Zfy1

Functionⁱ

Probable transcriptional activator. Binds to the consensus sequence 5'-AGGCCY-3' (By similarity).By similarity

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	403 – 425	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	434 – 456	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	466 – 488	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	497 – 520	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	526 – 548	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	554 – 577	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	583 – 605	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	611 – 634	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	640 – 662	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	668 – 691	C2H2-type 10PROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	697 – 719	C2H2-type 11PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	725 – 748	C2H2-type 12PROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	754 – 777	C2H2-type 13PROSITE-ProRule annotationAdd BLAST	24

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

regulation of transcription, DNA-templated Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger Y-chromosomal protein 1
Gene namesⁱ	Name:Zfy1 Synonyms:Zfy-1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome Y

Organism-specific databases

MGIⁱ	MGI:99212 Zfy1

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047263	1 – 782	Zinc finger Y-chromosomal protein 1Add BLAST		782

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P10925
PaxDbⁱ	P10925
PRIDEⁱ	P10925

PTM databases

iPTMnetⁱ	P10925
PhosphoSitePlusⁱ	P10925

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000053211 Expressed in 18 organ(s), highest expression level in male associated reproductive structure (mouse)
CleanExⁱ	MM_ZFY1
Genevisibleⁱ	P10925 MM

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000069364

STRINGⁱ

10090.ENSMUSP00000069364

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P10925
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	372 – 382	Nuclear localization signalSequence analysisAdd BLAST		11

Domainⁱ

The binding of ZFY to DNA is mediated by the interaction of the GGCC core base pairs with zinc fingers 12 and 13.By similarity

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family. ZFX/ZFY subfamily.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	403 – 425	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	434 – 456	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	466 – 488	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	497 – 520	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	526 – 548	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	554 – 577	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	583 – 605	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	611 – 634	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	640 – 662	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	668 – 691	C2H2-type 10PROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	697 – 719	C2H2-type 11PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	725 – 748	C2H2-type 12PROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	754 – 777	C2H2-type 13PROSITE-ProRule annotationAdd BLAST	24

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063297
HOGENOMⁱ	HOG000231717
HOVERGENⁱ	HBG000337
InParanoidⁱ	P10925
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02CA
TreeFamⁱ	TF335557

Family and domain databases

InterProⁱ	View protein in InterPro IPR006794 Transcrp_activ_Zfx/Zfy-dom IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 6 hits PF04704 Zfx_Zfy_act, 1 hit
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 13 hits
SUPFAMⁱ	SSF57667 SSF57667, 6 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 7 hits PS50157 ZINC_FINGER_C2H2_2, 9 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

P10925-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDEDEIELTP EEEKSFFDGI GADAVHMDSD QIVVEVQETV FLANSDVTVH 
        60         70         80         90        100
NFVPDNPGSV IIQDVIENVL IEDVHCSHIL EETDISDNVI IPEQVLNLGT 
       110        120        130        140        150
AEEVSLAQFL IPDILTSGIT STSLTMPEHV LMSEAIHVSD VGHFEQVIHD 
       160        170        180        190        200
SLVETEVITD PITADTSDIL VADCVSEAVL DSSGMPLEQQ DNDKINCEDY 
       210        220        230        240        250
LMMSLDEPSK ADLEGSSEVT MNAESGTDSS KLDEASPEVI KVCILKADSE 
       260        270        280        290        300
VDELGETIHA VESETKNGNE AEVTDQSTSI RVPRVNIYMS ASDSQKEEED 
       310        320        330        340        350
TEVIVGDEDA GGTAADTPEH EQQMDVSEIK AAFLPIAWTA AYDNNSDEIE 
       360        370        380        390        400
DQNVTASALL NQDESGGLDR VPKQKSKKKK RPESKQYQSA IFVAPDGQTL 
       410        420        430        440        450
RVYPCMFCGK KFKTKRFLKR HTKNHPEYLA NKKYHCTECD YSTNKKISLH 
       460        470        480        490        500
NHMESHKLTI KTEKTTECDD CRKNLSHAGT LCTHKTMHTE KGVNKTCKCK 
       510        520        530        540        550
FCDYETAEQT LLNHHLLVVH RKKFPHICGE CGKGFRHPSA LKKHIRVHTG 
       560        570        580        590        600
EKPYECQYCE YKSADSSNLK THIKSKHSKE IPLKCGICLL TFSDNKEAQQ 
       610        620        630        640        650
HAVLHQESRT HQCSHCNHKS SNSSDLKRHI ISVHTKAYPH KCDMCSKGFH 
       660        670        680        690        700
RPSELKKHVA THKSKKMHQC RHCDFNSPDP FLLSHHILSA HTKNVPFKCK 
       710        720        730        740        750
RCKKEFQQQC ELQTHMKTHS SRKVYQCEYC EYSTKDASGF KRHVISIHTK 
       760        770        780 
DYPHSCDFCK KGFRRPSEKN QHIMRHHKVG LP

Length:782

Mass (Da):88,230

Last modified:July 27, 2011 - v3

Checksum:ⁱ27473EF40C051236

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	8	L → S in CAA32552 (PubMed:2497440).Curated	1
Sequence conflictⁱ	211	A → T in CAA32552 (PubMed:2497440).Curated	1
Sequence conflictⁱ	226	G → E in CAA32552 (PubMed:2497440).Curated	1
Sequence conflictⁱ	253 – 254	EL → DV in CAA32552 (PubMed:2497440).Curated	2
Sequence conflictⁱ	388	Q → K in CAA32552 (PubMed:2497440).Curated	1
Sequence conflictⁱ	595	N → T in CAA32552 (PubMed:2497440).Curated	1
Sequence conflictⁱ	679	D → N in BAC36419 (PubMed:16141072).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X14382 mRNA Translation: CAA32552.1 AK076618 mRNA Translation: BAC36419.1 AC139318 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS30539.1
PIRⁱ	S04047
NCBI Reference Sequences More...RefSeqⁱ	NP_033596.3, NM_009570.4
UniGeneⁱ	Mm.4324

Genome annotation databases

Ensemblⁱ	ENSMUST00000065545; ENSMUSP00000069364; ENSMUSG00000053211 ENSMUST00000189888; ENSMUSP00000140600; ENSMUSG00000053211
GeneIDⁱ	22767
KEGGⁱ	mmu:22767
UCSC genome browser More...UCSCⁱ	uc009uyv.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P10925	Y-linked zinc finger protein 1 (Fragment)		eastern European house mouse		332	UniRef100_P10925

Protein	Similar proteins		Species	Score	Length	Source
P10925	Zinc finger Y-chromosomal protein 2		MOUSE		777	UniRef90_P10925
Y-linked zinc finger protein 1 (Fragment)		eastern European house mouse		332
Y-linked zinc finger protein 2 (Fragment)		MUSMC		326
Y-linked zinc finger protein 2 (Fragment)		eastern European house mouse		326
Y-linked zinc finger protein 2 (Fragment)		MOUSE		272
+1

Protein	Similar proteins		Species	Score	Length	Source
P10925	Isoform 2 of Zinc finger Y-chromosomal protein		HUMAN		610	UniRef50_P08048-2
Zinc finger autosomal protein		MOUSE		742
Zinc finger Y-chromosomal protein 1		XENLA		794
Uncharacterized protein		CALJA		611
Uncharacterized protein		AOTNA		611
+272

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X14382 mRNA Translation: CAA32552.1 AK076618 mRNA Translation: BAC36419.1 AC139318 Genomic DNA No translation available.
CCDSⁱ	CCDS30539.1
PIRⁱ	S04047
RefSeqⁱ	NP_033596.3, NM_009570.4
UniGeneⁱ	Mm.4324

3D structure databases

ProteinModelPortalⁱ	P10925
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000069364

STRINGⁱ

10090.ENSMUSP00000069364

PTM databases

iPTMnetⁱ	P10925
PhosphoSitePlusⁱ	P10925

Proteomic databases

MaxQBⁱ	P10925
PaxDbⁱ	P10925
PRIDEⁱ	P10925

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000065545; ENSMUSP00000069364; ENSMUSG00000053211 ENSMUST00000189888; ENSMUSP00000140600; ENSMUSG00000053211
GeneIDⁱ	22767
KEGGⁱ	mmu:22767
UCSCⁱ	uc009uyv.2 mouse

Organism-specific databases

CTDⁱ	22767
MGIⁱ	MGI:99212 Zfy1

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00530000063297
HOGENOMⁱ	HOG000231717
HOVERGENⁱ	HBG000337
InParanoidⁱ	P10925
OrthoDBⁱ	EOG091G02CA
TreeFamⁱ	TF335557

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P10925
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000053211 Expressed in 18 organ(s), highest expression level in male associated reproductive structure (mouse)
CleanExⁱ	MM_ZFY1
Genevisibleⁱ	P10925 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR006794 Transcrp_activ_Zfx/Zfy-dom IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 6 hits PF04704 Zfx_Zfy_act, 1 hit
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 13 hits
SUPFAMⁱ	SSF57667 SSF57667, 6 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 7 hits PS50157 ZINC_FINGER_C2H2_2, 9 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZFY1_MOUSE
Accessionⁱ	P10925Primary (citable) accession number: P10925 Secondary accession number(s): E9QKM5, Q8C638
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
	Last sequence update:	July 27, 2011
	Last modified:	November 7, 2018
	This is version 150 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P10925 (ZFY1_MOUSE)

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Zinc finger Y-chromosomal protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ