MYH3

Functionⁱ

Muscle contraction.

Caution

Represents a conventional myosin. This protein should not be confused with the unconventional myosin-3 (MYO3).Curated

Variants Ala-1622 and Val-1637 have been originally reported as DA2B pathogenic mutations (PubMed:16642020). These variants are now thought to be polymorphisms on the basis of additional family information and frequencies in large databases of control populations (PubMed:25957469).1 Publication1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	179 – 186	ATPSequence analysis		8

GO - Molecular functionⁱ

actin filament binding
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 16642020
ATPase activity, coupled
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 16642020
ATP binding Source: UniProtKB-KW
calmodulin binding
Source: BHF-UCL
Non-traceable author statementⁱ
- 16642020
microfilament motor activity
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 16642020
myosin phosphatase activity Source: Reactome

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

actin filament-based movement
Source: UniProtKB
Non-traceable author statementⁱ
- 1691980
ATP metabolic process
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 16642020
embryonic limb morphogenesis
Source: BHF-UCL
Inferred by curatorⁱ
- 16642020
face morphogenesis
Source: BHF-UCL
Inferred by curatorⁱ
- 16642020
muscle filament sliding Source: Reactome
muscle organ development
Source: ProtInc
Traceable author statementⁱ
- 2771643
sarcomere organization
Source: BHF-UCL
Non-traceable author statementⁱ
- 16642020
skeletal muscle contraction
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 16642020

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Actin-binding, Calmodulin-binding, Motor protein, Muscle protein, Myosin
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-390522 Striated Muscle Contraction
SIGNORⁱ	P11055

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Myosin-3 Alternative name(s): Muscle embryonic myosin heavy chain Myosin heavy chain 3 Myosin heavy chain, fast skeletal muscle, embryonic SMHCE
Gene namesⁱ	Name:MYH3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000109063.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7573 MYH3
MIMⁱ	160720 gene
neXtProtⁱ	NX_P11055

Keywords - Cellular componentⁱ

Cytoplasm, Thick filament

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Arthrogryposis, distal, 2A (DA2A)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of distal arthrogryposis, a disease characterized by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a primary neurological or muscle disease. DA2A is characterized by contractures of the hands and feet, oropharyngeal abnormalities, scoliosis, and a distinctive face that includes a very small oral orifice, puckered lips, and an H-shaped dimple of the chin.

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_030374	498	E → G in DA2A. 1 Publication	1
Natural variantⁱVAR_030376	583	Y → S in DA2A. 1 Publication	1
Natural variantⁱVAR_030377	672	R → C in DA2A. 1 PublicationCorresponds to variant dbSNP:rs121913618EnsemblClinVar.	1
Natural variantⁱVAR_030378	672	R → H in DA2A. 1 PublicationCorresponds to variant dbSNP:rs121913617EnsemblClinVar.	1
Natural variantⁱVAR_030380	825	V → D in DA2A. 1 PublicationCorresponds to variant dbSNP:rs121913620EnsemblClinVar.	1

Arthrogryposis, distal, 2B (DA2B)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of distal arthrogryposis, a disease characterized by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a primary neurological or muscle disease. DA2B is characterized by contractures of the hands and feet, and a distinctive face characterized by prominent nasolabial folds, small mouth and downslanting palpebral fissures.

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_030371	261	S → F in DA2B. 1 Publication	1
Natural variantⁱVAR_030372	292	S → C in DA2B. 1 PublicationCorresponds to variant dbSNP:rs139480342EnsemblClinVar.	1
Natural variantⁱVAR_030373	375	E → K in DA2B. 1 PublicationCorresponds to variant dbSNP:rs121913621EnsemblClinVar.	1
Natural variantⁱVAR_030375	517	D → Y in DA2B. 1 Publication	1
Natural variantⁱVAR_030379	769	G → V in DA2B. 1 Publication	1
Natural variantⁱVAR_030381	838	K → E in DA2B. 1 Publication	1
Natural variantⁱVAR_030382	841	Missing in DA2B. 1 Publication	1

Arthrogryposis, distal, 8 (DA8)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of distal arthrogryposis, a disease characterized by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a primary neurological or muscle disease.

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_074668	243	Missing in DA8. 1 Publication	1
Natural variantⁱVAR_074669	1072	N → NN in DA8. 1 Publication	1
Natural variantⁱVAR_074670	1075	Q → P in DA8. 1 PublicationCorresponds to variant dbSNP:rs796051884EnsemblClinVar.	1

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4621
MalaCards human disease database More...MalaCardsⁱ	MYH3
MIMⁱ	178110 phenotype 193700 phenotype 601680 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000109063
Orphanetⁱ	65743 Autosomal dominant multiple pterygium syndrome 1146 Digitotalar dysmorphism 2053 Freeman-Sheldon syndrome 1147 Sheldon-Hall syndrome 3275 Spondylocarpotarsal synostosis
PharmGKBⁱ	PA31370

Polymorphism and mutation databases

BioMutaⁱ	MYH3
DMDMⁱ	251757455

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000123394	1 – 1940	Myosin-3Add BLAST		1940

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	130	N6,N6,N6-trimethyllysineSequence analysis		1

Keywords - PTMⁱ

Methylation

Proteomic databases

EPDⁱ	P11055
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P11055
PaxDbⁱ	P11055
PeptideAtlas More...PeptideAtlasⁱ	P11055
PRIDEⁱ	P11055
ProteomicsDBⁱ	52691

PTM databases

iPTMnetⁱ	P11055
PhosphoSitePlusⁱ	P11055

Expressionⁱ

Tissue specificityⁱ

Developmental stageⁱ

Abundantly present in fetal skeletal muscle and not present or barely detectable in heart and adult skeletal muscle.

Gene expression databases

Bgeeⁱ	ENSG00000109063 Expressed in 147 organ(s), highest expression level in adrenal tissue
CleanExⁱ	HS_MYH3
Genevisibleⁱ	P11055 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA021808

HPAⁱ

HPA021808

Interactionⁱ

Subunit structureⁱ

Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).

GO - Molecular functionⁱ

actin filament binding
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 16642020
calmodulin binding
Source: BHF-UCL
Non-traceable author statementⁱ
- 16642020

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	110706, 14 interactors
IntActⁱ	P11055, 10 interactors
Molecular INTeraction database More...MINTⁱ	P11055
STRINGⁱ	9606.ENSP00000226209

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P11055
SMRⁱ	P11055
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	33 – 82	Myosin N-terminal SH3-likePROSITE-ProRule annotationAdd BLAST	50
Domainⁱ	86 – 779	Myosin motorPROSITE-ProRule annotationAdd BLAST	694
Domainⁱ	782 – 811	IQPROSITE-ProRule annotationAdd BLAST	30

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	656 – 678	Actin-bindingAdd BLAST		23
Regionⁱ	758 – 772	Actin-bindingAdd BLAST		15

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	840 – 1933	Sequence analysisAdd BLAST		1094

Domainⁱ

The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.

Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).Curated

Sequence similaritiesⁱ

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG0161 Eukaryota COG5022 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118919
HOGENOMⁱ	HOG000173959
HOVERGENⁱ	HBG004704
InParanoidⁱ	P11055
KEGG Orthology (KO) More...KOⁱ	K10352
OMAⁱ	NIRAWCT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G07UM
PhylomeDBⁱ	P11055
TreeFamⁱ	TF314375

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd14913 MYSc_Myh3, 1 hit
Gene3Dⁱ	2.30.30.360, 1 hit 3.40.850.10, 1 hit 4.10.270.10, 1 hit
InterProⁱ	View protein in InterPro IPR000048 IQ_motif_EF-hand-BS IPR036961 Kinesin_motor_dom_sf IPR001609 Myosin_head_motor_dom IPR027401 Myosin_IQ_contain_sf IPR004009 Myosin_N IPR008989 Myosin_S1_N IPR002928 Myosin_tail IPR036000 MYSc_Myh3 IPR027417 P-loop_NTPase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00063 Myosin_head, 1 hit PF02736 Myosin_N, 1 hit PF01576 Myosin_tail_1, 1 hit
PRINTSⁱ	PR00193 MYOSINHEAVY
SMARTⁱ	View protein in SMART SM00242 MYSc, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS50096 IQ, 1 hit PS51456 MYOSIN_MOTOR, 1 hit PS51844 SH3_LIKE, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P11055-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSSDTEMEVF GIAAPFLRKS EKERIEAQNQ PFDAKTYCFV VDSKEEYAKG 
        60         70         80         90        100
KIKSSQDGKV TVETEDNRTL VVKPEDVYAM NPPKFDRIED MAMLTHLNEP 
       110        120        130        140        150
AVLYNLKDRY TSWMIYTYSG LFCVTVNPYK WLPVYNPEVV EGYRGKKRQE 
       160        170        180        190        200
APPHIFSISD NAYQFMLTDR ENQSILITGE SGAGKTVNTK RVIQYFATIA 
       210        220        230        240        250
ATGDLAKKKD SKMKGTLEDQ IISANPLLEA FGNAKTVRND NSSRFGKFIR 
       260        270        280        290        300
IHFGTTGKLA SADIETYLLE KSRVTFQLKA ERSYHIFYQI LSNKKPELIE 
       310        320        330        340        350
LLLITTNPYD YPFISQGEIL VASIDDAEEL LATDSAIDIL GFTPEEKSGL 
       360        370        380        390        400
YKLTGAVMHY GNMKFKQKQR EEQAEPDGTE VADKTAYLMG LNSSDLLKAL 
       410        420        430        440        450
CFPRVKVGNE YVTKGQTVDQ VHHAVNALSK SVYEKLFLWM VTRINQQLDT 
       460        470        480        490        500
KLPRQHFIGV LDIAGFEIFE YNSLEQLCIN FTNEKLQQFF NHHMFVLEQE 
       510        520        530        540        550
EYKKEGIEWT FIDFGMDLAA CIELIEKPMG IFSILEEECM FPKATDTSFK 
       560        570        580        590        600
NKLYDQHLGK SNNFQKPKVV KGRAEAHFSL IHYAGTVDYS VSGWLEKNKD 
       610        620        630        640        650
PLNETVVGLY QKSSNRLLAH LYATFATADA DSGKKKVAKK KGSSFQTVSA 
       660        670        680        690        700
LFRENLNKLM SNLRTTHPHF VRCIIPNETK TPGAMEHSLV LHQLRCNGVL 
       710        720        730        740        750
EGIRICRKGF PNRILYGDFK QRYRVLNASA IPEGQFIDSK KACEKLLASI 
       760        770        780        790        800
DIDHTQYKFG HTKVFFKAGL LGTLEEMRDD RLAKLITRTQ AVCRGFLMRV 
       810        820        830        840        850
EFQKMVQRRE SIFCIQYNIR SFMNVKHWPW MKLFFKIKPL LKSAETEKEM 
       860        870        880        890        900
ATMKEEFQKT KDELAKSEAK RKELEEKLVT LVQEKNDLQL QVQAESENLL 
       910        920        930        940        950
DAEERCDQLI KAKFQLEAKI KEVTERAEDE EEINAELTAK KRKLEDECSE 
       960        970        980        990       1000
LKKDIDDLEL TLAKVEKEKH ATENKVKNLT EELSGLDETI AKLTREKKAL 
      1010       1020       1030       1040       1050
QEAHQQALDD LQAEEDKVNS LNKTKSKLEQ QVEDLESSLE QEKKLRVDLE 
      1060       1070       1080       1090       1100
RNKRKLEGDL KLAQESILDL ENDKQQLDER LKKKDFEYCQ LQSKVEDEQT 
      1110       1120       1130       1140       1150
LGLQFQKKIK ELQARIEELE EEIEAERATR AKTEKQRSDY ARELEELSER 
      1160       1170       1180       1190       1200
LEEAGGVTST QIELNKKREA EFLKLRRDLE EATLQHEAMV AALRKKHADS 
      1210       1220       1230       1240       1250
VAELGEQIDN LQRVKQKLEK EKSEFKLEID DLSSSMESVS KSKANLEKIC 
      1260       1270       1280       1290       1300
RTLEDQLSEA RGKNEEIQRS LSELTTQKSR LQTEAGELSR QLEEKESIVS 
      1310       1320       1330       1340       1350
QLSRSKQAFT QQTEELKRQL EEENKAKNAL AHALQSSRHD CDLLREQYEE 
      1360       1370       1380       1390       1400
EQEGKAELQR ALSKANSEVA QWRTKYETDA IQRTEELEEA KKKLAQRLQD 
      1410       1420       1430       1440       1450
SEEQVEAVNA KCASLEKTKQ RLQGEVEDLM VDVERANSLA AALDKKQRNF 
      1460       1470       1480       1490       1500
DKVLAEWKTK CEESQAELEA SLKESRSLST ELFKLKNAYE EALDQLETVK 
      1510       1520       1530       1540       1550
RENKNLEQEI ADLTEQIAEN GKTIHELEKS RKQIELEKAD IQLALEEAEA 
      1560       1570       1580       1590       1600
ALEHEEAKIL RIQLELTQVK SEIDRKIAEK DEEIEQLKRN YQRTVETMQS 
      1610       1620       1630       1640       1650
ALDAEVRSRN EAIRLKKKME GDLNEIEIQL SHANRQAAET LKHLRSVQGQ 
      1660       1670       1680       1690       1700
LKDTQLHLDD ALRGQEDLKE QLAIVERRAN LLQAEVEELR ATLEQTERAR 
      1710       1720       1730       1740       1750
KLAEQELLDS NERVQLLHTQ NTSLIHTKKK LETDLMQLQS EVEDASRDAR 
      1760       1770       1780       1790       1800
NAEEKAKKAI TDAAMMAEEL KKEQDTSAHL ERMKKNLEQT VKDLQHRLDE 
      1810       1820       1830       1840       1850
AEQLALKGGK KQIQKLETRI RELEFELEGE QKKNTESVKG LRKYERRVKE 
      1860       1870       1880       1890       1900
LTYQSEEDRK NVLRLQDLVD KLQVKVKSYK RQAEEADEQA NAHLTKFRKA 
      1910       1920       1930       1940
QHELEEAEER ADIAESQVNK LRAKTRDFTS SRMVVHESEE

Length:1,940

Mass (Da):223,905

Last modified:July 7, 2009 - v3

Checksum:ⁱB7D6AF219E88E5C8

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	327	A → R in CAA32167 (PubMed:2726495).Curated	1
Sequence conflictⁱ	732	P → L in CAA32167 (PubMed:2726495).Curated	1
Sequence conflictⁱ	1331	A → G in CAA35942 (PubMed:1691980).Curated	1
Sequence conflictⁱ	1391 – 1392	KK → QE in CAA32167 (PubMed:2726495).Curated	2
Sequence conflictⁱ	1391 – 1392	KK → QE in CAA31492 (PubMed:2806546).Curated	2
Sequence conflictⁱ	1608 – 1609	SR → RA in CAA35942 (PubMed:1691980).Curated	2
Sequence conflictⁱ	1663 – 1664	RG → QT in CAA31492 (PubMed:2806546).Curated	2

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_030370	178	T → I in DA2A and DA2B. 1 PublicationCorresponds to variant dbSNP:rs121913619EnsemblClinVar.	1
Natural variantⁱVAR_074668	243	Missing in DA8. 1 Publication	1
Natural variantⁱVAR_030371	261	S → F in DA2B. 1 Publication	1
Natural variantⁱVAR_030372	292	S → C in DA2B. 1 PublicationCorresponds to variant dbSNP:rs139480342EnsemblClinVar.	1
Natural variantⁱVAR_030373	375	E → K in DA2B. 1 PublicationCorresponds to variant dbSNP:rs121913621EnsemblClinVar.	1
Natural variantⁱVAR_030374	498	E → G in DA2A. 1 Publication	1
Natural variantⁱVAR_030375	517	D → Y in DA2B. 1 Publication	1
Natural variantⁱVAR_030376	583	Y → S in DA2A. 1 Publication	1
Natural variantⁱVAR_030377	672	R → C in DA2A. 1 PublicationCorresponds to variant dbSNP:rs121913618EnsemblClinVar.	1
Natural variantⁱVAR_030378	672	R → H in DA2A. 1 PublicationCorresponds to variant dbSNP:rs121913617EnsemblClinVar.	1
Natural variantⁱVAR_030379	769	G → V in DA2B. 1 Publication	1
Natural variantⁱVAR_030380	825	V → D in DA2A. 1 PublicationCorresponds to variant dbSNP:rs121913620EnsemblClinVar.	1
Natural variantⁱVAR_030381	838	K → E in DA2B. 1 Publication	1
Natural variantⁱVAR_030382	841	Missing in DA2B. 1 Publication	1
Natural variantⁱVAR_056173	1003	A → V. Corresponds to variant dbSNP:rs34088014EnsemblClinVar.	1
Natural variantⁱVAR_074669	1072	N → NN in DA8. 1 Publication	1
Natural variantⁱVAR_074670	1075	Q → P in DA8. 1 PublicationCorresponds to variant dbSNP:rs796051884EnsemblClinVar.	1
Natural variantⁱVAR_030196	1137	R → C. Corresponds to variant dbSNP:rs12941197EnsemblClinVar.	1
Natural variantⁱVAR_030197	1192	A → T4 PublicationsCorresponds to variant dbSNP:rs2285477EnsemblClinVar.	1
Natural variantⁱVAR_056174	1313	T → I. Corresponds to variant dbSNP:rs35230241EnsemblClinVar.	1
Natural variantⁱVAR_030383	1622	D → A Polymorphism; originally found in DA2B patients. 1 Publication1 PublicationCorresponds to variant dbSNP:rs1446303362Ensembl.	1
Natural variantⁱVAR_030384	1637	A → V Polymorphism; originally found in DA2B patients. 1 Publication1 PublicationCorresponds to variant dbSNP:rs34165480EnsemblClinVar.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X13988 mRNA Translation: CAA32167.1 AC002347 Genomic DNA No translation available. X13100 mRNA Translation: CAA31492.1 X51593 mRNA Translation: CAA35942.1 X15696 mRNA Translation: CAA33731.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11157.1
PIRⁱ	S04090
NCBI Reference Sequences More...RefSeqⁱ	NP_002461.2, NM_002470.3 XP_011522172.1, XM_011523870.2 XP_011522173.1, XM_011523871.2
UniGeneⁱ	Hs.440895

Genome annotation databases

Ensemblⁱ	ENST00000583535; ENSP00000464317; ENSG00000109063
GeneIDⁱ	4621
KEGGⁱ	hsa:4621
UCSC genome browser More...UCSCⁱ	uc002gmq.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P11055	Myosin-3		MOUSE		1940	UniRef90_P11055
Myosin-3		RAT		1940
Myosin-3		MYOBR		2137
Uncharacterized protein		LOXAF		1946
Uncharacterized protein		CHLSB		1942
+123

Protein	Similar proteins		Species	Score	Length	Source
P11055	Myosin-7	)	HUMAN		1935	UniRef50_P12883
Myosin-7		RAT		1935
Myosin-7		PIG		1935
Myosin-7	)	BOVIN		1935
Myosin-7		MOUSE		1935
+3042

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X13988 mRNA Translation: CAA32167.1 AC002347 Genomic DNA No translation available. X13100 mRNA Translation: CAA31492.1 X51593 mRNA Translation: CAA35942.1 X15696 mRNA Translation: CAA33731.1
CCDSⁱ	CCDS11157.1
PIRⁱ	S04090
RefSeqⁱ	NP_002461.2, NM_002470.3 XP_011522172.1, XM_011523870.2 XP_011522173.1, XM_011523871.2
UniGeneⁱ	Hs.440895

3D structure databases

ProteinModelPortalⁱ	P11055
SMRⁱ	P11055
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110706, 14 interactors
IntActⁱ	P11055, 10 interactors
MINTⁱ	P11055
STRINGⁱ	9606.ENSP00000226209

PTM databases

iPTMnetⁱ	P11055
PhosphoSitePlusⁱ	P11055

Polymorphism and mutation databases

BioMutaⁱ	MYH3
DMDMⁱ	251757455

Proteomic databases

EPDⁱ	P11055
MaxQBⁱ	P11055
PaxDbⁱ	P11055
PeptideAtlasⁱ	P11055
PRIDEⁱ	P11055
ProteomicsDBⁱ	52691

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	4621
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000583535; ENSP00000464317; ENSG00000109063
GeneIDⁱ	4621
KEGGⁱ	hsa:4621
UCSCⁱ	uc002gmq.3 human

Organism-specific databases

CTDⁱ	4621
DisGeNETⁱ	4621
EuPathDBⁱ	HostDB:ENSG00000109063.14
GeneCardsⁱ	MYH3
H-InvDBⁱ	HIX0039137
HGNCⁱ	HGNC:7573 MYH3
HPAⁱ	HPA021808
MalaCardsⁱ	MYH3
MIMⁱ	160720 gene 178110 phenotype 193700 phenotype 601680 phenotype
neXtProtⁱ	NX_P11055
OpenTargetsⁱ	ENSG00000109063
Orphanetⁱ	65743 Autosomal dominant multiple pterygium syndrome 1146 Digitotalar dysmorphism 2053 Freeman-Sheldon syndrome 1147 Sheldon-Hall syndrome 3275 Spondylocarpotarsal synostosis
PharmGKBⁱ	PA31370
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0161 Eukaryota COG5022 LUCA
GeneTreeⁱ	ENSGT00760000118919
HOGENOMⁱ	HOG000173959
HOVERGENⁱ	HBG004704
InParanoidⁱ	P11055
KOⁱ	K10352
OMAⁱ	NIRAWCT
OrthoDBⁱ	EOG091G07UM
PhylomeDBⁱ	P11055
TreeFamⁱ	TF314375

Enzyme and pathway databases

Reactomeⁱ	R-HSA-390522 Striated Muscle Contraction
SIGNORⁱ	P11055

Miscellaneous databases

ChiTaRSⁱ	MYH3 human
GeneWikiⁱ	MYH3
GenomeRNAiⁱ	4621
Protein Ontology More...PROⁱ	PR:P11055
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000109063 Expressed in 147 organ(s), highest expression level in adrenal tissue
CleanExⁱ	HS_MYH3
Genevisibleⁱ	P11055 HS

Family and domain databases

CDDⁱ	cd14913 MYSc_Myh3, 1 hit
Gene3Dⁱ	2.30.30.360, 1 hit 3.40.850.10, 1 hit 4.10.270.10, 1 hit
InterProⁱ	View protein in InterPro IPR000048 IQ_motif_EF-hand-BS IPR036961 Kinesin_motor_dom_sf IPR001609 Myosin_head_motor_dom IPR027401 Myosin_IQ_contain_sf IPR004009 Myosin_N IPR008989 Myosin_S1_N IPR002928 Myosin_tail IPR036000 MYSc_Myh3 IPR027417 P-loop_NTPase
Pfamⁱ	View protein in Pfam PF00063 Myosin_head, 1 hit PF02736 Myosin_N, 1 hit PF01576 Myosin_tail_1, 1 hit
PRINTSⁱ	PR00193 MYOSINHEAVY
SMARTⁱ	View protein in SMART SM00242 MYSc, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS50096 IQ, 1 hit PS51456 MYOSIN_MOTOR, 1 hit PS51844 SH3_LIKE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MYH3_HUMAN
Accessionⁱ	P11055Primary (citable) accession number: P11055 Secondary accession number(s): Q15492
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
	Last sequence update:	July 7, 2009
	Last modified:	November 7, 2018
	This is version 181 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM

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UniProtKB - P11055 (MYH3_HUMAN)

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Myosin-3

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Regions

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GO - Biological processi

Enzyme and pathway databases

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Extracellular region or secreted

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Polymorphism and mutation databases

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Molecule processing

Amino acid modifications

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Proteomic databases

PTM databases

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Gene expression databases

Organism-specific databases

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Protein-protein interaction databases

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3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

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Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

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Keywords - Coding sequence diversityi

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Sequence databases

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Proteomic databases

Protocols and materials databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ