IAPP

Functionⁱ

Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.

Miscellaneous

IAPP is the peptide subunit of amyloid found in pancreatic islets of type 2 diabetic patients and in insulinomas.

GO - Molecular functionⁱ

amyloid-beta binding
Source: ARUK-UCL
Traceable author statementⁱ
- 22500019
hormone activity Source: UniProtKB-KW
identical protein binding
Source: UniProtKB
Inferred from direct assayⁱ
- 22944668
signaling receptor binding
Source: ProtInc
Traceable author statementⁱ
- 10342886
- 2608057

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adenylate cyclase-activating G protein-coupled receptor signaling pathway
Source: ARUK-UCL
Inferred from genetic interactionⁱ
- 22500019
amylin receptor signaling pathway
Source: ARUK-UCL
Inferred from genetic interactionⁱ
- 22500019
amyloid fibril formation
Source: UniProtKB
Inferred from direct assayⁱ
- 22944668
apoptotic process
Source: ProtInc
Traceable author statementⁱ
- 8152488
cell-cell signaling
Source: ProtInc
Traceable author statementⁱ
- 2608057
cellular protein metabolic process Source: Reactome
eating behavior Source: Ensembl
G protein-coupled receptor signaling pathway Source: Reactome
negative regulation of amyloid fibril formation
Source: ARUK-UCL
Traceable author statementⁱ
- 22500019
negative regulation of bone resorption Source: Ensembl
negative regulation of cell differentiation Source: Ensembl
negative regulation of cell proliferation
Source: UniProtKB
Inferred from direct assayⁱ
- 22944668
negative regulation of mitochondrion organization
Source: ARUK-UCL
Traceable author statementⁱ
- 22500019
negative regulation of protein homooligomerization
Source: ARUK-UCL
Traceable author statementⁱ
- 22500019
positive regulation of apoptotic process
Source: ARUK-UCL
Traceable author statementⁱ
- 22500019
positive regulation of calcium ion import across plasma membrane
Source: ARUK-UCL
Inferred from genetic interactionⁱ
- 22500019
positive regulation of cell death
Source: ARUK-UCL
Inferred from genetic interactionⁱ
- 22500019
positive regulation of cytosolic calcium ion concentration
Source: ARUK-UCL
Non-traceable author statementⁱ
- 22500019
positive regulation of ERK1 and ERK2 cascade
Source: ARUK-UCL
Inferred from genetic interactionⁱ
- 22500019
positive regulation of gene expression
Source: ARUK-UCL
Inferred from genetic interactionⁱ
- 22500019
positive regulation of MAPK cascade
Source: ARUK-UCL
Non-traceable author statementⁱ
- 22500019
positive regulation of peptidyl-serine phosphorylation
Source: ARUK-UCL
Inferred from genetic interactionⁱ
- 22500019
positive regulation of protein kinase A signaling
Source: ARUK-UCL
Inferred from genetic interactionⁱ
- 22500019
positive regulation of protein kinase B signaling
Source: ARUK-UCL
Inferred from genetic interactionⁱ
- 22500019
protein destabilization
Source: UniProtKB
Inferred from direct assayⁱ
- 22944668
protein homooligomerization
Source: UniProtKB
Inferred from direct assayⁱ
- 22944668
sensory perception of pain Source: Ensembl
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 10342886

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hormone

Molecular function

Hormone

Enzyme and pathway databases

Reactomeⁱ	R-HSA-210745 Regulation of gene expression in beta cells R-HSA-418555 G alpha (s) signalling events R-HSA-419812 Calcitonin-like ligand receptors R-HSA-977225 Amyloid fiber formation

Reactomeⁱ

R-HSA-210745 Regulation of gene expression in beta cells
R-HSA-418555 G alpha (s) signalling events
R-HSA-419812 Calcitonin-like ligand receptors
R-HSA-977225 Amyloid fiber formation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Islet amyloid polypeptide Alternative name(s): Amylin Diabetes-associated peptide Short name: DAP Insulinoma amyloid peptide
Gene namesⁱ	Name:IAPP
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000121351.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5329 IAPP
MIMⁱ	147940 gene
neXtProtⁱ	NX_P10997

Keywords - Cellular componentⁱ

Amyloid, Secreted

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	48	F → A, D or S: Promotes formation of fibrillar aggregates. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3375
Open Targets More...OpenTargetsⁱ	ENSG00000121351
PharmGKBⁱ	PA29579

Chemistry databases

ChEMBLⁱ	CHEMBL1914266

ChEMBLⁱ

CHEMBL1914266

Polymorphism and mutation databases

BioMutaⁱ	IAPP
DMDMⁱ	124006

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 22	Sequence analysisAdd BLAST	22
PropeptideⁱPRO_0000004105	23 – 31		9
PeptideⁱPRO_0000004106	34 – 70	Islet amyloid polypeptideAdd BLAST	37
PropeptideⁱPRO_0000004107	74 – 89	Add BLAST	16

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Disulfide bondⁱ	35 ↔ 40	3 Publications
Modified residueⁱ	70	Tyrosine amide2 Publications		1

Post-translational modificationⁱ

Amyloid fibrils are degraded by IDE.

Keywords - PTMⁱ

Amidation, Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbⁱ	P10997
PeptideAtlas More...PeptideAtlasⁱ	P10997
PRIDEⁱ	P10997
ProteomicsDBⁱ	52687

PTM databases

iPTMnetⁱ	P10997
PhosphoSitePlusⁱ	P10997

Miscellaneous databases

PMAP-CutDBⁱ	P10997

PMAP-CutDBⁱ

P10997

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000121351 Expressed in 34 organ(s), highest expression level in islet of Langerhans
CleanExⁱ	HS_IAPP
ExpressionAtlasⁱ	P10997 baseline and differential
Genevisibleⁱ	P10997 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB000352 HPA053194

HPAⁱ

CAB000352
HPA053194

Interactionⁱ

Subunit structureⁱ

Interacts with IDE and INS. Can form homodimers. Interaction with INS inhibits homodimerization and fibril formation.2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
itself		12	EBI-8526679,EBI-8526679
IDE	P14735-1	3	EBI-8526679,EBI-15607031

GO - Molecular functionⁱ

hormone activity Source: UniProtKB-KW
identical protein binding
Source: UniProtKB
Inferred from direct assayⁱ
- 22944668
signaling receptor binding
Source: ProtInc
Traceable author statementⁱ
- 10342886
- 2608057

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	109604, 1 interactor
Database of interacting proteins More...DIPⁱ	DIP-29913N
IntActⁱ	P10997, 1 interactor
Molecular INTeraction database More...MINTⁱ	P10997
STRINGⁱ	9606.ENSP00000240652

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	36 – 38	Combined sources	3
Beta strandⁱ	45 – 47	Combined sources	3
Beta strandⁱ	49 – 57	Combined sources	9
Turnⁱ	59 – 61	Combined sources	3
Turnⁱ	63 – 69	Combined sources	7

Show more details

3D structure databases

ProteinModelPortalⁱ	P10997
SMRⁱ	P10997
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P10997

Family & Domainsⁱ

Domainⁱ

The mature protein is largely unstructured in the absence of a cognate ligand, and has a strong tendency to form fibrillar aggregates. Homodimerization may be the first step of amyloid formation.3 Publications

Sequence similaritiesⁱ

Belongs to the calcitonin family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410J0NB Eukaryota ENOG410Z7V7 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000048671
HOGENOMⁱ	HOG000038203
HOVERGENⁱ	HBG096065
InParanoidⁱ	P10997
KEGG Orthology (KO) More...KOⁱ	K08039
OMAⁱ	SHQMEKR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G15QG
PhylomeDBⁱ	P10997
TreeFamⁱ	TF330783

Family and domain databases

InterProⁱ	View protein in InterPro IPR021117 Calcitonin-like IPR021116 Calcitonin/adrenomedullin IPR018360 Calcitonin_CS IPR001693 Calcitonin_peptide-like IPR000443 Pro-islet_amyloid_polypep
PANTHERⁱ	PTHR10505 PTHR10505, 2 hits PTHR10505:SF4 PTHR10505:SF4, 2 hits
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00214 Calc_CGRP_IAPP, 1 hit
PRINTSⁱ	PR00818 ISLETAMYLOID
SMARTⁱ	View protein in SMART SM00113 CALCITONIN, 1 hit
PROSITEⁱ	View protein in PROSITE PS00258 CALCITONIN, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

P10997-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGILKLQVFL IVLSVALNHL KATPIESHQV EKRKCNTATC ATQRLANFLV 
        60         70         80 
HSSNNFGAIL SSTNVGSNTY GKRNAVEVLK REPLNYLPL

Length:89

Mass (Da):9,806

Last modified:July 1, 1989 - v1

Checksum:ⁱAA8B1F7FD9FCB4BD

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F5H0S1	F5H0S1_HUMAN	Islet amyloid polypeptide Islet amyloid polypeptide	IAPP	79	Annotation score:
F5H1F0	F5H1F0_HUMAN	Islet amyloid polypeptide Islet amyloid polypeptide	IAPP	79	Annotation score:
H0YF85	H0YF85_HUMAN	Islet amyloid polypeptide Islet amyloid polypeptide	IAPP	85	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	53	S → C in CAA39504 (PubMed:2365085).Curated		1

Mass spectrometryⁱ

Molecular mass is 3936 Da from positions 34 - 70. Determined by MALDI. 1 Publication

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_012080	53	S → G2 PublicationsCorresponds to variant dbSNP:rs1800203Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M27503 Genomic DNA Translation: AAA35524.1 X14904 mRNA Translation: CAA33032.1 X14905 mRNA Translation: CAA33033.1 X14902 Genomic DNA Translation: CAA33031.1 X14903 Genomic DNA Translation: CAB57804.1 X13859 Genomic DNA Translation: CAB57803.1 J04422 mRNA Translation: AAA52281.1 M21785 Genomic DNA Translation: AAA51728.1 M26650 Genomic DNA Translation: AAA35983.1 X52818, X52819 Genomic DNA Translation: CAA37002.1 X56030, X55634 Genomic DNA Translation: CAA39504.1 X68830 Genomic DNA Translation: CAA48724.1 DQ516082 mRNA Translation: ABG27010.1 CH471094 Genomic DNA Translation: EAW96426.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8688.1
PIRⁱ	S04016 TCHUIA
NCBI Reference Sequences More...RefSeqⁱ	NP_000406.1, NM_000415.2 NP_001316130.1, NM_001329201.1
UniGeneⁱ	Hs.46835

Genome annotation databases

Ensemblⁱ	ENST00000240652; ENSP00000240652; ENSG00000121351 ENST00000539393; ENSP00000437357; ENSG00000121351
GeneIDⁱ	3375
KEGGⁱ	hsa:3375
UCSC genome browser More...UCSCⁱ	uc001rev.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P10997	Islet amyloid polypeptide, isoform CRA_a		HUMAN		89	UniRef100_P10997
Islet amyloid polypeptide (Fragment)		HUMAN		79

Protein	Similar proteins		Species	Score	Length	Source
P10997	Islet amyloid polypeptide, isoform CRA_a		HUMAN		89	UniRef90_P10997
Amylin		MACMU		89
Islet amyloid polypeptide		MANLE		89
Amylin		MACFA		89
IAPP isoform 1		PANTR		89
+18

Protein	Similar proteins		Species	Score	Length	Source
P10997	Islet amyloid polypeptide		BOVIN		91	UniRef50_P10997
Islet amyloid polypeptide (Fragment)		SHEEP		32
Islet amyloid polypeptide		OCTDE		91
Islet amyloid polypeptide		CANLF		89
Islet amyloid polypeptide		FELCA		89
+99

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

Amylin entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M27503 Genomic DNA Translation: AAA35524.1 X14904 mRNA Translation: CAA33032.1 X14905 mRNA Translation: CAA33033.1 X14902 Genomic DNA Translation: CAA33031.1 X14903 Genomic DNA Translation: CAB57804.1 X13859 Genomic DNA Translation: CAB57803.1 J04422 mRNA Translation: AAA52281.1 M21785 Genomic DNA Translation: AAA51728.1 M26650 Genomic DNA Translation: AAA35983.1 X52818, X52819 Genomic DNA Translation: CAA37002.1 X56030, X55634 Genomic DNA Translation: CAA39504.1 X68830 Genomic DNA Translation: CAA48724.1 DQ516082 mRNA Translation: ABG27010.1 CH471094 Genomic DNA Translation: EAW96426.1
CCDSⁱ	CCDS8688.1
PIRⁱ	S04016 TCHUIA
RefSeqⁱ	NP_000406.1, NM_000415.2 NP_001316130.1, NM_001329201.1
UniGeneⁱ	Hs.46835

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1KUW	NMR	-	A	53-62	[»]
	2G48	X-ray	2.60	C/D	34-70	[»]
	2KB8	NMR	-	A	34-70	[»]
	2L86	NMR	-	A	34-70	[»]
	3DG1	X-ray	1.66	A	61-66	[»]
	3FPO	X-ray	1.50	A	51-56	[»]
	3FR1	X-ray	1.85	A	47-52	[»]
	3FTH	X-ray	1.84	A/B	47-53	[»]
	3FTK	X-ray	1.50	A	64-70	[»]
	3FTL	X-ray	1.60	A/B	64-70	[»]
	3FTR	X-ray	1.61	A	61-66	[»]
	3G7V	X-ray	1.86	A/B/C/D	34-69	[»]
	3G7W	X-ray	1.75	A	34-55	[»]
	3HGZ	X-ray	2.91	D/E	34-70	[»]
	5K5G	NMR	-	A	34-70	[»]
	5KNZ	electron microscopy	1.90	A	52-62	[»]
	5KO0	electron microscopy	1.40	A/B	48-58	[»]
	5MGQ	NMR	-	A	34-69	[»]
ProteinModelPortalⁱ	P10997
SMRⁱ	P10997
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109604, 1 interactor
DIPⁱ	DIP-29913N
IntActⁱ	P10997, 1 interactor
MINTⁱ	P10997
STRINGⁱ	9606.ENSP00000240652

Chemistry databases

ChEMBLⁱ	CHEMBL1914266

ChEMBLⁱ

CHEMBL1914266

PTM databases

iPTMnetⁱ	P10997
PhosphoSitePlusⁱ	P10997

Polymorphism and mutation databases

BioMutaⁱ	IAPP
DMDMⁱ	124006

Proteomic databases

PaxDbⁱ	P10997
PeptideAtlasⁱ	P10997
PRIDEⁱ	P10997
ProteomicsDBⁱ	52687

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3375
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000240652; ENSP00000240652; ENSG00000121351 ENST00000539393; ENSP00000437357; ENSG00000121351
GeneIDⁱ	3375
KEGGⁱ	hsa:3375
UCSCⁱ	uc001rev.4 human

Organism-specific databases

CTDⁱ	3375
DisGeNETⁱ	3375
EuPathDBⁱ	HostDB:ENSG00000121351.7
GeneCardsⁱ	IAPP
HGNCⁱ	HGNC:5329 IAPP
HPAⁱ	CAB000352 HPA053194
MIMⁱ	147940 gene
neXtProtⁱ	NX_P10997
OpenTargetsⁱ	ENSG00000121351
PharmGKBⁱ	PA29579
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J0NB Eukaryota ENOG410Z7V7 LUCA
GeneTreeⁱ	ENSGT00510000048671
HOGENOMⁱ	HOG000038203
HOVERGENⁱ	HBG096065
InParanoidⁱ	P10997
KOⁱ	K08039
OMAⁱ	SHQMEKR
OrthoDBⁱ	EOG091G15QG
PhylomeDBⁱ	P10997
TreeFamⁱ	TF330783

Enzyme and pathway databases

Reactomeⁱ	R-HSA-210745 Regulation of gene expression in beta cells R-HSA-418555 G alpha (s) signalling events R-HSA-419812 Calcitonin-like ligand receptors R-HSA-977225 Amyloid fiber formation

Reactomeⁱ

R-HSA-210745 Regulation of gene expression in beta cells
R-HSA-418555 G alpha (s) signalling events
R-HSA-419812 Calcitonin-like ligand receptors
R-HSA-977225 Amyloid fiber formation

Miscellaneous databases

EvolutionaryTraceⁱ	P10997
GeneWikiⁱ	Amylin
GenomeRNAiⁱ	3375
PMAP-CutDBⁱ	P10997
Protein Ontology More...PROⁱ	PR:P10997
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000121351 Expressed in 34 organ(s), highest expression level in islet of Langerhans
CleanExⁱ	HS_IAPP
ExpressionAtlasⁱ	P10997 baseline and differential
Genevisibleⁱ	P10997 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR021117 Calcitonin-like IPR021116 Calcitonin/adrenomedullin IPR018360 Calcitonin_CS IPR001693 Calcitonin_peptide-like IPR000443 Pro-islet_amyloid_polypep
PANTHERⁱ	PTHR10505 PTHR10505, 2 hits PTHR10505:SF4 PTHR10505:SF4, 2 hits
Pfamⁱ	View protein in Pfam PF00214 Calc_CGRP_IAPP, 1 hit
PRINTSⁱ	PR00818 ISLETAMYLOID
SMARTⁱ	View protein in SMART SM00113 CALCITONIN, 1 hit
PROSITEⁱ	View protein in PROSITE PS00258 CALCITONIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IAPP_HUMAN
Accessionⁱ	P10997Primary (citable) accession number: P10997 Secondary accession number(s): Q0ZD87, Q14598
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
	Last sequence update:	July 1, 1989
	Last modified:	November 7, 2018
	This is version 181 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM

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UniProtKB - P10997 (IAPP_HUMAN)

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Islet amyloid polypeptide

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

<p>This subsection of the ‘Sequence’ section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Mass spectrometryⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ