Laminin subunit beta-1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• animal organ development Source: FlyBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Drosophila laminins act as key regulators of basement membrane assembly and morphogenesis."
    Urbano J.M., Torgler C.N., Molnar C., Tepass U., Lopez-Varea A., Brown N.H., de Celis J.F., Martin-Bermudo M.D.
    Development 136:4165-4176(2009) [PubMed] [Europe PMC] [Abstract]
• animal organ morphogenesis Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• basement membrane assembly Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Drosophila laminins act as key regulators of basement membrane assembly and morphogenesis."
    Urbano J.M., Torgler C.N., Molnar C., Tepass U., Lopez-Varea A., Brown N.H., de Celis J.F., Martin-Bermudo M.D.
    Development 136:4165-4176(2009) [PubMed] [Europe PMC] [Abstract]
• basement membrane organization Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Characterization of Drosophila Nidogen/entactin reveals roles in basement membrane stability, barrier function and nervous system patterning."
    Wolfstetter G., Dahlitz I., Pfeifer K., Toepfer U., Alt J.A., Pfeifer D.C., Lakes-Harlan R., Baumgartner S., Palmer R.H., Holz A.
    Development 146:0-0(2019) [PubMed] [Europe PMC] [Abstract]
• cardiac muscle cell development Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Distinct functions of the laminin beta LN domain and collagen IV during cardiac extracellular matrix formation and stabilization of alary muscle attachments revealed by EMS mutagenesis in Drosophila."
    Hollfelder D., Frasch M., Reim I.
    BMC Dev Biol 14:26-26(2014) [PubMed] [Europe PMC] [Abstract]
• cell adhesion mediated by integrin Source: FlyBase <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Drosophila PS1 integrin is a laminin receptor and differs in ligand specificity from PS2."
    Gotwals P.J., Fessler L.I., Wehrli M., Hynes R.O.
    Proc. Natl. Acad. Sci. U.S.A. 91:11447-11451(1994) [PubMed] [Europe PMC] [Abstract]
• cell migration Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Drosophila laminins act as key regulators of basement membrane assembly and morphogenesis."
    Urbano J.M., Torgler C.N., Molnar C., Tepass U., Lopez-Varea A., Brown N.H., de Celis J.F., Martin-Bermudo M.D.
    Development 136:4165-4176(2009) [PubMed] [Europe PMC] [Abstract]
• defense response to Gram-negative bacterium Source: FlyBaseInferred from high throughput mutant phenotypeⁱ
  • "Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection."
    Cronin S.J., Nehme N.T., Limmer S., Liegeois S., Pospisilik J.A., Schramek D., Leibbrandt A., Simoes R.d.e. M., Gruber S., Puc U., Ebersberger I., Zoranovic T., Neely G.G., von Haeseler A., Ferrandon D., Penninger J.M.
    Science 325:340-343(2009) [PubMed] [Europe PMC] [Abstract]
• embryonic heart tube morphogenesis Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Distinct functions of the laminin beta LN domain and collagen IV during cardiac extracellular matrix formation and stabilization of alary muscle attachments revealed by EMS mutagenesis in Drosophila."
    Hollfelder D., Frasch M., Reim I.
    BMC Dev Biol 14:26-26(2014) [PubMed] [Europe PMC] [Abstract]
• extracellular matrix organization Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Distinct functions of the laminin beta LN domain and collagen IV during cardiac extracellular matrix formation and stabilization of alary muscle attachments revealed by EMS mutagenesis in Drosophila."
    Hollfelder D., Frasch M., Reim I.
    BMC Dev Biol 14:26-26(2014) [PubMed] [Europe PMC] [Abstract]
• gonad development Source: FlyBaseInferred from mutant phenotypeⁱ
  • "A genetic screen for mutations affecting gonad formation in Drosophila reveals a role for the slit/robo pathway."
    Weyers J.J., Milutinovich A.B., Takeda Y., Jemc J.C., Van Doren M.
    Dev Biol 353:217-228(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of innate immune response Source: FlyBaseInferred from high throughput mutant phenotypeⁱ
  • "Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection."
    Cronin S.J., Nehme N.T., Limmer S., Liegeois S., Pospisilik J.A., Schramek D., Leibbrandt A., Simoes R.d.e. M., Gruber S., Puc U., Ebersberger I., Zoranovic T., Neely G.G., von Haeseler A., Ferrandon D., Penninger J.M.
    Science 325:340-343(2009) [PubMed] [Europe PMC] [Abstract]
• substrate adhesion-dependent cell spreading Source: FlyBaseInferred from direct assayⁱ
  • "Drosophila PS1 integrin is a laminin receptor and differs in ligand specificity from PS2."
    Gotwals P.J., Fessler L.I., Wehrli M., Hynes R.O.
    Proc. Natl. Acad. Sci. U.S.A. 91:11447-11451(1994) [PubMed] [Europe PMC] [Abstract]
• tissue development Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypeⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Coiled coil

Motif

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

        10         20         30         40         50
MLELRLIVVI VLALLSWQWD PVDSQRPPQH GRRDRPKYPP NKFIKTHPCE 
        60         70         80         90        100
RSSCYPATGN LLIGRENRLT ASSTCGLHSP ERFCILSHLQ DKKCFLCDTR 
       110        120        130        140        150
EETKHDPYKN HRIGQIIYKT KPGTNIPTWW QSENGKENAT IQLDLEAEFH 
       160        170        180        190        200
FTHLIITFTT FRPAAMYIER SFDFGQTWHI YRYFAYDCKE SFPGVPTVLE 
       210        220        230        240        250
NITDVMCTSR YSNVEPSRNG EVIFRVLPPN INVTDPYAEH VQNQLKMTNL 
       260        270        280        290        300
RIQMTKLHKL GDNLLDSRLE NEEKYYYGIS NMVVRGSCSC YGHASQCLPL 
       310        320        330        340        350
DPAFSQADNE DGMVHGRCEC THNTKGMNCE ECEDFFNDLP WKPAFGKKTN 
       360        370        380        390        400
ACKKCECNDH AVSCHFDEAV FTASGFVSGG VCDNCLHNTR GQHCEECMPY 
       410        420        430        440        450
FYRDPEQDIT SERVCQPCDC DPQGSSDDGI CDSLNELEEG AVAGACHCKA 
       460        470        480        490        500
FVTGRRCNQC KDGYWNLQSD NPEGCEPCTC NPLGTLNNSG CVMRTGECKC 
       510        520        530        540        550
KKYVTGKDCN QCMPETYGLS ESPEGCSLCN CDAGGSYDNY CDVISGQCRC 
       560        570        580        590        600
RPHMTGRSCS QPKQNYFIPL LPEVHEAEVV DECISYGANG NCSLVAETPD 
       610        620        630        640        650
GSFTGIGFTR VPENSELVFT VGDIPRSMPY DAVIRYQSTS RGDWENAFIT 
       660        670        680        690        700
LVRPDQVDPE GGCGELAAAT SSETRIPFSL PDRSRQVVAL NEVCLEAGKV 
       710        720        730        740        750
YKFRIYFERK RHDVDSPTAT ILVDSLTLIP RIDVTPIFQG SVLADIRKKD 
       760        770        780        790        800
YEKYNCKSSL YDMNYKSDPK CQNLDNILSV FVHDGASMCN CNPTGSLSKV 
       810        820        830        840        850
CESNGGYCQC KPNVVGRQCD QCAPGTYGFG PEGCKACDCN SIGSKDKYCD 
       860        870        880        890        900
LITGQCQCVP NTYGRECNQC QPGYWNFPEC RVCQCNGHAA TCDPIQGTCI 
       910        920        930        940        950
DCQDSTTGYS CDSCLDGYYG NPLFGSEIGC RPCRCPETVA SGLAHADGCS 
       960        970        980        990       1000
LDTRNNNMLC HCQEGYSGSR CEICADNFFG NPDNGGTCSK CECSNNVDLY 
      1010       1020       1030       1040       1050
DTGNCDRQTG ACLKCLYQTT GDHCELCKDG FFGDALQQNC QQCECDFLGT 
      1060       1070       1080       1090       1100
NNTIAHCDRF TGQCPCLPNV QGVRCDQCAE NHWKIASGEG CESCNCDPIG 
      1110       1120       1130       1140       1150
ALHEQCNSYT GQCQCKPGFG GRACNQCQAH YWGNPNEKCQ PCECDQFGAA 
      1160       1170       1180       1190       1200
DFQCDRETGN CVCHEGIGGY KCNECARGYI GQFPHCSPCG ECFNNWDLIL 
      1210       1220       1230       1240       1250
SALEDATTAT ILRAKEIKQV GATGAYTSEF SELDKKLQHI RNLLQNTSVS 
      1260       1270       1280       1290       1300
LVDIEKLDYE TQSLRDQLQA SHGRLSETEQ NLDDIYNSLS LSGVELESLQ 
      1310       1320       1330       1340       1350
NHSRLVQQLS KELKENGIQL QESNIEGALN LTRHAYERVS NLSTLKDEAN 
      1360       1370       1380       1390       1400
ELASNTDRNC KRVENLSNKI QAEADDLANN NKLIEDYRAE LTSLTSQIPE 
      1410       1420       1430       1440       1450
LNNQVCGKPG DPCDSLCGGA GCGHCGGFLS CEHGAKTHSE EALKVAKDAE 
      1460       1470       1480       1490       1500
TAITSKKDQA DQTIRALTQA KLNASEAYEK AKRGFEQSER YLNQTNANIK 
      1510       1520       1530       1540       1550
LAENLFIALN NFQENKTASP SESKELAQKT LDLDLKLEPE EIETLGDQIN 
      1560       1570       1580       1590       1600
RAVSSLKNVE AIIYRTKPDL DRVNNLQSIA NATKEKADKI LDSANSVVES 
      1610       1620       1630       1640       1650
LAAADESQGK AKDAIQQANS NIELAGQDLE KIDEETYSAE APANNTAQQV 
      1660       1670       1680       1690       1700
EKLAKKVQKL QNNIMKNDRD AKEITKEAGS VKLEAMRARG EANNLQSATS 
      1710       1720       1730       1740       1750
ATNQTLTDRA SRSENARERA KQLLQRASKL TVDTNAKLKD LNDLQTVYLN 
      1760       1770       1780 
KNQQLLRLQA EIGPLNKELN EHLIHIKERG SHYRQCYT              

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Drosophila
   Drosophila: entries, gene names and cross-references to FlyBase