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UniProtKB - P10922 (H10_MOUSE)
Protein
Histone H1.0
Gene
H1-0
Organism
Mus musculus (Mouse)
Status
Functioni
Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The histones H1.0 are found in cells that are in terminal stages of differentiation or that have low rates of cell division.
GO - Molecular functioni
- chromatin DNA binding Source: MGI
- double-stranded DNA binding Source: CAFA
- minor groove of adenine-thymine-rich DNA binding Source: CAFA
- nucleosomal DNA binding Source: GO_Central
GO - Biological processi
- chromosome condensation Source: GO_Central
- heterochromatin assembly Source: MGI
- negative regulation of DNA recombination Source: GO_Central
- nucleosome assembly Source: InterPro
- nucleosome positioning Source: GO_Central
- positive regulation of transcription regulatory region DNA binding Source: MGI
Keywordsi
Molecular function | DNA-binding |
Enzyme and pathway databases
Reactomei | R-MMU-140342, Apoptosis induced DNA fragmentation R-MMU-2559584, Formation of Senescence-Associated Heterochromatin Foci (SAHF) |
Names & Taxonomyi
Protein namesi | Recommended name: Histone H1.0Alternative name(s): Histone H1' Histone H1(0) MyD196 Cleaved into the following chain: |
Gene namesi | Name:H1-0 Synonyms:H1f0, H1fv |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:95893, H1f0 |
VEuPathDBi | HostDB:ENSMUSG00000096210 |
Subcellular locationi
Nucleus
Other locations
Cytoskeleton
- actin cytoskeleton Source: MGI
Golgi apparatus
- Golgi apparatus Source: MGI
Nucleus
- nuclear body Source: MGI
- nucleoplasm Source: MGI
- nucleus Source: UniProtKB
Other locations
- chromatin Source: MGI
- euchromatin Source: MGI
- nucleosome Source: InterPro
- transcription repressor complex Source: MGI
Keywords - Cellular componenti
Chromosome, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000423208 | 1 – 194 | Histone H1.0Add BLAST | 194 | |
Initiator methioninei | Removed; alternateBy similarity | |||
ChainiPRO_0000195913 | 2 – 194 | Histone H1.0, N-terminally processedAdd BLAST | 193 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Modified residuei | 2 | N-acetylthreonine; in Histone H1.0, N-terminally processedBy similarity | 1 | |
Modified residuei | 42 | CitrullineBy similarity | 1 | |
Modified residuei | 104 | ADP-ribosylserineBy similarity | 1 |
Post-translational modificationi
ADP-ribosylated on Ser-104 in response to DNA damage.By similarity
Keywords - PTMi
Acetylation, ADP-ribosylation, CitrullinationProteomic databases
EPDi | P10922 |
jPOSTi | P10922 |
MaxQBi | P10922 |
PaxDbi | P10922 |
PeptideAtlasi | P10922 |
PRIDEi | P10922 |
ProteomicsDBi | 269665 |
TopDownProteomicsi | P10922 |
PTM databases
iPTMneti | P10922 |
PhosphoSitePlusi | P10922 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000096210, Expressed in retina and 315 other tissues |
Genevisiblei | P10922, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 200145, 11 interactors |
IntActi | P10922, 9 interactors |
STRINGi | 10090.ENSMUSP00000137309 |
Miscellaneous databases
RNActi | P10922, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 24 – 97 | H15PROSITE-ProRule annotationAdd BLAST | 74 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 28 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 86 – 194 | DisorderedSequence analysisAdd BLAST | 109 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 96 – 120 | Basic and acidic residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 121 – 194 | Basic residuesSequence analysisAdd BLAST | 74 |
Sequence similaritiesi
Belongs to the histone H1/H5 family.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | KOG4012, Eukaryota |
GeneTreei | ENSGT00810000125570 |
HOGENOMi | CLU_052897_1_1_1 |
InParanoidi | P10922 |
OMAi | HPAYSDM |
OrthoDBi | 1565299at2759 |
PhylomeDBi | P10922 |
TreeFami | TF313664 |
Family and domain databases
CDDi | cd00073, H15, 1 hit |
DisProti | DP00097 |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR005819, H1/H5 IPR005818, Histone_H1/H5_H15 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00538, Linker_histone, 1 hit |
PRINTSi | PR00624, HISTONEH5 |
SMARTi | View protein in SMART SM00526, H15, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS51504, H15, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P10922-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTENSTSAPA AKPKRAKASK KSTDHPKYSD MIVAAIQAEK NRAGSSRQSI
60 70 80 90 100
QKYIKSHYKV GENADSQIKL SIKRLVTTGV LKQTKGVGAS GSFRLAKGDE
110 120 130 140 150
PKRSVAFKKT KKEVKKVATP KKAAKPKKAA SKAPSKKPKA TPVKKAKKKP
160 170 180 190
AATPKKAKKP KVVKVKPVKA SKPKKAKTVK PKAKSSAKRA SKKK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 65 | D → N in CAA31569 (PubMed:2846273).Curated | 1 | |
Sequence conflicti | 190 | A → G in CAA31569 (PubMed:2846273).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X13171 mRNA Translation: CAA31569.1 U18295 Genomic DNA Translation: AAA69911.1 AK051213 mRNA Translation: BAC34559.1 AK077473 mRNA Translation: BAC36817.1 AK145675 mRNA Translation: BAE26583.1 AK146077 mRNA Translation: BAE26881.1 BC003830 mRNA Translation: AAH03830.1 BC011493 mRNA Translation: AAH11493.1 BC110361 mRNA Translation: AAI10362.1 |
CCDSi | CCDS56990.1 |
PIRi | I49150 |
RefSeqi | NP_032223.2, NM_008197.3 |
Genome annotation databases
Ensembli | ENSMUST00000180086; ENSMUSP00000137309; ENSMUSG00000096210 |
GeneIDi | 14958 |
KEGGi | mmu:14958 |
UCSCi | uc007wsd.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X13171 mRNA Translation: CAA31569.1 U18295 Genomic DNA Translation: AAA69911.1 AK051213 mRNA Translation: BAC34559.1 AK077473 mRNA Translation: BAC36817.1 AK145675 mRNA Translation: BAE26583.1 AK146077 mRNA Translation: BAE26881.1 BC003830 mRNA Translation: AAH03830.1 BC011493 mRNA Translation: AAH11493.1 BC110361 mRNA Translation: AAI10362.1 |
CCDSi | CCDS56990.1 |
PIRi | I49150 |
RefSeqi | NP_032223.2, NM_008197.3 |
3D structure databases
AlphaFoldDBi | P10922 |
SMRi | P10922 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 200145, 11 interactors |
IntActi | P10922, 9 interactors |
STRINGi | 10090.ENSMUSP00000137309 |
PTM databases
iPTMneti | P10922 |
PhosphoSitePlusi | P10922 |
Proteomic databases
EPDi | P10922 |
jPOSTi | P10922 |
MaxQBi | P10922 |
PaxDbi | P10922 |
PeptideAtlasi | P10922 |
PRIDEi | P10922 |
ProteomicsDBi | 269665 |
TopDownProteomicsi | P10922 |
Protocols and materials databases
ABCDi | P10922, 2 sequenced antibodies |
Antibodypediai | 211, 736 antibodies from 34 providers |
DNASUi | 14958 |
Genome annotation databases
Ensembli | ENSMUST00000180086; ENSMUSP00000137309; ENSMUSG00000096210 |
GeneIDi | 14958 |
KEGGi | mmu:14958 |
UCSCi | uc007wsd.1, mouse |
Organism-specific databases
CTDi | 14958 |
MGIi | MGI:95893, H1f0 |
VEuPathDBi | HostDB:ENSMUSG00000096210 |
Phylogenomic databases
eggNOGi | KOG4012, Eukaryota |
GeneTreei | ENSGT00810000125570 |
HOGENOMi | CLU_052897_1_1_1 |
InParanoidi | P10922 |
OMAi | HPAYSDM |
OrthoDBi | 1565299at2759 |
PhylomeDBi | P10922 |
TreeFami | TF313664 |
Enzyme and pathway databases
Reactomei | R-MMU-140342, Apoptosis induced DNA fragmentation R-MMU-2559584, Formation of Senescence-Associated Heterochromatin Foci (SAHF) |
Miscellaneous databases
BioGRID-ORCSi | 14958, 3 hits in 74 CRISPR screens |
ChiTaRSi | H1f0, mouse |
PROi | PR:P10922 |
RNActi | P10922, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000096210, Expressed in retina and 315 other tissues |
Genevisiblei | P10922, MM |
Family and domain databases
CDDi | cd00073, H15, 1 hit |
DisProti | DP00097 |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR005819, H1/H5 IPR005818, Histone_H1/H5_H15 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00538, Linker_histone, 1 hit |
PRINTSi | PR00624, HISTONEH5 |
SMARTi | View protein in SMART SM00526, H15, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS51504, H15, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | H10_MOUSE | |
Accessioni | P10922Primary (citable) accession number: P10922 Secondary accession number(s): Q3UKC0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | January 23, 2007 | |
Last modified: | May 25, 2022 | |
This is version 171 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families