UniProtKB - P11030 (ACBP_RAT)
Protein
Acyl-CoA-binding protein
Gene
Dbi
Organism
Rattus norvegicus (Rat)
Status
Functioni
Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 14 | Acyl-CoABy similarity | 1 | |
Binding sitei | 51 | Acyl-CoABy similarity | 1 | |
Binding sitei | 55 | Acyl-CoABy similarity | 1 | |
Binding sitei | 74 | Acyl-CoABy similarity | 1 |
GO - Molecular functioni
- benzodiazepine receptor binding Source: RGD
- fatty-acyl-CoA binding Source: RGD
- identical protein binding Source: RGD
- lipid binding Source: UniProtKB-KW
- long-chain fatty acyl-CoA binding Source: RGD
GO - Biological processi
- acyl-CoA metabolic process Source: RGD
- behavioral fear response Source: RGD
- brain development Source: RGD
- cellular response to nutrient Source: RGD
- glial cell proliferation Source: RGD
- hair follicle development Source: RGD
- lateral ventricle development Source: RGD
- learning or memory Source: RGD
- long-term synaptic potentiation Source: RGD
- negative regulation of fatty acid beta-oxidation Source: RGD
- negative regulation of protein lipidation Source: RGD
- pancreatic juice secretion Source: RGD
- phosphatidylcholine acyl-chain remodeling Source: RGD
- positive regulation of CoA-transferase activity Source: RGD
- positive regulation of lipid biosynthetic process Source: RGD
- positive regulation of phospholipid transport Source: RGD
- positive regulation of release of sequestered calcium ion into cytosol Source: RGD
- regulation of synaptic transmission, GABAergic Source: MGI
- skin development Source: RGD
- steroid biosynthetic process Source: RGD
- triglyceride metabolic process Source: RGD
Keywordsi
Biological process | Transport |
Ligand | Lipid-binding |
Enzyme and pathway databases
Reactomei | R-RNO-77289, Mitochondrial Fatty Acid Beta-Oxidation |
Names & Taxonomyi
Protein namesi | Recommended name: Acyl-CoA-binding proteinShort name: ACBP Alternative name(s): Diazepam-binding inhibitor Short name: DBI Endozepine Short name: EP Cleaved into the following 2 chains: |
Gene namesi | Name:Dbi |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 2490, Dbi |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum By similarity
Golgi apparatus
- Golgi apparatus By similarity
Note: Golgi localization is dependent on ligand binding.By similarity
Endoplasmic reticulum
- perinuclear endoplasmic reticulum Source: RGD
Extracellular region or secreted
- extracellular space Source: RGD
Golgi apparatus
- Golgi apparatus Source: RGD
Nucleus
- nucleus Source: RGD
Plasma Membrane
- plasma membrane Source: RGD
Other locations
- contractile fiber Source: RGD
- cytoplasm Source: RGD
- protein-lipid complex Source: RGD
- synaptic vesicle Source: MGI
Keywords - Cellular componenti
Endoplasmic reticulum, Golgi apparatusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000045273 | 2 – 87 | Acyl-CoA-binding proteinAdd BLAST | 86 | |
PeptideiPRO_0000000288 | 18 – 51 | Triakontatetraneuropeptide1 PublicationAdd BLAST | 34 | |
PeptideiPRO_0000000289 | 34 – 51 | OctadecaneuropeptideAdd BLAST | 18 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserine1 Publication | 1 | |
Modified residuei | 8 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 8 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 17 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 29 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 51 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 55 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 55 | N6-malonyllysine; alternateBy similarity | 1 | |
Modified residuei | 55 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 77 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 77 | N6-succinyllysine; alternateBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
jPOSTi | P11030 |
PaxDbi | P11030 |
PRIDEi | P11030 |
PTM databases
iPTMneti | P11030 |
PhosphoSitePlusi | P11030 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000046889, Expressed in kidney and 21 other tissues |
ExpressionAtlasi | P11030, baseline and differential |
Genevisiblei | P11030, RN |
Interactioni
Subunit structurei
Monomer.
GO - Molecular functioni
- benzodiazepine receptor binding Source: RGD
- identical protein binding Source: RGD
Protein-protein interaction databases
BioGRIDi | 247122, 1 interactor |
DIPi | DIP-1164N |
IntActi | P11030, 2 interactors |
STRINGi | 10116.ENSRNOP00000066874 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 87 | ACBPROSITE-ProRule annotationAdd BLAST | 86 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 29 – 33 | Acyl-CoA bindingBy similarity | 5 |
Sequence similaritiesi
Belongs to the ACBP family.Curated
Phylogenomic databases
eggNOGi | KOG0817, Eukaryota |
GeneTreei | ENSGT00940000154846 |
HOGENOMi | CLU_118853_4_1_1 |
InParanoidi | P11030 |
OMAi | RYKFEAW |
OrthoDBi | 1588000at2759 |
Family and domain databases
CDDi | cd00435, ACBP, 1 hit |
Gene3Di | 1.20.80.10, 1 hit |
InterProi | View protein in InterPro IPR022408, Acyl-CoA-binding_prot_CS IPR000582, Acyl-CoA-binding_protein IPR035984, Acyl-CoA-binding_sf IPR014352, FERM/acyl-CoA-bd_prot_sf |
Pfami | View protein in Pfam PF00887, ACBP, 1 hit |
PRINTSi | PR00689, ACOABINDINGP |
SUPFAMi | SSF47027, SSF47027, 1 hit |
PROSITEi | View protein in PROSITE PS00880, ACB_1, 1 hit PS51228, ACB_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P11030-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSQADFDKAA EEVKRLKTQP TDEEMLFIYS HFKQATVGDV NTDRPGLLDL
60 70 80
KGKAKWDSWN KLKGTSKENA MKTYVEKVEE LKKKYGI
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ6TXF3 | Q6TXF3_RAT | Acyl-CoA-binding protein | Dbi LOC679040 | 600 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M14201 mRNA Translation: AAA41078.1 M20268 mRNA Translation: AAA41079.1 Z11991 Genomic DNA No translation available. S51442, S51427, S51426 Genomic DNA Translation: AAA12824.1 X96560 Genomic DNA Translation: CAA65396.1 BC084717 mRNA Translation: AAH84717.1 Z21846 Genomic DNA Translation: CAA79894.1 |
PIRi | S27345, NZRT |
RefSeqi | NP_114054.1, NM_031853.4 |
Genome annotation databases
Ensembli | ENSRNOT00000074685; ENSRNOP00000067623; ENSRNOG00000046889 |
GeneIDi | 25045 |
KEGGi | rno:25045 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M14201 mRNA Translation: AAA41078.1 M20268 mRNA Translation: AAA41079.1 Z11991 Genomic DNA No translation available. S51442, S51427, S51426 Genomic DNA Translation: AAA12824.1 X96560 Genomic DNA Translation: CAA65396.1 BC084717 mRNA Translation: AAH84717.1 Z21846 Genomic DNA Translation: CAA79894.1 |
PIRi | S27345, NZRT |
RefSeqi | NP_114054.1, NM_031853.4 |
3D structure databases
SMRi | P11030 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 247122, 1 interactor |
DIPi | DIP-1164N |
IntActi | P11030, 2 interactors |
STRINGi | 10116.ENSRNOP00000066874 |
PTM databases
iPTMneti | P11030 |
PhosphoSitePlusi | P11030 |
Proteomic databases
jPOSTi | P11030 |
PaxDbi | P11030 |
PRIDEi | P11030 |
Genome annotation databases
Ensembli | ENSRNOT00000074685; ENSRNOP00000067623; ENSRNOG00000046889 |
GeneIDi | 25045 |
KEGGi | rno:25045 |
Organism-specific databases
CTDi | 1622 |
RGDi | 2490, Dbi |
Phylogenomic databases
eggNOGi | KOG0817, Eukaryota |
GeneTreei | ENSGT00940000154846 |
HOGENOMi | CLU_118853_4_1_1 |
InParanoidi | P11030 |
OMAi | RYKFEAW |
OrthoDBi | 1588000at2759 |
Enzyme and pathway databases
Reactomei | R-RNO-77289, Mitochondrial Fatty Acid Beta-Oxidation |
Miscellaneous databases
PROi | PR:P11030 |
Gene expression databases
Bgeei | ENSRNOG00000046889, Expressed in kidney and 21 other tissues |
ExpressionAtlasi | P11030, baseline and differential |
Genevisiblei | P11030, RN |
Family and domain databases
CDDi | cd00435, ACBP, 1 hit |
Gene3Di | 1.20.80.10, 1 hit |
InterProi | View protein in InterPro IPR022408, Acyl-CoA-binding_prot_CS IPR000582, Acyl-CoA-binding_protein IPR035984, Acyl-CoA-binding_sf IPR014352, FERM/acyl-CoA-bd_prot_sf |
Pfami | View protein in Pfam PF00887, ACBP, 1 hit |
PRINTSi | PR00689, ACOABINDINGP |
SUPFAMi | SSF47027, SSF47027, 1 hit |
PROSITEi | View protein in PROSITE PS00880, ACB_1, 1 hit PS51228, ACB_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ACBP_RAT | |
Accessioni | P11030Primary (citable) accession number: P11030 Secondary accession number(s): Q2V4X5, Q63160 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 162 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families