UniProtKB - P11047 (LAMC1_HUMAN)
Laminin subunit gamma-1
LAMC1
Functioni
GO - Molecular functioni
- extracellular matrix structural constituent Source: HGNC-UCL
GO - Biological processi
- animal organ morphogenesis Source: GO_Central
- cell adhesion Source: HGNC-UCL
- cell migration Source: HGNC-UCL
- cellular protein metabolic process Source: Reactome
- endoderm development Source: ProtInc
- extracellular matrix disassembly Source: HGNC-UCL
- extracellular matrix organization Source: Reactome
- hemidesmosome assembly Source: HGNC-UCL
- maintenance of blood-brain barrier Source: ARUK-UCL
- positive regulation of epithelial cell proliferation Source: HGNC-UCL
- post-translational protein modification Source: Reactome
- protein-containing complex assembly Source: HGNC-UCL
- substrate adhesion-dependent cell spreading Source: BHF-UCL
- tissue development Source: GO_Central
Keywordsi
Biological process | Cell adhesion |
Enzyme and pathway databases
PathwayCommonsi | P11047 |
Reactomei | R-HSA-1474228, Degradation of the extracellular matrix R-HSA-3000157, Laminin interactions R-HSA-3000171, Non-integrin membrane-ECM interactions R-HSA-3000178, ECM proteoglycans R-HSA-373760, L1CAM interactions R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8874081, MET activates PTK2 signaling R-HSA-8957275, Post-translational protein phosphorylation R-HSA-9619665, EGR2 and SOX10-mediated initiation of Schwann cell myelination |
SIGNORi | P11047 |
Names & Taxonomyi
Protein namesi | Recommended name: Laminin subunit gamma-1Alternative name(s): Laminin B2 chain Laminin-1 subunit gamma Laminin-10 subunit gamma Laminin-11 subunit gamma Laminin-2 subunit gamma Laminin-3 subunit gamma Laminin-4 subunit gamma Laminin-6 subunit gamma Laminin-7 subunit gamma Laminin-8 subunit gamma Laminin-9 subunit gamma S-laminin subunit gamma Short name: S-LAM gamma |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6492, LAMC1 |
MIMi | 150290, gene |
neXtProti | NX_P11047 |
VEuPathDBi | HostDB:ENSG00000135862.5 |
Subcellular locationi
Extracellular region or secreted
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
- extracellular space Source: UniProtKB
Other locations
- basement membrane Source: UniProtKB
- collagen-containing extracellular matrix Source: UniProtKB
- laminin-1 complex Source: HGNC-UCL
- laminin-10 complex Source: BHF-UCL
- laminin-11 complex Source: BHF-UCL
Keywords - Cellular componenti
Basement membrane, Extracellular matrix, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 3915 |
OpenTargetsi | ENSG00000135862 |
PharmGKBi | PA30280 |
Miscellaneous databases
Pharosi | P11047, Tbio |
Chemistry databases
ChEMBLi | CHEMBL2364187 |
DrugBanki | DB06245, Lanoteplase |
Genetic variation databases
BioMutai | LAMC1 |
DMDMi | 224471885 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 33 | Add BLAST | 33 | |
ChainiPRO_0000017074 | 34 – 1609 | Laminin subunit gamma-1Add BLAST | 1576 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 60 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 134 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 286 ↔ 295 | PROSITE-ProRule annotation | ||
Disulfide bondi | 288 ↔ 305 | PROSITE-ProRule annotation | ||
Disulfide bondi | 307 ↔ 316 | PROSITE-ProRule annotation | ||
Disulfide bondi | 319 ↔ 339 | PROSITE-ProRule annotation | ||
Disulfide bondi | 342 ↔ 351 | PROSITE-ProRule annotation | ||
Disulfide bondi | 344 ↔ 367 | PROSITE-ProRule annotation | ||
Disulfide bondi | 370 ↔ 379 | PROSITE-ProRule annotation | ||
Disulfide bondi | 382 ↔ 395 | PROSITE-ProRule annotation | ||
Disulfide bondi | 398 ↔ 410 | PROSITE-ProRule annotation | ||
Disulfide bondi | 400 ↔ 416 | PROSITE-ProRule annotation | ||
Disulfide bondi | 418 ↔ 427 | PROSITE-ProRule annotation | ||
Disulfide bondi | 430 ↔ 442 | PROSITE-ProRule annotation | ||
Disulfide bondi | 445 ↔ 456 | PROSITE-ProRule annotation | ||
Disulfide bondi | 447 ↔ 463 | PROSITE-ProRule annotation | ||
Disulfide bondi | 465 ↔ 474 | PROSITE-ProRule annotation | ||
Disulfide bondi | 477 ↔ 492 | PROSITE-ProRule annotation | ||
Glycosylationi | 576 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 650 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Disulfide bondi | 724 ↔ 733 | PROSITE-ProRule annotation | ||
Disulfide bondi | 726 ↔ 740 | PROSITE-ProRule annotation | ||
Disulfide bondi | 742 ↔ 751 | PROSITE-ProRule annotation | ||
Disulfide bondi | 754 ↔ 770 | PROSITE-ProRule annotation | ||
Disulfide bondi | 773 ↔ 781 | PROSITE-ProRule annotation | ||
Disulfide bondi | 775 ↔ 792 | PROSITE-ProRule annotation | ||
Disulfide bondi | 795 ↔ 804 | PROSITE-ProRule annotation | ||
Disulfide bondi | 807 ↔ 825 | PROSITE-ProRule annotation | ||
Disulfide bondi | 828 ↔ 842 | PROSITE-ProRule annotation | ||
Disulfide bondi | 830 ↔ 849 | PROSITE-ProRule annotation | ||
Disulfide bondi | 852 ↔ 861 | PROSITE-ProRule annotation | ||
Disulfide bondi | 864 ↔ 881 | PROSITE-ProRule annotation | ||
Disulfide bondi | 884 ↔ 898 | PROSITE-ProRule annotation | ||
Disulfide bondi | 886 ↔ 905 | PROSITE-ProRule annotation | ||
Disulfide bondi | 907 ↔ 916 | PROSITE-ProRule annotation | ||
Disulfide bondi | 919 ↔ 932 | PROSITE-ProRule annotation | ||
Disulfide bondi | 935 ↔ 947 | PROSITE-ProRule annotation | ||
Disulfide bondi | 937 ↔ 954 | PROSITE-ProRule annotation | ||
Disulfide bondi | 956 ↔ 965 | PROSITE-ProRule annotation | ||
Disulfide bondi | 968 ↔ 980 | PROSITE-ProRule annotation | ||
Disulfide bondi | 983 ↔ 995 | PROSITE-ProRule annotation | ||
Disulfide bondi | 985 ↔ 1001 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1003 ↔ 1012 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1015 ↔ 1028 | PROSITE-ProRule annotation | ||
Glycosylationi | 1022 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1031 | InterchainCurated | ||
Disulfide bondi | 1034 | InterchainCurated | ||
Glycosylationi | 1107 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Modified residuei | 1149 | Phosphoserine; by FAM20C1 Publication | 1 | |
Glycosylationi | 1161 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 1175 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 1205 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1223 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 1241 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 1380 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1395 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Glycosylationi | 1439 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 1493 | PhosphoserineCombined sources | 1 | |
Disulfide bondi | 1600 | InterchainCurated |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
EPDi | P11047 |
jPOSTi | P11047 |
MassIVEi | P11047 |
MaxQBi | P11047 |
PaxDbi | P11047 |
PeptideAtlasi | P11047 |
PRIDEi | P11047 |
ProteomicsDBi | 52689 |
PTM databases
CarbonylDBi | P11047 |
GlyConnecti | 1444, 60 N-Linked glycans (9 sites) |
GlyGeni | P11047, 15 sites, 4 N-linked glycans (3 sites), 3 O-linked glycans (1 site) |
iPTMneti | P11047 |
PhosphoSitePlusi | P11047 |
SwissPalmi | P11047 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000135862, Expressed in parietal pleura and 242 other tissues |
ExpressionAtlasi | P11047, baseline and differential |
Genevisiblei | P11047, HS |
Organism-specific databases
HPAi | ENSG00000135862, Low tissue specificity |
Interactioni
Subunit structurei
Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Gamma-1 is a subunit of laminin-1 (laminin-111 or EHS laminin), laminin-2 (laminin-211 or merosin), laminin-3 (laminin-121 or S-laminin), laminin-4 (laminin-221 or S-merosin), laminin-6 (laminin-311 or K-laminin), laminin-7 (laminin-321 or KS-laminin), laminin-8 (laminin-411), laminin-9 (laminin-421), laminin-10 (laminin-511) and laminin-11 (laminin-521).
Protein-protein interaction databases
BioGRIDi | 110109, 47 interactors |
ComplexPortali | CPX-1770, Laminin-111 complex CPX-1771, Laminin-211 complex CPX-1772, Laminin-121 complex CPX-1773, Laminin-221 complex CPX-1775, Laminin-311 complex variant A CPX-1776, Laminin-321 complex CPX-1777, Laminin-411 complex CPX-1778, Laminin-421 complex CPX-1779, Laminin-511 complex CPX-1780, Laminin-521 complex CPX-3166, Laminin-311 complex variant B |
CORUMi | P11047 |
IntActi | P11047, 25 interactors |
MINTi | P11047 |
STRINGi | 9606.ENSP00000258341 |
Miscellaneous databases
RNActi | P11047, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P11047 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 46 – 285 | Laminin N-terminalPROSITE-ProRule annotationAdd BLAST | 240 | |
Domaini | 286 – 341 | Laminin EGF-like 1PROSITE-ProRule annotationAdd BLAST | 56 | |
Domaini | 342 – 397 | Laminin EGF-like 2PROSITE-ProRule annotationAdd BLAST | 56 | |
Domaini | 398 – 444 | Laminin EGF-like 3PROSITE-ProRule annotationAdd BLAST | 47 | |
Domaini | 445 – 494 | Laminin EGF-like 4PROSITE-ProRule annotationAdd BLAST | 50 | |
Domaini | 495 – 504 | Laminin EGF-like 5; first partPROSITE-ProRule annotation | 10 | |
Domaini | 514 – 689 | Laminin IV type APROSITE-ProRule annotationAdd BLAST | 176 | |
Domaini | 690 – 723 | Laminin EGF-like 5; second partPROSITE-ProRule annotationAdd BLAST | 34 | |
Domaini | 724 – 772 | Laminin EGF-like 6PROSITE-ProRule annotationAdd BLAST | 49 | |
Domaini | 773 – 827 | Laminin EGF-like 7PROSITE-ProRule annotationAdd BLAST | 55 | |
Domaini | 828 – 883 | Laminin EGF-like 8PROSITE-ProRule annotationAdd BLAST | 56 | |
Domaini | 884 – 934 | Laminin EGF-like 9PROSITE-ProRule annotationAdd BLAST | 51 | |
Domaini | 935 – 982 | Laminin EGF-like 10PROSITE-ProRule annotationAdd BLAST | 48 | |
Domaini | 983 – 1030 | Laminin EGF-like 11PROSITE-ProRule annotationAdd BLAST | 48 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1030 – 1609 | Domain II and IAdd BLAST | 580 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1038 – 1609 | Sequence analysisAdd BLAST | 572 |
Domaini
Keywords - Domaini
Coiled coil, Laminin EGF-like domain, Repeat, SignalPhylogenomic databases
eggNOGi | KOG1836, Eukaryota |
GeneTreei | ENSGT00940000158069 |
HOGENOMi | CLU_002471_1_0_1 |
InParanoidi | P11047 |
OMAi | TSEDGPW |
OrthoDBi | 156553at2759 |
PhylomeDBi | P11047 |
TreeFami | TF352481 |
Family and domain databases
Gene3Di | 2.60.120.1490, 1 hit |
InterProi | View protein in InterPro IPR000742, EGF-like_dom IPR002049, Laminin_EGF IPR000034, Laminin_IV IPR008211, Laminin_N IPR038684, Laminin_N_sf |
Pfami | View protein in Pfam PF00052, Laminin_B, 1 hit PF00053, Laminin_EGF, 10 hits PF00055, Laminin_N, 1 hit |
SMARTi | View protein in SMART SM00181, EGF, 8 hits SM00180, EGF_Lam, 10 hits SM00281, LamB, 1 hit SM00136, LamNT, 1 hit |
PROSITEi | View protein in PROSITE PS00022, EGF_1, 8 hits PS01186, EGF_2, 2 hits PS01248, EGF_LAM_1, 11 hits PS50027, EGF_LAM_2, 10 hits PS51115, LAMININ_IVA, 1 hit PS51117, LAMININ_NTER, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MRGSHRAAPA LRPRGRLWPV LAVLAAAAAA GCAQAAMDEC TDEGGRPQRC
60 70 80 90 100
MPEFVNAAFN VTVVATNTCG TPPEEYCVQT GVTGVTKSCH LCDAGQPHLQ
110 120 130 140 150
HGAAFLTDYN NQADTTWWQS QTMLAGVQYP SSINLTLHLG KAFDITYVRL
160 170 180 190 200
KFHTSRPESF AIYKRTREDG PWIPYQYYSG SCENTYSKAN RGFIRTGGDE
210 220 230 240 250
QQALCTDEFS DISPLTGGNV AFSTLEGRPS AYNFDNSPVL QEWVTATDIR
260 270 280 290 300
VTLNRLNTFG DEVFNDPKVL KSYYYAISDF AVGGRCKCNG HASECMKNEF
310 320 330 340 350
DKLVCNCKHN TYGVDCEKCL PFFNDRPWRR ATAESASECL PCDCNGRSQE
360 370 380 390 400
CYFDPELYRS TGHGGHCTNC QDNTDGAHCE RCRENFFRLG NNEACSSCHC
410 420 430 440 450
SPVGSLSTQC DSYGRCSCKP GVMGDKCDRC QPGFHSLTEA GCRPCSCDPS
460 470 480 490 500
GSIDECNIET GRCVCKDNVE GFNCERCKPG FFNLESSNPR GCTPCFCFGH
510 520 530 540 550
SSVCTNAVGY SVYSISSTFQ IDEDGWRAEQ RDGSEASLEW SSERQDIAVI
560 570 580 590 600
SDSYFPRYFI APAKFLGKQV LSYGQNLSFS FRVDRRDTRL SAEDLVLEGA
610 620 630 640 650
GLRVSVPLIA QGNSYPSETT VKYVFRLHEA TDYPWRPALT PFEFQKLLNN
660 670 680 690 700
LTSIKIRGTY SERSAGYLDD VTLASARPGP GVPATWVESC TCPVGYGGQF
710 720 730 740 750
CEMCLSGYRR ETPNLGPYSP CVLCACNGHS ETCDPETGVC NCRDNTAGPH
760 770 780 790 800
CEKCSDGYYG DSTAGTSSDC QPCPCPGGSS CAVVPKTKEV VCTNCPTGTT
810 820 830 840 850
GKRCELCDDG YFGDPLGRNG PVRLCRLCQC SDNIDPNAVG NCNRLTGECL
860 870 880 890 900
KCIYNTAGFY CDRCKDGFFG NPLAPNPADK CKACNCNLYG TMKQQSSCNP
910 920 930 940 950
VTGQCECLPH VTGQDCGACD PGFYNLQSGQ GCERCDCHAL GSTNGQCDIR
960 970 980 990 1000
TGQCECQPGI TGQHCERCEV NHFGFGPEGC KPCDCHPEGS LSLQCKDDGR
1010 1020 1030 1040 1050
CECREGFVGN RCDQCEENYF YNRSWPGCQE CPACYRLVKD KVADHRVKLQ
1060 1070 1080 1090 1100
ELESLIANLG TGDEMVTDQA FEDRLKEAER EVMDLLREAQ DVKDVDQNLM
1110 1120 1130 1140 1150
DRLQRVNNTL SSQISRLQNI RNTIEETGNL AEQARAHVEN TERLIEIASR
1160 1170 1180 1190 1200
ELEKAKVAAA NVSVTQPEST GDPNNMTLLA EEARKLAERH KQEADDIVRV
1210 1220 1230 1240 1250
AKTANDTSTE AYNLLLRTLA GENQTAFEIE ELNRKYEQAK NISQDLEKQA
1260 1270 1280 1290 1300
ARVHEEAKRA GDKAVEIYAS VAQLSPLDSE TLENEANNIK MEAENLEQLI
1310 1320 1330 1340 1350
DQKLKDYEDL REDMRGKELE VKNLLEKGKT EQQTADQLLA RADAAKALAE
1360 1370 1380 1390 1400
EAAKKGRDTL QEANDILNNL KDFDRRVNDN KTAAEEALRK IPAINQTITE
1410 1420 1430 1440 1450
ANEKTREAQQ ALGSAAADAT EAKNKAHEAE RIASAVQKNA TSTKAEAERT
1460 1470 1480 1490 1500
FAEVTDLDNE VNNMLKQLQE AEKELKRKQD DADQDMMMAG MASQAAQEAE
1510 1520 1530 1540 1550
INARKAKNSV TSLLSIINDL LEQLGQLDTV DLNKLNEIEG TLNKAKDEMK
1560 1570 1580 1590 1600
VSDLDRKVSD LENEAKKQEA AIMDYNRDIE EIMKDIRNLE DIRKTLPSGC
FNTPSIEKP
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketR4GNC7 | R4GNC7_HUMAN | Laminin subunit gamma-1 | LAMC1 | 37 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 212 | I → F in AAA59492 (PubMed:1985895).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_080757 | 363 | H → L Found in a consanguineous family with intellectual disability; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_014700 | 458 | I → V2 PublicationsCorresponds to variant dbSNP:rs20563Ensembl. | 1 | |
Natural variantiVAR_054488 | 731 | E → K. Corresponds to variant dbSNP:rs2230157EnsemblClinVar. | 1 | |
Natural variantiVAR_014701 | 888 | L → P2 PublicationsCorresponds to variant dbSNP:rs20558Ensembl. | 1 | |
Natural variantiVAR_035821 | 1116 | R → H in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs548688323Ensembl. | 1 | |
Natural variantiVAR_014702 | 1121 | R → Q. Corresponds to variant dbSNP:rs20559Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03202 mRNA Translation: AAA59488.1 M55210 , M55217, M55201, M55211, M55212, M55213, M55214, M55215, M55216, M55192, M55193, M55194, M55195, M55196, M55197, M55198, M55199, M55200, M55202, M55203, M55204, M55205, M55206, M55207, M55208, M55209 Genomic DNA Translation: AAA59492.1 AL354953 Genomic DNA No translation available. AL450304 Genomic DNA No translation available. X13939 mRNA Translation: CAA32122.1 M27654 mRNA Translation: AAA59489.1 |
CCDSi | CCDS1351.1 |
PIRi | S13548, MMHUB2 |
RefSeqi | NP_002284.3, NM_002293.3 |
Genome annotation databases
Ensembli | ENST00000258341; ENSP00000258341; ENSG00000135862 |
GeneIDi | 3915 |
KEGGi | hsa:3915 |
UCSCi | uc001gpy.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03202 mRNA Translation: AAA59488.1 M55210 , M55217, M55201, M55211, M55212, M55213, M55214, M55215, M55216, M55192, M55193, M55194, M55195, M55196, M55197, M55198, M55199, M55200, M55202, M55203, M55204, M55205, M55206, M55207, M55208, M55209 Genomic DNA Translation: AAA59492.1 AL354953 Genomic DNA No translation available. AL450304 Genomic DNA No translation available. X13939 mRNA Translation: CAA32122.1 M27654 mRNA Translation: AAA59489.1 |
CCDSi | CCDS1351.1 |
PIRi | S13548, MMHUB2 |
RefSeqi | NP_002284.3, NM_002293.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5XAU | X-ray | 1.80 | C/F | 1528-1609 | [»] | |
SMRi | P11047 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110109, 47 interactors |
ComplexPortali | CPX-1770, Laminin-111 complex CPX-1771, Laminin-211 complex CPX-1772, Laminin-121 complex CPX-1773, Laminin-221 complex CPX-1775, Laminin-311 complex variant A CPX-1776, Laminin-321 complex CPX-1777, Laminin-411 complex CPX-1778, Laminin-421 complex CPX-1779, Laminin-511 complex CPX-1780, Laminin-521 complex CPX-3166, Laminin-311 complex variant B |
CORUMi | P11047 |
IntActi | P11047, 25 interactors |
MINTi | P11047 |
STRINGi | 9606.ENSP00000258341 |
Chemistry databases
ChEMBLi | CHEMBL2364187 |
DrugBanki | DB06245, Lanoteplase |
PTM databases
CarbonylDBi | P11047 |
GlyConnecti | 1444, 60 N-Linked glycans (9 sites) |
GlyGeni | P11047, 15 sites, 4 N-linked glycans (3 sites), 3 O-linked glycans (1 site) |
iPTMneti | P11047 |
PhosphoSitePlusi | P11047 |
SwissPalmi | P11047 |
Genetic variation databases
BioMutai | LAMC1 |
DMDMi | 224471885 |
Proteomic databases
EPDi | P11047 |
jPOSTi | P11047 |
MassIVEi | P11047 |
MaxQBi | P11047 |
PaxDbi | P11047 |
PeptideAtlasi | P11047 |
PRIDEi | P11047 |
ProteomicsDBi | 52689 |
Protocols and materials databases
Antibodypediai | 1055, 511 antibodies |
Genome annotation databases
Ensembli | ENST00000258341; ENSP00000258341; ENSG00000135862 |
GeneIDi | 3915 |
KEGGi | hsa:3915 |
UCSCi | uc001gpy.4, human |
Organism-specific databases
CTDi | 3915 |
DisGeNETi | 3915 |
GeneCardsi | LAMC1 |
HGNCi | HGNC:6492, LAMC1 |
HPAi | ENSG00000135862, Low tissue specificity |
MIMi | 150290, gene |
neXtProti | NX_P11047 |
OpenTargetsi | ENSG00000135862 |
PharmGKBi | PA30280 |
VEuPathDBi | HostDB:ENSG00000135862.5 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1836, Eukaryota |
GeneTreei | ENSGT00940000158069 |
HOGENOMi | CLU_002471_1_0_1 |
InParanoidi | P11047 |
OMAi | TSEDGPW |
OrthoDBi | 156553at2759 |
PhylomeDBi | P11047 |
TreeFami | TF352481 |
Enzyme and pathway databases
PathwayCommonsi | P11047 |
Reactomei | R-HSA-1474228, Degradation of the extracellular matrix R-HSA-3000157, Laminin interactions R-HSA-3000171, Non-integrin membrane-ECM interactions R-HSA-3000178, ECM proteoglycans R-HSA-373760, L1CAM interactions R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-8874081, MET activates PTK2 signaling R-HSA-8957275, Post-translational protein phosphorylation R-HSA-9619665, EGR2 and SOX10-mediated initiation of Schwann cell myelination |
SIGNORi | P11047 |
Miscellaneous databases
BioGRID-ORCSi | 3915, 6 hits in 989 CRISPR screens |
ChiTaRSi | LAMC1, human |
GeneWikii | Laminin,_gamma_1 |
GenomeRNAii | 3915 |
Pharosi | P11047, Tbio |
PROi | PR:P11047 |
RNActi | P11047, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000135862, Expressed in parietal pleura and 242 other tissues |
ExpressionAtlasi | P11047, baseline and differential |
Genevisiblei | P11047, HS |
Family and domain databases
Gene3Di | 2.60.120.1490, 1 hit |
InterProi | View protein in InterPro IPR000742, EGF-like_dom IPR002049, Laminin_EGF IPR000034, Laminin_IV IPR008211, Laminin_N IPR038684, Laminin_N_sf |
Pfami | View protein in Pfam PF00052, Laminin_B, 1 hit PF00053, Laminin_EGF, 10 hits PF00055, Laminin_N, 1 hit |
SMARTi | View protein in SMART SM00181, EGF, 8 hits SM00180, EGF_Lam, 10 hits SM00281, LamB, 1 hit SM00136, LamNT, 1 hit |
PROSITEi | View protein in PROSITE PS00022, EGF_1, 8 hits PS01186, EGF_2, 2 hits PS01248, EGF_LAM_1, 11 hits PS50027, EGF_LAM_2, 10 hits PS51115, LAMININ_IVA, 1 hit PS51117, LAMININ_NTER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LAMC1_HUMAN | |
Accessioni | P11047Primary (citable) accession number: P11047 Secondary accession number(s): Q5VYE7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | March 3, 2009 | |
Last modified: | April 7, 2021 | |
This is version 228 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references