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Entry version 179 (29 Sep 2021)
Sequence version 1 (01 Jul 1989)
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Protein

Actin

Gene

act1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SPO-114608, Platelet degranulation
R-SPO-190873, Gap junction degradation
R-SPO-196025, Formation of annular gap junctions
R-SPO-2029482, Regulation of actin dynamics for phagocytic cup formation
R-SPO-5626467, RHO GTPases activate IQGAPs
R-SPO-5663213, RHO GTPases Activate WASPs and WAVEs
R-SPO-8856828, Clathrin-mediated endocytosis
R-SPO-8980692, RHOA GTPase cycle
R-SPO-9013026, RHOB GTPase cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Actin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:act1
Synonyms:cps8
ORF Names:pi012, SPBC32H8.12c
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

Schizosaccharomyces pombe database

More...
PomBasei
SPBC32H8.12c, act1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:SPBC32H8.12c

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi273G → D: Causes a defect in the maintenance of cell polarity and septum organization. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000890071 – 375ActinAdd BLAST375

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei202Phosphothreonine1 Publication1
Modified residuei324Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P10989

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P10989

PRoteomics IDEntifications database

More...
PRIDEi
P10989

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P10989

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
276589, 43 interactors

Protein interaction database and analysis system

More...
IntActi
P10989, 4 interactors

STRING: functional protein association networks

More...
STRINGi
4896.SPBC32H8.12c.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P10989

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the actin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0676, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_027965_0_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P10989

Identification of Orthologs from Complete Genome Data

More...
OMAi
FHTTAER

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P10989

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004000, Actin
IPR020902, Actin/actin-like_CS
IPR004001, Actin_CS
IPR043129, ATPase_NBD

The PANTHER Classification System

More...
PANTHERi
PTHR11937, PTHR11937, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00022, Actin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00190, ACTIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00268, ACTIN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53067, SSF53067, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00406, ACTINS_1, 1 hit
PS00432, ACTINS_2, 1 hit
PS01132, ACTINS_ACT_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P10989-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEEIAALVI DNGSGMCKAG FAGDDAPRAV FPSIVGRPRH HGIMVGMGQK
60 70 80 90 100
DSYVGDEAQS KRGILTLKYP IEHGIVNNWD DMEKIWHHTF YNELRVAPEE
110 120 130 140 150
HPCLLTEAPL NPKSNREKMT QIIFETFNAP AFYVAIQAVL SLYASGRTTG
160 170 180 190 200
IVLDSGDGVT HTVPIYEGYA LPHAIMRLDL AGRDLTDYLM KILMERGYTF
210 220 230 240 250
STTAEREIVR DIKEKLCYVA LDFEQELQTA AQSSSLEKSY ELPDGQVITI
260 270 280 290 300
GNERFRAPEA LFQPSALGLE NAGIHEATYN SIMKCDVDIR KDLYGNVVMS
310 320 330 340 350
GGTTMYPGIA DRMQKEIQAL APSSMKVKIV APPERKYSVW IGGSILASLS
360 370
TFQQMWISKQ EYDESGPGIV YRKCF
Length:375
Mass (Da):41,765
Last modified:July 1, 1989 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i372C0B2CDBAE1B68
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y00447 Genomic DNA Translation: CAA68501.1
D84318 Genomic DNA Translation: BAA12315.1
AB004534 Genomic DNA Translation: BAA21389.1
CU329671 Genomic DNA Translation: CAC37502.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A26836

NCBI Reference Sequences

More...
RefSeqi
NP_595618.1, NM_001021513.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPBC32H8.12c.1; SPBC32H8.12c.1:pep; SPBC32H8.12c

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2540051

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPBC32H8.12c

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00447 Genomic DNA Translation: CAA68501.1
D84318 Genomic DNA Translation: BAA12315.1
AB004534 Genomic DNA Translation: BAA21389.1
CU329671 Genomic DNA Translation: CAC37502.1
PIRiA26836
RefSeqiNP_595618.1, NM_001021513.2

3D structure databases

SMRiP10989
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi276589, 43 interactors
IntActiP10989, 4 interactors
STRINGi4896.SPBC32H8.12c.1

PTM databases

iPTMnetiP10989

Proteomic databases

MaxQBiP10989
PaxDbiP10989
PRIDEiP10989

Genome annotation databases

EnsemblFungiiSPBC32H8.12c.1; SPBC32H8.12c.1:pep; SPBC32H8.12c
GeneIDi2540051
KEGGispo:SPBC32H8.12c

Organism-specific databases

PomBaseiSPBC32H8.12c, act1
VEuPathDBiFungiDB:SPBC32H8.12c

Phylogenomic databases

eggNOGiKOG0676, Eukaryota
HOGENOMiCLU_027965_0_2_1
InParanoidiP10989
OMAiFHTTAER
PhylomeDBiP10989

Enzyme and pathway databases

ReactomeiR-SPO-114608, Platelet degranulation
R-SPO-190873, Gap junction degradation
R-SPO-196025, Formation of annular gap junctions
R-SPO-2029482, Regulation of actin dynamics for phagocytic cup formation
R-SPO-5626467, RHO GTPases activate IQGAPs
R-SPO-5663213, RHO GTPases Activate WASPs and WAVEs
R-SPO-8856828, Clathrin-mediated endocytosis
R-SPO-8980692, RHOA GTPase cycle
R-SPO-9013026, RHOB GTPase cycle

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P10989

Family and domain databases

InterProiView protein in InterPro
IPR004000, Actin
IPR020902, Actin/actin-like_CS
IPR004001, Actin_CS
IPR043129, ATPase_NBD
PANTHERiPTHR11937, PTHR11937, 1 hit
PfamiView protein in Pfam
PF00022, Actin, 1 hit
PRINTSiPR00190, ACTIN
SMARTiView protein in SMART
SM00268, ACTIN, 1 hit
SUPFAMiSSF53067, SSF53067, 2 hits
PROSITEiView protein in PROSITE
PS00406, ACTINS_1, 1 hit
PS00432, ACTINS_2, 1 hit
PS01132, ACTINS_ACT_LIKE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiACT_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P10989
Secondary accession number(s): Q10288
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: September 29, 2021
This is version 179 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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