRT MERSINAWRS
1960 1970 1980 1990 2000
VIVEILQGYY EFDDEDFRLY CPAMYALVIQ ILDKSVPTEL RHAIKQFLSR
VGELYLSTD
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 188 | A → S in AAB04031 (PubMed:3042778).Curated | 1 | |
Sequence conflicti | 399 – 400 | FV → LL (PubMed:3042778).Curated | 2 | |
Sequence conflicti | 402 | S → C (PubMed:3042778).Curated | 1 | |
Sequence conflicti | 1031 – 1034 | QQSA → PAIC (PubMed:3042778).Curated | 4 | |
Sequence conflicti | 1036 – 1037 | NF → QL (PubMed:3042778).Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03918 Genomic DNA Translation: AAB04031.1 Z46727 Genomic DNA Translation: CAA86696.1 Z47813 Genomic DNA Translation: CAA87801.1 BK006938 Genomic DNA Translation: DAA12011.1 |
PIRi | S49764 |
RefSeqi | NP_010454.3, NM_001180477.3 |
Genome annotation databases
EnsemblFungii | YDR170C_mRNA; YDR170C; YDR170C |
GeneIDi | 851748 |
KEGGi | sce:YDR170C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03918 Genomic DNA Translation: AAB04031.1 Z46727 Genomic DNA Translation: CAA86696.1 Z47813 Genomic DNA Translation: CAA87801.1 BK006938 Genomic DNA Translation: DAA12011.1 |
PIRi | S49764 |
RefSeqi | NP_010454.3, NM_001180477.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4OIY | X-ray | 1.50 | A/B | 824-1010 | [»] | |
SMRi | P11075 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 32221, 294 interactors |
DIPi | DIP-830N |
IntActi | P11075, 59 interactors |
MINTi | P11075 |
STRINGi | 4932.YDR170C |
PTM databases
CarbonylDBi | P11075 |
iPTMneti | P11075 |
Proteomic databases
MaxQBi | P11075 |
PaxDbi | P11075 |
PRIDEi | P11075 |
Genome annotation databases
EnsemblFungii | YDR170C_mRNA; YDR170C; YDR170C |
GeneIDi | 851748 |
KEGGi | sce:YDR170C |
Organism-specific databases
SGDi | S000002577, SEC7 |
VEuPathDBi | FungiDB:YDR170C |
Phylogenomic databases
eggNOGi | KOG0929, Eukaryota |
HOGENOMi | CLU_000691_1_1_1 |
InParanoidi | P11075 |
OMAi | LLWNMEM |
Miscellaneous databases
PROi | PR:P11075 |
RNActi | P11075, protein |
Family and domain databases
CDDi | cd00171, Sec7, 1 hit |
Gene3Di | 1.10.1000.11, 1 hit |
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR032629, DCB_dom IPR015403, Sec7_C IPR023394, Sec7_C_sf IPR000904, Sec7_dom IPR035999, Sec7_dom_sf IPR032691, Sec7_N |
Pfami | View protein in Pfam PF16213, DCB, 1 hit PF09324, DUF1981, 1 hit PF01369, Sec7, 1 hit PF12783, Sec7_N, 1 hit |
SMARTi | View protein in SMART SM00222, Sec7, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit SSF48425, SSF48425, 1 hit |
PROSITEi | View protein in PROSITE PS50190, SEC7, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SEC7_YEAST | |
Accessioni | P11075Primary (citable) accession number: P11075 Secondary accession number(s): D6VSF1, Q03960, Q04139 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | November 1, 1997 | |
Last modified: | February 23, 2022 | |
This is version 194 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome IV
Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references