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Protein

50S ribosomal protein L22

Gene

rpl22

Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.UniRule annotation
Contacts all 6 domains of the 23S rRNA, helping stabilize their relative orientation. An extended beta-hairpin in the C-terminus forms part of the polypeptide exit tunnel, in which it helps forms a bend with protein L4, while most of the rest of the protein is located at the polypeptide exit tunnel on the outside of the subunit.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L22UniRule annotation
Alternative name(s):
Hl23
Hmal22
Gene namesi
Name:rpl22UniRule annotation
Ordered Locus Names:rrnAC1606
OrganismiHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Taxonomic identifieri272569 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaStenosarchaea groupHalobacteriaHalobacterialesHaloarculaceaeHaloarcula
Proteomesi
  • UP000001169 Componenti: Chromosome I

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00001252722 – 15550S ribosomal protein L22Add BLAST154

Interactioni

Subunit structurei

Part of the 50S ribosomal subunit. Contacts the macrolide antibiotic tylosin in the polypeptide exit tunnel.UniRule annotation2 Publications

Protein-protein interaction databases

STRINGi272569.rrnAC1606

Structurei

Secondary structure

1155
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP10970
SMRiP10970
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10970

Family & Domainsi

Sequence similaritiesi

Belongs to the universal ribosomal protein uL22 family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04098 Archaea
COG0091 LUCA
HOGENOMiHOG000205045
KOiK02890
OMAiANAEYKG
OrthoDBiPOG093Z0GN5

Family and domain databases

CDDicd00336 Ribosomal_L22, 1 hit
Gene3Di3.90.470.10, 1 hit
HAMAPiMF_01331_A Ribosomal_L22_A, 1 hit
InterProiView protein in InterPro
IPR001063 Ribosomal_L22
IPR018260 Ribosomal_L22/L17_CS
IPR005721 Ribosomal_L22/L17_euk/arc
IPR036394 Ribosomal_L22/L17_sf
PANTHERiPTHR11593 PTHR11593, 1 hit
PfamiView protein in Pfam
PF00237 Ribosomal_L22, 1 hit
SUPFAMiSSF54843 SSF54843, 1 hit
TIGRFAMsiTIGR01038 uL22_arch_euk, 1 hit
PROSITEiView protein in PROSITE
PS00464 RIBOSOMAL_L22, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10970-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGISYSVEAD PDTTAKAMLR ERQMSFKHSK AIAREIKGKT AGEAVDYLEA
60 70 80 90 100
VIEGDQPVPF KQHNSGVGHK SKVDGWDAGR YPEKASKAFL DLLENAVGNA
110 120 130 140 150
DHQGFDGEAM TIKHVAAHKV GEQQGRKPRA MGRASAWNSP QVDVELILEE

PEVED
Length:155
Mass (Da):16,941
Last modified:January 23, 2007 - v2
Checksum:iE6730272296C0D7C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05222 Genomic DNA Translation: AAA86864.1
AY596297 Genomic DNA Translation: AAV46523.1
PIRiH35063 R5HS22
RefSeqiWP_011223742.1, NC_006396.1

Genome annotation databases

EnsemblBacteriaiAAV46523; AAV46523; rrnAC1606
GeneIDi3128443
KEGGihma:rrnAC1606
PATRICifig|272569.17.peg.2296

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05222 Genomic DNA Translation: AAA86864.1
AY596297 Genomic DNA Translation: AAV46523.1
PIRiH35063 R5HS22
RefSeqiWP_011223742.1, NC_006396.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FFKX-ray2.40O2-155[»]
1JJ2X-ray2.40Q2-155[»]
1K73X-ray3.01S2-155[»]
1K8AX-ray3.00S2-155[»]
1K9MX-ray3.00S2-155[»]
1KC8X-ray3.01S2-155[»]
1KD1X-ray3.00S2-155[»]
1KQSX-ray3.10Q2-155[»]
1M1KX-ray3.20S2-155[»]
1M90X-ray2.80S2-155[»]
1N8RX-ray3.00S2-155[»]
1NJIX-ray3.00S2-155[»]
1Q7YX-ray3.20S2-155[»]
1Q81X-ray2.95S2-155[»]
1Q82X-ray2.98S2-155[»]
1Q86X-ray3.00S2-155[»]
1QVFX-ray3.10Q2-155[»]
1QVGX-ray2.90Q2-155[»]
1S72X-ray2.40R1-155[»]
1VQ4X-ray2.70R1-155[»]
1VQ5X-ray2.60R1-155[»]
1VQ6X-ray2.70R1-155[»]
1VQ7X-ray2.50R1-155[»]
1VQ8X-ray2.20R1-155[»]
1VQ9X-ray2.40R1-155[»]
1VQKX-ray2.30R1-155[»]
1VQLX-ray2.30R1-155[»]
1VQMX-ray2.30R1-155[»]
1VQNX-ray2.40R1-155[»]
1VQOX-ray2.20R1-155[»]
1VQPX-ray2.25R1-155[»]
1W2BX-ray3.50Q2-155[»]
1YHQX-ray2.40R1-155[»]
1YI2X-ray2.65R1-155[»]
1YIJX-ray2.60R1-155[»]
1YITX-ray2.80R1-155[»]
1YJ9X-ray2.80R1-152[»]
1YJNX-ray3.00R1-155[»]
1YJWX-ray2.90R1-155[»]
2OTJX-ray2.90R1-155[»]
2OTLX-ray2.70R1-155[»]
2QA4X-ray3.00R1-155[»]
2QEXX-ray2.90R1-155[»]
3CC2X-ray2.40R1-155[»]
3CC4X-ray2.70R1-155[»]
3CC7X-ray2.70R1-155[»]
3CCEX-ray2.75R1-155[»]
3CCJX-ray2.70R1-155[»]
3CCLX-ray2.90R1-155[»]
3CCMX-ray2.55R1-155[»]
3CCQX-ray2.90R1-155[»]
3CCRX-ray3.00R1-155[»]
3CCSX-ray2.95R1-155[»]
3CCUX-ray2.80R1-155[»]
3CCVX-ray2.90R1-155[»]
3CD6X-ray2.75R1-155[»]
3CMAX-ray2.80R1-155[»]
3CMEX-ray2.95R1-155[»]
3CPWX-ray2.70Q1-155[»]
3CXCX-ray3.00Q2-155[»]
3G4SX-ray3.20R2-151[»]
3G6EX-ray2.70R2-151[»]
3G71X-ray2.85R2-151[»]
3I55X-ray3.11R1-155[»]
3I56X-ray2.90R1-155[»]
3OW2X-ray2.70Q2-151[»]
4ADXelectron microscopy6.60R1-155[»]
4V9FX-ray2.40R1-155[»]
ProteinModelPortaliP10970
SMRiP10970
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272569.rrnAC1606

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAV46523; AAV46523; rrnAC1606
GeneIDi3128443
KEGGihma:rrnAC1606
PATRICifig|272569.17.peg.2296

Phylogenomic databases

eggNOGiarCOG04098 Archaea
COG0091 LUCA
HOGENOMiHOG000205045
KOiK02890
OMAiANAEYKG
OrthoDBiPOG093Z0GN5

Miscellaneous databases

EvolutionaryTraceiP10970

Family and domain databases

CDDicd00336 Ribosomal_L22, 1 hit
Gene3Di3.90.470.10, 1 hit
HAMAPiMF_01331_A Ribosomal_L22_A, 1 hit
InterProiView protein in InterPro
IPR001063 Ribosomal_L22
IPR018260 Ribosomal_L22/L17_CS
IPR005721 Ribosomal_L22/L17_euk/arc
IPR036394 Ribosomal_L22/L17_sf
PANTHERiPTHR11593 PTHR11593, 1 hit
PfamiView protein in Pfam
PF00237 Ribosomal_L22, 1 hit
SUPFAMiSSF54843 SSF54843, 1 hit
TIGRFAMsiTIGR01038 uL22_arch_euk, 1 hit
PROSITEiView protein in PROSITE
PS00464 RIBOSOMAL_L22, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRL22_HALMA
AccessioniPrimary (citable) accession number: P10970
Secondary accession number(s): Q5V1S9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: October 10, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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