UniProtKB - P11012 (CALR_ONCVO)
Protein
Calreticulin
Gene
crt-1
Organism
Onchocerca volvulus
Status
Functioni
Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (By similarity).By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 107 | CarbohydrateBy similarity | 1 | |
Binding sitei | 109 | CarbohydrateBy similarity | 1 | |
Binding sitei | 126 | CarbohydrateBy similarity | 1 | |
Binding sitei | 133 | CarbohydrateBy similarity | 1 | |
Binding sitei | 315 | CarbohydrateBy similarity | 1 |
GO - Molecular functioni
- calcium ion binding Source: InterPro
- carbohydrate binding Source: UniProtKB-KW
- unfolded protein binding Source: InterPro
GO - Biological processi
- protein folding Source: InterPro
Keywordsi
Molecular function | Chaperone |
Ligand | Calcium, Lectin, Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: CalreticulinAlternative name(s): 41 kDa larval antigen Protein ral-1 RAL1 antigen |
Gene namesi | Name:crt-1 Synonyms:ral-1 |
Organismi | Onchocerca volvulus |
Taxonomic identifieri | 6282 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Spirurina › Spiruromorpha › Filarioidea › Onchocercidae › Onchocerca |
Proteomesi |
|
Subcellular locationi
Endoplasmic reticulum
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: UniProtKB-SubCell
Keywords - Cellular componenti
Endoplasmic reticulumPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | Sequence analysisAdd BLAST | 17 | |
ChainiPRO_0000004196 | 18 – 388 | CalreticulinAdd BLAST | 371 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 103 ↔ 135 | By similarity |
Keywords - PTMi
Disulfide bondFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 189 – 200 | 1-1Add BLAST | 12 | |
Repeati | 208 – 219 | 1-2Add BLAST | 12 | |
Repeati | 225 – 236 | 1-3Add BLAST | 12 | |
Repeati | 242 – 253 | 1-4Add BLAST | 12 | |
Repeati | 257 – 267 | 2-1Add BLAST | 11 | |
Repeati | 271 – 281 | 2-2Add BLAST | 11 | |
Repeati | 285 – 295 | 2-3Add BLAST | 11 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 189 – 253 | 4 X approximate repeatsAdd BLAST | 65 | |
Regioni | 257 – 295 | 3 X approximate repeatsAdd BLAST | 39 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 353 – 388 | Arg/Lys-rich (basic)Add BLAST | 36 |
Sequence similaritiesi
Belongs to the calreticulin family.Curated
Keywords - Domaini
Repeat, SignalPhylogenomic databases
HOGENOMi | CLU_328267_0_0_1 |
Family and domain databases
Gene3Di | 2.10.250.10, 2 hits |
InterProi | View protein in InterPro IPR001580, Calret/calnex IPR018124, Calret/calnex_CS IPR009169, Calreticulin IPR009033, Calreticulin/calnexin_P_dom_sf IPR013320, ConA-like_dom_sf |
PANTHERi | PTHR11073, PTHR11073, 1 hit |
Pfami | View protein in Pfam PF00262, Calreticulin, 2 hits |
PIRSFi | PIRSF002356, Calreticulin, 1 hit |
PRINTSi | PR00626, CALRETICULIN |
SUPFAMi | SSF49899, SSF49899, 1 hit SSF63887, SSF63887, 1 hit |
PROSITEi | View protein in PROSITE PS00803, CALRETICULIN_1, 1 hit PS00804, CALRETICULIN_2, 1 hit PS00805, CALRETICULIN_REPEAT, 3 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P11012-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQLSLLVGLV CFSAINAKIY FKEDFSDDDW EKRWIKSKHK DDFGKWEISH
60 70 80 90 100
GKFYGDAVKD KGLKTTQDAK FYSIGAKFDK SFSNKGKSLV IQFSVKHEQD
110 120 130 140 150
IDCGGGYVKL MASDVNLEDS HGETPYHIMF GPDICGPGTK KVHVIFHYKD
160 170 180 190 200
RNHMIKKDIR CKDDVFTHLY TLIVNSDNTY EVQIDGEKAE SGELEADWDF
210 220 230 240 250
LPPKKIKDPD AKKPEDWDER EFIDDEDDKK PEDWDKPEHI PDPDAKKPED
260 270 280 290 300
WDDEMDGEWE PPMVDNPEYK GEWKPKQKKN PAYKGKWIHP EIEIPDYTPD
310 320 330 340 350
DNLYVYDDIG AIGFDLWQVK SGTIFDDVIV TDSVEEAKKF GEKTLKITRE
360 370 380
GEKKKGKKTK KQKKKEKNEK IKKEKMKKRK RANRKKKK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M20565 mRNA Translation: AAA59056.1 |
PIRi | A32507 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M20565 mRNA Translation: AAA59056.1 |
PIRi | A32507 |
3D structure databases
SMRi | P11012 |
ModBasei | Search... |
Phylogenomic databases
HOGENOMi | CLU_328267_0_0_1 |
Family and domain databases
Gene3Di | 2.10.250.10, 2 hits |
InterProi | View protein in InterPro IPR001580, Calret/calnex IPR018124, Calret/calnex_CS IPR009169, Calreticulin IPR009033, Calreticulin/calnexin_P_dom_sf IPR013320, ConA-like_dom_sf |
PANTHERi | PTHR11073, PTHR11073, 1 hit |
Pfami | View protein in Pfam PF00262, Calreticulin, 2 hits |
PIRSFi | PIRSF002356, Calreticulin, 1 hit |
PRINTSi | PR00626, CALRETICULIN |
SUPFAMi | SSF49899, SSF49899, 1 hit SSF63887, SSF63887, 1 hit |
PROSITEi | View protein in PROSITE PS00803, CALRETICULIN_1, 1 hit PS00804, CALRETICULIN_2, 1 hit PS00805, CALRETICULIN_REPEAT, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CALR_ONCVO | |
Accessioni | P11012Primary (citable) accession number: P11012 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | November 1, 1995 | |
Last modified: | December 2, 2020 | |
This is version 110 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families