Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mu-agatoxin-Aa1e

Gene
N/A
Organism
Agelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Insecticidal neurotoxin that induces an irreversible spastic paralysis when injected into insects. Modifies presynaptic voltage-gated sodium channels (Nav), causing them to open at the normal resting potential of the nerve. This leads to spontaneous release of neurotransmitter and repetitive action potentials in motor neurons.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Presynaptic neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Mu-agatoxin-Aa1e
Short name:
Mu-AGTX-Aa1e
Alternative name(s):
Mu-agatoxin V1 Publication
Mu-agatoxin-5
OrganismiAgelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)
Taxonomic identifieri6908 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeAraneomorphaeEntelegynaeAgelenidaeAgelenopsis

Organism-specific databases

ArachnoServeriAS000383 mu-agatoxin-Aa1e

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Toxic dosei

Lethal dose is 48 +-11 mg/kg into third stadium larvae of M.sexta.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000449591 – 37Mu-agatoxin-Aa1eAdd BLAST37

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi2 ↔ 181 Publication
Disulfide bondi9 ↔ 231 Publication
Disulfide bondi17 ↔ 331 Publication
Disulfide bondi25 ↔ 311 Publication
Modified residuei37Asparagine amide1 Publication1

Keywords - PTMi

Amidation, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

3D structure databases

ProteinModelPortaliP11061
SMRiP11061
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.

Sequence similaritiesi

Keywords - Domaini

Knottin

Family and domain databases

InterProiView protein in InterPro
IPR016328 Beta/delta-agatoxin_fam
PIRSFiPIRSF001882 Curtatoxin, 1 hit
PROSITEiView protein in PROSITE
PS60015 MU_AGATOXIN, 1 hit

Sequencei

Sequence statusi: Complete.

P11061-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
ACVGENKQCA DWAGPHCCDG YYCTCRYFPK CICRNNN
Length:37
Mass (Da):4,208
Last modified:July 1, 1989 - v1
Checksum:iE742F3A18C59BBE5
GO

Sequence databases

PIRiE32038

Similar proteinsi

Entry informationi

Entry nameiT4G1E_AGEAP
AccessioniPrimary (citable) accession number: P11061
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: June 20, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health