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UniProtKB - P11075 (SEC7_YEAST)

Protein

Protein transport protein SEC7

Gene

SEC7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in vesicular budding and traffic between compartments of the Golgi apparatus.

Miscellaneous

Present with 3670 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • ARF guanyl-nucleotide exchange factor activity Source: SGD
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29759-MONOMER
ReactomeiR-SCE-6811438 Intra-Golgi traffic

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein SEC7
Gene namesi
Name:SEC7
Ordered Locus Names:YDR170C
ORF Names:YD9395.01C, YD9489.05C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR170C
SGDiS000002577 SEC7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001202141 – 2009Protein transport protein SEC7Add BLAST2009

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei212PhosphoserineCombined sources1
Modified residuei215PhosphoserineCombined sources1
Modified residuei334PhosphothreonineCombined sources1
Modified residuei447PhosphoserineCombined sources1
Modified residuei452PhosphoserineCombined sources1
Modified residuei455PhosphoserineCombined sources1
Cross-linki797Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Modified residuei807PhosphoserineCombined sources1
Modified residuei1226PhosphoserineCombined sources1
Modified residuei1240PhosphothreonineCombined sources1
Modified residuei1741PhosphoserineCombined sources1
Modified residuei1752PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP11075
PaxDbiP11075
PRIDEiP11075

PTM databases

CarbonylDBiP11075
iPTMnetiP11075

Interactioni

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi32221, 279 interactors
DIPiDIP-830N
IntActiP11075, 59 interactors
MINTiP11075
STRINGi4932.YDR170C

Structurei

Secondary structure

12009
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP11075
SMRiP11075
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini824 – 1010SEC7PROSITE-ProRule annotationAdd BLAST187

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi89 – 213Asp/Glu-rich (highly acidic)Add BLAST125

Domaini

The highly charged acidic domain may serve a structural role to interact with lipids or proteins on the cytoplasmic surface of the Golgi apparatus.

Phylogenomic databases

GeneTreeiENSGT00760000119036
HOGENOMiHOG000181045
InParanoidiP11075
KOiK18442
OMAiLLWNMEM
OrthoDBiEOG092C066Z

Family and domain databases

CDDicd00171 Sec7, 1 hit
Gene3Di1.10.1000.11, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR032629 DCB_dom
IPR015403 Sec7_C
IPR023394 Sec7_C_sf
IPR000904 Sec7_dom
IPR035999 Sec7_dom_sf
IPR032691 Sec7_N
PfamiView protein in Pfam
PF16213 DCB, 1 hit
PF09324 DUF1981, 1 hit
PF01369 Sec7, 1 hit
PF12783 Sec7_N, 1 hit
SMARTiView protein in SMART
SM00222 Sec7, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits
SSF48425 SSF48425, 1 hit
PROSITEiView protein in PROSITE
PS50190 SEC7, 1 hit

Sequencei

Sequence statusi: Complete.

P11075-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEQNSVVNA EKGDGEISSN VETASSVNPS VKPQNAIKEE AKETNGEDQK 
        60         70         80         90        100
CKGPENAGST AETKETSNDA TNGMKTPEET EDTNDKRHDD EGEDGDEDED 
       110        120        130        140        150
EDEDEDEDNG DEDDEDVDSS SSETSSEDGE DSESVSGEST ESSSGEDEES 
       160        170        180        190        200
DESDGNTSNS SSGDESGSEE EEEEEEEEEE EENAGEPAIA HQDSVPTNDS 
       210        220        230        240        250
TAPRSTHTRN ISLSSNGSNT NSTIILVKTT LETILNDKDI KKNSNAQKAI 
       260        270        280        290        300
ERTLQKFKEF DPQTTNNPHY VDSILVFEAL RASCRTKSSK VQSLALDCLS 
       310        320        330        340        350
KLFSFRSLDE TLLVNPPDSL ASNDQRQDAA DGITPPPKQK IIDAAIDTIS 
       360        370        380        390        400
DCFQGEGTDD RVELQIVRAL SSCILEEDSS SLCHGASLLK AIRTIYNVFV 
       410        420        430        440        450
FSLNPSNQGI AQATLTQIIS SVYDKIDLKQ STSSAVSLST KNHQQQSAIE 
       460        470        480        490        500
LSEASENAET PAPLTLENMD KLNDDEERLM DAQQPDSIAI TNQDLAVKDA 
       510        520        530        540        550
FLVFRVMAKI CAKPLETELD MRSHAVRSKL LSLHIIYSII KDHIDVFLSH 
       560        570        580        590        600
NIFLPGKERV CFIDSIRQYL RLVLSRNAAS PLAPVFEVTL EIMWLLIANL 
       610        620        630        640        650
RADFVKEIPV FLTEIYFPIS ELTTSTSQQK RYFLSVIQRI CNDPRTLVEF 
       660        670        680        690        700
YLNYDCNPGM PNVMEITVDY LTRLALTRVE ITQTQRSYYD EQISKSLSTY 
       710        720        730        740        750
NFSQLPLLTS SNLSSSPDVG QVNLLFPLDF ALKMVSLNCI VSVLRSLSSW 
       760        770        780        790        800
AHKALNPNTH TANKVLLNTT SSARQESRSS LSNDVRSSIM TSNDDFKPTY 
       810        820        830        840        850
EDEESRSLSS QNIDADDPTQ FENLKLRKTA LSECIAIFNN KPKKAIPVLI 
       860        870        880        890        900
KKGFLKDDSP ISIAKWLLET EGLDMAAVGD YLGEGDDKNI AIMHAFVDEF 
       910        920        930        940        950
DFTGMSIVDA LRSFLQSFRL PGEGQKIDRF MLKFAERFVD QNPGVFSKAD 
       960        970        980        990       1000
TAYVLSYSLI MLNTDLHSSQ IKNKMSLQEF LENNEGIDNG RDLPRDFLEG 
      1010       1020       1030       1040       1050
LFNEIANNEI KLISEQHQAM LSGDTNLVQQ QQSAFNFFNS RDLTREAYNQ 
      1060       1070       1080       1090       1100
VSKEISSKTE LVFKNLNKNK GGPDVYYAAS HVEHVKSIFE TLWMSFLAAL 
      1110       1120       1130       1140       1150
TPPFKDYDDI DTTNKCLEGL KISIKIASTF RINDARTSFV GALVQFCNLQ 
      1160       1170       1180       1190       1200
NLEEIKVKNV NAMVILLEVA LSEGNYLEGS WKDILLVVSQ MERLQLISKG 
      1210       1220       1230       1240       1250
IDRDTVPDVA QARVANPRVS YESSRSNNTS FFDVWGKKAT PTELAQEKHH 
      1260       1270       1280       1290       1300
NQTLSPEISK FISSSELVVL MDNIFTKSSE LSGNAIVDFI KALTAVSLEE 
      1310       1320       1330       1340       1350
IESSENASTP RMFSLQKMVD VCYYNMDRIK LEWTPLWAVM GKAFNKIATN 
      1360       1370       1380       1390       1400
SNLAVVFFAI DSLRQLSMRF LDIEELSGFE FQHDFLKPFE YTVQNSGNTE 
      1410       1420       1430       1440       1450
VQEMIIECFR NFILTKSESI KSGWKPILES LQYTARSSTE SIVLKTQLLV 
      1460       1470       1480       1490       1500
SNDIVTNHFE NVFSQEDAFS ELVGVFREIT KNKRFQKLSL HALESLRKMT 
      1510       1520       1530       1540       1550
QNVADICFYN ENKTEEERKH NDALLRGKDI FQDVWFPMLF CFNDTIMTAE 
      1560       1570       1580       1590       1600
DLEVRSRALN YMFDALVAYG GKFNDDFWEK ICKKLLFPIF GVLSKHWEVN 
      1610       1620       1630       1640       1650
QFNSHDDLSV WLSTTLIQAL RNLIALFTHY FESLNRMLDG FLGLLVSCIC 
      1660       1670       1680       1690       1700
QENDTIARIG RSCLQQLILQ NVSKFNEYHW NQIGDVFDKL FDLTTANELF 
      1710       1720       1730       1740       1750
DYDPLQQGRK SSVSHHQTTN DTSQHSDDDS NDRRENDSNI SETVERAHQE 
      1760       1770       1780       1790       1800
ESSEDVGGDM VETLNGQTKL NNGNSVPTVK DELNPKPASL SIPKKTKHMK 
      1810       1820       1830       1840       1850
RNESNEDIRR RINIKNSIVV KCVLQLLMIE LLNELFENED FAHCIPYKEA 
      1860       1870       1880       1890       1900
IRITRLLEKS YEFSRDFNED YGLRTRLVEA RVVDKIPNLL KQETSAAAVL 
      1910       1920       1930       1940       1950
LDIMFQLYLN DDEKKADLIT RLITICIQVV EGYVSLDDRT MERSINAWRS 
      1960       1970       1980       1990       2000
VIVEILQGYY EFDDEDFRLY CPAMYALVIQ ILDKSVPTEL RHAIKQFLSR 

VGELYLSTD
Length:2,009
Mass (Da):226,886
Last modified:November 1, 1997 - v2
Checksum:i02B2D370DD2E4661
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti188A → S in AAB04031 (PubMed:3042778).Curated1
Sequence conflicti399 – 400FV → LL (PubMed:3042778).Curated2
Sequence conflicti402S → C (PubMed:3042778).Curated1
Sequence conflicti1031 – 1034QQSA → PAIC (PubMed:3042778).Curated4
Sequence conflicti1036 – 1037NF → QL (PubMed:3042778).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03918 Genomic DNA Translation: AAB04031.1
Z46727 Genomic DNA Translation: CAA86696.1
Z47813 Genomic DNA Translation: CAA87801.1
BK006938 Genomic DNA Translation: DAA12011.1
PIRiS49764
RefSeqiNP_010454.3, NM_001180477.3

Genome annotation databases

EnsemblFungiiYDR170C; YDR170C; YDR170C
GeneIDi851748
KEGGisce:YDR170C

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03918 Genomic DNA Translation: AAB04031.1
Z46727 Genomic DNA Translation: CAA86696.1
Z47813 Genomic DNA Translation: CAA87801.1
BK006938 Genomic DNA Translation: DAA12011.1
PIRiS49764
RefSeqiNP_010454.3, NM_001180477.3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4OIYX-ray1.50A/B824-1010[»]
ProteinModelPortaliP11075
SMRiP11075
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32221, 279 interactors
DIPiDIP-830N
IntActiP11075, 59 interactors
MINTiP11075
STRINGi4932.YDR170C

PTM databases

CarbonylDBiP11075
iPTMnetiP11075

Proteomic databases

MaxQBiP11075
PaxDbiP11075
PRIDEiP11075

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR170C; YDR170C; YDR170C
GeneIDi851748
KEGGisce:YDR170C

Organism-specific databases

EuPathDBiFungiDB:YDR170C
SGDiS000002577 SEC7

Phylogenomic databases

GeneTreeiENSGT00760000119036
HOGENOMiHOG000181045
InParanoidiP11075
KOiK18442
OMAiLLWNMEM
OrthoDBiEOG092C066Z

Enzyme and pathway databases

BioCyciYEAST:G3O-29759-MONOMER
ReactomeiR-SCE-6811438 Intra-Golgi traffic

Miscellaneous databases

PROiPR:P11075

Family and domain databases

CDDicd00171 Sec7, 1 hit
Gene3Di1.10.1000.11, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR032629 DCB_dom
IPR015403 Sec7_C
IPR023394 Sec7_C_sf
IPR000904 Sec7_dom
IPR035999 Sec7_dom_sf
IPR032691 Sec7_N
PfamiView protein in Pfam
PF16213 DCB, 1 hit
PF09324 DUF1981, 1 hit
PF01369 Sec7, 1 hit
PF12783 Sec7_N, 1 hit
SMARTiView protein in SMART
SM00222 Sec7, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits
SSF48425 SSF48425, 1 hit
PROSITEiView protein in PROSITE
PS50190 SEC7, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSEC7_YEAST
AccessioniPrimary (citable) accession number: P11075
Secondary accession number(s): D6VSF1, Q03960, Q04139
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1997
Last modified: September 12, 2018
This is version 175 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
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