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Protein

Hyaluronan and proteoglycan link protein 1

Gene

HAPLN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: InterPro
  • central nervous system development Source: GO_Central
  • extracellular matrix organization Source: Reactome

Keywordsi

LigandHyaluronic acid

Enzyme and pathway databases

ReactomeiR-HSA-3000178 ECM proteoglycans

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronan and proteoglycan link protein 1
Alternative name(s):
Cartilage-linking protein 1
Short name:
Cartilage-link protein
Proteoglycan link protein
Gene namesi
Name:HAPLN1
Synonyms:CRTL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000145681.10
HGNCiHGNC:2380 HAPLN1
MIMi115435 gene
neXtProtiNX_P10915

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi1404
OpenTargetsiENSG00000145681
PharmGKBiPA26901

Chemistry databases

DrugBankiDB08818 Hyaluronic acid

Polymorphism and mutation databases

BioMutaiHAPLN1
DMDMi130310

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000131771 – 15Add BLAST15
ChainiPRO_000001317816 – 354Hyaluronan and proteoglycan link protein 1Add BLAST339

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi21N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi56N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi61 ↔ 139By similarity
Disulfide bondi181 ↔ 252By similarity
Disulfide bondi205 ↔ 226By similarity
Disulfide bondi279 ↔ 349By similarity
Disulfide bondi304 ↔ 325By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP10915
MaxQBiP10915
PaxDbiP10915
PeptideAtlasiP10915
PRIDEiP10915
ProteomicsDBi52677

PTM databases

GlyConnecti1380
iPTMnetiP10915
PhosphoSitePlusiP10915

Miscellaneous databases

PMAP-CutDBiP10915

Expressioni

Tissue specificityi

Widely expressed. Weakly expressed in the brain.2 Publications

Gene expression databases

BgeeiENSG00000145681 Expressed in 133 organ(s), highest expression level in tibia
CleanExiHS_HAPLN1
ExpressionAtlasiP10915 baseline and differential
GenevisibleiP10915 HS

Organism-specific databases

HPAiHPA019105
HPA019482
HPA025238

Interactioni

Protein-protein interaction databases

BioGridi107794, 2 interactors
STRINGi9606.ENSP00000274341

Structurei

3D structure databases

ProteinModelPortaliP10915
SMRiP10915
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 152Ig-like V-typeAdd BLAST115
Domaini159 – 254Link 1PROSITE-ProRule annotationAdd BLAST96
Domaini259 – 351Link 2PROSITE-ProRule annotationAdd BLAST93

Sequence similaritiesi

Belongs to the HAPLN family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGiENOG410IF28 Eukaryota
ENOG410XRS8 LUCA
GeneTreeiENSGT00760000119025
HOGENOMiHOG000234353
HOVERGENiHBG051922
InParanoidiP10915
KOiK06848
OMAiWRSGLDW
OrthoDBiEOG091G09EL
PhylomeDBiP10915
TreeFamiTF332134

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.100.10, 2 hits
InterProiView protein in InterPro
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
IPR000538 Link_dom
PfamiView protein in Pfam
PF07686 V-set, 1 hit
PF00193 Xlink, 2 hits
PRINTSiPR01265 LINKMODULE
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SM00445 LINK, 2 hits
SUPFAMiSSF48726 SSF48726, 1 hit
SSF56436 SSF56436, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS01241 LINK_1, 2 hits
PS50963 LINK_2, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

P10915-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKSLLLLVLI SICWADHLSD NYTLDHDRAI HIQAENGPHL LVEAEQAKVF
60 70 80 90 100
SHRGGNVTLP CKFYRDPTAF GSGIHKIRIK WTKLTSDYLK EVDVFVSMGY
110 120 130 140 150
HKKTYGGYQG RVFLKGGSDS DASLVITDLT LEDYGRYKCE VIEGLEDDTV
160 170 180 190 200
VVALDLQGVV FPYFPRLGRY NLNFHEAQQA CLDQDAVIAS FDQLYDAWRG
210 220 230 240 250
GLDWCNAGWL SDGSVQYPIT KPREPCGGQN TVPGVRNYGF WDKDKSRYDV
260 270 280 290 300
FCFTSNFNGR FYYLIHPTKL TYDEAVQACL NDGAQIAKVG QIFAAWKILG
310 320 330 340 350
YDRCDAGWLA DGSVRYPISR PRRRCSPTEA AVRFVGFPDK KHKLYGVYCF

RAYN
Length:354
Mass (Da):40,166
Last modified:April 1, 1990 - v2
Checksum:i315C96EC3AC2626A
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RBS1D6RBS1_HUMAN
Hyaluronan and proteoglycan link pr...
HAPLN1
258Annotation score:
D6RG04D6RG04_HUMAN
Hyaluronan and proteoglycan link pr...
HAPLN1
199Annotation score:
D6RFI7D6RFI7_HUMAN
Hyaluronan and proteoglycan link pr...
HAPLN1
182Annotation score:
D6RAK7D6RAK7_HUMAN
Hyaluronan and proteoglycan link pr...
HAPLN1
161Annotation score:
D6RBX9D6RBX9_HUMAN
Hyaluronan and proteoglycan link pr...
HAPLN1
169Annotation score:
D6RC59D6RC59_HUMAN
Hyaluronan and proteoglycan link pr...
HAPLN1
153Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti274E → V in AAH57808 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049316281N → S. Corresponds to variant dbSNP:rs6864342Ensembl.1
Natural variantiVAR_036168333R → H in a colorectal cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17405 mRNA Translation: CAA35462.1
U43328 mRNA Translation: AAA85216.1
AK313713 mRNA Translation: BAG36456.1
CH471084 Genomic DNA Translation: EAW95912.1
BC057808 mRNA Translation: AAH57808.1
CCDSiCCDS4061.1
PIRiS14914 LKHU
RefSeqiNP_001875.1, NM_001884.3
XP_011541470.1, XM_011543168.2
XP_016864540.1, XM_017009051.1
XP_016864541.1, XM_017009052.1
UniGeneiHs.2799

Genome annotation databases

EnsembliENST00000274341; ENSP00000274341; ENSG00000145681
GeneIDi1404
KEGGihsa:1404
UCSCiuc003kin.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17405 mRNA Translation: CAA35462.1
U43328 mRNA Translation: AAA85216.1
AK313713 mRNA Translation: BAG36456.1
CH471084 Genomic DNA Translation: EAW95912.1
BC057808 mRNA Translation: AAH57808.1
CCDSiCCDS4061.1
PIRiS14914 LKHU
RefSeqiNP_001875.1, NM_001884.3
XP_011541470.1, XM_011543168.2
XP_016864540.1, XM_017009051.1
XP_016864541.1, XM_017009052.1
UniGeneiHs.2799

3D structure databases

ProteinModelPortaliP10915
SMRiP10915
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107794, 2 interactors
STRINGi9606.ENSP00000274341

Chemistry databases

DrugBankiDB08818 Hyaluronic acid

PTM databases

GlyConnecti1380
iPTMnetiP10915
PhosphoSitePlusiP10915

Polymorphism and mutation databases

BioMutaiHAPLN1
DMDMi130310

Proteomic databases

EPDiP10915
MaxQBiP10915
PaxDbiP10915
PeptideAtlasiP10915
PRIDEiP10915
ProteomicsDBi52677

Protocols and materials databases

DNASUi1404
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274341; ENSP00000274341; ENSG00000145681
GeneIDi1404
KEGGihsa:1404
UCSCiuc003kin.4 human

Organism-specific databases

CTDi1404
DisGeNETi1404
EuPathDBiHostDB:ENSG00000145681.10
GeneCardsiHAPLN1
HGNCiHGNC:2380 HAPLN1
HPAiHPA019105
HPA019482
HPA025238
MIMi115435 gene
neXtProtiNX_P10915
OpenTargetsiENSG00000145681
PharmGKBiPA26901
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF28 Eukaryota
ENOG410XRS8 LUCA
GeneTreeiENSGT00760000119025
HOGENOMiHOG000234353
HOVERGENiHBG051922
InParanoidiP10915
KOiK06848
OMAiWRSGLDW
OrthoDBiEOG091G09EL
PhylomeDBiP10915
TreeFamiTF332134

Enzyme and pathway databases

ReactomeiR-HSA-3000178 ECM proteoglycans

Miscellaneous databases

ChiTaRSiHAPLN1 human
GeneWikiiHAPLN1
GenomeRNAii1404
PMAP-CutDBiP10915
PROiPR:P10915
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000145681 Expressed in 133 organ(s), highest expression level in tibia
CleanExiHS_HAPLN1
ExpressionAtlasiP10915 baseline and differential
GenevisibleiP10915 HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.100.10, 2 hits
InterProiView protein in InterPro
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
IPR000538 Link_dom
PfamiView protein in Pfam
PF07686 V-set, 1 hit
PF00193 Xlink, 2 hits
PRINTSiPR01265 LINKMODULE
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SM00445 LINK, 2 hits
SUPFAMiSSF48726 SSF48726, 1 hit
SSF56436 SSF56436, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS01241 LINK_1, 2 hits
PS50963 LINK_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiHPLN1_HUMAN
AccessioniPrimary (citable) accession number: P10915
Secondary accession number(s): B2R9A9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: April 1, 1990
Last modified: November 7, 2018
This is version 178 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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