UniProtKB - P10970 (RL22_HALMA)
Protein
50S ribosomal protein L22
Gene
rpl22
Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Status
Functioni
This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.UniRule annotation
Contacts all 6 domains of the 23S rRNA, helping stabilize their relative orientation. An extended beta-hairpin in the C-terminus forms part of the polypeptide exit tunnel, in which it helps forms a bend with protein L4, while most of the rest of the protein is located at the polypeptide exit tunnel on the outside of the subunit.
GO - Molecular functioni
- rRNA binding Source: UniProtKB-UniRule
- structural constituent of ribosome Source: InterPro
GO - Biological processi
- translation Source: UniProtKB-UniRule
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding |
Names & Taxonomyi
Protein namesi | Recommended name: 50S ribosomal protein L22UniRule annotationAlternative name(s): Hl23 Hmal22 |
Gene namesi | Name:rpl22UniRule annotation Ordered Locus Names:rrnAC1606 |
Organismi | Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui) |
Taxonomic identifieri | 272569 [NCBI] |
Taxonomic lineagei | Archaea › Euryarchaeota › Stenosarchaea group › Halobacteria › Halobacteriales › Haloarculaceae › Haloarcula › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed2 Publications | |||
ChainiPRO_0000125272 | 2 – 155 | 50S ribosomal protein L22Add BLAST | 154 |
Interactioni
Subunit structurei
Part of the 50S ribosomal subunit. Contacts the macrolide antibiotic tylosin in the polypeptide exit tunnel.
UniRule annotation2 PublicationsProtein-protein interaction databases
STRINGi | 272569.rrnAC1606 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P10970 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P10970 |
Family & Domainsi
Sequence similaritiesi
Belongs to the universal ribosomal protein uL22 family.UniRule annotation
Phylogenomic databases
eggNOGi | arCOG04098, Archaea |
HOGENOMi | CLU_083987_0_2_2 |
OMAi | ANAEYKG |
Family and domain databases
CDDi | cd00336, Ribosomal_L22, 1 hit |
Gene3Di | 3.90.470.10, 1 hit |
HAMAPi | MF_01331_A, Ribosomal_L22_A, 1 hit |
InterProi | View protein in InterPro IPR001063, Ribosomal_L22 IPR018260, Ribosomal_L22/L17_CS IPR005721, Ribosomal_L22/L17_euk/arc IPR036394, Ribosomal_L22/L17_sf |
PANTHERi | PTHR11593, PTHR11593, 1 hit |
Pfami | View protein in Pfam PF00237, Ribosomal_L22, 1 hit |
SUPFAMi | SSF54843, SSF54843, 1 hit |
TIGRFAMsi | TIGR01038, uL22_arch_euk, 1 hit |
PROSITEi | View protein in PROSITE PS00464, RIBOSOMAL_L22, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P10970-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGISYSVEAD PDTTAKAMLR ERQMSFKHSK AIAREIKGKT AGEAVDYLEA
60 70 80 90 100
VIEGDQPVPF KQHNSGVGHK SKVDGWDAGR YPEKASKAFL DLLENAVGNA
110 120 130 140 150
DHQGFDGEAM TIKHVAAHKV GEQQGRKPRA MGRASAWNSP QVDVELILEE
PEVED
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J05222 Genomic DNA Translation: AAA86864.1 AY596297 Genomic DNA Translation: AAV46523.1 |
PIRi | H35063, R5HS22 |
RefSeqi | WP_011223742.1, NZ_CP039138.1 |
Genome annotation databases
EnsemblBacteriai | AAV46523; AAV46523; rrnAC1606 |
GeneIDi | 40152572 |
KEGGi | hma:rrnAC1606 |
PATRICi | fig|272569.17.peg.2296 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J05222 Genomic DNA Translation: AAA86864.1 AY596297 Genomic DNA Translation: AAV46523.1 |
PIRi | H35063, R5HS22 |
RefSeqi | WP_011223742.1, NZ_CP039138.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1FFK | X-ray | 2.40 | O | 2-155 | [»] | |
1JJ2 | X-ray | 2.40 | Q | 2-155 | [»] | |
1K73 | X-ray | 3.01 | S | 2-155 | [»] | |
1K8A | X-ray | 3.00 | S | 2-155 | [»] | |
1K9M | X-ray | 3.00 | S | 2-155 | [»] | |
1KC8 | X-ray | 3.01 | S | 2-155 | [»] | |
1KD1 | X-ray | 3.00 | S | 2-155 | [»] | |
1KQS | X-ray | 3.10 | Q | 2-155 | [»] | |
1M1K | X-ray | 3.20 | S | 2-155 | [»] | |
1M90 | X-ray | 2.80 | S | 2-155 | [»] | |
1N8R | X-ray | 3.00 | S | 2-155 | [»] | |
1NJI | X-ray | 3.00 | S | 2-155 | [»] | |
1Q7Y | X-ray | 3.20 | S | 2-155 | [»] | |
1Q81 | X-ray | 2.95 | S | 2-155 | [»] | |
1Q82 | X-ray | 2.98 | S | 2-155 | [»] | |
1Q86 | X-ray | 3.00 | S | 2-155 | [»] | |
1QVF | X-ray | 3.10 | Q | 2-155 | [»] | |
1QVG | X-ray | 2.90 | Q | 2-155 | [»] | |
1S72 | X-ray | 2.40 | R | 1-155 | [»] | |
1VQ4 | X-ray | 2.70 | R | 1-155 | [»] | |
1VQ5 | X-ray | 2.60 | R | 1-155 | [»] | |
1VQ6 | X-ray | 2.70 | R | 1-155 | [»] | |
1VQ7 | X-ray | 2.50 | R | 1-155 | [»] | |
1VQ8 | X-ray | 2.20 | R | 1-155 | [»] | |
1VQ9 | X-ray | 2.40 | R | 1-155 | [»] | |
1VQK | X-ray | 2.30 | R | 1-155 | [»] | |
1VQL | X-ray | 2.30 | R | 1-155 | [»] | |
1VQM | X-ray | 2.30 | R | 1-155 | [»] | |
1VQN | X-ray | 2.40 | R | 1-155 | [»] | |
1VQO | X-ray | 2.20 | R | 1-155 | [»] | |
1VQP | X-ray | 2.25 | R | 1-155 | [»] | |
1W2B | X-ray | 3.50 | Q | 2-155 | [»] | |
1YHQ | X-ray | 2.40 | R | 1-155 | [»] | |
1YI2 | X-ray | 2.65 | R | 1-155 | [»] | |
1YIJ | X-ray | 2.60 | R | 1-155 | [»] | |
1YIT | X-ray | 2.80 | R | 1-155 | [»] | |
1YJ9 | X-ray | 2.80 | R | 1-152 | [»] | |
1YJN | X-ray | 3.00 | R | 1-155 | [»] | |
1YJW | X-ray | 2.90 | R | 1-155 | [»] | |
2OTJ | X-ray | 2.90 | R | 1-155 | [»] | |
2OTL | X-ray | 2.70 | R | 1-155 | [»] | |
2QA4 | X-ray | 3.00 | R | 1-155 | [»] | |
2QEX | X-ray | 2.90 | R | 1-155 | [»] | |
3CC2 | X-ray | 2.40 | R | 1-155 | [»] | |
3CC4 | X-ray | 2.70 | R | 1-155 | [»] | |
3CC7 | X-ray | 2.70 | R | 1-155 | [»] | |
3CCE | X-ray | 2.75 | R | 1-155 | [»] | |
3CCJ | X-ray | 2.70 | R | 1-155 | [»] | |
3CCL | X-ray | 2.90 | R | 1-155 | [»] | |
3CCM | X-ray | 2.55 | R | 1-155 | [»] | |
3CCQ | X-ray | 2.90 | R | 1-155 | [»] | |
3CCR | X-ray | 3.00 | R | 1-155 | [»] | |
3CCS | X-ray | 2.95 | R | 1-155 | [»] | |
3CCU | X-ray | 2.80 | R | 1-155 | [»] | |
3CCV | X-ray | 2.90 | R | 1-155 | [»] | |
3CD6 | X-ray | 2.75 | R | 1-155 | [»] | |
3CMA | X-ray | 2.80 | R | 1-155 | [»] | |
3CME | X-ray | 2.95 | R | 1-155 | [»] | |
3CPW | X-ray | 2.70 | Q | 1-155 | [»] | |
3CXC | X-ray | 3.00 | Q | 2-155 | [»] | |
3G4S | X-ray | 3.20 | R | 2-151 | [»] | |
3G6E | X-ray | 2.70 | R | 2-151 | [»] | |
3G71 | X-ray | 2.85 | R | 2-151 | [»] | |
3I55 | X-ray | 3.11 | R | 1-155 | [»] | |
3I56 | X-ray | 2.90 | R | 1-155 | [»] | |
3OW2 | X-ray | 2.70 | Q | 2-151 | [»] | |
4ADX | electron microscopy | 6.60 | R | 1-155 | [»] | |
4V9F | X-ray | 2.40 | R | 1-155 | [»] | |
SMRi | P10970 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 272569.rrnAC1606 |
Genome annotation databases
EnsemblBacteriai | AAV46523; AAV46523; rrnAC1606 |
GeneIDi | 40152572 |
KEGGi | hma:rrnAC1606 |
PATRICi | fig|272569.17.peg.2296 |
Phylogenomic databases
eggNOGi | arCOG04098, Archaea |
HOGENOMi | CLU_083987_0_2_2 |
OMAi | ANAEYKG |
Miscellaneous databases
EvolutionaryTracei | P10970 |
Family and domain databases
CDDi | cd00336, Ribosomal_L22, 1 hit |
Gene3Di | 3.90.470.10, 1 hit |
HAMAPi | MF_01331_A, Ribosomal_L22_A, 1 hit |
InterProi | View protein in InterPro IPR001063, Ribosomal_L22 IPR018260, Ribosomal_L22/L17_CS IPR005721, Ribosomal_L22/L17_euk/arc IPR036394, Ribosomal_L22/L17_sf |
PANTHERi | PTHR11593, PTHR11593, 1 hit |
Pfami | View protein in Pfam PF00237, Ribosomal_L22, 1 hit |
SUPFAMi | SSF54843, SSF54843, 1 hit |
TIGRFAMsi | TIGR01038, uL22_arch_euk, 1 hit |
PROSITEi | View protein in PROSITE PS00464, RIBOSOMAL_L22, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RL22_HALMA | |
Accessioni | P10970Primary (citable) accession number: P10970 Secondary accession number(s): Q5V1S9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | January 23, 2007 | |
Last modified: | April 7, 2021 | |
This is version 144 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Ribosomal proteins
Ribosomal proteins families and list of entries - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families