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UniProtKB - P10923 (OSTP_MOUSE)

Entry version 189 (23 Feb 2022)
Sequence version 1 (01 Jul 1989)
Previous versions | rss
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Protein

Osteopontin

Gene

Spp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction.

By similarity

Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.

2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine
Biological processBiomineralization, Cell adhesion
LigandSialic acid

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-1474228, Degradation of the extracellular matrix
R-MMU-186797, Signaling by PDGF
R-MMU-216083, Integrin cell surface interactions
R-MMU-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275, Post-translational protein phosphorylation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Osteopontin
Alternative name(s):
2AR
Bone sialoprotein 1
Calcium oxalate crystal growth inhibitor protein
Early T-lymphocyte activation 1 protein
Minopontin
Secreted phosphoprotein 1
Short name:
SPP-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Spp1
Synonyms:Eta-1, Op, Spp-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:98389, Spp1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000029304

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 16Sequence analysisAdd BLAST16
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002032217 – 294OsteopontinAdd BLAST278

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei24PhosphoserineBy similarity1
Modified residuei26PhosphoserineCombined sources1
Modified residuei27PhosphoserineBy similarity1
Modified residuei61PhosphoserineBy similarity1
Modified residuei62PhosphoserineBy similarity1
Modified residuei75PhosphoserineBy similarity1
Modified residuei77PhosphoserineBy similarity1
Modified residuei80PhosphoserineBy similarity1
Modified residuei106PhosphoserineBy similarity1
Modified residuei109PhosphoserineBy similarity1
Modified residuei112PhosphoserineBy similarity1
Modified residuei115PhosphoserineBy similarity1
Modified residuei118PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi123O-linked (GalNAc...) threonineBy similarity1
Glycosylationi132O-linked (GalNAc...) threonineBy similarity1
Glycosylationi137O-linked (GalNAc...) threonineBy similarity1
Modified residuei170PhosphothreonineBy similarity1
Modified residuei175PhosphothreonineBy similarity1
Modified residuei176PhosphoserineBy similarity1
Modified residuei180PhosphoserineBy similarity1
Modified residuei200PhosphoserineBy similarity1
Modified residuei209PhosphoserineBy similarity1
Modified residuei213PhosphoserineBy similarity1
Modified residuei219PhosphoserineBy similarity1
Modified residuei222PhosphothreonineBy similarity1
Modified residuei228PhosphoserineCombined sources1
Modified residuei231PhosphoserineCombined sources1
Modified residuei234PhosphoserineCombined sources1
Modified residuei238PhosphoserineBy similarity1
Modified residuei243PhosphoserineBy similarity1
Modified residuei247PhosphoserineBy similarity1
Modified residuei250PhosphoserineBy similarity1
Modified residuei255PhosphoserineBy similarity1
Modified residuei260PhosphoserineBy similarity1
Modified residuei271PhosphoserineBy similarity1
Modified residuei283PhosphoserineCombined sources1
Modified residuei288PhosphoserineCombined sources1
Modified residuei290PhosphoserineCombined sources1
Modified residuei291PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Extensively phosphorylated by FAM20C in the extracellular medium at multiple sites within the S-x-E/pS motif (By similarity). The phosphorylated form inhibits hydroxyapatite crystallization (PubMed:23427088). Dephosphorylation via a mechanism involving ALPL/TNAP promotes hydroxyapatite crystallization (PubMed:23427088).By similarity1 Publication
O-glycosylated.By similarity
Forms covalent cross-links mediated by transglutaminase TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers, increasing its collagen binding properties.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		non-CPTAC-3592

Encyclopedia of Proteome Dynamics

More...EPDi		P10923

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P10923

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P10923

PeptideAtlas

More...PeptideAtlasi		P10923

PRoteomics IDEntifications database

More...PRIDEi		P10923

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		294082

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P10923, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P10923

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P10923

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000029304, Expressed in cochlea and 307 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P10923, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Ligand for integrin alpha-V/beta-3.

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		203467, 15 interactors

Protein interaction database and analysis system

More...IntActi		P10923, 1 interactor

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000108367

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P10923, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni42 – 274DisorderedSequence analysisAdd BLAST233

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi144 – 146Cell attachment site3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi45 – 59Polar residuesSequence analysisAdd BLAST15
Compositional biasi62 – 82Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi83 – 106Acidic residuesSequence analysisAdd BLAST24
Compositional biasi170 – 184Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi197 – 213Polar residuesSequence analysisAdd BLAST17
Compositional biasi214 – 236Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi237 – 251Polar residuesSequence analysisAdd BLAST15
Compositional biasi252 – 274Basic and acidic residuesSequence analysisAdd BLAST23

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the osteopontin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S5R4, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000002509

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_953033_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P10923

Database of Orthologous Groups

More...OrthoDBi		1280650at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P10923

TreeFam database of animal gene trees

More...TreeFami		TF350201

Family and domain databases

Database of protein disorder

More...DisProti		DP01448

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002038, Osteopontin
IPR019841, Osteopontin_CS

The PANTHER Classification System

More...PANTHERi		PTHR10607, PTHR10607, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00865, Osteopontin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00216, OSTEOPONTIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00017, OSTEO, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00884, OSTEOPONTIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P10923-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLAVICFCL FGIASSLPVK VTDSGSSEEK LYSLHPDPIA TWLVPDPSQK 
        60         70         80         90        100
QNLLAPQNAV SSEEKDDFKQ ETLPSNSNES HDHMDDDDDD DDDDGDHAES 
       110        120        130        140        150
EDSVDSDESD ESHHSDESDE TVTASTQADT FTPIVPTVDV PNGRGDSLAY 
       160        170        180        190        200
GLRSKSRSFQ VSDEQYPDAT DEDLTSHMKS GESKESLDVI PVAQLLSMPS 
       210        220        230        240        250
DQDNNGKGSH ESSQLDEPSL ETHRLEHSKE SQESADQSDV IDSQASSKAS 
       260        270        280        290 
LEHQSHKFHS HKDKLVLDPK SKEDDRYLKF RISHELESSS SEVN
Length:294
Mass (Da):32,459
Last modified:July 1, 1989 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9D5F32D67ABC53EA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WIP8F8WIP8_MOUSE
Osteopontin
Spp1
295Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z4N2D3Z4N2_MOUSE
Osteopontin
Spp1
164Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z513D3Z513_MOUSE
Osteopontin
Spp1
152Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z116D3Z116_MOUSE
Osteopontin
Spp1
48Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH14284 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti43L → P in CAA34276 (PubMed:2787378).Curated1
Sequence conflicti99E → G in AAA57265 (PubMed:2722855).Curated1
Sequence conflicti100S → N in AAH14284 (PubMed:15489334).Curated1
Sequence conflicti122V → F in CAA32165 (PubMed:2726465).Curated1
Sequence conflicti122V → F in AAH14284 (PubMed:15489334).Curated1
Sequence conflicti142N → D in AAH14284 (PubMed:15489334).Curated1
Sequence conflicti171D → Y in AAH14284 (PubMed:15489334).Curated1
Sequence conflicti188D → N in AAH14284 (PubMed:15489334).Curated1
Sequence conflicti207K → R in AAH14284 (PubMed:15489334).Curated1
Sequence conflicti224R → S in AAH14284 (PubMed:15489334).Curated1
Sequence conflicti232Q → H in AAH14284 (PubMed:15489334).Curated1
Sequence conflicti277Y → H in AAH14284 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
J04806 mRNA Translation: AAA57265.1
X16151 mRNA Translation: CAA34276.1
X13986 mRNA Translation: CAA32165.1
X51834 Genomic DNA Translation: CAA36132.1
BC014284 mRNA Translation: AAH14284.1 Different initiation.
BC057858 mRNA Translation: AAH57858.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS19486.1

Protein sequence database of the Protein Information Resource

More...PIRi		A37818

NCBI Reference Sequences

More...RefSeqi		NP_001191162.1, NM_001204233.1
NP_033289.2, NM_009263.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000031243; ENSMUSP00000031243; ENSMUSG00000029304
ENSMUST00000112747; ENSMUSP00000108367; ENSMUSG00000029304
ENSMUST00000112748; ENSMUSP00000108368; ENSMUSG00000029304

Database of genes from NCBI RefSeq genomes

More...GeneIDi		20750

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:20750

UCSC genome browser

More...UCSCi		uc008yki.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04806 mRNA Translation: AAA57265.1
X16151 mRNA Translation: CAA34276.1
X13986 mRNA Translation: CAA32165.1
X51834 Genomic DNA Translation: CAA36132.1
BC014284 mRNA Translation: AAH14284.1 Different initiation.
BC057858 mRNA Translation: AAH57858.1
CCDSiCCDS19486.1
PIRiA37818
RefSeqiNP_001191162.1, NM_001204233.1
NP_033289.2, NM_009263.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi203467, 15 interactors
IntActiP10923, 1 interactor
STRINGi10090.ENSMUSP00000108367

PTM databases

GlyGeniP10923, 3 sites
iPTMnetiP10923
PhosphoSitePlusiP10923

Proteomic databases

CPTACinon-CPTAC-3592
EPDiP10923
jPOSTiP10923
PaxDbiP10923
PeptideAtlasiP10923
PRIDEiP10923
ProteomicsDBi294082

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P10923, 7 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3695, 1523 antibodies from 49 providers

The DNASU plasmid repository

More...DNASUi		20750

Genome annotation databases

EnsembliENSMUST00000031243; ENSMUSP00000031243; ENSMUSG00000029304
ENSMUST00000112747; ENSMUSP00000108367; ENSMUSG00000029304
ENSMUST00000112748; ENSMUSP00000108368; ENSMUSG00000029304
GeneIDi20750
KEGGimmu:20750
UCSCiuc008yki.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6696
MGIiMGI:98389, Spp1
VEuPathDBiHostDB:ENSMUSG00000029304

Phylogenomic databases

eggNOGiENOG502S5R4, Eukaryota
GeneTreeiENSGT00390000002509
HOGENOMiCLU_953033_0_0_1
InParanoidiP10923
OrthoDBi1280650at2759
PhylomeDBiP10923
TreeFamiTF350201

Enzyme and pathway databases

ReactomeiR-MMU-1474228, Degradation of the extracellular matrix
R-MMU-186797, Signaling by PDGF
R-MMU-216083, Integrin cell surface interactions
R-MMU-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275, Post-translational protein phosphorylation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		20750, 0 hits in 65 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Spp1, mouse

Protein Ontology

More...PROi		PR:P10923
RNActiP10923, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000029304, Expressed in cochlea and 307 other tissues
GenevisibleiP10923, MM

Family and domain databases

DisProtiDP01448
InterProiView protein in InterPro
IPR002038, Osteopontin
IPR019841, Osteopontin_CS
PANTHERiPTHR10607, PTHR10607, 1 hit
PfamiView protein in Pfam
PF00865, Osteopontin, 1 hit
PRINTSiPR00216, OSTEOPONTIN
SMARTiView protein in SMART
SM00017, OSTEO, 1 hit
PROSITEiView protein in PROSITE
PS00884, OSTEOPONTIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOSTP_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P10923
Secondary accession number(s): P19008, Q91VH4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: February 23, 2022
This is version 189 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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