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Entry version 142 (16 Oct 2019)
Sequence version 4 (23 Jan 2007)
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Protein

Hut operon positive regulatory protein

Gene

hutP

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, RNA-binding
Biological processHistidine metabolism, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
BSUB:BSU39340-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Hut operon positive regulatory protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:hutP
Ordered Locus Names:BSU39340
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBacillus subtilis (strain 168)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri224308 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001570 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2T → A: Great decrease in binding affinity for mRNA. 1 Publication1
Mutagenesisi3L → A: Great decrease in binding affinity for mRNA. 1 Publication1
Mutagenesisi4H → A: Decrease in binding affinity for mRNA. 1 Publication1
Mutagenesisi5K → A: No effect. 1 Publication1
Mutagenesisi5K → R: No effect. 1 Publication1
Mutagenesisi6E → A: No effect. 1 Publication1
Mutagenesisi7R → A: Decrease in binding affinity for mRNA. 1 Publication1
Mutagenesisi7R → K: Slight decrease in binding affinity for mRNA. 1 Publication1
Mutagenesisi8R → A or K: No effect. 1 Publication1
Mutagenesisi8R → P: Great decrease in binding affinity for mRNA. 1 Publication1
Mutagenesisi9I → A: Great decrease in binding affinity for mRNA. 1 Publication1
Mutagenesisi10G → A: Decrease in binding affinity for mRNA. 1 Publication1
Mutagenesisi11R → A or K: No effect. 1 Publication1
Mutagenesisi11R → A: No effect. 1 Publication1
Mutagenesisi13S → A: No effect. 1 Publication1
Mutagenesisi14V → A: No effect. 1 Publication1
Mutagenesisi15L → A: Decrease in binding affinity for mRNA. 1 Publication1
Mutagenesisi16L → A: No effect. 1 Publication1
Mutagenesisi17L → A: Decrease in binding affinity for mRNA. 1 Publication1
Mutagenesisi18L → A: Great decrease in binding affinity for mRNA. 1 Publication1
Mutagenesisi19N → A: No effect. 1 Publication1
Mutagenesisi20E → A: No effect. 1 Publication1
Mutagenesisi22E → A: No effect. 1 Publication1
Mutagenesisi23E → A: No effect. 1 Publication1
Mutagenesisi24S → A: No effect. 1 Publication1
Mutagenesisi25T → A: No effect. 1 Publication1
Mutagenesisi26Q → A: Decrease in binding affinity for mRNA. 1 Publication1
Mutagenesisi32R → A: No effect. 1 Publication1
Mutagenesisi35W → A: Great decrease in binding affinity for mRNA. 1 Publication1
Mutagenesisi51V → I: Increased ability to bind to hut mRNA in the presence of histidine. 1 Publication1

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB01938 L-Histidine Beta Naphthylamide

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002037912 – 148Hut operon positive regulatory proteinAdd BLAST147

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P10943

PRoteomics IDEntifications database

More...
PRIDEi
P10943

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homohexamer.

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
224308.BSU39340

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1148
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P10943

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P10943

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the HutP family.Curated

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000261742

KEGG Orthology (KO)

More...
KOi
K09683

Identification of Orthologs from Complete Genome Data

More...
OMAi
MHALYHA

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.1510.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00779 HutP, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015111 Regulatory_HutP
IPR023552 Regulatory_HutP_bacillales
IPR036482 Regulatory_HutP_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09021 HutP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF111064 SSF111064, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P10943-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTLHKERRIG RLSVLLLLNE AEESTQVEEL ERDGWKVCLG KVGSMDAHKV
60 70 80 90 100
VAAIETASKK SGVIQSEGYR ESHALYHATM EALHGVTRGE MLLGSLLRTV
110 120 130 140
GLRFAVLRGN PYESEAEGDW IAVSLYGTIG APIKGLEHET FGVGINHI
Length:148
Mass (Da):16,196
Last modified:January 23, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i33876C6E8489116F
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA22537 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAA06645 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M20659 Genomic DNA Translation: AAA22537.1 Different initiation.
D31856 Genomic DNA Translation: BAA06645.1 Different initiation.
AL009126 Genomic DNA Translation: CAB15970.2

Protein sequence database of the Protein Information Resource

More...
PIRi
S18809 RGBSHP

NCBI Reference Sequences

More...
RefSeqi
NP_391813.1, NC_000964.3
WP_003227146.1, NZ_JNCM01000034.1
WP_003243875.1, NC_000964.3

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CAB15970; CAB15970; BSU39340

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
937529

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bsu:BSU39340

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|224308.179.peg.4259

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20659 Genomic DNA Translation: AAA22537.1 Different initiation.
D31856 Genomic DNA Translation: BAA06645.1 Different initiation.
AL009126 Genomic DNA Translation: CAB15970.2
PIRiS18809 RGBSHP
RefSeqiNP_391813.1, NC_000964.3
WP_003227146.1, NZ_JNCM01000034.1
WP_003243875.1, NC_000964.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VEAX-ray2.80A/B1-148[»]
1WMQX-ray1.60A/B2-148[»]
1WPSX-ray2.80A/B2-148[»]
1WPTX-ray2.70A/B2-148[»]
1WPUX-ray1.48A/B2-148[»]
1WPVX-ray1.70A/B/C2-148[»]
1WRNX-ray2.30A/B/C2-148[»]
1WROX-ray2.35A/B/C2-148[»]
1WRQX-ray2.20A/B2-148[»]
3BOYX-ray1.70A/B/C2-148[»]
4H4LX-ray2.50A/B/C/D/E/F/G/H/I/J/K/L1-148[»]
SMRiP10943
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi224308.BSU39340

Chemistry databases

DrugBankiDB01938 L-Histidine Beta Naphthylamide

Proteomic databases

PaxDbiP10943
PRIDEiP10943

Genome annotation databases

EnsemblBacteriaiCAB15970; CAB15970; BSU39340
GeneIDi937529
KEGGibsu:BSU39340
PATRICifig|224308.179.peg.4259

Phylogenomic databases

HOGENOMiHOG000261742
KOiK09683
OMAiMHALYHA

Enzyme and pathway databases

BioCyciBSUB:BSU39340-MONOMER

Miscellaneous databases

EvolutionaryTraceiP10943

Protein Ontology

More...
PROi
PR:P10943

Family and domain databases

Gene3Di3.40.1510.10, 1 hit
HAMAPiMF_00779 HutP, 1 hit
InterProiView protein in InterPro
IPR015111 Regulatory_HutP
IPR023552 Regulatory_HutP_bacillales
IPR036482 Regulatory_HutP_sf
PfamiView protein in Pfam
PF09021 HutP, 1 hit
SUPFAMiSSF111064 SSF111064, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHUTP_BACSU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P10943
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: October 16, 2019
This is version 142 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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