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Entry version 103 (31 Jul 2019)
Sequence version 1 (01 Jul 1989)
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Protein

Retrovirus-related Pol polyprotein from transposon TNT 1-94

Gene
N/A
Organism
Nicotiana tabacum (Common tobacco)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei297For protease activityBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri230 – 247CCHC-typePROSITE-ProRule annotationAdd BLAST18

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAspartyl protease, Endonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Protease, RNA-directed DNA polymerase, Transferase
LigandMetal-binding, Zinc

Protein family/group databases

MEROPS protease database

More...
MEROPSi
A11.002

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Retrovirus-related Pol polyprotein from transposon TNT 1-94
Including the following 3 domains:
Protease (EC:3.4.23.-)
Reverse transcriptase (EC:2.7.7.49)
Endonuclease
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNicotiana tabacum (Common tobacco)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri4097 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000084051 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001995611 – 1328Retrovirus-related Pol polyprotein from transposon TNT 1-94Add BLAST1328

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini473 – 642Integrase catalyticPROSITE-ProRule annotationAdd BLAST170

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri230 – 247CCHC-typePROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Zinc-finger

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.420.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025724 GAG-pre-integrase_dom
IPR001584 Integrase_cat-core
IPR039537 Retrotran_Ty1/copia-like
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
IPR013103 RVT_2
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11439 PTHR11439, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13976 gag_pre-integrs, 1 hit
PF00665 rve, 1 hit
PF07727 RVT_2, 1 hit
PF00098 zf-CCHC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00343 ZnF_C2HC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53098 SSF53098, 1 hit
SSF57756 SSF57756, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50994 INTEGRASE, 1 hit
PS50158 ZF_CCHC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P10978-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGVKYEVAK FNGDNGFSTW QRRMRDLLIQ QGLHKVLDVD SKKPDTMKAE
60 70 80 90 100
DWADLDERAA SAIRLHLSDD VVNNIIDEDT ARGIWTRLES LYMSKTLTNK
110 120 130 140 150
LYLKKQLYAL HMSEGTNFLS HLNVFNGLIT QLANLGVKIE EEDKAILLLN
160 170 180 190 200
SLPSSYDNLA TTILHGKTTI ELKDVTSALL LNEKMRKKPE NQGQALITEG
210 220 230 240 250
RGRSYQRSSN NYGRSGARGK SKNRSKSRVR NCYNCNQPGH FKRDCPNPRK
260 270 280 290 300
GKGETSGQKN DDNTAAMVQN NDNVVLFINE EEECMHLSGP ESEWVVDTAA
310 320 330 340 350
SHHATPVRDL FCRYVAGDFG TVKMGNTSYS KIAGIGDICI KTNVGCTLVL
360 370 380 390 400
KDVRHVPDLR MNLISGIALD RDGYESYFAN QKWRLTKGSL VIAKGVARGT
410 420 430 440 450
LYRTNAEICQ GELNAAQDEI SVDLWHKRMG HMSEKGLQIL AKKSLISYAK
460 470 480 490 500
GTTVKPCDYC LFGKQHRVSF QTSSERKLNI LDLVYSDVCG PMEIESMGGN
510 520 530 540 550
KYFVTFIDDA SRKLWVYILK TKDQVFQVFQ KFHALVERET GRKLKRLRSD
560 570 580 590 600
NGGEYTSREF EEYCSSHGIR HEKTVPGTPQ HNGVAERMNR TIVEKVRSML
610 620 630 640 650
RMAKLPKSFW GEAVQTACYL INRSPSVPLA FEIPERVWTN KEVSYSHLKV
660 670 680 690 700
FGCRAFAHVP KEQRTKLDDK SIPCIFIGYG DEEFGYRLWD PVKKKVIRSR
710 720 730 740 750
DVVFRESEVR TAADMSEKVK NGIIPNFVTI PSTSNNPTSA ESTTDEVSEQ
760 770 780 790 800
GEQPGEVIEQ GEQLDEGVEE VEHPTQGEEQ HQPLRRSERP RVESRRYPST
810 820 830 840 850
EYVLISDDRE PESLKEVLSH PEKNQLMKAM QEEMESLQKN GTYKLVELPK
860 870 880 890 900
GKRPLKCKWV FKLKKDGDCK LVRYKARLVV KGFEQKKGID FDEIFSPVVK
910 920 930 940 950
MTSIRTILSL AASLDLEVEQ LDVKTAFLHG DLEEEIYMEQ PEGFEVAGKK
960 970 980 990 1000
HMVCKLNKSL YGLKQAPRQW YMKFDSFMKS QTYLKTYSDP CVYFKRFSEN
1010 1020 1030 1040 1050
NFIILLLYVD DMLIVGKDKG LIAKLKGDLS KSFDMKDLGP AQQILGMKIV
1060 1070 1080 1090 1100
RERTSRKLWL SQEKYIERVL ERFNMKNAKP VSTPLAGHLK LSKKMCPTTV
1110 1120 1130 1140 1150
EEKGNMAKVP YSSAVGSLMY AMVCTRPDIA HAVGVVSRFL ENPGKEHWEA
1160 1170 1180 1190 1200
VKWILRYLRG TTGDCLCFGG SDPILKGYTD ADMAGDIDNR KSSTGYLFTF
1210 1220 1230 1240 1250
SGGAISWQSK LQKCVALSTT EAEYIAATET GKEMIWLKRF LQELGLHQKE
1260 1270 1280 1290 1300
YVVYCDSQSA IDLSKNSMYH ARTKHIDVRY HWIREMVDDE SLKVLKISTN
1310 1320
ENPADMLTKV VPRNKFELCK ELVGMHSN
Length:1,328
Mass (Da):151,077
Last modified:July 1, 1989 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF27E76C504B19B1B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X13777 Genomic DNA Translation: CAA32025.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S04273

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13777 Genomic DNA Translation: CAA32025.1
PIRiS04273

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

MEROPSiA11.002

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR025724 GAG-pre-integrase_dom
IPR001584 Integrase_cat-core
IPR039537 Retrotran_Ty1/copia-like
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
IPR013103 RVT_2
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf
PANTHERiPTHR11439 PTHR11439, 1 hit
PfamiView protein in Pfam
PF13976 gag_pre-integrs, 1 hit
PF00665 rve, 1 hit
PF07727 RVT_2, 1 hit
PF00098 zf-CCHC, 1 hit
SMARTiView protein in SMART
SM00343 ZnF_C2HC, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit
SSF57756 SSF57756, 1 hit
PROSITEiView protein in PROSITE
PS50994 INTEGRASE, 1 hit
PS50158 ZF_CCHC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPOLX_TOBAC
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P10978
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: July 31, 2019
This is version 103 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome, Transposable element
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