HAPLN1

Protein namesⁱ	Recommended name: Hyaluronan and proteoglycan link protein 1 Alternative name(s): Cartilage-linking protein 1 Short name: Cartilage-link protein Proteoglycan link protein
Gene namesⁱ	Name:HAPLN1 Synonyms:CRTL1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000145681.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2380 HAPLN1
MIMⁱ	115435 gene
neXtProtⁱ	NX_P10915

Keywords - Cellular componentⁱ

Extracellular matrix, Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1404
Open Targets More...OpenTargetsⁱ	ENSG00000145681
PharmGKBⁱ	PA26901

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB08818 Hyaluronic acid

DrugBankⁱ

DB08818 Hyaluronic acid

Polymorphism and mutation databases

BioMutaⁱ	HAPLN1
DMDMⁱ	130310

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
PropeptideⁱPRO_0000013177	1 – 15	Add BLAST		15
ChainⁱPRO_0000013178	16 – 354	Hyaluronan and proteoglycan link protein 1Add BLAST		339

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	21	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	56	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	61 ↔ 139	By similarity
Disulfide bondⁱ	181 ↔ 252	By similarity
Disulfide bondⁱ	205 ↔ 226	By similarity
Disulfide bondⁱ	279 ↔ 349	By similarity
Disulfide bondⁱ	304 ↔ 325	By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

EPDⁱ	P10915
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P10915
PaxDbⁱ	P10915
PeptideAtlas More...PeptideAtlasⁱ	P10915
PRIDEⁱ	P10915
ProteomicsDBⁱ	52677

PTM databases

GlyConnectⁱ	1380
iPTMnetⁱ	P10915
PhosphoSitePlusⁱ	P10915

Miscellaneous databases

PMAP-CutDBⁱ	P10915

PMAP-CutDBⁱ

P10915

Expressionⁱ

Tissue specificityⁱ

Widely expressed. Weakly expressed in the brain.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000145681 Expressed in 133 organ(s), highest expression level in tibia
CleanExⁱ	HS_HAPLN1
ExpressionAtlasⁱ	P10915 baseline and differential
Genevisibleⁱ	P10915 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA019105 HPA019482 HPA025238

HPAⁱ

HPA019105
HPA019482
HPA025238

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	107794, 2 interactors
STRINGⁱ	9606.ENSP00000274341

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P10915
SMRⁱ	P10915
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	38 – 152	Ig-like V-typeAdd BLAST	115
Domainⁱ	159 – 254	Link 1PROSITE-ProRule annotationAdd BLAST	96
Domainⁱ	259 – 351	Link 2PROSITE-ProRule annotationAdd BLAST	93

Sequence similaritiesⁱ

Belongs to the HAPLN family.Curated

Keywords - Domainⁱ

Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGⁱ	ENOG410IF28 Eukaryota ENOG410XRS8 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119025
HOGENOMⁱ	HOG000234353
HOVERGENⁱ	HBG051922
InParanoidⁱ	P10915
KEGG Orthology (KO) More...KOⁱ	K06848
OMAⁱ	WRSGLDW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09EL
PhylomeDBⁱ	P10915
TreeFamⁱ	TF332134

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit 3.10.100.10, 2 hits
InterProⁱ	View protein in InterPro IPR016186 C-type_lectin-like/link_sf IPR016187 CTDL_fold IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR013106 Ig_V-set IPR000538 Link_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07686 V-set, 1 hit PF00193 Xlink, 2 hits
PRINTSⁱ	PR01265 LINKMODULE
SMARTⁱ	View protein in SMART SM00409 IG, 1 hit SM00406 IGv, 1 hit SM00445 LINK, 2 hits
SUPFAMⁱ	SSF48726 SSF48726, 1 hit SSF56436 SSF56436, 2 hits
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit PS01241 LINK_1, 2 hits PS50963 LINK_2, 2 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show all Align All

P10915-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKSLLLLVLI SICWADHLSD NYTLDHDRAI HIQAENGPHL LVEAEQAKVF 
        60         70         80         90        100
SHRGGNVTLP CKFYRDPTAF GSGIHKIRIK WTKLTSDYLK EVDVFVSMGY 
       110        120        130        140        150
HKKTYGGYQG RVFLKGGSDS DASLVITDLT LEDYGRYKCE VIEGLEDDTV 
       160        170        180        190        200
VVALDLQGVV FPYFPRLGRY NLNFHEAQQA CLDQDAVIAS FDQLYDAWRG 
       210        220        230        240        250
GLDWCNAGWL SDGSVQYPIT KPREPCGGQN TVPGVRNYGF WDKDKSRYDV 
       260        270        280        290        300
FCFTSNFNGR FYYLIHPTKL TYDEAVQACL NDGAQIAKVG QIFAAWKILG 
       310        320        330        340        350
YDRCDAGWLA DGSVRYPISR PRRRCSPTEA AVRFVGFPDK KHKLYGVYCF 

RAYN

Length:354

Mass (Da):40,166

Last modified:April 1, 1990 - v2

Checksum:ⁱ315C96EC3AC2626A

GO

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

D6RBS1	D6RBS1_HUMAN	Hyaluronan and proteoglycan link pr... Hyaluronan and proteoglycan link protein 1	HAPLN1	258	Annotation score:
D6RG04	D6RG04_HUMAN	Hyaluronan and proteoglycan link pr... Hyaluronan and proteoglycan link protein 1	HAPLN1	199	Annotation score:
D6RFI7	D6RFI7_HUMAN	Hyaluronan and proteoglycan link pr... Hyaluronan and proteoglycan link protein 1	HAPLN1	182	Annotation score:
D6RAK7	D6RAK7_HUMAN	Hyaluronan and proteoglycan link pr... Hyaluronan and proteoglycan link protein 1	HAPLN1	161	Annotation score:
D6RBX9	D6RBX9_HUMAN	Hyaluronan and proteoglycan link pr... Hyaluronan and proteoglycan link protein 1	HAPLN1	169	Annotation score:
D6RC59	D6RC59_HUMAN	Hyaluronan and proteoglycan link pr... Hyaluronan and proteoglycan link protein 1	HAPLN1	153	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	274	E → V in AAH57808 (PubMed:15489334).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_049316	281	N → S. Corresponds to variant dbSNP:rs6864342Ensembl.		1
Natural variantⁱVAR_036168	333	R → H in a colorectal cancer sample; somatic mutation. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X17405 mRNA Translation: CAA35462.1 U43328 mRNA Translation: AAA85216.1 AK313713 mRNA Translation: BAG36456.1 CH471084 Genomic DNA Translation: EAW95912.1 BC057808 mRNA Translation: AAH57808.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4061.1
PIRⁱ	S14914 LKHU
NCBI Reference Sequences More...RefSeqⁱ	NP_001875.1, NM_001884.3 XP_011541470.1, XM_011543168.2 XP_016864540.1, XM_017009051.1 XP_016864541.1, XM_017009052.1
UniGeneⁱ	Hs.2799

Genome annotation databases

Ensemblⁱ	ENST00000274341; ENSP00000274341; ENSG00000145681
GeneIDⁱ	1404
KEGGⁱ	hsa:1404
UCSC genome browser More...UCSCⁱ	uc003kin.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P10915	Hyaluronan and proteoglycan link protein 1, isoform CRA_a		HUMAN		354	UniRef100_P10915
Hyaluronan and proteoglycan link protein 1 (Fragment)		HUMAN		199
Hyaluronan and proteoglycan link protein 1 (Fragment)		HUMAN		258
Hyaluronan and proteoglycan link protein 1 (Fragment)		HUMAN		169
Hyaluronan and proteoglycan link protein 1 (Fragment)		HUMAN		153

Protein	Similar proteins		Species	Score	Length	Source
P10915	Hyaluronan and proteoglycan link protein 1		MOUSE		356	UniRef90_P10915
Hyaluronan and proteoglycan link protein 1		BOVIN		354
Hyaluronan and proteoglycan link protein 1		HORSE		354
Hyaluronan and proteoglycan link protein 1		PIG		354
Hyaluronan and proteoglycan link protein 1		RAT		354
+131

Protein	Similar proteins		Species	Score	Length	Source
P10915	Hyaluronan and proteoglycan link protein 1		MOUSE		356	UniRef50_P10915
Hyaluronan and proteoglycan link protein 1		BOVIN		354
Hyaluronan and proteoglycan link protein 1		HORSE		354
Hyaluronan and proteoglycan link protein 1		RAT		354
Hyaluronan and proteoglycan link protein 1		PIG		354
+254

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X17405 mRNA Translation: CAA35462.1 U43328 mRNA Translation: AAA85216.1 AK313713 mRNA Translation: BAG36456.1 CH471084 Genomic DNA Translation: EAW95912.1 BC057808 mRNA Translation: AAH57808.1
CCDSⁱ	CCDS4061.1
PIRⁱ	S14914 LKHU
RefSeqⁱ	NP_001875.1, NM_001884.3 XP_011541470.1, XM_011543168.2 XP_016864540.1, XM_017009051.1 XP_016864541.1, XM_017009052.1
UniGeneⁱ	Hs.2799

3D structure databases

ProteinModelPortalⁱ	P10915
SMRⁱ	P10915
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107794, 2 interactors
STRINGⁱ	9606.ENSP00000274341

Chemistry databases

DrugBankⁱ	DB08818 Hyaluronic acid

DrugBankⁱ

DB08818 Hyaluronic acid

PTM databases

GlyConnectⁱ	1380
iPTMnetⁱ	P10915
PhosphoSitePlusⁱ	P10915

Polymorphism and mutation databases

BioMutaⁱ	HAPLN1
DMDMⁱ	130310

Proteomic databases

EPDⁱ	P10915
MaxQBⁱ	P10915
PaxDbⁱ	P10915
PeptideAtlasⁱ	P10915
PRIDEⁱ	P10915
ProteomicsDBⁱ	52677

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1404
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000274341; ENSP00000274341; ENSG00000145681
GeneIDⁱ	1404
KEGGⁱ	hsa:1404
UCSCⁱ	uc003kin.4 human

Organism-specific databases

CTDⁱ	1404
DisGeNETⁱ	1404
EuPathDBⁱ	HostDB:ENSG00000145681.10
GeneCardsⁱ	HAPLN1
HGNCⁱ	HGNC:2380 HAPLN1
HPAⁱ	HPA019105 HPA019482 HPA025238
MIMⁱ	115435 gene
neXtProtⁱ	NX_P10915
OpenTargetsⁱ	ENSG00000145681
PharmGKBⁱ	PA26901
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IF28 Eukaryota ENOG410XRS8 LUCA
GeneTreeⁱ	ENSGT00760000119025
HOGENOMⁱ	HOG000234353
HOVERGENⁱ	HBG051922
InParanoidⁱ	P10915
KOⁱ	K06848
OMAⁱ	WRSGLDW
OrthoDBⁱ	EOG091G09EL
PhylomeDBⁱ	P10915
TreeFamⁱ	TF332134

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3000178 ECM proteoglycans

Reactomeⁱ

R-HSA-3000178 ECM proteoglycans

Miscellaneous databases

ChiTaRSⁱ	HAPLN1 human
GeneWikiⁱ	HAPLN1
GenomeRNAiⁱ	1404
PMAP-CutDBⁱ	P10915
Protein Ontology More...PROⁱ	PR:P10915
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000145681 Expressed in 133 organ(s), highest expression level in tibia
CleanExⁱ	HS_HAPLN1
ExpressionAtlasⁱ	P10915 baseline and differential
Genevisibleⁱ	P10915 HS

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit 3.10.100.10, 2 hits
InterProⁱ	View protein in InterPro IPR016186 C-type_lectin-like/link_sf IPR016187 CTDL_fold IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR013106 Ig_V-set IPR000538 Link_dom
Pfamⁱ	View protein in Pfam PF07686 V-set, 1 hit PF00193 Xlink, 2 hits
PRINTSⁱ	PR01265 LINKMODULE
SMARTⁱ	View protein in SMART SM00409 IG, 1 hit SM00406 IGv, 1 hit SM00445 LINK, 2 hits
SUPFAMⁱ	SSF48726 SSF48726, 1 hit SSF56436 SSF56436, 2 hits
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit PS01241 LINK_1, 2 hits PS50963 LINK_2, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HPLN1_HUMAN
Accessionⁱ	P10915Primary (citable) accession number: P10915 Secondary accession number(s): B2R9A9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
	Last sequence update:	April 1, 1990
	Last modified:	November 7, 2018
	This is version 178 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM

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UniProtKB - P10915 (HPLN1_HUMAN)

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Hyaluronan and proteoglycan link protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ