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Entry version 195 (16 Oct 2019)
Sequence version 2 (01 Nov 1997)
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Protein

DNA-directed RNA polymerase I subunit RPA190

Gene

RPA190

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I (Pol I) which synthesizes ribosomal RNA precursors. Besides, RNA polymerase I has intrinsic RNA cleavage activity. RPA190 and RPA135 both contribute to the polymerase catalytic activity and together form the Pol I active center. In addition, subunit RPA12 contributes a catalytic zinc ribbon that is required for RNA cleavage by Pol I. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA190 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.3 Publications

Miscellaneous

Present with 2840 molecules/cell in log phase SD medium.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi62Zinc 1Combined sources1 Publication1
Metal bindingi65Zinc 1Combined sources1 Publication1
Metal bindingi72Zinc 1Combined sources1 Publication1
Metal bindingi75Zinc 1; via tele nitrogenCombined sources1 Publication1
Metal bindingi102Zinc 2Combined sources1 Publication1
Metal bindingi105Zinc 2Combined sources1 Publication1
Metal bindingi233Zinc 2Combined sources1 Publication1
Metal bindingi236Zinc 2Combined sources1 Publication1
Metal bindingi627Magnesium; catalyticBy similarity1
Metal bindingi629Magnesium; catalyticBy similarity1
Metal bindingi631Magnesium; catalyticBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processRibosome biogenesis, Transcription
LigandMagnesium, Metal-binding, Zinc

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-33816-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-73762 RNA Polymerase I Transcription Initiation
R-SCE-73772 RNA Polymerase I Promoter Escape

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA-directed RNA polymerase I subunit RPA190 (EC:2.7.7.6)
Alternative name(s):
DNA-directed RNA polymerase I 190 kDa polypeptide
Short name:
A190
DNA-directed RNA polymerase I largest subunit
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RPA190
Synonyms:RPA1, RRN1
Ordered Locus Names:YOR341W
ORF Names:O6276
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XV

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YOR341W

Saccharomyces Genome Database

More...
SGDi
S000005868 RPA190

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000739301 – 1664DNA-directed RNA polymerase I subunit RPA190Add BLAST1664

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei889PhosphoserineCombined sources1
Modified residuei1636PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P10964

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P10964

PRoteomics IDEntifications database

More...
PRIDEi
P10964

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P10964

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P10964

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the RNA polymerase I (Pol I) complex consisting of 14 subunits: RPA135, RPA190, RPC40, RPA14, RPB5, RPO26, RPA43, RPB8, RPA12, RPB10, RPC19, RPC10, RPA49 and RPA34. The complex is composed of a horseshoe-shaped core containing ten subunits (RPA135, RPA190, RPB5, RPO26, RPB8, RPB10, RPC10, RPA12, RPC19 and RPC40) where RPA135 and RPA190 form the DNA-binding cleft. Outside of the core, RPA14 and RPA43 form the stalk that mediates interactions with transcription initiation factors and newly synthesized RNA.

6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
34724, 465 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1664 DNA-directed RNA Polymerase I complex

Database of interacting proteins

More...
DIPi
DIP-999N

Protein interaction database and analysis system

More...
IntActi
P10964, 45 interactors

Molecular INTeraction database

More...
MINTi
P10964

STRING: functional protein association networks

More...
STRINGi
4932.YOR341W

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11664
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P10964

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni992 – 1004Bridging helixBy similarityAdd BLAST13

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RNA polymerase beta' chain family.Curated

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000205401

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P10964

KEGG Orthology (KO)

More...
KOi
K02999

Identification of Orthologs from Complete Genome Data

More...
OMAi
RFFNRED

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.132.30, 1 hit
1.10.274.100, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015699 DNA-dir_RNA_pol1_lsu
IPR000722 RNA_pol_asu
IPR006592 RNA_pol_N
IPR007080 RNA_pol_Rpb1_1
IPR007066 RNA_pol_Rpb1_3
IPR042102 RNA_pol_Rpb1_3_sf
IPR007083 RNA_pol_Rpb1_4
IPR007081 RNA_pol_Rpb1_5
IPR038120 Rpb1_funnel_sf

The PANTHER Classification System

More...
PANTHERi
PTHR19376:SF11 PTHR19376:SF11, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04997 RNA_pol_Rpb1_1, 1 hit
PF00623 RNA_pol_Rpb1_2, 1 hit
PF04983 RNA_pol_Rpb1_3, 1 hit
PF05000 RNA_pol_Rpb1_4, 1 hit
PF04998 RNA_pol_Rpb1_5, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00663 RPOLA_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P10964-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDISKPVGSE ITSVDFGILT AKEIRNLSAK QITNPTVLDN LGHPVSGGLY
60 70 80 90 100
DLALGAFLRN LCSTCGLDEK FCPGHQGHIE LPVPCYNPLF FNQLYIYLRA
110 120 130 140 150
SCLFCHHFRL KSVEVHRYAC KLRLLQYGLI DESYKLDEIT LGSLNSSMYT
160 170 180 190 200
DDEAIEDNED EMDGEGSKQS KDISSTLLNE LKSKRSEYVD MAIAKALSDG
210 220 230 240 250
RTTERGSFTA TVNDERKKLV HEFHKKLLSR GKCDNCGMFS PKFRKDGFTK
260 270 280 290 300
IFETALNEKQ ITNNRVKGFI RQDMIKKQKQ AKKLDGSNEA SANDEESFDV
310 320 330 340 350
GRNPTTRPKT GSTYILSTEV KNILDTVFRK EQCVLQYVFH SRPNLSRKLV
360 370 380 390 400
KADSFFMDVL VVPPTRFRLP SKLGEEVHEN SQNQLLSKVL TTSLLIRDLN
410 420 430 440 450
DDLSKLQKDK VSLEDRRVIF SRLMNAFVTI QNDVNAFIDS TKAQGRTSGK
460 470 480 490 500
VPIPGVKQAL EKKEGLFRKH MMGKRVNYAA RSVISPDPNI ETNEIGVPPV
510 520 530 540 550
FAVKLTYPEP VTAYNIAELR QAVINGPDKW PGATQIQNED GSLVSLIGMS
560 570 580 590 600
VEQRKALANQ LLTPSSNVST HTLNKKVYRH IKNRDVVLMN RQPTLHKASM
610 620 630 640 650
MGHKVRVLPN EKTLRLHYAN TGAYNADFDG DEMNMHFPQN ENARAEALNL
660 670 680 690 700
ANTDSQYLTP TSGSPVRGLI QDHISAGVWL TSKDSFFTRE QYQQYIYGCI
710 720 730 740 750
RPEDGHTTRS KIVTLPPTIF KPYPLWTGKQ IITTVLLNVT PPDMPGINLI
760 770 780 790 800
SKNKIKNEYW GKGSLENEVL FKDGALLCGI LDKSQYGASK YGIVHSLHEV
810 820 830 840 850
YGPEVAAKVL SVLGRLFTNY ITATAFTCGM DDLRLTAEGN KWRTDILKTS
860 870 880 890 900
VDTGREAAAE VTNLDKDTPA DDPELLKRLQ EILRDNNKSG ILDAVTSSKV
910 920 930 940 950
NAITSQVVSK CVPDGTMKKF PCNSMQAMAL SGAKGSNVNV SQIMCLLGQQ
960 970 980 990 1000
ALEGRRVPVM VSGKTLPSFK PYETDAMAGG YVKGRFYSGI KPQEYYFHCM
1010 1020 1030 1040 1050
AGREGLIDTA VKTSRSGYLQ RCLTKQLEGV HVSYDNSIRD ADGTLVQFMY
1060 1070 1080 1090 1100
GGDAIDITKE SHMTQFEFCL DNYYALLKKY NPSALIEHLD VESALKYSKK
1110 1120 1130 1140 1150
TLKYRKKHSK EPHYKQSVKY DPVLAKYNPA KYLGSVSENF QDKLESFLDK
1160 1170 1180 1190 1200
NSKLFKSSDG VNEKKFRALM QLKYMRSLIN PGEAVGIIAS QSVGEPSTQM
1210 1220 1230 1240 1250
TLNTFHFAGH GAANVTLGIP RLREIVMTAS AAIKTPQMTL PIWNDVSDEQ
1260 1270 1280 1290 1300
ADTFCKSISK VLLSEVIDKV IVTETTGTSN TAGGNAARSY VIHMRFFDNN
1310 1320 1330 1340 1350
EYSEEYDVSK EELQNVISNQ FIHLLEAAIV KEIKKQKRTT GPDIGVAVPR
1360 1370 1380 1390 1400
LQTDVANSSS NSKRLEEDND EEQSHKKTKQ AVSYDEPDED EIETMREAEK
1410 1420 1430 1440 1450
SSDEEGIDSD KESDSDSEDE DVDMNEQINK SIVEANNNMN KVQRDRQSAI
1460 1470 1480 1490 1500
ISHHRFITKY NFDDESGKWC EFKLELAADT EKLLMVNIVE EICRKSIIRQ
1510 1520 1530 1540 1550
IPHIDRCVHP EPENGKRVLV TEGVNFQAMW DQEAFIDVDG ITSNDVAAVL
1560 1570 1580 1590 1600
KTYGVEAARN TIVNEINNVF SRYAISVSFR HLDLIADMMT RQGTYLAFNR
1610 1620 1630 1640 1650
QGMETSTSSF MKMSYETTCQ FLTKAVLDNE REQLDSPSAR IVVGKLNNVG
1660
TGSFDVLAKV PNAA
Length:1,664
Mass (Da):186,432
Last modified:November 1, 1997 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDF65A7AA459D5E6D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti158N → T in AAA34890 (PubMed:2830265).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J03530 Genomic DNA Translation: AAA34890.1
X95720 Genomic DNA Translation: CAA65029.1
Z75249 Genomic DNA Translation: CAA99665.1
BK006948 Genomic DNA Translation: DAA11102.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S67250

NCBI Reference Sequences

More...
RefSeqi
NP_014986.3, NM_001183761.3

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YOR341W_mRNA; YOR341W; YOR341W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
854519

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YOR341W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03530 Genomic DNA Translation: AAA34890.1
X95720 Genomic DNA Translation: CAA65029.1
Z75249 Genomic DNA Translation: CAA99665.1
BK006948 Genomic DNA Translation: DAA11102.1
PIRiS67250
RefSeqiNP_014986.3, NM_001183761.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4C2MX-ray2.80A/P1-1664[»]
4C3HX-ray3.27A1-1664[»]
4C3IX-ray3.0A1-1664[»]
4C3JX-ray3.35A1-1664[»]
4YM7X-ray5.50AA/BA/CA/DA/EA/FA1-1664[»]
5G5Lelectron microscopy4.80A1-1664[»]
5LMXelectron microscopy4.90A1-1664[»]
5M3Felectron microscopy3.80A1-1664[»]
5M3Melectron microscopy4.00A1-1664[»]
5M5Welectron microscopy3.80A1-1664[»]
5M5Xelectron microscopy4.00A1-1664[»]
5M5Yelectron microscopy4.00A1-1664[»]
5M64electron microscopy4.60A1-1664[»]
5N5Yelectron microscopy7.70A1-1664[»]
5N5Zelectron microscopy7.70A1-1664[»]
5N60electron microscopy7.70A1-1664[»]
5N61electron microscopy3.40A1-1664[»]
5OA1electron microscopy4.40A1-1664[»]
5W5Yelectron microscopy3.80A1-1664[»]
5W64electron microscopy4.20A1-1664[»]
5W65electron microscopy4.30A1-1664[»]
5W66electron microscopy3.90A1-1664[»]
6H67electron microscopy3.60A1-1664[»]
6H68electron microscopy4.60A1-1664[»]
6HKOelectron microscopy3.42A1-1664[»]
6HLQelectron microscopy3.18A1-1664[»]
6HLRelectron microscopy3.18A1-1664[»]
6HLSelectron microscopy3.21A1-1664[»]
SMRiP10964
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi34724, 465 interactors
ComplexPortaliCPX-1664 DNA-directed RNA Polymerase I complex
DIPiDIP-999N
IntActiP10964, 45 interactors
MINTiP10964
STRINGi4932.YOR341W

PTM databases

iPTMnetiP10964

Proteomic databases

MaxQBiP10964
PaxDbiP10964
PRIDEiP10964
TopDownProteomicsiP10964

Genome annotation databases

EnsemblFungiiYOR341W_mRNA; YOR341W; YOR341W
GeneIDi854519
KEGGisce:YOR341W

Organism-specific databases

EuPathDBiFungiDB:YOR341W
SGDiS000005868 RPA190

Phylogenomic databases

HOGENOMiHOG000205401
InParanoidiP10964
KOiK02999
OMAiRFFNRED

Enzyme and pathway databases

BioCyciYEAST:G3O-33816-MONOMER
ReactomeiR-SCE-73762 RNA Polymerase I Transcription Initiation
R-SCE-73772 RNA Polymerase I Promoter Escape

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P10964

Family and domain databases

Gene3Di1.10.132.30, 1 hit
1.10.274.100, 1 hit
InterProiView protein in InterPro
IPR015699 DNA-dir_RNA_pol1_lsu
IPR000722 RNA_pol_asu
IPR006592 RNA_pol_N
IPR007080 RNA_pol_Rpb1_1
IPR007066 RNA_pol_Rpb1_3
IPR042102 RNA_pol_Rpb1_3_sf
IPR007083 RNA_pol_Rpb1_4
IPR007081 RNA_pol_Rpb1_5
IPR038120 Rpb1_funnel_sf
PANTHERiPTHR19376:SF11 PTHR19376:SF11, 1 hit
PfamiView protein in Pfam
PF04997 RNA_pol_Rpb1_1, 1 hit
PF00623 RNA_pol_Rpb1_2, 1 hit
PF04983 RNA_pol_Rpb1_3, 1 hit
PF05000 RNA_pol_Rpb1_4, 1 hit
PF04998 RNA_pol_Rpb1_5, 1 hit
SMARTiView protein in SMART
SM00663 RPOLA_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRPA1_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P10964
Secondary accession number(s): D6W336, Q99330
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1997
Last modified: October 16, 2019
This is version 195 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
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