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Entry version 72 (07 Oct 2020)
Sequence version 2 (10 May 2005)
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Protein

Polyprotein p69

Gene
N/A
Organism
Cryphonectria hypovirus 1 (strain EP713) (CHV-1/EP713) (Chestnut blight fungus hypovirulence-associated virus)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

P40 protein is involved in reduction of conidiation of the host. Not necessary for replication. Also involved in reduction of orange pigmentation of the host.
Cysteine protease of the peptidase family C7 that contributes to hypovirulence-associated traits like the reduction in conidiation and laccase activity, but not to virulence attenuation. Acts as suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of viral defense that limits the accumulation of viral RNAs. Enhances viral dsRNA accumulation and virus transmission. Also involved in the reduction in orange pigmentation of the host, an effect independent of the intrinsic protease activity.PROSITE-ProRule annotation

Miscellaneous

Hypoviruses induce hypovirulence in their fungal host Cryphonectria parasitica. The consequence is attenuation of the related fungal disease, chestnut blight, that causes cankers that enlarge and kill branches and trunks. The virus-like genetic elements consist of cytoplasmically replicating double-stranded RNA.
CHV-1 strain EP713 is a highly hypovirulent strain.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei162For papain-like protease p29 activityPROSITE-ProRule annotation1
Active sitei215For papain-like protease p29 activityPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Suppressor of RNA silencing, Thiol protease

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C07.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Polyprotein p69
Alternative name(s):
ORFA polyprotein
Cleaved into the following 2 chains:
Papain-like protease p29PROSITE-ProRule annotation (EC:3.4.22.-PROSITE-ProRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCryphonectria hypovirus 1 (strain EP713) (CHV-1/EP713) (Chestnut blight fungus hypovirulence-associated virus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri12478 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraePisuviricotaDuplopiviricetesDurnaviralesHypoviridaeHypovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiCryphonectria parasitica (Chestnut blight fungus) (Endothia parasitica) [TaxID: 5116]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007251 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi38C → G: No effect on colony morphology. 1 Publication1
Mutagenesisi48C → G: No effect on colony morphology. 1 Publication1
Mutagenesisi70C → G: Alters colony morphology, with extremely reduced growth. Complete loss of ability to enhance viral dsRNA replication and virus transmission. 2 Publications1
Mutagenesisi72C → G: Mild alteration of colony morphology. Complete loss of ability to enhance viral dsRNA replication and virus transmission. 2 Publications1
Mutagenesisi147C → S: Reduces autocatalytic cleavage. 1 Publication1
Mutagenesisi162C → S: Complete loss of autocatalytic cleavage of p29. 1 Publication1
Mutagenesisi182C → S: No effect on autocatalytic cleavage of p29. 1 Publication1
Mutagenesisi212H → S: Reduces autocatalytic cleavage of p29. 1 Publication1
Mutagenesisi215H → S: Complete loss of autocatalytic cleavage of p29. 1 Publication1
Mutagenesisi223Q → K: No effect on autocatalytic cleavage of p29. 1 Publication1
Mutagenesisi230L → P: Reduces autocatalytic cleavage of p29; when associated with K-233. 1 Publication1
Mutagenesisi233Q → K: No effect on autocatalytic cleavage of p29. Reduces autocatalytic cleavage of p29; when associated with P-230. 1 Publication1
Mutagenesisi234A → C: No effect on autocatalytic cleavage of p29. 1 Publication1
Mutagenesisi248G → R: Complete loss of autocatalytic cleavage of p29. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000388771 – 248Papain-like protease p29Add BLAST248
ChainiPRO_0000038878249 – 622p40 proteinAdd BLAST374

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autocatalytically processed.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei248 – 249Cleavage; by papain-like protease p29PROSITE-ProRule annotation2

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P10941

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 248Peptidase C7PROSITE-ProRule annotationAdd BLAST248

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni25 – 73Involved in colony morphology alterationAdd BLAST49

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002704, Peptidase_C7_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01830, Peptidase_C7, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51877, HAV_P29_PRO, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P10941-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQLRKPSQS LVLSESVDPT TVDPFVSVRT EEVVPAGCIT LWEYRDSCGD
60 70 80 90 100
VPGPLSHGDL RRLRTPDGVC KCQVHFELPT VLKSGSTGTV PEHPAVLAAF
110 120 130 140 150
IGRPRRCSLE QRTKELDSRF LQLVHGGLPA RPSYMIARPP RPVRGLCSSR
160 170 180 190 200
NGSLAQFGQG YCYLSAIVDS ARWRVARTTG WCVRVADYLR LLQWVGRRSF
210 220 230 240 250
GSFQIEKSAV DHVYHVVVDA EYQSEQDGAL FYQAILGLAE KDPLARIGGR
260 270 280 290 300
LNPLAAEFAP GSALRVEPVT PQVTRRKGST RMTGRDPTIV SVGKVGMAIT
310 320 330 340 350
SIQDALVATE LRNVNFGRRD TEAECRRLWA RYEVNDYFRR HKAELLKFDA
360 370 380 390 400
RLRSRMAKKP ASSRARPSDA KIQCIGWRDR HLLPQRLAGL SKQGRSLVWS
410 420 430 440 450
RFATSNIRRK TPPCVVNPSA DPVVHNWKDS AALAVKKIAE ARRRQEIRAA
460 470 480 490 500
AYAERAKARG QTNVVASISE AIETTLRRNK TRFALDGLHL AASAIVTTRL
510 520 530 540 550
RSWNQEEIRA GREFRKSTTS WIWRHVPSSI QDALNLTSVR DKLDPGRAFG
560 570 580 590 600
YVQAAVAQGM SDFRRAKRAL AIVAKPVIRN IRDPYEHGFV KRDGKLRHSR
610 620
DAFNKKLRTK AVAATKVHKI KF
Length:622
Mass (Da):69,688
Last modified:May 10, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAFCB274E2197B732
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA32666 differs from that shown. Reason: Frameshift.Curated
The sequence CAA32667 differs from that shown. Reason: Frameshift.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X14524 mRNA Translation: CAA32666.1 Frameshift.
X14524 mRNA Translation: CAA32667.1 Frameshift.
M57938 Genomic RNA Translation: AAA67457.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S03833
S15009

NCBI Reference Sequences

More...
RefSeqi
NP_041090.1, NC_001492.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1403615

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vg:1403615

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14524 mRNA Translation: CAA32666.1 Frameshift.
X14524 mRNA Translation: CAA32667.1 Frameshift.
M57938 Genomic RNA Translation: AAA67457.1
PIRiS03833
S15009
RefSeqiNP_041090.1, NC_001492.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

MEROPSiC07.001

Proteomic databases

PRIDEiP10941

Genome annotation databases

GeneIDi1403615
KEGGivg:1403615

Family and domain databases

InterProiView protein in InterPro
IPR002704, Peptidase_C7_dom
PfamiView protein in Pfam
PF01830, Peptidase_C7, 1 hit
PROSITEiView protein in PROSITE
PS51877, HAV_P29_PRO, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPOLA_CHPVE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P10941
Secondary accession number(s): P10942, Q04349
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: May 10, 2005
Last modified: October 7, 2020
This is version 72 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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