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Protein

Zinc finger Y-chromosomal protein 1

Gene

Zfy1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable transcriptional activator. Binds to the consensus sequence 5'-AGGCCY-3' (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri403 – 425C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri434 – 456C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 488C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri497 – 520C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri526 – 548C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri554 – 577C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri583 – 605C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri611 – 634C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri640 – 662C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri668 – 691C2H2-type 10PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri697 – 719C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri725 – 748C2H2-type 12PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri754 – 777C2H2-type 13PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger Y-chromosomal protein 1
Gene namesi
Name:Zfy1
Synonyms:Zfy-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome Y

Organism-specific databases

MGIiMGI:99212 Zfy1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000472631 – 782Zinc finger Y-chromosomal protein 1Add BLAST782

Proteomic databases

MaxQBiP10925
PaxDbiP10925
PRIDEiP10925

PTM databases

iPTMnetiP10925
PhosphoSitePlusiP10925

Expressioni

Gene expression databases

BgeeiENSMUSG00000053211 Expressed in 18 organ(s), highest expression level in male associated reproductive structure (mouse)
CleanExiMM_ZFY1
GenevisibleiP10925 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000069364

Structurei

3D structure databases

ProteinModelPortaliP10925
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi372 – 382Nuclear localization signalSequence analysisAdd BLAST11

Domaini

The binding of ZFY to DNA is mediated by the interaction of the GGCC core base pairs with zinc fingers 12 and 13.By similarity

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri403 – 425C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri434 – 456C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 488C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri497 – 520C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri526 – 548C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri554 – 577C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri583 – 605C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri611 – 634C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri640 – 662C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri668 – 691C2H2-type 10PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri697 – 719C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri725 – 748C2H2-type 12PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri754 – 777C2H2-type 13PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063297
HOGENOMiHOG000231717
HOVERGENiHBG000337
InParanoidiP10925
OrthoDBiEOG091G02CA
TreeFamiTF335557

Family and domain databases

InterProiView protein in InterPro
IPR006794 Transcrp_activ_Zfx/Zfy-dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 6 hits
PF04704 Zfx_Zfy_act, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 9 hits

Sequencei

Sequence statusi: Complete.

P10925-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDEDEIELTP EEEKSFFDGI GADAVHMDSD QIVVEVQETV FLANSDVTVH
60 70 80 90 100
NFVPDNPGSV IIQDVIENVL IEDVHCSHIL EETDISDNVI IPEQVLNLGT
110 120 130 140 150
AEEVSLAQFL IPDILTSGIT STSLTMPEHV LMSEAIHVSD VGHFEQVIHD
160 170 180 190 200
SLVETEVITD PITADTSDIL VADCVSEAVL DSSGMPLEQQ DNDKINCEDY
210 220 230 240 250
LMMSLDEPSK ADLEGSSEVT MNAESGTDSS KLDEASPEVI KVCILKADSE
260 270 280 290 300
VDELGETIHA VESETKNGNE AEVTDQSTSI RVPRVNIYMS ASDSQKEEED
310 320 330 340 350
TEVIVGDEDA GGTAADTPEH EQQMDVSEIK AAFLPIAWTA AYDNNSDEIE
360 370 380 390 400
DQNVTASALL NQDESGGLDR VPKQKSKKKK RPESKQYQSA IFVAPDGQTL
410 420 430 440 450
RVYPCMFCGK KFKTKRFLKR HTKNHPEYLA NKKYHCTECD YSTNKKISLH
460 470 480 490 500
NHMESHKLTI KTEKTTECDD CRKNLSHAGT LCTHKTMHTE KGVNKTCKCK
510 520 530 540 550
FCDYETAEQT LLNHHLLVVH RKKFPHICGE CGKGFRHPSA LKKHIRVHTG
560 570 580 590 600
EKPYECQYCE YKSADSSNLK THIKSKHSKE IPLKCGICLL TFSDNKEAQQ
610 620 630 640 650
HAVLHQESRT HQCSHCNHKS SNSSDLKRHI ISVHTKAYPH KCDMCSKGFH
660 670 680 690 700
RPSELKKHVA THKSKKMHQC RHCDFNSPDP FLLSHHILSA HTKNVPFKCK
710 720 730 740 750
RCKKEFQQQC ELQTHMKTHS SRKVYQCEYC EYSTKDASGF KRHVISIHTK
760 770 780
DYPHSCDFCK KGFRRPSEKN QHIMRHHKVG LP
Length:782
Mass (Da):88,230
Last modified:July 27, 2011 - v3
Checksum:i27473EF40C051236
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8L → S in CAA32552 (PubMed:2497440).Curated1
Sequence conflicti211A → T in CAA32552 (PubMed:2497440).Curated1
Sequence conflicti226G → E in CAA32552 (PubMed:2497440).Curated1
Sequence conflicti253 – 254EL → DV in CAA32552 (PubMed:2497440).Curated2
Sequence conflicti388Q → K in CAA32552 (PubMed:2497440).Curated1
Sequence conflicti595N → T in CAA32552 (PubMed:2497440).Curated1
Sequence conflicti679D → N in BAC36419 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14382 mRNA Translation: CAA32552.1
AK076618 mRNA Translation: BAC36419.1
AC139318 Genomic DNA No translation available.
CCDSiCCDS30539.1
PIRiS04047
RefSeqiNP_033596.3, NM_009570.4
UniGeneiMm.4324

Genome annotation databases

EnsembliENSMUST00000065545; ENSMUSP00000069364; ENSMUSG00000053211
ENSMUST00000189888; ENSMUSP00000140600; ENSMUSG00000053211
GeneIDi22767
KEGGimmu:22767
UCSCiuc009uyv.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14382 mRNA Translation: CAA32552.1
AK076618 mRNA Translation: BAC36419.1
AC139318 Genomic DNA No translation available.
CCDSiCCDS30539.1
PIRiS04047
RefSeqiNP_033596.3, NM_009570.4
UniGeneiMm.4324

3D structure databases

ProteinModelPortaliP10925
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000069364

PTM databases

iPTMnetiP10925
PhosphoSitePlusiP10925

Proteomic databases

MaxQBiP10925
PaxDbiP10925
PRIDEiP10925

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000065545; ENSMUSP00000069364; ENSMUSG00000053211
ENSMUST00000189888; ENSMUSP00000140600; ENSMUSG00000053211
GeneIDi22767
KEGGimmu:22767
UCSCiuc009uyv.2 mouse

Organism-specific databases

CTDi22767
MGIiMGI:99212 Zfy1

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063297
HOGENOMiHOG000231717
HOVERGENiHBG000337
InParanoidiP10925
OrthoDBiEOG091G02CA
TreeFamiTF335557

Miscellaneous databases

PROiPR:P10925
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000053211 Expressed in 18 organ(s), highest expression level in male associated reproductive structure (mouse)
CleanExiMM_ZFY1
GenevisibleiP10925 MM

Family and domain databases

InterProiView protein in InterPro
IPR006794 Transcrp_activ_Zfx/Zfy-dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 6 hits
PF04704 Zfx_Zfy_act, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 9 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZFY1_MOUSE
AccessioniPrimary (citable) accession number: P10925
Secondary accession number(s): E9QKM5, Q8C638
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 150 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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