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UniProtKB - P10925 (ZFY1_MOUSE)
Protein
Zinc finger Y-chromosomal protein 1
Gene
Zfy1
Organism
Mus musculus (Mouse)
Status
Functioni
Probable transcriptional activator. Binds to the consensus sequence 5'-AGGCCY-3' (By similarity).
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 403 – 425 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 434 – 456 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 466 – 488 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 497 – 520 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 526 – 548 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 554 – 577 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 583 – 605 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 611 – 634 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 640 – 662 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 668 – 691 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 697 – 719 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 725 – 748 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 754 – 777 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger Y-chromosomal protein 1 |
Gene namesi | Name:Zfy1 Synonyms:Zfy-1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:99212, Zfy1 |
VEuPathDBi | HostDB:ENSMUSG00000053211 |
Subcellular locationi
Nucleus
Nucleus
- nucleolus Source: MGI
- nucleoplasm Source: MGI
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047263 | 1 – 782 | Zinc finger Y-chromosomal protein 1Add BLAST | 782 |
Proteomic databases
MaxQBi | P10925 |
PaxDbi | P10925 |
PRIDEi | P10925 |
ProteomicsDBi | 302057 |
PTM databases
iPTMneti | P10925 |
PhosphoSitePlusi | P10925 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000053211, Expressed in male associated reproductive structure (mouse) and 26 other tissues |
Genevisiblei | P10925, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000069364 |
Miscellaneous databases
RNActi | P10925, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 211 – 233 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 360 – 386 | DisorderedSequence analysisAdd BLAST | 27 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 372 – 382 | Nuclear localization signalSequence analysisAdd BLAST | 11 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 215 – 232 | Polar residuesSequence analysisAdd BLAST | 18 |
Domaini
The binding of ZFY to DNA is mediated by the interaction of the GGCC core base pairs with zinc fingers 12 and 13.By similarity
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 403 – 425 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 434 – 456 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 466 – 488 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 497 – 520 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 526 – 548 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 554 – 577 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 583 – 605 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 611 – 634 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 640 – 662 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 668 – 691 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 697 – 719 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 725 – 748 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 754 – 777 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000164731 |
HOGENOMi | CLU_021097_0_0_1 |
InParanoidi | P10925 |
OrthoDBi | 1318335at2759 |
PhylomeDBi | P10925 |
TreeFami | TF335557 |
Family and domain databases
InterProi | View protein in InterPro IPR006794, Transcrp_activ_Zfx/Zfy-dom IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 6 hits PF04704, Zfx_Zfy_act, 1 hit |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 13 hits |
SUPFAMi | SSF57667, SSF57667, 6 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 7 hits PS50157, ZINC_FINGER_C2H2_2, 9 hits |
i Sequence
Sequence statusi: Complete.
P10925-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDEDEIELTP EEEKSFFDGI GADAVHMDSD QIVVEVQETV FLANSDVTVH
60 70 80 90 100
NFVPDNPGSV IIQDVIENVL IEDVHCSHIL EETDISDNVI IPEQVLNLGT
110 120 130 140 150
AEEVSLAQFL IPDILTSGIT STSLTMPEHV LMSEAIHVSD VGHFEQVIHD
160 170 180 190 200
SLVETEVITD PITADTSDIL VADCVSEAVL DSSGMPLEQQ DNDKINCEDY
210 220 230 240 250
LMMSLDEPSK ADLEGSSEVT MNAESGTDSS KLDEASPEVI KVCILKADSE
260 270 280 290 300
VDELGETIHA VESETKNGNE AEVTDQSTSI RVPRVNIYMS ASDSQKEEED
310 320 330 340 350
TEVIVGDEDA GGTAADTPEH EQQMDVSEIK AAFLPIAWTA AYDNNSDEIE
360 370 380 390 400
DQNVTASALL NQDESGGLDR VPKQKSKKKK RPESKQYQSA IFVAPDGQTL
410 420 430 440 450
RVYPCMFCGK KFKTKRFLKR HTKNHPEYLA NKKYHCTECD YSTNKKISLH
460 470 480 490 500
NHMESHKLTI KTEKTTECDD CRKNLSHAGT LCTHKTMHTE KGVNKTCKCK
510 520 530 540 550
FCDYETAEQT LLNHHLLVVH RKKFPHICGE CGKGFRHPSA LKKHIRVHTG
560 570 580 590 600
EKPYECQYCE YKSADSSNLK THIKSKHSKE IPLKCGICLL TFSDNKEAQQ
610 620 630 640 650
HAVLHQESRT HQCSHCNHKS SNSSDLKRHI ISVHTKAYPH KCDMCSKGFH
660 670 680 690 700
RPSELKKHVA THKSKKMHQC RHCDFNSPDP FLLSHHILSA HTKNVPFKCK
710 720 730 740 750
RCKKEFQQQC ELQTHMKTHS SRKVYQCEYC EYSTKDASGF KRHVISIHTK
760 770 780
DYPHSCDFCK KGFRRPSEKN QHIMRHHKVG LP
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 8 | L → S in CAA32552 (PubMed:2497440).Curated | 1 | |
Sequence conflicti | 211 | A → T in CAA32552 (PubMed:2497440).Curated | 1 | |
Sequence conflicti | 226 | G → E in CAA32552 (PubMed:2497440).Curated | 1 | |
Sequence conflicti | 253 – 254 | EL → DV in CAA32552 (PubMed:2497440).Curated | 2 | |
Sequence conflicti | 388 | Q → K in CAA32552 (PubMed:2497440).Curated | 1 | |
Sequence conflicti | 595 | N → T in CAA32552 (PubMed:2497440).Curated | 1 | |
Sequence conflicti | 679 | D → N in BAC36419 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X14382 mRNA Translation: CAA32552.1 AK076618 mRNA Translation: BAC36419.1 AC139318 Genomic DNA No translation available. |
CCDSi | CCDS30539.1 |
PIRi | S04047 |
RefSeqi | NP_033596.3, NM_009570.4 |
Genome annotation databases
Ensembli | ENSMUST00000065545; ENSMUSP00000069364; ENSMUSG00000053211 ENSMUST00000189888; ENSMUSP00000140600; ENSMUSG00000053211 |
GeneIDi | 22767 |
KEGGi | mmu:22767 |
UCSCi | uc009uyv.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X14382 mRNA Translation: CAA32552.1 AK076618 mRNA Translation: BAC36419.1 AC139318 Genomic DNA No translation available. |
CCDSi | CCDS30539.1 |
PIRi | S04047 |
RefSeqi | NP_033596.3, NM_009570.4 |
3D structure databases
SMRi | P10925 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000069364 |
PTM databases
iPTMneti | P10925 |
PhosphoSitePlusi | P10925 |
Proteomic databases
MaxQBi | P10925 |
PaxDbi | P10925 |
PRIDEi | P10925 |
ProteomicsDBi | 302057 |
Protocols and materials databases
DNASUi | 22767 |
Genome annotation databases
Ensembli | ENSMUST00000065545; ENSMUSP00000069364; ENSMUSG00000053211 ENSMUST00000189888; ENSMUSP00000140600; ENSMUSG00000053211 |
GeneIDi | 22767 |
KEGGi | mmu:22767 |
UCSCi | uc009uyv.2, mouse |
Organism-specific databases
CTDi | 22767 |
MGIi | MGI:99212, Zfy1 |
VEuPathDBi | HostDB:ENSMUSG00000053211 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000164731 |
HOGENOMi | CLU_021097_0_0_1 |
InParanoidi | P10925 |
OrthoDBi | 1318335at2759 |
PhylomeDBi | P10925 |
TreeFami | TF335557 |
Miscellaneous databases
BioGRID-ORCSi | 22767, 1 hit in 64 CRISPR screens |
ChiTaRSi | Zfy1, mouse |
PROi | PR:P10925 |
RNActi | P10925, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000053211, Expressed in male associated reproductive structure (mouse) and 26 other tissues |
Genevisiblei | P10925, MM |
Family and domain databases
InterProi | View protein in InterPro IPR006794, Transcrp_activ_Zfx/Zfy-dom IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 6 hits PF04704, Zfx_Zfy_act, 1 hit |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 13 hits |
SUPFAMi | SSF57667, SSF57667, 6 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 7 hits PS50157, ZINC_FINGER_C2H2_2, 9 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZFY1_MOUSE | |
Accessioni | P10925Primary (citable) accession number: P10925 Secondary accession number(s): E9QKM5, Q8C638 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | July 27, 2011 | |
Last modified: | February 23, 2022 | |
This is version 165 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families