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Entry version 165 (16 Oct 2019)
Sequence version 2 (01 Nov 1990)
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Protein

Leukocyte antigen CD37

Gene

CD37

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leukocyte antigen CD37
Alternative name(s):
Tetraspanin-26
Short name:
Tspan-26
CD_antigen: CD37
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CD37
Synonyms:TSPAN26
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1666 CD37

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
151523 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P11049

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 17CytoplasmicSequence analysisAdd BLAST17
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei18 – 38HelicalSequence analysisAdd BLAST21
Topological domaini39 – 59ExtracellularSequence analysisAdd BLAST21
Transmembranei60 – 74HelicalSequence analysisAdd BLAST15
Topological domaini75 – 85CytoplasmicSequence analysisAdd BLAST11
Transmembranei86 – 111HelicalSequence analysisAdd BLAST26
Topological domaini112 – 241ExtracellularSequence analysisAdd BLAST130
Transmembranei242 – 266HelicalSequence analysisAdd BLAST25
Topological domaini267 – 281CytoplasmicSequence analysisAdd BLAST15

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
951

Open Targets

More...
OpenTargetsi
ENSG00000104894

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26213

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P11049

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3712880

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
3010

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CD37

Domain mapping of disease mutations (DMDM)

More...
DMDMi
115983

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002192091 – 281Leukocyte antigen CD37Add BLAST281

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi170N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi183N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P11049

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P11049

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P11049

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P11049

PeptideAtlas

More...
PeptideAtlasi
P11049

PRoteomics IDEntifications database

More...
PRIDEi
P11049

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
52690 [P11049-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P11049

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P11049

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P11049

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

B-lymphocytes.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000104894 Expressed in 137 organ(s), highest expression level in leukocyte

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P11049 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P11049 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB002492
HPA032120
HPA032121

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SCIMP.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
P11049, 10 interactors

Molecular INTeraction database

More...
MINTi
P11049

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000325708

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3882 Eukaryota
ENOG4111IRY LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161485

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230651

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P11049

KEGG Orthology (KO)

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KOi
K06475

Identification of Orthologs from Complete Genome Data

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OMAi
LSIFMCR

Database of Orthologous Groups

More...
OrthoDBi
1207549at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P11049

TreeFam database of animal gene trees

More...
TreeFami
TF352892

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1450.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00335 Tetraspanin, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002419 Tetraspanin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00259 TMFOUR

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48652 SSF48652, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00421 TM4_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P11049-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSAQESCLSL IKYFLFVFNL FFFVLGSLIF CFGIWILIDK TSFVSFVGLA
60 70 80 90 100
FVPLQIWSKV LAISGIFTMG IALLGCVGAL KELRCLLGLY FGMLLLLFAT
110 120 130 140 150
QITLGILIST QRAQLERSLR DVVEKTIQKY GTNPEETAAE ESWDYVQFQL
160 170 180 190 200
RCCGWHYPQD WFQVLILRGN GSEAHRVPCS CYNLSATNDS TILDKVILPQ
210 220 230 240 250
LSRLGHLARS RHSADICAVP AESHIYREGC AQGLQKWLHN NLISIVGICL
260 270 280
GVGLLELGFM TLSIFLCRNL DHVYNRLARY R
Length:281
Mass (Da):31,703
Last modified:November 1, 1990 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4342C5FB4479FDC8
GO
Isoform 2 (identifier: P11049-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-68: Missing.

Note: Gene prediction based on EST data.
Show »
Length:213
Mass (Da):23,996
Checksum:i7F046007C0A4F044
GO
Isoform 3 (identifier: P11049-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-68: Missing.
     257-281: LGFMTLSIFLCRNLDHVYNRLARYR → VIWPRPHPRSALNP

Note: No experimental confirmation available.
Show »
Length:202
Mass (Da):22,563
Checksum:iD3CDB33CF37804E9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7ZAN3B7ZAN3_HUMAN
Tetraspanin
CD37
270Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q96LM7Q96LM7_HUMAN
Leukocyte antigen CD37
CD37
156Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZP6M0QZP6_HUMAN
Leukocyte antigen CD37
CD37
254Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R1J1M0R1J1_HUMAN
Leukocyte antigen CD37
CD37
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZ33M0QZ33_HUMAN
Leukocyte antigen CD37
CD37
160Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R083M0R083_HUMAN
Leukocyte antigen CD37
CD37
26Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0472281 – 68Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST68
Alternative sequenceiVSP_047229257 – 281LGFMT…LARYR → VIWPRPHPRSALNP in isoform 3. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X14046 mRNA Translation: CAA32204.1
AK301016 mRNA Translation: BAG62633.1
CR541877 mRNA Translation: CAG46675.1
BT019851 mRNA Translation: AAV38654.1
AC010524 Genomic DNA No translation available.
AC011450 Genomic DNA No translation available.
BC106752 mRNA Translation: AAI06753.1
BC110379 mRNA Translation: AAI10380.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS12760.1 [P11049-1]
CCDS46139.1 [P11049-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
A47629

NCBI Reference Sequences

More...
RefSeqi
NP_001035120.1, NM_001040031.1 [P11049-2]
NP_001765.1, NM_001774.2 [P11049-1]
XP_011525846.1, XM_011527544.2 [P11049-2]
XP_016883002.1, XM_017027513.1 [P11049-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000323906; ENSP00000325708; ENSG00000104894 [P11049-1]
ENST00000426897; ENSP00000413151; ENSG00000104894 [P11049-2]
ENST00000598095; ENSP00000470394; ENSG00000104894 [P11049-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
951

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:951

UCSC genome browser

More...
UCSCi
uc002pnd.4 human [P11049-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14046 mRNA Translation: CAA32204.1
AK301016 mRNA Translation: BAG62633.1
CR541877 mRNA Translation: CAG46675.1
BT019851 mRNA Translation: AAV38654.1
AC010524 Genomic DNA No translation available.
AC011450 Genomic DNA No translation available.
BC106752 mRNA Translation: AAI06753.1
BC110379 mRNA Translation: AAI10380.1
CCDSiCCDS12760.1 [P11049-1]
CCDS46139.1 [P11049-2]
PIRiA47629
RefSeqiNP_001035120.1, NM_001040031.1 [P11049-2]
NP_001765.1, NM_001774.2 [P11049-1]
XP_011525846.1, XM_011527544.2 [P11049-2]
XP_016883002.1, XM_017027513.1 [P11049-2]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiP11049, 10 interactors
MINTiP11049
STRINGi9606.ENSP00000325708

Chemistry databases

ChEMBLiCHEMBL3712880
GuidetoPHARMACOLOGYi3010

PTM databases

iPTMnetiP11049
PhosphoSitePlusiP11049
SwissPalmiP11049

Polymorphism and mutation databases

BioMutaiCD37
DMDMi115983

Proteomic databases

jPOSTiP11049
MassIVEiP11049
MaxQBiP11049
PaxDbiP11049
PeptideAtlasiP11049
PRIDEiP11049
ProteomicsDBi52690 [P11049-1]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
P11049

The DNASU plasmid repository

More...
DNASUi
951

Genome annotation databases

EnsembliENST00000323906; ENSP00000325708; ENSG00000104894 [P11049-1]
ENST00000426897; ENSP00000413151; ENSG00000104894 [P11049-2]
ENST00000598095; ENSP00000470394; ENSG00000104894 [P11049-3]
GeneIDi951
KEGGihsa:951
UCSCiuc002pnd.4 human [P11049-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
951
DisGeNETi951

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CD37
HGNCiHGNC:1666 CD37
HPAiCAB002492
HPA032120
HPA032121
MIMi151523 gene
neXtProtiNX_P11049
OpenTargetsiENSG00000104894
PharmGKBiPA26213

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00940000161485
HOGENOMiHOG000230651
InParanoidiP11049
KOiK06475
OMAiLSIFMCR
OrthoDBi1207549at2759
PhylomeDBiP11049
TreeFamiTF352892

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CD37 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CD37

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
951
PharosiP11049

Protein Ontology

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PROi
PR:P11049

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000104894 Expressed in 137 organ(s), highest expression level in leukocyte
ExpressionAtlasiP11049 baseline and differential
GenevisibleiP11049 HS

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspanin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit
PROSITEiView protein in PROSITE
PS00421 TM4_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCD37_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P11049
Secondary accession number(s): B4DVC1, Q3KPF9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1990
Last modified: October 16, 2019
This is version 165 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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