Acyl-CoA-binding protein

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• benzodiazepine receptor binding Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Isolation, characterization, and purification to homogeneity of an endogenous polypeptide with agonistic action on benzodiazepine receptors."
    Guidotti A., Forchetti C.M., Corda M.G., Konkel D., Bennett C.D., Costa E.
    Proc Natl Acad Sci U S A 80:3531-3535(1983) [PubMed] [Europe PMC] [Abstract]
• fatty-acyl-CoA binding Source: RGD <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "The interaction of acyl-CoA with acyl-CoA binding protein and carnitine palmitoyltransferase I."
    Abo-Hashema K.A., Cake M.H., Lukas M.A., Knudsen J.
    Int J Biochem Cell Biol 33:807-815(2001) [PubMed] [Europe PMC] [Abstract]
• identical protein binding Source: RGD
• lipid binding Source: UniProtKB-KW
• long-chain fatty acyl-CoA binding Source: RGD

GO - Biological processⁱ

• acyl-CoA metabolic process Source: RGD <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • Ref.6

    "Cloning and tissue-specific functional characterization of the promoter of the rat diazepam binding inhibitor, a peptide with multiple biological actions."
    Kolmer M., Alho H., Costa E., Pani L.
    Proc. Natl. Acad. Sci. U.S.A. 90:8439-8443(1993) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-42.
• behavioral fear response Source: RGD
• brain development Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Ontogeny of diazepam binding inhibitor/acyl-CoA binding protein mRNA and peripheral benzodiazepine receptor mRNA expression in the rat."
    Burgi B., Lichtensteiger W., Lauber M.E., Schlumpf M.
    J Neuroendocrinol 11:85-100(1999) [PubMed] [Europe PMC] [Abstract]
• cellular response to nutrient Source: RGDInferred from expression patternⁱ
  • "Dietary n-3 polyunsaturated fatty acids increase T-lymphocyte phospholipid mass and acyl-CoA binding protein expression."
    Collison L.W., Collison R.E., Murphy E.J., Jolly C.A.
    Lipids 40:81-87(2005) [PubMed] [Europe PMC] [Abstract]
• glial cell proliferation Source: RGDInferred from direct assayⁱ
  • "The triakontatetraneuropeptide (TTN) stimulates thymidine incorporation in rat astrocytes through peripheral-type benzodiazepine receptors."
    Gandolfo P., Patte C., Leprince J., Rego J.L., Mensah-Nyagan A.G., Vaudry H., Tonon M.C.
    J Neurochem 75:701-707(2000) [PubMed] [Europe PMC] [Abstract]
• hair follicle development Source: RGD
• lateral ventricle development Source: RGD
• learning or memory Source: RGD
• long-term synaptic potentiation Source: RGD
• negative regulation of fatty acid beta-oxidation Source: RGDInferred from direct assayⁱ
  • "Overexpression of acyl-coA binding protein and its effects on the flux of free fatty acids in McA-RH 7777 cells."
    Yang Y., Pritchard P.H., Bhuiyan J., Seccombe D.W., Moghadasian M.H.
    Lipids 36:595-600(2001) [PubMed] [Europe PMC] [Abstract]
• negative regulation of protein lipidation Source: RGD
• pancreatic juice secretion Source: RGDInferred from expression patternⁱ
  • "Diazepam-binding inhibitor mediates feedback regulation of pancreatic secretion and postprandial release of cholecystokinin."
    Li Y., Hao Y., Owyang C.
    J Clin Invest 105:351-359(2000) [PubMed] [Europe PMC] [Abstract]
• phosphatidylcholine acyl-chain remodeling Source: RGD
• positive regulation of CoA-transferase activity Source: RGD
• positive regulation of lipid biosynthetic process Source: RGDInferred from direct assayⁱ
  • "Overexpression of acyl-coA binding protein and its effects on the flux of free fatty acids in McA-RH 7777 cells."
    Yang Y., Pritchard P.H., Bhuiyan J., Seccombe D.W., Moghadasian M.H.
    Lipids 36:595-600(2001) [PubMed] [Europe PMC] [Abstract]
• positive regulation of phospholipid transport Source: RGD
• positive regulation of release of sequestered calcium ion into cytosol Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Structure-activity relationships of a series of analogues of the octadecaneuropeptide ODN on calcium mobilization in rat astrocytes."
    Leprince J., Gandolfo P., Thoumas J.L., Patte C., Fauchere J.L., Vaudry H., Tonon M.C.
    J Med Chem 41:4433-4438(1998) [PubMed] [Europe PMC] [Abstract]
• regulation of synaptic transmission, GABAergic Source: MGIInferred from direct assayⁱ
  • "Study of an octadecaneuropeptide derived from diazepam binding inhibitor (DBI): biological activity and presence in rat brain."
    Ferrero P., Santi M.R., Conti-Tronconi B., Costa E., Guidotti A.
    Proc Natl Acad Sci U S A 83:827-831(1986) [PubMed] [Europe PMC] [Abstract]
• skin development Source: RGD
• steroid biosynthetic process Source: RGDTraceable author statementⁱ
  • Ref.6

    "Cloning and tissue-specific functional characterization of the promoter of the rat diazepam binding inhibitor, a peptide with multiple biological actions."
    Kolmer M., Alho H., Costa E., Pani L.
    Proc. Natl. Acad. Sci. U.S.A. 90:8439-8443(1993) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-42.
• triglyceride metabolic process Source: RGD

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• benzodiazepine receptor binding Source: RGDInferred from direct assayⁱ
  • "Isolation, characterization, and purification to homogeneity of an endogenous polypeptide with agonistic action on benzodiazepine receptors."
    Guidotti A., Forchetti C.M., Corda M.G., Konkel D., Bennett C.D., Costa E.
    Proc Natl Acad Sci U S A 80:3531-3535(1983) [PubMed] [Europe PMC] [Abstract]
• identical protein binding Source: RGD

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MSQADFDKAA EEVKRLKTQP TDEEMLFIYS HFKQATVGDV NTDRPGLLDL 
        60         70         80 
KGKAKWDSWN KLKGTSKENA MKTYVEKVEE LKKKYGI               

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families