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Protein

Leukocyte antigen CD37

Gene

CD37

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte antigen CD37
Alternative name(s):
Tetraspanin-26
Short name:
Tspan-26
CD_antigen: CD37
Gene namesi
Name:CD37
Synonyms:TSPAN26
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000104894.11
HGNCiHGNC:1666 CD37
MIMi151523 gene
neXtProtiNX_P11049

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 17CytoplasmicSequence analysisAdd BLAST17
Transmembranei18 – 38HelicalSequence analysisAdd BLAST21
Topological domaini39 – 59ExtracellularSequence analysisAdd BLAST21
Transmembranei60 – 74HelicalSequence analysisAdd BLAST15
Topological domaini75 – 85CytoplasmicSequence analysisAdd BLAST11
Transmembranei86 – 111HelicalSequence analysisAdd BLAST26
Topological domaini112 – 241ExtracellularSequence analysisAdd BLAST130
Transmembranei242 – 266HelicalSequence analysisAdd BLAST25
Topological domaini267 – 281CytoplasmicSequence analysisAdd BLAST15

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi951
OpenTargetsiENSG00000104894
PharmGKBiPA26213

Chemistry databases

ChEMBLiCHEMBL3712880
GuidetoPHARMACOLOGYi3010

Polymorphism and mutation databases

BioMutaiCD37
DMDMi115983

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192091 – 281Leukocyte antigen CD37Add BLAST281

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi170N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi183N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP11049
PaxDbiP11049
PeptideAtlasiP11049
PRIDEiP11049
ProteomicsDBi52690

PTM databases

iPTMnetiP11049
PhosphoSitePlusiP11049
SwissPalmiP11049

Expressioni

Tissue specificityi

B-lymphocytes.

Gene expression databases

BgeeiENSG00000104894 Expressed in 137 organ(s), highest expression level in leukocyte
CleanExiHS_CD37
ExpressionAtlasiP11049 baseline and differential
GenevisibleiP11049 HS

Organism-specific databases

HPAiCAB002492
HPA032120
HPA032121

Interactioni

Subunit structurei

Interacts with SCIMP.1 Publication

Binary interactionsi

Protein-protein interaction databases

IntActiP11049, 9 interactors
STRINGi9606.ENSP00000325708

Structurei

3D structure databases

ProteinModelPortaliP11049
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00880000137858
HOGENOMiHOG000230651
HOVERGENiHBG002324
InParanoidiP11049
KOiK06475
OMAiRCCGWHS
OrthoDBiEOG091G0H71
PhylomeDBiP11049
TreeFamiTF352892

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 2 hits
PROSITEiView protein in PROSITE
PS00421 TM4_1, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P11049-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSAQESCLSL IKYFLFVFNL FFFVLGSLIF CFGIWILIDK TSFVSFVGLA
60 70 80 90 100
FVPLQIWSKV LAISGIFTMG IALLGCVGAL KELRCLLGLY FGMLLLLFAT
110 120 130 140 150
QITLGILIST QRAQLERSLR DVVEKTIQKY GTNPEETAAE ESWDYVQFQL
160 170 180 190 200
RCCGWHYPQD WFQVLILRGN GSEAHRVPCS CYNLSATNDS TILDKVILPQ
210 220 230 240 250
LSRLGHLARS RHSADICAVP AESHIYREGC AQGLQKWLHN NLISIVGICL
260 270 280
GVGLLELGFM TLSIFLCRNL DHVYNRLARY R
Length:281
Mass (Da):31,703
Last modified:November 1, 1990 - v2
Checksum:i4342C5FB4479FDC8
GO
Isoform 2 (identifier: P11049-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-68: Missing.

Note: Gene prediction based on EST data.
Show »
Length:213
Mass (Da):23,996
Checksum:i7F046007C0A4F044
GO
Isoform 3 (identifier: P11049-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-68: Missing.
     257-281: LGFMTLSIFLCRNLDHVYNRLARYR → VIWPRPHPRSALNP

Note: No experimental confirmation available.
Show »
Length:202
Mass (Da):22,563
Checksum:iD3CDB33CF37804E9
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7ZAN3B7ZAN3_HUMAN
Tetraspanin
CD37
270Annotation score:
Q96LM7Q96LM7_HUMAN
Leukocyte antigen CD37
CD37
156Annotation score:
M0QZP6M0QZP6_HUMAN
Leukocyte antigen CD37
CD37
254Annotation score:
M0QZ33M0QZ33_HUMAN
Leukocyte antigen CD37
CD37
160Annotation score:
M0R1J1M0R1J1_HUMAN
Leukocyte antigen CD37
CD37
121Annotation score:
M0R083M0R083_HUMAN
Leukocyte antigen CD37
CD37
26Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0472281 – 68Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST68
Alternative sequenceiVSP_047229257 – 281LGFMT…LARYR → VIWPRPHPRSALNP in isoform 3. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14046 mRNA Translation: CAA32204.1
AK301016 mRNA Translation: BAG62633.1
CR541877 mRNA Translation: CAG46675.1
BT019851 mRNA Translation: AAV38654.1
AC010524 Genomic DNA No translation available.
AC011450 Genomic DNA No translation available.
BC106752 mRNA Translation: AAI06753.1
BC110379 mRNA Translation: AAI10380.1
CCDSiCCDS12760.1 [P11049-1]
CCDS46139.1 [P11049-2]
PIRiA47629
RefSeqiNP_001035120.1, NM_001040031.1 [P11049-2]
NP_001765.1, NM_001774.2 [P11049-1]
XP_011525846.1, XM_011527544.2 [P11049-2]
XP_016883002.1, XM_017027513.1 [P11049-2]
UniGeneiHs.166556

Genome annotation databases

EnsembliENST00000323906; ENSP00000325708; ENSG00000104894 [P11049-1]
ENST00000426897; ENSP00000413151; ENSG00000104894 [P11049-2]
ENST00000598095; ENSP00000470394; ENSG00000104894 [P11049-3]
GeneIDi951
KEGGihsa:951
UCSCiuc002pnd.4 human [P11049-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14046 mRNA Translation: CAA32204.1
AK301016 mRNA Translation: BAG62633.1
CR541877 mRNA Translation: CAG46675.1
BT019851 mRNA Translation: AAV38654.1
AC010524 Genomic DNA No translation available.
AC011450 Genomic DNA No translation available.
BC106752 mRNA Translation: AAI06753.1
BC110379 mRNA Translation: AAI10380.1
CCDSiCCDS12760.1 [P11049-1]
CCDS46139.1 [P11049-2]
PIRiA47629
RefSeqiNP_001035120.1, NM_001040031.1 [P11049-2]
NP_001765.1, NM_001774.2 [P11049-1]
XP_011525846.1, XM_011527544.2 [P11049-2]
XP_016883002.1, XM_017027513.1 [P11049-2]
UniGeneiHs.166556

3D structure databases

ProteinModelPortaliP11049
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP11049, 9 interactors
STRINGi9606.ENSP00000325708

Chemistry databases

ChEMBLiCHEMBL3712880
GuidetoPHARMACOLOGYi3010

PTM databases

iPTMnetiP11049
PhosphoSitePlusiP11049
SwissPalmiP11049

Polymorphism and mutation databases

BioMutaiCD37
DMDMi115983

Proteomic databases

MaxQBiP11049
PaxDbiP11049
PeptideAtlasiP11049
PRIDEiP11049
ProteomicsDBi52690

Protocols and materials databases

DNASUi951
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000323906; ENSP00000325708; ENSG00000104894 [P11049-1]
ENST00000426897; ENSP00000413151; ENSG00000104894 [P11049-2]
ENST00000598095; ENSP00000470394; ENSG00000104894 [P11049-3]
GeneIDi951
KEGGihsa:951
UCSCiuc002pnd.4 human [P11049-1]

Organism-specific databases

CTDi951
DisGeNETi951
EuPathDBiHostDB:ENSG00000104894.11
GeneCardsiCD37
HGNCiHGNC:1666 CD37
HPAiCAB002492
HPA032120
HPA032121
MIMi151523 gene
neXtProtiNX_P11049
OpenTargetsiENSG00000104894
PharmGKBiPA26213
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00880000137858
HOGENOMiHOG000230651
HOVERGENiHBG002324
InParanoidiP11049
KOiK06475
OMAiRCCGWHS
OrthoDBiEOG091G0H71
PhylomeDBiP11049
TreeFamiTF352892

Miscellaneous databases

ChiTaRSiCD37 human
GeneWikiiCD37
GenomeRNAii951
PROiPR:P11049
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000104894 Expressed in 137 organ(s), highest expression level in leukocyte
CleanExiHS_CD37
ExpressionAtlasiP11049 baseline and differential
GenevisibleiP11049 HS

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 2 hits
PROSITEiView protein in PROSITE
PS00421 TM4_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCD37_HUMAN
AccessioniPrimary (citable) accession number: P11049
Secondary accession number(s): B4DVC1, Q3KPF9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1990
Last modified: September 12, 2018
This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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