UniProtKB - P10915 (HPLN1_HUMAN)
Protein
Hyaluronan and proteoglycan link protein 1
Gene
HAPLN1
Organism
Homo sapiens (Human)
Status
Functioni
Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.
GO - Molecular functioni
- hyaluronic acid binding Source: UniProtKB-KW
GO - Biological processi
- cell adhesion Source: InterPro
- central nervous system development Source: GO_Central
- extracellular matrix organization Source: Reactome
- skeletal system development Source: GO_Central
Keywordsi
Ligand | Hyaluronic acid |
Enzyme and pathway databases
PathwayCommonsi | P10915 |
Reactomei | R-HSA-3000178, ECM proteoglycans |
SIGNORi | P10915 |
Names & Taxonomyi
Protein namesi | Recommended name: Hyaluronan and proteoglycan link protein 1Alternative name(s): Cartilage-linking protein 1 Short name: Cartilage-link protein Proteoglycan link protein |
Gene namesi | Name:HAPLN1 Synonyms:CRTL1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000145681.10 |
HGNCi | HGNC:2380, HAPLN1 |
MIMi | 115435, gene |
neXtProti | NX_P10915 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- collagen-containing extracellular matrix Source: BHF-UCL
- extracellular matrix Source: GO_Central
- extracellular region Source: Reactome
Other locations
- synapse Source: Ensembl
Keywords - Cellular componenti
Extracellular matrix, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 1404 |
OpenTargetsi | ENSG00000145681 |
PharmGKBi | PA26901 |
Miscellaneous databases
Pharosi | P10915, Tbio |
Chemistry databases
DrugBanki | DB08818, Hyaluronic acid |
Polymorphism and mutation databases
BioMutai | HAPLN1 |
DMDMi | 130310 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
PropeptideiPRO_0000013177 | 1 – 15 | Add BLAST | 15 | |
ChainiPRO_0000013178 | 16 – 354 | Hyaluronan and proteoglycan link protein 1Add BLAST | 339 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 21 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 56 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 61 ↔ 139 | By similarity | ||
Disulfide bondi | 181 ↔ 252 | By similarity | ||
Disulfide bondi | 205 ↔ 226 | By similarity | ||
Disulfide bondi | 279 ↔ 349 | By similarity | ||
Disulfide bondi | 304 ↔ 325 | By similarity |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | P10915 |
jPOSTi | P10915 |
MassIVEi | P10915 |
MaxQBi | P10915 |
PaxDbi | P10915 |
PeptideAtlasi | P10915 |
PRIDEi | P10915 |
ProteomicsDBi | 52677 |
PTM databases
GlyConnecti | 1380, 1 N-Linked glycan (1 site) |
GlyGeni | P10915, 2 sites |
iPTMneti | P10915 |
PhosphoSitePlusi | P10915 |
Expressioni
Tissue specificityi
Widely expressed. Weakly expressed in the brain.2 Publications
Gene expression databases
Bgeei | ENSG00000145681, Expressed in tibia and 148 other tissues |
ExpressionAtlasi | P10915, baseline and differential |
Genevisiblei | P10915, HS |
Organism-specific databases
HPAi | ENSG00000145681, Tissue enriched (placenta) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 107794, 2 interactors |
IntActi | P10915, 2 interactors |
STRINGi | 9606.ENSP00000274341 |
Miscellaneous databases
RNActi | P10915, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 38 – 152 | Ig-like V-typeAdd BLAST | 115 | |
Domaini | 159 – 254 | Link 1PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 259 – 351 | Link 2PROSITE-ProRule annotationAdd BLAST | 93 |
Sequence similaritiesi
Belongs to the HAPLN family.Curated
Keywords - Domaini
Immunoglobulin domain, RepeatPhylogenomic databases
eggNOGi | ENOG502QRAR, Eukaryota |
GeneTreei | ENSGT00940000159267 |
HOGENOMi | CLU_052285_1_0_1 |
InParanoidi | P10915 |
OMAi | ISVCWAD |
OrthoDBi | 743812at2759 |
PhylomeDBi | P10915 |
TreeFami | TF332134 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.10.100.10, 2 hits |
InterProi | View protein in InterPro IPR016186, C-type_lectin-like/link_sf IPR016187, CTDL_fold IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set IPR000538, Link_dom |
Pfami | View protein in Pfam PF07686, V-set, 1 hit PF00193, Xlink, 2 hits |
PRINTSi | PR01265, LINKMODULE |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00406, IGv, 1 hit SM00445, LINK, 2 hits |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF56436, SSF56436, 2 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS01241, LINK_1, 2 hits PS50963, LINK_2, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
P10915-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKSLLLLVLI SICWADHLSD NYTLDHDRAI HIQAENGPHL LVEAEQAKVF
60 70 80 90 100
SHRGGNVTLP CKFYRDPTAF GSGIHKIRIK WTKLTSDYLK EVDVFVSMGY
110 120 130 140 150
HKKTYGGYQG RVFLKGGSDS DASLVITDLT LEDYGRYKCE VIEGLEDDTV
160 170 180 190 200
VVALDLQGVV FPYFPRLGRY NLNFHEAQQA CLDQDAVIAS FDQLYDAWRG
210 220 230 240 250
GLDWCNAGWL SDGSVQYPIT KPREPCGGQN TVPGVRNYGF WDKDKSRYDV
260 270 280 290 300
FCFTSNFNGR FYYLIHPTKL TYDEAVQACL NDGAQIAKVG QIFAAWKILG
310 320 330 340 350
YDRCDAGWLA DGSVRYPISR PRRRCSPTEA AVRFVGFPDK KHKLYGVYCF
RAYN
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD6RBS1 | D6RBS1_HUMAN | Hyaluronan and proteoglycan link pr... | HAPLN1 | 258 | Annotation score: | ||
D6RFI7 | D6RFI7_HUMAN | Hyaluronan and proteoglycan link pr... | HAPLN1 | 182 | Annotation score: | ||
D6RG04 | D6RG04_HUMAN | Hyaluronan and proteoglycan link pr... | HAPLN1 | 199 | Annotation score: | ||
D6RBX9 | D6RBX9_HUMAN | Hyaluronan and proteoglycan link pr... | HAPLN1 | 169 | Annotation score: | ||
D6RAK7 | D6RAK7_HUMAN | Hyaluronan and proteoglycan link pr... | HAPLN1 | 161 | Annotation score: | ||
D6RC59 | D6RC59_HUMAN | Hyaluronan and proteoglycan link pr... | HAPLN1 | 153 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 274 | E → V in AAH57808 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049316 | 281 | N → S. Corresponds to variant dbSNP:rs6864342Ensembl. | 1 | |
Natural variantiVAR_036168 | 333 | R → H in a colorectal cancer sample; somatic mutation. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X17405 mRNA Translation: CAA35462.1 U43328 mRNA Translation: AAA85216.1 AK313713 mRNA Translation: BAG36456.1 CH471084 Genomic DNA Translation: EAW95912.1 BC057808 mRNA Translation: AAH57808.1 |
CCDSi | CCDS4061.1 |
PIRi | S14914, LKHU |
RefSeqi | NP_001875.1, NM_001884.3 XP_011541470.1, XM_011543168.2 XP_016864540.1, XM_017009051.1 XP_016864541.1, XM_017009052.1 |
Genome annotation databases
Ensembli | ENST00000274341; ENSP00000274341; ENSG00000145681 |
GeneIDi | 1404 |
KEGGi | hsa:1404 |
UCSCi | uc003kin.4, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X17405 mRNA Translation: CAA35462.1 U43328 mRNA Translation: AAA85216.1 AK313713 mRNA Translation: BAG36456.1 CH471084 Genomic DNA Translation: EAW95912.1 BC057808 mRNA Translation: AAH57808.1 |
CCDSi | CCDS4061.1 |
PIRi | S14914, LKHU |
RefSeqi | NP_001875.1, NM_001884.3 XP_011541470.1, XM_011543168.2 XP_016864540.1, XM_017009051.1 XP_016864541.1, XM_017009052.1 |
3D structure databases
SMRi | P10915 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 107794, 2 interactors |
IntActi | P10915, 2 interactors |
STRINGi | 9606.ENSP00000274341 |
Chemistry databases
DrugBanki | DB08818, Hyaluronic acid |
PTM databases
GlyConnecti | 1380, 1 N-Linked glycan (1 site) |
GlyGeni | P10915, 2 sites |
iPTMneti | P10915 |
PhosphoSitePlusi | P10915 |
Polymorphism and mutation databases
BioMutai | HAPLN1 |
DMDMi | 130310 |
Proteomic databases
EPDi | P10915 |
jPOSTi | P10915 |
MassIVEi | P10915 |
MaxQBi | P10915 |
PaxDbi | P10915 |
PeptideAtlasi | P10915 |
PRIDEi | P10915 |
ProteomicsDBi | 52677 |
Protocols and materials databases
Antibodypediai | 12888, 226 antibodies |
DNASUi | 1404 |
Genome annotation databases
Ensembli | ENST00000274341; ENSP00000274341; ENSG00000145681 |
GeneIDi | 1404 |
KEGGi | hsa:1404 |
UCSCi | uc003kin.4, human |
Organism-specific databases
CTDi | 1404 |
DisGeNETi | 1404 |
EuPathDBi | HostDB:ENSG00000145681.10 |
GeneCardsi | HAPLN1 |
HGNCi | HGNC:2380, HAPLN1 |
HPAi | ENSG00000145681, Tissue enriched (placenta) |
MIMi | 115435, gene |
neXtProti | NX_P10915 |
OpenTargetsi | ENSG00000145681 |
PharmGKBi | PA26901 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QRAR, Eukaryota |
GeneTreei | ENSGT00940000159267 |
HOGENOMi | CLU_052285_1_0_1 |
InParanoidi | P10915 |
OMAi | ISVCWAD |
OrthoDBi | 743812at2759 |
PhylomeDBi | P10915 |
TreeFami | TF332134 |
Enzyme and pathway databases
PathwayCommonsi | P10915 |
Reactomei | R-HSA-3000178, ECM proteoglycans |
SIGNORi | P10915 |
Miscellaneous databases
BioGRID-ORCSi | 1404, 4 hits in 843 CRISPR screens |
ChiTaRSi | HAPLN1, human |
GeneWikii | HAPLN1 |
GenomeRNAii | 1404 |
Pharosi | P10915, Tbio |
PROi | PR:P10915 |
RNActi | P10915, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000145681, Expressed in tibia and 148 other tissues |
ExpressionAtlasi | P10915, baseline and differential |
Genevisiblei | P10915, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.10.100.10, 2 hits |
InterProi | View protein in InterPro IPR016186, C-type_lectin-like/link_sf IPR016187, CTDL_fold IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set IPR000538, Link_dom |
Pfami | View protein in Pfam PF07686, V-set, 1 hit PF00193, Xlink, 2 hits |
PRINTSi | PR01265, LINKMODULE |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00406, IGv, 1 hit SM00445, LINK, 2 hits |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF56436, SSF56436, 2 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS01241, LINK_1, 2 hits PS50963, LINK_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HPLN1_HUMAN | |
Accessioni | P10915Primary (citable) accession number: P10915 Secondary accession number(s): B2R9A9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | April 1, 1990 | |
Last modified: | December 2, 2020 | |
This is version 191 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations