IRF1

Functionⁱ

Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. These include the regulation of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired immune responses through the activation of specific target genes and can act as a transcriptional activator and repressor regulating target genes by binding to an interferon-stimulated response element (ISRE) in their promoters. Its target genes for transcriptional activation activity include: genes involved in anti-viral response, such as IFN-alpha/beta, DDX58/RIG-I, TNFSF10/TRAIL, OAS1/2, PIAS1/GBP, EIF2AK2/PKR and RSAD2/viperin; antibacterial response, such as NOS2/INOS; anti-proliferative response, such as p53/TP53, LOX and CDKN1A; apoptosis, such as BBC3/PUMA, CASP1, CASP7 and CASP8; immune response, such as IL7, IL12A/B and IL15, PTGS2/COX2 and CYBB; DNA damage responses and DNA repair, such as POLQ/POLH; MHC class I expression, such as TAP1, PSMB9/LMP2, PSME1/PA28A, PSME2/PA28B and B2M and MHC class II expression, such as CIITA. Represses genes involved in anti-proliferative response, such as BIRC5/survivin, CCNB1, CCNE1, CDK1, CDK2 and CDK4 and in immune response, such as FOXP3, IL4, ANXA2 and TLR4. Stimulates p53/TP53-dependent transcription through enhanced recruitment of EP300 leading to increased acetylation of p53/TP53. Plays an important role in immune response directly affecting NK maturation and activity, macrophage production of IL12, Th1 development and maturation of CD8+ T-cells. Also implicated in the differentiation and maturation of dendritic cells and in the suppression of regulatory T (Treg) cells development. Acts as a tumor suppressor and plays a role not only in antagonism of tumor cell growth but also in stimulating an immune response against tumor cells.12 Publications

Miscellaneous

Deletion or rearrangement of IRF1 are found in preleukemic myelodysplastic syndrome (MDS) and acute myelogenous leukemia (AML).

Activity regulationⁱ

Activated by MYD88.By similarity

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	5 – 113	IRF tryptophan pentad repeatPROSITE-ProRule annotationAdd BLAST		109

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

apoptotic process
Source: UniProtKB
Inferred from direct assayⁱ
- 19851330
blood coagulation Source: Reactome
CD8-positive, alpha-beta T cell differentiation Source: Ensembl
cell cycle arrest
Source: UniProtKB
Inferred from direct assayⁱ
- 22200613
cellular response to interferon-beta
Source: BHF-UCL
Inferred from direct assayⁱ
- 18035482
cellular response to mechanical stimulus
Source: UniProtKB
Inferred from expression patternⁱ
- 19593445
defense response to virus
Source: UniProtKB
Inferred from direct assayⁱ
- 21389130
- 21478870
interferon-gamma-mediated signaling pathway Source: UniProtKB
negative regulation of cell proliferation
Source: UniProtKB
Traceable author statementⁱ
- 11846974
negative regulation of regulatory T cell differentiation Source: UniProtKB
negative regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18084608
- 22200613
positive regulation of interferon-beta production
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21389130
positive regulation of interleukin-12 biosynthetic process Source: Ensembl
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 22200613
positive regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from mutant phenotypeⁱ
- 15509808
positive regulation of type I interferon production Source: UniProtKB
regulation of adaptive immune response
Source: UniProtKB
Traceable author statementⁱ
- 11846971
regulation of CD8-positive, alpha-beta T cell proliferation Source: UniProtKB
regulation of cell cycle
Source: UniProtKB
Traceable author statementⁱ
- 11846974
regulation of innate immune response
Source: UniProtKB
Traceable author statementⁱ
- 11846971
regulation of MyD88-dependent toll-like receptor signaling pathway Source: UniProtKB
transcription by RNA polymerase II
Source: ProtInc
Traceable author statementⁱ
- 2475256
type I interferon signaling pathway Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding, Repressor
Biological process	Antiviral defense, Immunity, Innate immunity, Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-877300 Interferon gamma signaling R-HSA-909733 Interferon alpha/beta signaling R-HSA-983231 Factors involved in megakaryocyte development and platelet production
SignaLinkⁱ	P10914
SIGNORⁱ	P10914

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Interferon regulatory factor 1 Short name: IRF-1
Gene namesⁱ	Name:IRF1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000125347.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6116 IRF1
MIMⁱ	147575 gene
neXtProtⁱ	NX_P10914

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Gastric cancer (GASC)2 Publications

Disease susceptibility is associated with variations affecting the gene represented in this entry.

Disease descriptionA malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	78	K → R: Loss of acetylation. Partial loss of DNA-binding and transcriptional activity. 1 Publication	1
Mutagenesisⁱ	275	K → R: Some loss of sumoylation. Partial inhibition of acetylation and activity. Abolishes sumoylation, diminished ubiquitination, higher resistance to degradation, and increased apoptotic activity; when associated with R-299. 1 Publication	1
Mutagenesisⁱ	299	K → R: Large loss of sumoylation. Abolishes sumoylation, diminished ubiquitination, higher resistance to degradation, and increased apoptotic activity; when associated with R-275. 1 Publication	1

Keywords - Diseaseⁱ

Disease mutation, Tumor suppressor

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3659
MalaCards human disease database More...MalaCardsⁱ	IRF1
MIMⁱ	613659 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000125347
PharmGKBⁱ	PA29915

Polymorphism and mutation databases

BioMutaⁱ	IRF1
DMDMⁱ	20178295

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000154545	1 – 325	Interferon regulatory factor 1Add BLAST		325

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	78	N6-acetyllysine1 Publication	1
Cross-linkⁱ	275	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
Cross-linkⁱ	299	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)

Post-translational modificationⁱ

Phosphorylated by CK2 and this positively regulates its activity.1 Publication

Sumoylation represses the transcriptional activity and displays enhanced resistance to protein degradation. Inactivates the tumor suppressor activity. Elevated levels in tumor cells. Major site is Lys-275. Sumoylation is enhanced by PIAS3 (By similarity). Desumoylated by SENP1 in tumor cells and appears to compete with ubiquitination on C-terminal sites.By similarity1 Publication

Ubiquitinated. Appears to compete with sumoylation on C-terminal sites.1 Publication

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P10914
PaxDbⁱ	P10914
PeptideAtlas More...PeptideAtlasⁱ	P10914
PRIDEⁱ	P10914
ProteomicsDBⁱ	52676

PTM databases

iPTMnetⁱ	P10914
PhosphoSitePlusⁱ	P10914

Expressionⁱ

Inductionⁱ

By viruses and interferon (IFN).

Gene expression databases

Bgeeⁱ	ENSG00000125347 Expressed in 206 organ(s), highest expression level in blood
CleanExⁱ	HS_IRF1
ExpressionAtlasⁱ	P10914 baseline and differential
Genevisibleⁱ	P10914 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB011662 HPA063131

HPAⁱ

CAB011662
HPA063131

Interactionⁱ

Subunit structureⁱ

Monomer. Homodimer. Interacts with MYD88 and PIAS3 (By similarity). Interacts with EP300.By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
E7	P03129	3	EBI-1055781,EBI-866453	From Human papillomavirus type 16.
SUMO1	P63165	2	EBI-1055781,EBI-80140

Protein-protein interaction databases

BioGridⁱ	109867, 34 interactors
Database of interacting proteins More...DIPⁱ	DIP-40988N
IntActⁱ	P10914, 5 interactors
Molecular INTeraction database More...MINTⁱ	P10914
STRINGⁱ	9606.ENSP00000245414

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P10914
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the IRF family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG410IER3 Eukaryota ENOG4111HM7 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119093
HOGENOMⁱ	HOG000037937
HOVERGENⁱ	HBG003455
InParanoidⁱ	P10914
KEGG Orthology (KO) More...KOⁱ	K09444
OMAⁱ	CKEEPEV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0CB8
PhylomeDBⁱ	P10914
TreeFamⁱ	TF328512

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00103 IRF, 1 hit
Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR019817 Interferon_reg_fac_CS IPR001346 Interferon_reg_fact_DNA-bd_dom IPR031215 IRF1 IPR017431 IRF1/IRF2 IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
PANTHERⁱ	PTHR11949 PTHR11949, 1 hit PTHR11949:SF3 PTHR11949:SF3, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00605 IRF, 1 hit
PIRSFⁱ	PIRSF038196 IFN_RF1/2, 1 hit
PRINTSⁱ	PR00267 INTFRNREGFCT
SMARTⁱ	View protein in SMART SM00348 IRF, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit
PROSITEⁱ	View protein in PROSITE PS00601 IRF_1, 1 hit PS51507 IRF_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show all Align All

P10914-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPITRMRMRP WLEMQINSNQ IPGLIWINKE EMIFQIPWKH AAKHGWDINK 
        60         70         80         90        100
DACLFRSWAI HTGRYKAGEK EPDPKTWKAN FRCAMNSLPD IEEVKDQSRN 
       110        120        130        140        150
KGSSAVRVYR MLPPLTKNQR KERKSKSSRD AKSKAKRKSC GDSSPDTFSD 
       160        170        180        190        200
GLSSSTLPDD HSSYTVPGYM QDLEVEQALT PALSPCAVSS TLPDWHIPVE 
       210        220        230        240        250
VVPDSTSDLY NFQVSPMPST SEATTDEDEE GKLPEDIMKL LEQSEWQPTN 
       260        270        280        290        300
VDGKGYLLNE PGVQPTSVYG DFSCKEEPEI DSPGGDIGLS LQRVFTDLKN 
       310        320 
MDATWLDSLL TPVRLPSIQA IPCAP

Length:325

Mass (Da):36,502

Last modified:April 16, 2002 - v2

Checksum:ⁱ2E06245A212D1541

GO

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9J9C5	C9J9C5_HUMAN	Interferon regulatory factor 1 Interferon regulatory factor 1	IRF1	198	Annotation score:
C9JD95	C9JD95_HUMAN	Interferon regulatory factor 1 Interferon regulatory factor 1	IRF1	192	Annotation score:
R4GNI0	R4GNI0_HUMAN	Interferon regulatory factor 1 Interferon regulatory factor 1	IRF1	118	Annotation score:
V9P921	V9P921_HUMAN	Interferon regulatory factor 1 isof... Interferon regulatory factor 1 isoform d78	IRF1	201	Annotation score:
F8WCM1	F8WCM1_HUMAN	Interferon regulatory factor 1 Interferon regulatory factor 1	IRF1	51	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	5	R → W no nucleotide entry (PubMed:2726461).Curated	1
Sequence conflictⁱ	5	R → W no nucleotide entry (PubMed:3409321).Curated	1
Sequence conflictⁱ	34 – 35	FQ → LE no nucleotide entry (PubMed:2726461).Curated	2
Sequence conflictⁱ	34 – 35	FQ → LE no nucleotide entry (PubMed:3409321).Curated	2
Sequence conflictⁱ	220	T → I no nucleotide entry (PubMed:2726461).Curated	1
Sequence conflictⁱ	220	T → I no nucleotide entry (PubMed:3409321).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_065134	8	M → L in GASC; somatic mutation; produces a protein with markedly reduced transcriptional activity but unaltered DNA-binding activity. 1 PublicationCorresponds to variant dbSNP:rs121912469EnsemblClinVar.		1
Natural variantⁱVAR_065135	11	W → R in GASC; the mutation abolishes DNA binding and transactivating activities. 1 PublicationCorresponds to variant dbSNP:rs121912470EnsemblClinVar.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X14454 mRNA Translation: CAA32624.1 L05072 Genomic DNA Translation: AAA36043.1 BT019756 mRNA Translation: AAV38561.1 BC009483 mRNA Translation: AAH09483.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4155.1
PIRⁱ	B31595 I52998
NCBI Reference Sequences More...RefSeqⁱ	NP_002189.1, NM_002198.2
UniGeneⁱ	Hs.436061

Genome annotation databases

Ensemblⁱ	ENST00000245414; ENSP00000245414; ENSG00000125347 ENST00000405885; ENSP00000384406; ENSG00000125347
GeneIDⁱ	3659
KEGGⁱ	hsa:3659

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P10914	IRF1 protein (Fragment)		HUMAN		325	UniRef100_P10914
Interferon regulatory factor 1 (Fragment)		HUMAN		192
UPI0003E6E0FA		HUMAN		241

Protein	Similar proteins		Species	Score	Length	Source
P10914	IRF1 protein (Fragment)		HUMAN		325	UniRef90_P10914
Interferon regulatory factor		RHIFE		328
Interferon regulatory factor		CAVPO		326
Interferon regulatory factor 1 (Fragment)		MOUSE		62
Interferon regulatory factor		FUKDA		326
+58

Protein	Similar proteins		Species	Score	Length	Source
P10914	Interferon regulatory factor 1		CHICK		313	UniRef50_P10914
Interferon regulatory factor 1		PIG		322
Interferon regulatory factor 1		BOVIN		322
IRF1 protein (Fragment)		HUMAN		325
Interferon regulatory factor		RHIFE		328
+175

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X14454 mRNA Translation: CAA32624.1 L05072 Genomic DNA Translation: AAA36043.1 BT019756 mRNA Translation: AAV38561.1 BC009483 mRNA Translation: AAH09483.1
CCDSⁱ	CCDS4155.1
PIRⁱ	B31595 I52998
RefSeqⁱ	NP_002189.1, NM_002198.2
UniGeneⁱ	Hs.436061

3D structure databases

ProteinModelPortalⁱ	P10914
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109867, 34 interactors
DIPⁱ	DIP-40988N
IntActⁱ	P10914, 5 interactors
MINTⁱ	P10914
STRINGⁱ	9606.ENSP00000245414

PTM databases

iPTMnetⁱ	P10914
PhosphoSitePlusⁱ	P10914

Polymorphism and mutation databases

BioMutaⁱ	IRF1
DMDMⁱ	20178295

Proteomic databases

EPDⁱ	P10914
PaxDbⁱ	P10914
PeptideAtlasⁱ	P10914
PRIDEⁱ	P10914
ProteomicsDBⁱ	52676

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3659
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000245414; ENSP00000245414; ENSG00000125347 ENST00000405885; ENSP00000384406; ENSG00000125347
GeneIDⁱ	3659
KEGGⁱ	hsa:3659

Organism-specific databases

CTDⁱ	3659
DisGeNETⁱ	3659
EuPathDBⁱ	HostDB:ENSG00000125347.13
GeneCardsⁱ	IRF1
H-InvDBⁱ	HIX0200727
HGNCⁱ	HGNC:6116 IRF1
HPAⁱ	CAB011662 HPA063131
MalaCardsⁱ	IRF1
MIMⁱ	147575 gene 613659 phenotype
neXtProtⁱ	NX_P10914
OpenTargetsⁱ	ENSG00000125347
PharmGKBⁱ	PA29915
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IER3 Eukaryota ENOG4111HM7 LUCA
GeneTreeⁱ	ENSGT00760000119093
HOGENOMⁱ	HOG000037937
HOVERGENⁱ	HBG003455
InParanoidⁱ	P10914
KOⁱ	K09444
OMAⁱ	CKEEPEV
OrthoDBⁱ	EOG091G0CB8
PhylomeDBⁱ	P10914
TreeFamⁱ	TF328512

Enzyme and pathway databases

Reactomeⁱ	R-HSA-877300 Interferon gamma signaling R-HSA-909733 Interferon alpha/beta signaling R-HSA-983231 Factors involved in megakaryocyte development and platelet production
SignaLinkⁱ	P10914
SIGNORⁱ	P10914

Miscellaneous databases

ChiTaRSⁱ	IRF1 human
GeneWikiⁱ	IRF1
GenomeRNAiⁱ	3659
Protein Ontology More...PROⁱ	PR:P10914
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000125347 Expressed in 206 organ(s), highest expression level in blood
CleanExⁱ	HS_IRF1
ExpressionAtlasⁱ	P10914 baseline and differential
Genevisibleⁱ	P10914 HS

Family and domain databases

CDDⁱ	cd00103 IRF, 1 hit
Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR019817 Interferon_reg_fac_CS IPR001346 Interferon_reg_fact_DNA-bd_dom IPR031215 IRF1 IPR017431 IRF1/IRF2 IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
PANTHERⁱ	PTHR11949 PTHR11949, 1 hit PTHR11949:SF3 PTHR11949:SF3, 1 hit
Pfamⁱ	View protein in Pfam PF00605 IRF, 1 hit
PIRSFⁱ	PIRSF038196 IFN_RF1/2, 1 hit
PRINTSⁱ	PR00267 INTFRNREGFCT
SMARTⁱ	View protein in SMART SM00348 IRF, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit
PROSITEⁱ	View protein in PROSITE PS00601 IRF_1, 1 hit PS51507 IRF_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IRF1_HUMAN
Accessionⁱ	P10914Primary (citable) accession number: P10914 Secondary accession number(s): Q96GG7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
	Last sequence update:	April 16, 2002
	Last modified:	November 7, 2018
	This is version 175 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM

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UniProtKB - P10914 (IRF1_HUMAN)

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Interferon regulatory factor 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

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<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ