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UniProtKB - P10961 (HSF_YEAST)
Protein
Heat shock transcription factor
Gene
HSF1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
DNA-binding transcription factor that specifically binds heat shock promoter elements (HSE) and activates transcription.
3 PublicationsRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 170 – 259 | 2 PublicationsAdd BLAST | 90 |
GO - Molecular functioni
- DNA binding Source: CAFA
- DNA-binding transcription factor activity Source: SGD
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific DNA binding Source: UniProtKB
GO - Biological processi
- negative regulation of TORC1 signaling Source: SGD
- positive regulation of transcription by RNA polymerase II Source: SGD
- regulation of establishment of protein localization to chromosome Source: SGD
- regulation of transcription by RNA polymerase II Source: SGD
- regulation of translation in response to stress Source: SGD
- response to heat Source: SGD
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Stress response, Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-SCE-3371453, Regulation of HSF1-mediated heat shock response R-SCE-3371511, HSF1 activation R-SCE-3371568, Attenuation phase R-SCE-3371571, HSF1-dependent transactivation |
Names & Taxonomyi
Protein namesi | Recommended name: Heat shock transcription factor1 PublicationShort name: HSTFCurated Alternative name(s): Heat shock factor proteinCurated Short name: HSF1 Publication |
Gene namesi | Name:HSF11 Publication Ordered Locus Names:YGL073W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000003041, HSF1 |
VEuPathDBi | FungiDB:YGL073W |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Mitochondrion
- mitochondrion Source: SGD
Nucleus
- nucleus Source: SGD
Other locations
- protein-DNA complex Source: CAFA
Keywords - Cellular componenti
NucleusPathology & Biotechi
Disruption phenotypei
Inviable vegetative cell population.2 Publications
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 260 – 332 | Missing : Inviable vegetative cell population. 1 PublicationAdd BLAST | 73 | |
Mutagenesisi | 260 – 312 | Missing : Inviable vegetative cell population. 1 PublicationAdd BLAST | 53 | |
Mutagenesisi | 270 – 332 | Missing : Inviable vegetative cell population. 1 PublicationAdd BLAST | 63 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000124581 | 1 – 833 | Heat shock transcription factorAdd BLAST | 833 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Modified residuei | 97 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 450 | PhosphoserineCombined sources | 1 | |
Modified residuei | 458 | PhosphoserineCombined sources | 1 | |
Modified residuei | 471 | PhosphoserineCombined sources | 1 | |
Modified residuei | 478 | PhosphoserineCombined sources | 1 | |
Modified residuei | 528 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Exhibits temperature-dependent phosphorylation that activates the transcriptional capacity.1 Publication
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
MaxQBi | P10961 |
PaxDbi | P10961 |
PRIDEi | P10961 |
PTM databases
iPTMneti | P10961 |
Interactioni
Subunit structurei
Protein-protein interaction databases
BioGRIDi | 33176, 417 interactors |
DIPi | DIP-2374N |
IntActi | P10961, 14 interactors |
MINTi | P10961 |
STRINGi | 4932.YGL073W |
Miscellaneous databases
RNActi | P10961, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 31 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 62 – 92 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 150 – 170 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 260 – 280 | Flexible linker1 PublicationAdd BLAST | 21 | |
Regioni | 277 – 309 | DisorderedSequence analysisAdd BLAST | 33 | |
Regioni | 350 – 403 | Involved in trimerizationBy similarityAdd BLAST | 54 | |
Regioni | 447 – 493 | DisorderedSequence analysisAdd BLAST | 47 | |
Regioni | 542 – 626 | DisorderedSequence analysisAdd BLAST | 85 | |
Regioni | 657 – 765 | DisorderedSequence analysisAdd BLAST | 109 | |
Regioni | 778 – 799 | DisorderedSequence analysisAdd BLAST | 22 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 17 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 447 – 490 | Polar residuesSequence analysisAdd BLAST | 44 | |
Compositional biasi | 542 – 561 | Polar residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 586 – 604 | Polar residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 606 – 626 | Basic and acidic residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 658 – 765 | Polar residuesSequence analysisAdd BLAST | 108 | |
Compositional biasi | 778 – 797 | Polar residuesSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Belongs to the HSF family.Curated
Phylogenomic databases
eggNOGi | KOG0627, Eukaryota |
GeneTreei | ENSGT00940000169930 |
HOGENOMi | CLU_017670_1_0_1 |
InParanoidi | P10961 |
OMAi | NKLWSML |
Family and domain databases
DisProti | DP00135 |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR000232, HSF_DNA-bd IPR027725, HSF_fam IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR10015, PTHR10015, 1 hit |
Pfami | View protein in Pfam PF00447, HSF_DNA-bind, 1 hit |
PRINTSi | PR00056, HSFDOMAIN |
SMARTi | View protein in SMART SM00415, HSF, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00434, HSF_DOMAIN, 1 hit |
i Sequence
Sequence statusi: Complete.
P10961-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNNAANTGTT NESNVSDAPR IEPLPSLNDD DIEKILQPND IFTTDRTDAS
60 70 80 90 100
TTSSTAIEDI INPSLDPQSA ASPVPSSSFF HDSRKPSTST HLVRRGTPLG
110 120 130 140 150
IYQTNLYGHN SRENTNPNST LLSSKLLAHP PVPYGQNPDL LQHAVYRAQP
160 170 180 190 200
SSGTTNAQPR QTTRRYQSHK SRPAFVNKLW SMLNDDSNTK LIQWAEDGKS
210 220 230 240 250
FIVTNREEFV HQILPKYFKH SNFASFVRQL NMYGWHKVQD VKSGSIQSSS
260 270 280 290 300
DDKWQFENEN FIRGREDLLE KIIRQKGSSN NHNSPSGNGN PANGSNIPLD
310 320 330 340 350
NAAGSNNSNN NISSSNSFFN NGHLLQGKTL RLMNEANLGD KNDVTAILGE
360 370 380 390 400
LEQIKYNQIA ISKDLLRINK DNELLWQENM MARERHRTQQ QALEKMFRFL
410 420 430 440 450
TSIVPHLDPK MIMDGLGDPK VNNEKLNSAN NIGLNRDNTG TIDELKSNDS
460 470 480 490 500
FINDDRNSFT NATTNARNNM SPNNDDNSID TASTNTTNRK KNIDENIKNN
510 520 530 540 550
NDIINDIIFN TNLANNLSNY NSNNNAGSPI RPYKQRYLLK NRANSSTSSE
560 570 580 590 600
NPSLTPFDIE SNNDRKISEI PFDDEEEEET DFRPFTSRDP NNQTSENTFD
610 620 630 640 650
PNRFTMLSDD DLKKDSHTND NKHNESDLFW DNVHRNIDEQ DARLQNLENM
660 670 680 690 700
VHILSPGYPN KSFNNKTSST NTNSNMESAV NVNSPGFNLQ DYLTGESNSP
710 720 730 740 750
NSVHSVPSNG SGSTPLPMPN DNDTEHASTS VNQGENGSGL TPFLTVDDHT
760 770 780 790 800
LNDNNTSEGS TRVSPDIKFS ATENTKVSDN LPSFNDHSYS TQADTAPENA
810 820 830
KKRFVEEIPE PAIVEIQDPT EYNDHRLPKR AKK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 522 | S → F in AAA34689 (PubMed:3044612).Curated | 1 | |
Sequence conflicti | 557 – 580 | FDIES…EEEET → LISNLIMTAKFQKFLLMTKK KKKP in AAA34689 (PubMed:3044612).CuratedAdd BLAST | 24 | |
Sequence conflicti | 831 | A → V in AAA34689 (PubMed:3044612).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03139 Genomic DNA Translation: AAA34688.1 M22040 Genomic DNA Translation: AAA34689.1 Z72596 Genomic DNA Translation: CAA96777.1 BK006941 Genomic DNA Translation: DAA08031.1 |
PIRi | A31593 |
RefSeqi | NP_011442.3, NM_001180938.3 |
Genome annotation databases
EnsemblFungii | YGL073W_mRNA; YGL073W; YGL073W |
GeneIDi | 852806 |
KEGGi | sce:YGL073W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03139 Genomic DNA Translation: AAA34688.1 M22040 Genomic DNA Translation: AAA34689.1 Z72596 Genomic DNA Translation: CAA96777.1 BK006941 Genomic DNA Translation: DAA08031.1 |
PIRi | A31593 |
RefSeqi | NP_011442.3, NM_001180938.3 |
3D structure databases
SMRi | P10961 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 33176, 417 interactors |
DIPi | DIP-2374N |
IntActi | P10961, 14 interactors |
MINTi | P10961 |
STRINGi | 4932.YGL073W |
PTM databases
iPTMneti | P10961 |
Proteomic databases
MaxQBi | P10961 |
PaxDbi | P10961 |
PRIDEi | P10961 |
Genome annotation databases
EnsemblFungii | YGL073W_mRNA; YGL073W; YGL073W |
GeneIDi | 852806 |
KEGGi | sce:YGL073W |
Organism-specific databases
SGDi | S000003041, HSF1 |
VEuPathDBi | FungiDB:YGL073W |
Phylogenomic databases
eggNOGi | KOG0627, Eukaryota |
GeneTreei | ENSGT00940000169930 |
HOGENOMi | CLU_017670_1_0_1 |
InParanoidi | P10961 |
OMAi | NKLWSML |
Enzyme and pathway databases
Reactomei | R-SCE-3371453, Regulation of HSF1-mediated heat shock response R-SCE-3371511, HSF1 activation R-SCE-3371568, Attenuation phase R-SCE-3371571, HSF1-dependent transactivation |
Miscellaneous databases
PROi | PR:P10961 |
RNActi | P10961, protein |
Family and domain databases
DisProti | DP00135 |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR000232, HSF_DNA-bd IPR027725, HSF_fam IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR10015, PTHR10015, 1 hit |
Pfami | View protein in Pfam PF00447, HSF_DNA-bind, 1 hit |
PRINTSi | PR00056, HSFDOMAIN |
SMARTi | View protein in SMART SM00415, HSF, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00434, HSF_DOMAIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HSF_YEAST | |
Accessioni | P10961Primary (citable) accession number: P10961 Secondary accession number(s): D6VU70, P11529 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | July 1, 1989 | |
Last modified: | February 23, 2022 | |
This is version 188 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome VII
Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names - SIMILARITY comments
Index of protein domains and families