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Protein

Carboxylesterase 1C

Gene

Ces1c

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Involved in the extracellular metabolism of lung surfactant (By similarity).By similarity

Catalytic activityi

A carboxylic ester + H2O = an alcohol + a carboxylate.PROSITE-ProRule annotation1 Publication

Kineticsi

  1. KM=69 µM for retinyl palmitate1 Publication
  1. Vmax=3.1 nmol/min/mg enzyme with retinyl palmitate as substrate1 Publication

pH dependencei

Optimum pH is 7.0. Active from pH 4.0-8.0.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei221Acyl-ester intermediatePROSITE-ProRule annotation1
Active sitei340Charge relay systemBy similarity1
Active sitei453Charge relay systemBy similarity1

GO - Molecular functioni

  • carboxylic ester hydrolase activity Source: RGD

Keywordsi

Molecular functionHydrolase, Serine esterase

Protein family/group databases

ESTHERiratno-Ces1c Carb_B_Chordata

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxylesterase 1C (EC:3.1.1.1)
Alternative name(s):
Carboxyesterase ES-1
Short name:
E1
ES-THET
Esterase-2
Liver carboxylesterase 1
Neutral retinyl ester hydrolase
Short name:
NREH
Retinyl ester hydrolase
Short name:
REH
Gene namesi
Name:Ces1c
Synonyms:Es2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2571 Ces1c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 181 PublicationAdd BLAST18
ChainiPRO_000000857919 – 549Carboxylesterase 1CAdd BLAST531

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi79N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi87 ↔ 116By similarity
Disulfide bondi273 ↔ 284By similarity
Glycosylationi274N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi275N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi302N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi375N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei471PhosphoserineCombined sources1
Glycosylationi476N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP10959
PRIDEiP10959

PTM databases

iPTMnetiP10959
PhosphoSitePlusiP10959

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024622

Structurei

3D structure databases

ProteinModelPortaliP10959
SMRiP10959
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi546 – 549Prevents secretion from ERSequence analysis4

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1516 Eukaryota
COG2272 LUCA
HOVERGENiHBG008839
InParanoidiP10959
KOiK01044
PhylomeDBiP10959

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR002018 CarbesteraseB
IPR019826 Carboxylesterase_B_AS
IPR019819 Carboxylesterase_B_CS
PfamiView protein in Pfam
PF00135 COesterase, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00122 CARBOXYLESTERASE_B_1, 1 hit
PS00941 CARBOXYLESTERASE_B_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10959-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLCALVWAS LAVCPIWGHP SSPPVVDTTK GKVLGKYVSL EGFTQPVAVF
60 70 80 90 100
LGVPFAKPPL GSLRFAPPEP AEPWSFVKNT TTYPPMCSQD GVVGKLLADM
110 120 130 140 150
LSTGKESIPL EFSEDCLYLN IYSPADLTKN SRLPVMVWIH GGGLIIGGAS
160 170 180 190 200
PYSGLALSAH ENVVVVTIQY RLGIWGLFST GDEHSRGNWA HLDQLAALRW
210 220 230 240 250
VQDNIANFGG NPDSVTIFGE SAGGVSVSAL VLSPLAKNLF HRAISESGVV
260 270 280 290 300
LTTNLDKKNT QAVAQMIATL SGCNNTSSAA MVQCLRQKTE AELLELTVKL
310 320 330 340 350
DNTSMSTVID GVVLPKTPEE ILTEKSFNTV PYIVGFNKQE FGWIIPTMMG
360 370 380 390 400
NLLSEGRMNE KMASSFLKRF SPNLNISESV IPAIIEKYLR GTDDPAKKKE
410 420 430 440 450
LLLDMFSDVF FGIPAVLMSR SLRDAGAPTY MYEFQYRPSF VSDQRPQTVQ
460 470 480 490 500
GDHGDEIFSV FGTPFLKEGA SEEETNLSKL VMKFWANFAR NGNPNGEGLP
510 520 530 540
HWPKYDQKEG YLQIGATTQQ AQKLKGEEVA FWTELLAKNP PQTEHTEHT
Length:549
Mass (Da):60,175
Last modified:November 1, 1997 - v3
Checksum:i18D6A586DA50E662
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5A → V in AAH88251 (PubMed:15489334).Curated1
Sequence conflicti13V → A in AAH88251 (PubMed:15489334).Curated1
Sequence conflicti48A → R in CAA55241 (PubMed:8006016).Curated1
Sequence conflicti107S → N in AAH88251 (PubMed:15489334).Curated1
Sequence conflicti174 – 175IW → FG in AAA40871 (PubMed:2973315).Curated2
Sequence conflicti229A → V in AAH88251 (PubMed:15489334).Curated1
Sequence conflicti250V → L in BAA06310 (PubMed:3235453).Curated1
Sequence conflicti250V → L in BAA20565 (PubMed:3235453).Curated1
Sequence conflicti366 – 368FLK → LLR in AAH88251 (PubMed:15489334).Curated3
Sequence conflicti399K → N in BAA06310 (PubMed:3235453).Curated1
Sequence conflicti399K → N in BAA20565 (PubMed:3235453).Curated1
Sequence conflicti504K → E in BAA06310 (PubMed:3235453).Curated1
Sequence conflicti504K → E in BAA20565 (PubMed:3235453).Curated1
Sequence conflicti504K → E in AAH88251 (PubMed:15489334).Curated1
Sequence conflicti512 – 513LQ → FE in CAA55241 (PubMed:8006016).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti372P → L. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D30620 mRNA Translation: BAA06310.1
D00362 mRNA Translation: BAA20565.1
BC088251 mRNA Translation: AAH88251.1
M20629 mRNA Translation: AAA40871.1
X78489 mRNA Translation: CAA55241.1
PIRiA31584
JX0054
RefSeqiNP_058700.1, NM_017004.1
UniGeneiRn.2549

Genome annotation databases

GeneIDi24346
KEGGirno:24346

Similar proteinsi

Entry informationi

Entry nameiEST1C_RAT
AccessioniPrimary (citable) accession number: P10959
Secondary accession number(s): Q5I0K0, Q63106, Q64626
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1997
Last modified: February 28, 2018
This is version 131 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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