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Entry version 219 (16 Oct 2019)
Sequence version 3 (03 Mar 2009)
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Protein

Laminin subunit gamma-1

Gene

LAMC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1474228 Degradation of the extracellular matrix
R-HSA-3000157 Laminin interactions
R-HSA-3000171 Non-integrin membrane-ECM interactions
R-HSA-3000178 ECM proteoglycans
R-HSA-373760 L1CAM interactions
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8874081 MET activates PTK2 signaling
R-HSA-8957275 Post-translational protein phosphorylation

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P11047

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Laminin subunit gamma-1
Alternative name(s):
Laminin B2 chain
Laminin-1 subunit gamma
Laminin-10 subunit gamma
Laminin-11 subunit gamma
Laminin-2 subunit gamma
Laminin-3 subunit gamma
Laminin-4 subunit gamma
Laminin-6 subunit gamma
Laminin-7 subunit gamma
Laminin-8 subunit gamma
Laminin-9 subunit gamma
S-laminin subunit gamma
Short name:
S-LAM gamma
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LAMC11 PublicationImported
Synonyms:LAMB2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6492 LAMC1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
150290 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P11047

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3915

Open Targets

More...
OpenTargetsi
ENSG00000135862

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30280

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P11047

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2364187

Drug and drug target database

More...
DrugBanki
DB06245 Lanoteplase

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LAMC1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
224471885

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 33Add BLAST33
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001707434 – 1609Laminin subunit gamma-1Add BLAST1576

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi60N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi286 ↔ 295PROSITE-ProRule annotation
Disulfide bondi288 ↔ 305PROSITE-ProRule annotation
Disulfide bondi307 ↔ 316PROSITE-ProRule annotation
Disulfide bondi319 ↔ 339PROSITE-ProRule annotation
Disulfide bondi342 ↔ 351PROSITE-ProRule annotation
Disulfide bondi344 ↔ 367PROSITE-ProRule annotation
Disulfide bondi370 ↔ 379PROSITE-ProRule annotation
Disulfide bondi382 ↔ 395PROSITE-ProRule annotation
Disulfide bondi398 ↔ 410PROSITE-ProRule annotation
Disulfide bondi400 ↔ 416PROSITE-ProRule annotation
Disulfide bondi418 ↔ 427PROSITE-ProRule annotation
Disulfide bondi430 ↔ 442PROSITE-ProRule annotation
Disulfide bondi445 ↔ 456PROSITE-ProRule annotation
Disulfide bondi447 ↔ 463PROSITE-ProRule annotation
Disulfide bondi465 ↔ 474PROSITE-ProRule annotation
Disulfide bondi477 ↔ 492PROSITE-ProRule annotation
Glycosylationi576N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi650N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi724 ↔ 733PROSITE-ProRule annotation
Disulfide bondi726 ↔ 740PROSITE-ProRule annotation
Disulfide bondi742 ↔ 751PROSITE-ProRule annotation
Disulfide bondi754 ↔ 770PROSITE-ProRule annotation
Disulfide bondi773 ↔ 781PROSITE-ProRule annotation
Disulfide bondi775 ↔ 792PROSITE-ProRule annotation
Disulfide bondi795 ↔ 804PROSITE-ProRule annotation
Disulfide bondi807 ↔ 825PROSITE-ProRule annotation
Disulfide bondi828 ↔ 842PROSITE-ProRule annotation
Disulfide bondi830 ↔ 849PROSITE-ProRule annotation
Disulfide bondi852 ↔ 861PROSITE-ProRule annotation
Disulfide bondi864 ↔ 881PROSITE-ProRule annotation
Disulfide bondi884 ↔ 898PROSITE-ProRule annotation
Disulfide bondi886 ↔ 905PROSITE-ProRule annotation
Disulfide bondi907 ↔ 916PROSITE-ProRule annotation
Disulfide bondi919 ↔ 932PROSITE-ProRule annotation
Disulfide bondi935 ↔ 947PROSITE-ProRule annotation
Disulfide bondi937 ↔ 954PROSITE-ProRule annotation
Disulfide bondi956 ↔ 965PROSITE-ProRule annotation
Disulfide bondi968 ↔ 980PROSITE-ProRule annotation
Disulfide bondi983 ↔ 995PROSITE-ProRule annotation
Disulfide bondi985 ↔ 1001PROSITE-ProRule annotation
Disulfide bondi1003 ↔ 1012PROSITE-ProRule annotation
Disulfide bondi1015 ↔ 1028PROSITE-ProRule annotation
Glycosylationi1022N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1031InterchainCurated
Disulfide bondi1034InterchainCurated
Glycosylationi1107N-linked (GlcNAc...) asparagine2 Publications1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1149Phosphoserine; by FAM20C1 Publication1
Glycosylationi1161N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1175N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1205N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1223N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1241N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1380N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1395N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi1439N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1493PhosphoserineCombined sources1
Disulfide bondi1600InterchainCurated

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P11047

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P11047

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P11047

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P11047

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P11047

PeptideAtlas

More...
PeptideAtlasi
P11047

PRoteomics IDEntifications database

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PRIDEi
P11047

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
52689

PTM databases

CarbonylDB database of protein carbonylation sites

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CarbonylDBi
P11047

GlyConnect protein glycosylation platform

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GlyConnecti
1444

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P11047

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P11047

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P11047

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Found in the basement membranes (major component).

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000135862 Expressed in 232 organ(s), highest expression level in parietal pleura

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P11047 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P11047 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB004486
CAB078163
HPA001908
HPA001909

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Gamma-1 is a subunit of laminin-1 (laminin-111 or EHS laminin), laminin-2 (laminin-211 or merosin), laminin-3 (laminin-121 or S-laminin), laminin-4 (laminin-221 or S-merosin), laminin-6 (laminin-311 or K-laminin), laminin-7 (laminin-321 or KS-laminin), laminin-8 (laminin-411), laminin-9 (laminin-421), laminin-10 (laminin-511) and laminin-11 (laminin-521).

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110109, 40 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1770 Laminin-111 complex
CPX-1771 Laminin-211 complex
CPX-1772 Laminin-121 complex
CPX-1773 Laminin-221 complex
CPX-1775 Laminin-311 complex variant A
CPX-1776 Laminin-321 complex
CPX-1777 Laminin-411 complex
CPX-1778 Laminin-421 complex
CPX-1779 Laminin-511 complex
CPX-1780 Laminin-521 complex
CPX-3166 Laminin-311 complex variant B

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P11047

Protein interaction database and analysis system

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IntActi
P11047, 24 interactors

Molecular INTeraction database

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MINTi
P11047

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000258341

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11609
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P11047

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini46 – 285Laminin N-terminalPROSITE-ProRule annotationAdd BLAST240
Domaini286 – 341Laminin EGF-like 1PROSITE-ProRule annotationAdd BLAST56
Domaini342 – 397Laminin EGF-like 2PROSITE-ProRule annotationAdd BLAST56
Domaini398 – 444Laminin EGF-like 3PROSITE-ProRule annotationAdd BLAST47
Domaini445 – 494Laminin EGF-like 4PROSITE-ProRule annotationAdd BLAST50
Domaini495 – 504Laminin EGF-like 5; first partPROSITE-ProRule annotation10
Domaini514 – 689Laminin IV type APROSITE-ProRule annotationAdd BLAST176
Domaini690 – 723Laminin EGF-like 5; second partPROSITE-ProRule annotationAdd BLAST34
Domaini724 – 772Laminin EGF-like 6PROSITE-ProRule annotationAdd BLAST49
Domaini773 – 827Laminin EGF-like 7PROSITE-ProRule annotationAdd BLAST55
Domaini828 – 883Laminin EGF-like 8PROSITE-ProRule annotationAdd BLAST56
Domaini884 – 934Laminin EGF-like 9PROSITE-ProRule annotationAdd BLAST51
Domaini935 – 982Laminin EGF-like 10PROSITE-ProRule annotationAdd BLAST48
Domaini983 – 1030Laminin EGF-like 11PROSITE-ProRule annotationAdd BLAST48

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1030 – 1609Domain II and IAdd BLAST580

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1038 – 1609Sequence analysisAdd BLAST572

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
Domains VI and IV are globular.

Keywords - Domaini

Coiled coil, Laminin EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1836 Eukaryota
ENOG410XRDC LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158069

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000019301

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P11047

KEGG Orthology (KO)

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KOi
K05635

Identification of Orthologs from Complete Genome Data

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OMAi
FYSATCR

Database of Orthologous Groups

More...
OrthoDBi
156553at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P11047

TreeFam database of animal gene trees

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TreeFami
TF352481

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.120.1490, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000742 EGF-like_dom
IPR002049 Laminin_EGF
IPR000034 Laminin_IV
IPR008211 Laminin_N
IPR038684 Laminin_N_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00052 Laminin_B, 1 hit
PF00053 Laminin_EGF, 10 hits
PF00055 Laminin_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 8 hits
SM00180 EGF_Lam, 10 hits
SM00281 LamB, 1 hit
SM00136 LamNT, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022 EGF_1, 8 hits
PS01186 EGF_2, 2 hits
PS01248 EGF_LAM_1, 11 hits
PS50027 EGF_LAM_2, 10 hits
PS51115 LAMININ_IVA, 1 hit
PS51117 LAMININ_NTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P11047-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRGSHRAAPA LRPRGRLWPV LAVLAAAAAA GCAQAAMDEC TDEGGRPQRC
60 70 80 90 100
MPEFVNAAFN VTVVATNTCG TPPEEYCVQT GVTGVTKSCH LCDAGQPHLQ
110 120 130 140 150
HGAAFLTDYN NQADTTWWQS QTMLAGVQYP SSINLTLHLG KAFDITYVRL
160 170 180 190 200
KFHTSRPESF AIYKRTREDG PWIPYQYYSG SCENTYSKAN RGFIRTGGDE
210 220 230 240 250
QQALCTDEFS DISPLTGGNV AFSTLEGRPS AYNFDNSPVL QEWVTATDIR
260 270 280 290 300
VTLNRLNTFG DEVFNDPKVL KSYYYAISDF AVGGRCKCNG HASECMKNEF
310 320 330 340 350
DKLVCNCKHN TYGVDCEKCL PFFNDRPWRR ATAESASECL PCDCNGRSQE
360 370 380 390 400
CYFDPELYRS TGHGGHCTNC QDNTDGAHCE RCRENFFRLG NNEACSSCHC
410 420 430 440 450
SPVGSLSTQC DSYGRCSCKP GVMGDKCDRC QPGFHSLTEA GCRPCSCDPS
460 470 480 490 500
GSIDECNIET GRCVCKDNVE GFNCERCKPG FFNLESSNPR GCTPCFCFGH
510 520 530 540 550
SSVCTNAVGY SVYSISSTFQ IDEDGWRAEQ RDGSEASLEW SSERQDIAVI
560 570 580 590 600
SDSYFPRYFI APAKFLGKQV LSYGQNLSFS FRVDRRDTRL SAEDLVLEGA
610 620 630 640 650
GLRVSVPLIA QGNSYPSETT VKYVFRLHEA TDYPWRPALT PFEFQKLLNN
660 670 680 690 700
LTSIKIRGTY SERSAGYLDD VTLASARPGP GVPATWVESC TCPVGYGGQF
710 720 730 740 750
CEMCLSGYRR ETPNLGPYSP CVLCACNGHS ETCDPETGVC NCRDNTAGPH
760 770 780 790 800
CEKCSDGYYG DSTAGTSSDC QPCPCPGGSS CAVVPKTKEV VCTNCPTGTT
810 820 830 840 850
GKRCELCDDG YFGDPLGRNG PVRLCRLCQC SDNIDPNAVG NCNRLTGECL
860 870 880 890 900
KCIYNTAGFY CDRCKDGFFG NPLAPNPADK CKACNCNLYG TMKQQSSCNP
910 920 930 940 950
VTGQCECLPH VTGQDCGACD PGFYNLQSGQ GCERCDCHAL GSTNGQCDIR
960 970 980 990 1000
TGQCECQPGI TGQHCERCEV NHFGFGPEGC KPCDCHPEGS LSLQCKDDGR
1010 1020 1030 1040 1050
CECREGFVGN RCDQCEENYF YNRSWPGCQE CPACYRLVKD KVADHRVKLQ
1060 1070 1080 1090 1100
ELESLIANLG TGDEMVTDQA FEDRLKEAER EVMDLLREAQ DVKDVDQNLM
1110 1120 1130 1140 1150
DRLQRVNNTL SSQISRLQNI RNTIEETGNL AEQARAHVEN TERLIEIASR
1160 1170 1180 1190 1200
ELEKAKVAAA NVSVTQPEST GDPNNMTLLA EEARKLAERH KQEADDIVRV
1210 1220 1230 1240 1250
AKTANDTSTE AYNLLLRTLA GENQTAFEIE ELNRKYEQAK NISQDLEKQA
1260 1270 1280 1290 1300
ARVHEEAKRA GDKAVEIYAS VAQLSPLDSE TLENEANNIK MEAENLEQLI
1310 1320 1330 1340 1350
DQKLKDYEDL REDMRGKELE VKNLLEKGKT EQQTADQLLA RADAAKALAE
1360 1370 1380 1390 1400
EAAKKGRDTL QEANDILNNL KDFDRRVNDN KTAAEEALRK IPAINQTITE
1410 1420 1430 1440 1450
ANEKTREAQQ ALGSAAADAT EAKNKAHEAE RIASAVQKNA TSTKAEAERT
1460 1470 1480 1490 1500
FAEVTDLDNE VNNMLKQLQE AEKELKRKQD DADQDMMMAG MASQAAQEAE
1510 1520 1530 1540 1550
INARKAKNSV TSLLSIINDL LEQLGQLDTV DLNKLNEIEG TLNKAKDEMK
1560 1570 1580 1590 1600
VSDLDRKVSD LENEAKKQEA AIMDYNRDIE EIMKDIRNLE DIRKTLPSGC

FNTPSIEKP
Length:1,609
Mass (Da):177,603
Last modified:March 3, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i42D9A9958EEBBB01
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
R4GNC7R4GNC7_HUMAN
Laminin subunit gamma-1
LAMC1
37Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti212I → F in AAA59492 (PubMed:1985895).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_080757363H → L Found in a consanguineous family with intellectual disability; unknown pathological significance. 1 Publication1
Natural variantiVAR_014700458I → V2 PublicationsCorresponds to variant dbSNP:rs20563Ensembl.1
Natural variantiVAR_054488731E → K. Corresponds to variant dbSNP:rs2230157Ensembl.1
Natural variantiVAR_014701888L → P2 PublicationsCorresponds to variant dbSNP:rs20558Ensembl.1
Natural variantiVAR_0358211116R → H in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs548688323Ensembl.1
Natural variantiVAR_0147021121R → Q. Corresponds to variant dbSNP:rs20559Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J03202 mRNA Translation: AAA59488.1
M55210
, M55217, M55201, M55211, M55212, M55213, M55214, M55215, M55216, M55192, M55193, M55194, M55195, M55196, M55197, M55198, M55199, M55200, M55202, M55203, M55204, M55205, M55206, M55207, M55208, M55209 Genomic DNA Translation: AAA59492.1
AL354953 Genomic DNA No translation available.
AL450304 Genomic DNA No translation available.
X13939 mRNA Translation: CAA32122.1
M27654 mRNA Translation: AAA59489.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1351.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S13548 MMHUB2

NCBI Reference Sequences

More...
RefSeqi
NP_002284.3, NM_002293.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000258341; ENSP00000258341; ENSG00000135862

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3915

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3915

UCSC genome browser

More...
UCSCi
uc001gpy.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03202 mRNA Translation: AAA59488.1
M55210
, M55217, M55201, M55211, M55212, M55213, M55214, M55215, M55216, M55192, M55193, M55194, M55195, M55196, M55197, M55198, M55199, M55200, M55202, M55203, M55204, M55205, M55206, M55207, M55208, M55209 Genomic DNA Translation: AAA59492.1
AL354953 Genomic DNA No translation available.
AL450304 Genomic DNA No translation available.
X13939 mRNA Translation: CAA32122.1
M27654 mRNA Translation: AAA59489.1
CCDSiCCDS1351.1
PIRiS13548 MMHUB2
RefSeqiNP_002284.3, NM_002293.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5XAUX-ray1.80C/F1528-1609[»]
SMRiP11047
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi110109, 40 interactors
ComplexPortaliCPX-1770 Laminin-111 complex
CPX-1771 Laminin-211 complex
CPX-1772 Laminin-121 complex
CPX-1773 Laminin-221 complex
CPX-1775 Laminin-311 complex variant A
CPX-1776 Laminin-321 complex
CPX-1777 Laminin-411 complex
CPX-1778 Laminin-421 complex
CPX-1779 Laminin-511 complex
CPX-1780 Laminin-521 complex
CPX-3166 Laminin-311 complex variant B
CORUMiP11047
IntActiP11047, 24 interactors
MINTiP11047
STRINGi9606.ENSP00000258341

Chemistry databases

ChEMBLiCHEMBL2364187
DrugBankiDB06245 Lanoteplase

PTM databases

CarbonylDBiP11047
GlyConnecti1444
iPTMnetiP11047
PhosphoSitePlusiP11047
SwissPalmiP11047

Polymorphism and mutation databases

BioMutaiLAMC1
DMDMi224471885

Proteomic databases

EPDiP11047
jPOSTiP11047
MassIVEiP11047
MaxQBiP11047
PaxDbiP11047
PeptideAtlasiP11047
PRIDEiP11047
ProteomicsDBi52689

Genome annotation databases

EnsembliENST00000258341; ENSP00000258341; ENSG00000135862
GeneIDi3915
KEGGihsa:3915
UCSCiuc001gpy.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3915
DisGeNETi3915

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LAMC1
HGNCiHGNC:6492 LAMC1
HPAiCAB004486
CAB078163
HPA001908
HPA001909
MIMi150290 gene
neXtProtiNX_P11047
OpenTargetsiENSG00000135862
PharmGKBiPA30280

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1836 Eukaryota
ENOG410XRDC LUCA
GeneTreeiENSGT00940000158069
HOGENOMiHOG000019301
InParanoidiP11047
KOiK05635
OMAiFYSATCR
OrthoDBi156553at2759
PhylomeDBiP11047
TreeFamiTF352481

Enzyme and pathway databases

ReactomeiR-HSA-1474228 Degradation of the extracellular matrix
R-HSA-3000157 Laminin interactions
R-HSA-3000171 Non-integrin membrane-ECM interactions
R-HSA-3000178 ECM proteoglycans
R-HSA-373760 L1CAM interactions
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8874081 MET activates PTK2 signaling
R-HSA-8957275 Post-translational protein phosphorylation
SIGNORiP11047

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
LAMC1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Laminin,_gamma_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3915
PharosiP11047

Protein Ontology

More...
PROi
PR:P11047

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000135862 Expressed in 232 organ(s), highest expression level in parietal pleura
ExpressionAtlasiP11047 baseline and differential
GenevisibleiP11047 HS

Family and domain databases

Gene3Di2.60.120.1490, 1 hit
InterProiView protein in InterPro
IPR000742 EGF-like_dom
IPR002049 Laminin_EGF
IPR000034 Laminin_IV
IPR008211 Laminin_N
IPR038684 Laminin_N_sf
PfamiView protein in Pfam
PF00052 Laminin_B, 1 hit
PF00053 Laminin_EGF, 10 hits
PF00055 Laminin_N, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 8 hits
SM00180 EGF_Lam, 10 hits
SM00281 LamB, 1 hit
SM00136 LamNT, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 8 hits
PS01186 EGF_2, 2 hits
PS01248 EGF_LAM_1, 11 hits
PS50027 EGF_LAM_2, 10 hits
PS51115 LAMININ_IVA, 1 hit
PS51117 LAMININ_NTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLAMC1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P11047
Secondary accession number(s): Q5VYE7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: March 3, 2009
Last modified: October 16, 2019
This is version 219 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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