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UniProtKB - P11047 (LAMC1_HUMAN)

Entry version 228 (07 Apr 2021)
Sequence version 3 (03 Mar 2009)
Previous versions | rss
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Protein

Laminin subunit gamma-1

Gene

LAMC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P11047

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1474228, Degradation of the extracellular matrix
R-HSA-3000157, Laminin interactions
R-HSA-3000171, Non-integrin membrane-ECM interactions
R-HSA-3000178, ECM proteoglycans
R-HSA-373760, L1CAM interactions
R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8874081, MET activates PTK2 signaling
R-HSA-8957275, Post-translational protein phosphorylation
R-HSA-9619665, EGR2 and SOX10-mediated initiation of Schwann cell myelination

SIGNOR Signaling Network Open Resource

More...SIGNORi		P11047

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Laminin subunit gamma-1
Alternative name(s):
Laminin B2 chain
Laminin-1 subunit gamma
Laminin-10 subunit gamma
Laminin-11 subunit gamma
Laminin-2 subunit gamma
Laminin-3 subunit gamma
Laminin-4 subunit gamma
Laminin-6 subunit gamma
Laminin-7 subunit gamma
Laminin-8 subunit gamma
Laminin-9 subunit gamma
S-laminin subunit gamma
Short name:
S-LAM gamma
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LAMC11 PublicationImported
Synonyms:LAMB2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6492, LAMC1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		150290, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P11047

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000135862.5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		3915

Open Targets

More...OpenTargetsi		ENSG00000135862

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30280

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P11047, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2364187

Drug and drug target database

More...DrugBanki		DB06245, Lanoteplase

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		LAMC1

Domain mapping of disease mutations (DMDM)

More...DMDMi		224471885

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 33Add BLAST33
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001707434 – 1609Laminin subunit gamma-1Add BLAST1576

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi60N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi286 ↔ 295PROSITE-ProRule annotation
Disulfide bondi288 ↔ 305PROSITE-ProRule annotation
Disulfide bondi307 ↔ 316PROSITE-ProRule annotation
Disulfide bondi319 ↔ 339PROSITE-ProRule annotation
Disulfide bondi342 ↔ 351PROSITE-ProRule annotation
Disulfide bondi344 ↔ 367PROSITE-ProRule annotation
Disulfide bondi370 ↔ 379PROSITE-ProRule annotation
Disulfide bondi382 ↔ 395PROSITE-ProRule annotation
Disulfide bondi398 ↔ 410PROSITE-ProRule annotation
Disulfide bondi400 ↔ 416PROSITE-ProRule annotation
Disulfide bondi418 ↔ 427PROSITE-ProRule annotation
Disulfide bondi430 ↔ 442PROSITE-ProRule annotation
Disulfide bondi445 ↔ 456PROSITE-ProRule annotation
Disulfide bondi447 ↔ 463PROSITE-ProRule annotation
Disulfide bondi465 ↔ 474PROSITE-ProRule annotation
Disulfide bondi477 ↔ 492PROSITE-ProRule annotation
Glycosylationi576N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi650N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi724 ↔ 733PROSITE-ProRule annotation
Disulfide bondi726 ↔ 740PROSITE-ProRule annotation
Disulfide bondi742 ↔ 751PROSITE-ProRule annotation
Disulfide bondi754 ↔ 770PROSITE-ProRule annotation
Disulfide bondi773 ↔ 781PROSITE-ProRule annotation
Disulfide bondi775 ↔ 792PROSITE-ProRule annotation
Disulfide bondi795 ↔ 804PROSITE-ProRule annotation
Disulfide bondi807 ↔ 825PROSITE-ProRule annotation
Disulfide bondi828 ↔ 842PROSITE-ProRule annotation
Disulfide bondi830 ↔ 849PROSITE-ProRule annotation
Disulfide bondi852 ↔ 861PROSITE-ProRule annotation
Disulfide bondi864 ↔ 881PROSITE-ProRule annotation
Disulfide bondi884 ↔ 898PROSITE-ProRule annotation
Disulfide bondi886 ↔ 905PROSITE-ProRule annotation
Disulfide bondi907 ↔ 916PROSITE-ProRule annotation
Disulfide bondi919 ↔ 932PROSITE-ProRule annotation
Disulfide bondi935 ↔ 947PROSITE-ProRule annotation
Disulfide bondi937 ↔ 954PROSITE-ProRule annotation
Disulfide bondi956 ↔ 965PROSITE-ProRule annotation
Disulfide bondi968 ↔ 980PROSITE-ProRule annotation
Disulfide bondi983 ↔ 995PROSITE-ProRule annotation
Disulfide bondi985 ↔ 1001PROSITE-ProRule annotation
Disulfide bondi1003 ↔ 1012PROSITE-ProRule annotation
Disulfide bondi1015 ↔ 1028PROSITE-ProRule annotation
Glycosylationi1022N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1031InterchainCurated
Disulfide bondi1034InterchainCurated
Glycosylationi1107N-linked (GlcNAc...) asparagine2 Publications1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1149Phosphoserine; by FAM20C1 Publication1
Glycosylationi1161N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1175N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1205N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1223N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1241N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1380N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1395N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi1439N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1493PhosphoserineCombined sources1
Disulfide bondi1600InterchainCurated

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P11047

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P11047

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P11047

MaxQB - The MaxQuant DataBase

More...MaxQBi		P11047

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P11047

PeptideAtlas

More...PeptideAtlasi		P11047

PRoteomics IDEntifications database

More...PRIDEi		P11047

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		52689

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		P11047

GlyConnect protein glycosylation platform

More...GlyConnecti		1444, 60 N-Linked glycans (9 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P11047, 15 sites, 4 N-linked glycans (3 sites), 3 O-linked glycans (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P11047

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P11047

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P11047

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Found in the basement membranes (major component).

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000135862, Expressed in parietal pleura and 242 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P11047, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P11047, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000135862, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Gamma-1 is a subunit of laminin-1 (laminin-111 or EHS laminin), laminin-2 (laminin-211 or merosin), laminin-3 (laminin-121 or S-laminin), laminin-4 (laminin-221 or S-merosin), laminin-6 (laminin-311 or K-laminin), laminin-7 (laminin-321 or KS-laminin), laminin-8 (laminin-411), laminin-9 (laminin-421), laminin-10 (laminin-511) and laminin-11 (laminin-521).

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110109, 47 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-1770, Laminin-111 complex
CPX-1771, Laminin-211 complex
CPX-1772, Laminin-121 complex
CPX-1773, Laminin-221 complex
CPX-1775, Laminin-311 complex variant A
CPX-1776, Laminin-321 complex
CPX-1777, Laminin-411 complex
CPX-1778, Laminin-421 complex
CPX-1779, Laminin-511 complex
CPX-1780, Laminin-521 complex
CPX-3166, Laminin-311 complex variant B

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P11047

Protein interaction database and analysis system

More...IntActi		P11047, 25 interactors

Molecular INTeraction database

More...MINTi		P11047

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000258341

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P11047, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11609
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P11047

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini46 – 285Laminin N-terminalPROSITE-ProRule annotationAdd BLAST240
Domaini286 – 341Laminin EGF-like 1PROSITE-ProRule annotationAdd BLAST56
Domaini342 – 397Laminin EGF-like 2PROSITE-ProRule annotationAdd BLAST56
Domaini398 – 444Laminin EGF-like 3PROSITE-ProRule annotationAdd BLAST47
Domaini445 – 494Laminin EGF-like 4PROSITE-ProRule annotationAdd BLAST50
Domaini495 – 504Laminin EGF-like 5; first partPROSITE-ProRule annotation10
Domaini514 – 689Laminin IV type APROSITE-ProRule annotationAdd BLAST176
Domaini690 – 723Laminin EGF-like 5; second partPROSITE-ProRule annotationAdd BLAST34
Domaini724 – 772Laminin EGF-like 6PROSITE-ProRule annotationAdd BLAST49
Domaini773 – 827Laminin EGF-like 7PROSITE-ProRule annotationAdd BLAST55
Domaini828 – 883Laminin EGF-like 8PROSITE-ProRule annotationAdd BLAST56
Domaini884 – 934Laminin EGF-like 9PROSITE-ProRule annotationAdd BLAST51
Domaini935 – 982Laminin EGF-like 10PROSITE-ProRule annotationAdd BLAST48
Domaini983 – 1030Laminin EGF-like 11PROSITE-ProRule annotationAdd BLAST48

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1030 – 1609Domain II and IAdd BLAST580

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1038 – 1609Sequence analysisAdd BLAST572

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
Domains VI and IV are globular.

Keywords - Domaini

Coiled coil, Laminin EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1836, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158069

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002471_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P11047

Identification of Orthologs from Complete Genome Data

More...OMAi		TSEDGPW

Database of Orthologous Groups

More...OrthoDBi		156553at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P11047

TreeFam database of animal gene trees

More...TreeFami		TF352481

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.120.1490, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000742, EGF-like_dom
IPR002049, Laminin_EGF
IPR000034, Laminin_IV
IPR008211, Laminin_N
IPR038684, Laminin_N_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00052, Laminin_B, 1 hit
PF00053, Laminin_EGF, 10 hits
PF00055, Laminin_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00181, EGF, 8 hits
SM00180, EGF_Lam, 10 hits
SM00281, LamB, 1 hit
SM00136, LamNT, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00022, EGF_1, 8 hits
PS01186, EGF_2, 2 hits
PS01248, EGF_LAM_1, 11 hits
PS50027, EGF_LAM_2, 10 hits
PS51115, LAMININ_IVA, 1 hit
PS51117, LAMININ_NTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P11047-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRGSHRAAPA LRPRGRLWPV LAVLAAAAAA GCAQAAMDEC TDEGGRPQRC 
        60         70         80         90        100
MPEFVNAAFN VTVVATNTCG TPPEEYCVQT GVTGVTKSCH LCDAGQPHLQ 
       110        120        130        140        150
HGAAFLTDYN NQADTTWWQS QTMLAGVQYP SSINLTLHLG KAFDITYVRL 
       160        170        180        190        200
KFHTSRPESF AIYKRTREDG PWIPYQYYSG SCENTYSKAN RGFIRTGGDE 
       210        220        230        240        250
QQALCTDEFS DISPLTGGNV AFSTLEGRPS AYNFDNSPVL QEWVTATDIR 
       260        270        280        290        300
VTLNRLNTFG DEVFNDPKVL KSYYYAISDF AVGGRCKCNG HASECMKNEF 
       310        320        330        340        350
DKLVCNCKHN TYGVDCEKCL PFFNDRPWRR ATAESASECL PCDCNGRSQE 
       360        370        380        390        400
CYFDPELYRS TGHGGHCTNC QDNTDGAHCE RCRENFFRLG NNEACSSCHC 
       410        420        430        440        450
SPVGSLSTQC DSYGRCSCKP GVMGDKCDRC QPGFHSLTEA GCRPCSCDPS 
       460        470        480        490        500
GSIDECNIET GRCVCKDNVE GFNCERCKPG FFNLESSNPR GCTPCFCFGH 
       510        520        530        540        550
SSVCTNAVGY SVYSISSTFQ IDEDGWRAEQ RDGSEASLEW SSERQDIAVI 
       560        570        580        590        600
SDSYFPRYFI APAKFLGKQV LSYGQNLSFS FRVDRRDTRL SAEDLVLEGA 
       610        620        630        640        650
GLRVSVPLIA QGNSYPSETT VKYVFRLHEA TDYPWRPALT PFEFQKLLNN 
       660        670        680        690        700
LTSIKIRGTY SERSAGYLDD VTLASARPGP GVPATWVESC TCPVGYGGQF 
       710        720        730        740        750
CEMCLSGYRR ETPNLGPYSP CVLCACNGHS ETCDPETGVC NCRDNTAGPH 
       760        770        780        790        800
CEKCSDGYYG DSTAGTSSDC QPCPCPGGSS CAVVPKTKEV VCTNCPTGTT 
       810        820        830        840        850
GKRCELCDDG YFGDPLGRNG PVRLCRLCQC SDNIDPNAVG NCNRLTGECL 
       860        870        880        890        900
KCIYNTAGFY CDRCKDGFFG NPLAPNPADK CKACNCNLYG TMKQQSSCNP 
       910        920        930        940        950
VTGQCECLPH VTGQDCGACD PGFYNLQSGQ GCERCDCHAL GSTNGQCDIR 
       960        970        980        990       1000
TGQCECQPGI TGQHCERCEV NHFGFGPEGC KPCDCHPEGS LSLQCKDDGR 
      1010       1020       1030       1040       1050
CECREGFVGN RCDQCEENYF YNRSWPGCQE CPACYRLVKD KVADHRVKLQ 
      1060       1070       1080       1090       1100
ELESLIANLG TGDEMVTDQA FEDRLKEAER EVMDLLREAQ DVKDVDQNLM 
      1110       1120       1130       1140       1150
DRLQRVNNTL SSQISRLQNI RNTIEETGNL AEQARAHVEN TERLIEIASR 
      1160       1170       1180       1190       1200
ELEKAKVAAA NVSVTQPEST GDPNNMTLLA EEARKLAERH KQEADDIVRV 
      1210       1220       1230       1240       1250
AKTANDTSTE AYNLLLRTLA GENQTAFEIE ELNRKYEQAK NISQDLEKQA 
      1260       1270       1280       1290       1300
ARVHEEAKRA GDKAVEIYAS VAQLSPLDSE TLENEANNIK MEAENLEQLI 
      1310       1320       1330       1340       1350
DQKLKDYEDL REDMRGKELE VKNLLEKGKT EQQTADQLLA RADAAKALAE 
      1360       1370       1380       1390       1400
EAAKKGRDTL QEANDILNNL KDFDRRVNDN KTAAEEALRK IPAINQTITE 
      1410       1420       1430       1440       1450
ANEKTREAQQ ALGSAAADAT EAKNKAHEAE RIASAVQKNA TSTKAEAERT 
      1460       1470       1480       1490       1500
FAEVTDLDNE VNNMLKQLQE AEKELKRKQD DADQDMMMAG MASQAAQEAE 
      1510       1520       1530       1540       1550
INARKAKNSV TSLLSIINDL LEQLGQLDTV DLNKLNEIEG TLNKAKDEMK 
      1560       1570       1580       1590       1600
VSDLDRKVSD LENEAKKQEA AIMDYNRDIE EIMKDIRNLE DIRKTLPSGC 

FNTPSIEKP
Length:1,609
Mass (Da):177,603
Last modified:March 3, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i42D9A9958EEBBB01
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
R4GNC7R4GNC7_HUMAN
Laminin subunit gamma-1
LAMC1
37Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti212I → F in AAA59492 (PubMed:1985895).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_080757363H → L Found in a consanguineous family with intellectual disability; unknown pathological significance. 1 Publication1
Natural variantiVAR_014700458I → V2 PublicationsCorresponds to variant dbSNP:rs20563Ensembl.1
Natural variantiVAR_054488731E → K. Corresponds to variant dbSNP:rs2230157EnsemblClinVar.1
Natural variantiVAR_014701888L → P2 PublicationsCorresponds to variant dbSNP:rs20558Ensembl.1
Natural variantiVAR_0358211116R → H in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs548688323Ensembl.1
Natural variantiVAR_0147021121R → Q. Corresponds to variant dbSNP:rs20559Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
J03202 mRNA Translation: AAA59488.1
M55210 M55209 Genomic DNA Translation: AAA59492.1
AL354953 Genomic DNA No translation available.
AL450304 Genomic DNA No translation available.
X13939 mRNA Translation: CAA32122.1
M27654 mRNA Translation: AAA59489.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1351.1

Protein sequence database of the Protein Information Resource

More...PIRi		S13548, MMHUB2

NCBI Reference Sequences

More...RefSeqi		NP_002284.3, NM_002293.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000258341; ENSP00000258341; ENSG00000135862

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3915

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3915

UCSC genome browser

More...UCSCi		uc001gpy.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03202 mRNA Translation: AAA59488.1
M55210 M55209 Genomic DNA Translation: AAA59492.1
AL354953 Genomic DNA No translation available.
AL450304 Genomic DNA No translation available.
X13939 mRNA Translation: CAA32122.1
M27654 mRNA Translation: AAA59489.1
CCDSiCCDS1351.1
PIRiS13548, MMHUB2
RefSeqiNP_002284.3, NM_002293.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5XAUX-ray1.80C/F1528-1609[»]
SMRiP11047
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi110109, 47 interactors
ComplexPortaliCPX-1770, Laminin-111 complex
CPX-1771, Laminin-211 complex
CPX-1772, Laminin-121 complex
CPX-1773, Laminin-221 complex
CPX-1775, Laminin-311 complex variant A
CPX-1776, Laminin-321 complex
CPX-1777, Laminin-411 complex
CPX-1778, Laminin-421 complex
CPX-1779, Laminin-511 complex
CPX-1780, Laminin-521 complex
CPX-3166, Laminin-311 complex variant B
CORUMiP11047
IntActiP11047, 25 interactors
MINTiP11047
STRINGi9606.ENSP00000258341

Chemistry databases

ChEMBLiCHEMBL2364187
DrugBankiDB06245, Lanoteplase

PTM databases

CarbonylDBiP11047
GlyConnecti1444, 60 N-Linked glycans (9 sites)
GlyGeniP11047, 15 sites, 4 N-linked glycans (3 sites), 3 O-linked glycans (1 site)
iPTMnetiP11047
PhosphoSitePlusiP11047
SwissPalmiP11047

Genetic variation databases

BioMutaiLAMC1
DMDMi224471885

Proteomic databases

EPDiP11047
jPOSTiP11047
MassIVEiP11047
MaxQBiP11047
PaxDbiP11047
PeptideAtlasiP11047
PRIDEiP11047
ProteomicsDBi52689

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1055, 511 antibodies

Genome annotation databases

EnsembliENST00000258341; ENSP00000258341; ENSG00000135862
GeneIDi3915
KEGGihsa:3915
UCSCiuc001gpy.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3915
DisGeNETi3915

GeneCards: human genes, protein and diseases

More...GeneCardsi		LAMC1
HGNCiHGNC:6492, LAMC1
HPAiENSG00000135862, Low tissue specificity
MIMi150290, gene
neXtProtiNX_P11047
OpenTargetsiENSG00000135862
PharmGKBiPA30280
VEuPathDBiHostDB:ENSG00000135862.5

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1836, Eukaryota
GeneTreeiENSGT00940000158069
HOGENOMiCLU_002471_1_0_1
InParanoidiP11047
OMAiTSEDGPW
OrthoDBi156553at2759
PhylomeDBiP11047
TreeFamiTF352481

Enzyme and pathway databases

PathwayCommonsiP11047
ReactomeiR-HSA-1474228, Degradation of the extracellular matrix
R-HSA-3000157, Laminin interactions
R-HSA-3000171, Non-integrin membrane-ECM interactions
R-HSA-3000178, ECM proteoglycans
R-HSA-373760, L1CAM interactions
R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8874081, MET activates PTK2 signaling
R-HSA-8957275, Post-translational protein phosphorylation
R-HSA-9619665, EGR2 and SOX10-mediated initiation of Schwann cell myelination
SIGNORiP11047

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3915, 6 hits in 989 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		LAMC1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Laminin,_gamma_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3915
PharosiP11047, Tbio

Protein Ontology

More...PROi		PR:P11047
RNActiP11047, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000135862, Expressed in parietal pleura and 242 other tissues
ExpressionAtlasiP11047, baseline and differential
GenevisibleiP11047, HS

Family and domain databases

Gene3Di2.60.120.1490, 1 hit
InterProiView protein in InterPro
IPR000742, EGF-like_dom
IPR002049, Laminin_EGF
IPR000034, Laminin_IV
IPR008211, Laminin_N
IPR038684, Laminin_N_sf
PfamiView protein in Pfam
PF00052, Laminin_B, 1 hit
PF00053, Laminin_EGF, 10 hits
PF00055, Laminin_N, 1 hit
SMARTiView protein in SMART
SM00181, EGF, 8 hits
SM00180, EGF_Lam, 10 hits
SM00281, LamB, 1 hit
SM00136, LamNT, 1 hit
PROSITEiView protein in PROSITE
PS00022, EGF_1, 8 hits
PS01186, EGF_2, 2 hits
PS01248, EGF_LAM_1, 11 hits
PS50027, EGF_LAM_2, 10 hits
PS51115, LAMININ_IVA, 1 hit
PS51117, LAMININ_NTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLAMC1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P11047
Secondary accession number(s): Q5VYE7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: March 3, 2009
Last modified: April 7, 2021
This is version 228 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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