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UniProtKB - P10912 (GHR_HUMAN)

Entry version 225 (22 Apr 2020)
Sequence version 1 (01 Jul 1989)
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Protein

Growth hormone receptor

Gene

GHR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity).By similarity
The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.
Isoform 2 up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei345Required for endocytosis and down-regulationBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processEndocytosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1170546 Prolactin receptor signaling
R-HSA-982772 Growth hormone receptor signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P10912

SIGNOR Signaling Network Open Resource

More...SIGNORi		P10912

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Growth hormone receptor
Short name:
GH receptor
Alternative name(s):
Somatotropin receptor
Cleaved into the following chain:
Growth hormone-binding protein
Short name:
GH-binding protein
Short name:
GHBP
Alternative name(s):
Serum-binding protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GHR
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:4263 GHR

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600946 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P10912

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini19 – 264ExtracellularSequence analysisAdd BLAST246
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei265 – 288HelicalSequence analysisAdd BLAST24
Topological domaini289 – 638CytoplasmicSequence analysisAdd BLAST350

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Laron syndrome (LARS)9 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA severe form of growth hormone insensitivity characterized by growth impairment, short stature, dysfunctional growth hormone receptor, and failure to generate insulin-like growth factor I in response to growth hormone.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01842656C → S in LARS. 1 Publication1
Natural variantiVAR_01842758S → L in LARS. 1 Publication1
Natural variantiVAR_01842868W → R in LARS. 1 Publication1
Natural variantiVAR_00270989R → K in LARS. 1 Publication1
Natural variantiVAR_002710114F → S in LARS; loss of ability to bind ligand. 2 PublicationsCorresponds to variant dbSNP:rs121909357EnsemblClinVar.1
Natural variantiVAR_002711143V → A in LARS. 1
Natural variantiVAR_018429149P → Q in LARS; disrupts GH binding. 2 PublicationsCorresponds to variant dbSNP:rs121909365EnsemblClinVar.1
Natural variantiVAR_002712162V → D in LARS. 1 Publication1
Natural variantiVAR_002713170D → H in LARS; abolishes receptor homodimerization. 2 PublicationsCorresponds to variant dbSNP:rs121909366EnsemblClinVar.1
Natural variantiVAR_018431171I → T in LARS; almost completely abolishes GH-binding at cell surface: 53% binding to membrane fractions. 1 PublicationCorresponds to variant dbSNP:rs121909367EnsemblClinVar.1
Natural variantiVAR_018432172Q → P in LARS; almost completely abolishes GH-binding at cell surface and in membrane fractions. 1 PublicationCorresponds to variant dbSNP:rs121909368EnsemblClinVar.1
Natural variantiVAR_018433173V → G in LARS; almost completely abolishes GH-binding at cell surface: 26% binding to membrane fractions. 1 PublicationCorresponds to variant dbSNP:rs121909369EnsemblClinVar.1
Natural variantiVAR_002714179R → C in LARS and GHIP. 2 PublicationsCorresponds to variant dbSNP:rs121909362EnsemblClinVar.1
Natural variantiVAR_018434226Y → C in LARS. 1 Publication1
Natural variantiVAR_002715229R → G in LARS. 1 Publication1
Natural variantiVAR_018435244S → I in LARS. 1 PublicationCorresponds to variant dbSNP:rs1164396446Ensembl.1
Natural variantiVAR_018436262D → N in LARS. 1 Publication1
Growth hormone insensitivity, partial (GHIP)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by partial resistance to growth hormone resulting in short stature. Short stature is defined by a standing height more than 2 standard deviations below the mean (or below the 2.5 percentile) for sex and chronological age, compared with a well-nourished, healthy, genetically relevant population.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00270862E → K in GHIP. 1 PublicationCorresponds to variant dbSNP:rs121909361EnsemblClinVar.1
Natural variantiVAR_002714179R → C in LARS and GHIP. 2 PublicationsCorresponds to variant dbSNP:rs121909362EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi260E → A: No change in shedding activity: No change in hormone binding. 1 Publication1
Mutagenesisi261E → A: No change in shedding activity: No change in hormone binding. 1 Publication1
Mutagenesisi262D → A: No change in shedding activity: No change in hormone binding. 1 Publication1

Keywords - Diseasei

Disease mutation, Dwarfism

Organism-specific databases

DisGeNET

More...DisGeNETi		2690

MalaCards human disease database

More...MalaCardsi		GHR
MIMi143890 phenotype
262500 phenotype
604271 phenotype

Open Targets

More...OpenTargetsi		ENSG00000112964

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		633 Laron syndrome
314802 Short stature due to partial GHR deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA28674

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P10912 Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1976

Drug and drug target database

More...DrugBanki		DB00082 Pegvisomant
DB00052 Somatotropin
DB09098 Somatrem

DrugCentral

More...DrugCentrali		P10912

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		GHR

Domain mapping of disease mutations (DMDM)

More...DMDMi		121180

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001095719 – 638Growth hormone receptorAdd BLAST620
ChainiPRO_000001095819 – 256Growth hormone-binding proteinBy similarityAdd BLAST238

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi46N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi56 ↔ 661 Publication
Disulfide bondi101 ↔ 1121 Publication
Glycosylationi115N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi126 ↔ 1401 Publication
Glycosylationi156N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi161N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi200N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei341PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The soluble form (GHBP) is produced by phorbol ester-promoted proteolytic cleavage at the cell surface (shedding) by ADAM17/TACE. Shedding is inhibited by growth hormone (GH) binding to the receptor probably due to a conformational change in GHR rendering the receptor inaccessible to ADAM17 (By similarity).By similarity
On GH binding, phosphorylated on tyrosine residues in the cytoplasmic domain by JAK2.By similarity
On ligand binding, ubiquitinated on lysine residues in the cytoplasmic domain. This ubiquitination is not sufficient for GHR internalization (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P10912

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P10912

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P10912

PeptideAtlas

More...PeptideAtlasi		P10912

PRoteomics IDEntifications database

More...PRIDEi		P10912

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		52672 [P10912-1]
52673 [P10912-2]
52674 [P10912-3]
52675 [P10912-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P10912

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P10912

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in various tissues with high expression in liver and skeletal muscle. Isoform 4 is predominantly expressed in kidney, bladder, adrenal gland and brain stem. Isoform 1 expression in placenta is predominant in chorion and decidua. Isoform 4 is highly expressed in placental villi. Isoform 2 is expressed in lung, stomach and muscle. Low levels in liver.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000112964 Expressed in adipose tissue and 191 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P10912 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P10912 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000112964 Group enriched (adipose tissue, breast, liver, skeletal muscle)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

On growth hormone (GH) binding, forms homodimers and binds JAK2 via a box 1-containing domain. Binding to SOCS3 inhibits JAK2 activation, binding to CIS and SOCS2 inhibits STAT5 activation.

Interacts with ADAM17.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		108957, 43 interactors

Database of interacting proteins

More...DIPi		DIP-630N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		P10912

Protein interaction database and analysis system

More...IntActi		P10912, 22 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000483403

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P10912 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1638
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P10912

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P10912

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini151 – 254Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST104

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni260 – 262Required for ADAM17-mediated proteolysisBy similarity3

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi240 – 244WSXWS motif5
Motifi297 – 305Box 1 motif9
Motifi340 – 349UbE motif10

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.
The extracellular domain is the ligand-binding domain representing the growth hormone-binding protein (GHBP).
The ubiquitination-dependent endocytosis motif (UbE) is required for recruitment of the ubiquitin conjugation system on to the receptor and for its internalization.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the type I cytokine receptor family. Type 1 subfamily.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IFQI Eukaryota
ENOG410XTHJ LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159987

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_022322_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P10912

KEGG Orthology (KO)

More...KOi		K05080

Database of Orthologous Groups

More...OrthoDBi		346239at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P10912

TreeFam database of animal gene trees

More...TreeFami		TF330851

Family and domain databases

Conserved Domains Database

More...CDDi		cd00063 FN3, 1 hit

Database of protein disorder

More...DisProti		DP00033

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR025871 GHBP
IPR015152 Growth/epo_recpt_lig-bind
IPR013783 Ig-like_fold
IPR003528 Long_hematopoietin_rcpt_CS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF09067 EpoR_lig-bind, 1 hit
PF00041 fn3, 1 hit
PF12772 GHBP, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49265 SSF49265, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50853 FN3, 1 hit
PS01352 HEMATOPO_REC_L_F1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P10912-1) [UniParc]FASTAAdd to basket
Also known as: GHRfl

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDLWQLLLTL ALAGSSDAFS GSEATAAILS RAPWSLQSVN PGLKTNSSKE 
        60         70         80         90        100
PKFTKCRSPE RETFSCHWTD EVHHGTKNLG PIQLFYTRRN TQEWTQEWKE 
       110        120        130        140        150
CPDYVSAGEN SCYFNSSFTS IWIPYCIKLT SNGGTVDEKC FSVDEIVQPD 
       160        170        180        190        200
PPIALNWTLL NVSLTGIHAD IQVRWEAPRN ADIQKGWMVL EYELQYKEVN 
       210        220        230        240        250
ETKWKMMDPI LTTSVPVYSL KVDKEYEVRV RSKQRNSGNY GEFSEVLYVT 
       260        270        280        290        300
LPQMSQFTCE EDFYFPWLLI IIFGIFGLTV MLFVFLFSKQ QRIKMLILPP 
       310        320        330        340        350
VPVPKIKGID PDLLKEGKLE EVNTILAIHD SYKPEFHSDD SWVEFIELDI 
       360        370        380        390        400
DEPDEKTEES DTDRLLSSDH EKSHSNLGVK DGDSGRTSCC EPDILETDFN 
       410        420        430        440        450
ANDIHEGTSE VAQPQRLKGE ADLLCLDQKN QNNSPYHDAC PATQQPSVIQ 
       460        470        480        490        500
AEKNKPQPLP TEGAESTHQA AHIQLSNPSS LSNIDFYAQV SDITPAGSVV 
       510        520        530        540        550
LSPGQKNKAG MSQCDMHPEM VSLCQENFLM DNAYFCEADA KKCIPVAPHI 
       560        570        580        590        600
KVESHIQPSL NQEDIYITTE SLTTAAGRPG TGEHVPGSEM PVPDYTSIHI 
       610        620        630 
VQSPQGLILN ATALPLPDKE FLSSCGYVST DQLNKIMP
Length:638
Mass (Da):71,500
Last modified:July 1, 1989 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEAF77EADE4787822
GO
Isoform 2 (identifier: P10912-2) [UniParc]FASTAAdd to basket
Also known as: GHRtr, GHR1-279

The sequence of this isoform differs from the canonical sequence as follows:
     292-297: RIKMLI → SSSSKD
     298-638: Missing.

Show »
Length:297
Mass (Da):34,109
Checksum:iF690295F6BB01AC8
GO
Isoform 3 (identifier: P10912-3) [UniParc]FASTAAdd to basket
Also known as: GHR1-277

The sequence of this isoform differs from the canonical sequence as follows:
     292-294: RIK → KEN
     295-638: Missing.

Show »
Length:294
Mass (Da):33,889
Checksum:i0E85069AC8F6FDBF
GO
Isoform 4 (identifier: P10912-4) [UniParc]FASTAAdd to basket
Also known as: GHRd3

The sequence of this isoform differs from the canonical sequence as follows:
     24-24: A → D
     25-46: Missing.

Note: Arises by species-specific retrovirus-mediated alternative splice mimicry.Curated
Show »
Length:616
Mass (Da):69,237
Checksum:i5F12CD731F49E1F1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X0H5A0A087X0H5_HUMAN
Growth hormone receptor
GHR
645Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X162A0A087X162_HUMAN
Growth hormone receptor
GHR
295Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PCN7E9PCN7_HUMAN
Growth hormone receptor
GHR
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ES05E7ES05_HUMAN
Growth hormone receptor
GHR
85Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Genetic variation in GHR may act as phenotype modifier in familial hypercholesterolemia [MIMi:143890] patients carrying a mutation in the LDLR gene.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01842656C → S in LARS. 1 Publication1
Natural variantiVAR_01842758S → L in LARS. 1 Publication1
Natural variantiVAR_00270862E → K in GHIP. 1 PublicationCorresponds to variant dbSNP:rs121909361EnsemblClinVar.1
Natural variantiVAR_01842868W → R in LARS. 1 Publication1
Natural variantiVAR_00270989R → K in LARS. 1 Publication1
Natural variantiVAR_002710114F → S in LARS; loss of ability to bind ligand. 2 PublicationsCorresponds to variant dbSNP:rs121909357EnsemblClinVar.1
Natural variantiVAR_002711143V → A in LARS. 1
Natural variantiVAR_018429149P → Q in LARS; disrupts GH binding. 2 PublicationsCorresponds to variant dbSNP:rs121909365EnsemblClinVar.1
Natural variantiVAR_002712162V → D in LARS. 1 Publication1
Natural variantiVAR_020002162V → F. Corresponds to variant dbSNP:rs6413484EnsemblClinVar.1
Natural variantiVAR_018430162V → I Found in a patient with idiopathic short stature; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs6413484EnsemblClinVar.1
Natural variantiVAR_002713170D → H in LARS; abolishes receptor homodimerization. 2 PublicationsCorresponds to variant dbSNP:rs121909366EnsemblClinVar.1
Natural variantiVAR_018431171I → T in LARS; almost completely abolishes GH-binding at cell surface: 53% binding to membrane fractions. 1 PublicationCorresponds to variant dbSNP:rs121909367EnsemblClinVar.1
Natural variantiVAR_018432172Q → P in LARS; almost completely abolishes GH-binding at cell surface and in membrane fractions. 1 PublicationCorresponds to variant dbSNP:rs121909368EnsemblClinVar.1
Natural variantiVAR_018433173V → G in LARS; almost completely abolishes GH-binding at cell surface: 26% binding to membrane fractions. 1 PublicationCorresponds to variant dbSNP:rs121909369EnsemblClinVar.1
Natural variantiVAR_002714179R → C in LARS and GHIP. 2 PublicationsCorresponds to variant dbSNP:rs121909362EnsemblClinVar.1
Natural variantiVAR_013937179R → H1 PublicationCorresponds to variant dbSNP:rs6181Ensembl.1
Natural variantiVAR_018434226Y → C in LARS. 1 Publication1
Natural variantiVAR_002715229R → G in LARS. 1 Publication1
Natural variantiVAR_013938229R → H Found in a patient with idiopathic short stature; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs6177EnsemblClinVar.1
Natural variantiVAR_002716242E → D Found in a patient with idiopathic short stature; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs45588036EnsemblClinVar.1
Natural variantiVAR_018435244S → I in LARS. 1 PublicationCorresponds to variant dbSNP:rs1164396446Ensembl.1
Natural variantiVAR_018436262D → N in LARS. 1 Publication1
Natural variantiVAR_013939440C → F2 PublicationsCorresponds to variant dbSNP:rs6182EnsemblClinVar.1
Natural variantiVAR_032704465E → K. Corresponds to variant dbSNP:rs34283856Ensembl.1
Natural variantiVAR_013940495P → T1 PublicationCorresponds to variant dbSNP:rs6183EnsemblClinVar.1
Natural variantiVAR_013941544I → L Polymorphism with a modifier effect on plasma HDL cholesterol levels in familial hypercholesterolemia patients. 3 PublicationsCorresponds to variant dbSNP:rs6180EnsemblClinVar.1
Natural variantiVAR_013942579P → T1 PublicationCorresponds to variant dbSNP:rs6184EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01022524A → D in isoform 4. 1 Publication1
Alternative sequenceiVSP_01022625 – 46Missing in isoform 4. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_010227292 – 297RIKMLI → SSSSKD in isoform 2. 3 Publications6
Alternative sequenceiVSP_010229292 – 294RIK → KEN in isoform 3. 1 Publication3
Alternative sequenceiVSP_010230295 – 638Missing in isoform 3. 1 PublicationAdd BLAST344
Alternative sequenceiVSP_010228298 – 638Missing in isoform 2. 3 PublicationsAdd BLAST341

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X06562 mRNA Translation: CAA29808.1
M28466 M28465 Genomic DNA Translation: AAA52555.1
AJ278681 Genomic DNA Translation: CAC06613.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3940.1 [P10912-1]
CCDS56364.1 [P10912-4]

Protein sequence database of the Protein Information Resource

More...PIRi		A33991

NCBI Reference Sequences

More...RefSeqi		NP_000154.1, NM_000163.4 [P10912-1]
NP_001229328.1, NM_001242399.2
NP_001229329.1, NM_001242400.2 [P10912-1]
NP_001229330.1, NM_001242401.3 [P10912-1]
NP_001229331.1, NM_001242402.2 [P10912-1]
NP_001229332.1, NM_001242403.2 [P10912-1]
NP_001229333.1, NM_001242404.2 [P10912-1]
NP_001229334.1, NM_001242405.2 [P10912-1]
NP_001229335.1, NM_001242406.2 [P10912-1]
NP_001229389.1, NM_001242460.1 [P10912-4]
NP_001229391.1, NM_001242462.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000230882; ENSP00000230882; ENSG00000112964 [P10912-1]
ENST00000357703; ENSP00000350335; ENSG00000112964 [P10912-4]
ENST00000537449; ENSP00000442206; ENSG00000112964 [P10912-1]
ENST00000612382; ENSP00000478332; ENSG00000112964 [P10912-1]
ENST00000612626; ENSP00000479846; ENSG00000112964 [P10912-1]
ENST00000615111; ENSP00000478291; ENSG00000112964 [P10912-1]
ENST00000618088; ENSP00000482373; ENSG00000112964 [P10912-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2690

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:2690

UCSC genome browser

More...UCSCi		uc003jmt.4 human [P10912-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06562 mRNA Translation: CAA29808.1
M28466 M28465 Genomic DNA Translation: AAA52555.1
AJ278681 Genomic DNA Translation: CAC06613.1
CCDSiCCDS3940.1 [P10912-1]
CCDS56364.1 [P10912-4]
PIRiA33991
RefSeqiNP_000154.1, NM_000163.4 [P10912-1]
NP_001229328.1, NM_001242399.2
NP_001229329.1, NM_001242400.2 [P10912-1]
NP_001229330.1, NM_001242401.3 [P10912-1]
NP_001229331.1, NM_001242402.2 [P10912-1]
NP_001229332.1, NM_001242403.2 [P10912-1]
NP_001229333.1, NM_001242404.2 [P10912-1]
NP_001229334.1, NM_001242405.2 [P10912-1]
NP_001229335.1, NM_001242406.2 [P10912-1]
NP_001229389.1, NM_001242460.1 [P10912-4]
NP_001229391.1, NM_001242462.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A22X-ray2.60B19-256[»]
1AXIX-ray2.10B19-254[»]
1HWGX-ray2.50B/C19-255[»]
1HWHX-ray2.90B19-255[»]
1KF9X-ray2.60B/C/E/F19-256[»]
2AEWX-ray2.70A/B47-251[»]
3HHRX-ray2.80B/C50-254[»]
5OEKNMR-A/B254-294[»]
5OHDNMR-A/B254-294[»]
SMRiP10912
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi108957, 43 interactors
DIPiDIP-630N
ELMiP10912
IntActiP10912, 22 interactors
STRINGi9606.ENSP00000483403

Chemistry databases

ChEMBLiCHEMBL1976
DrugBankiDB00082 Pegvisomant
DB00052 Somatotropin
DB09098 Somatrem
DrugCentraliP10912

PTM databases

iPTMnetiP10912
PhosphoSitePlusiP10912

Polymorphism and mutation databases

BioMutaiGHR
DMDMi121180

Proteomic databases

EPDiP10912
MassIVEiP10912
PaxDbiP10912
PeptideAtlasiP10912
PRIDEiP10912
ProteomicsDBi52672 [P10912-1]
52673 [P10912-2]
52674 [P10912-3]
52675 [P10912-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		23220 374 antibodies

Genome annotation databases

EnsembliENST00000230882; ENSP00000230882; ENSG00000112964 [P10912-1]
ENST00000357703; ENSP00000350335; ENSG00000112964 [P10912-4]
ENST00000537449; ENSP00000442206; ENSG00000112964 [P10912-1]
ENST00000612382; ENSP00000478332; ENSG00000112964 [P10912-1]
ENST00000612626; ENSP00000479846; ENSG00000112964 [P10912-1]
ENST00000615111; ENSP00000478291; ENSG00000112964 [P10912-1]
ENST00000618088; ENSP00000482373; ENSG00000112964 [P10912-1]
GeneIDi2690
KEGGihsa:2690
UCSCiuc003jmt.4 human [P10912-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2690
DisGeNETi2690

GeneCards: human genes, protein and diseases

More...GeneCardsi		GHR
HGNCiHGNC:4263 GHR
HPAiENSG00000112964 Group enriched (adipose tissue, breast, liver, skeletal muscle)
MalaCardsiGHR
MIMi143890 phenotype
262500 phenotype
600946 gene
604271 phenotype
neXtProtiNX_P10912
OpenTargetsiENSG00000112964
Orphaneti633 Laron syndrome
314802 Short stature due to partial GHR deficiency
PharmGKBiPA28674

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IFQI Eukaryota
ENOG410XTHJ LUCA
GeneTreeiENSGT00940000159987
HOGENOMiCLU_022322_0_0_1
InParanoidiP10912
KOiK05080
OrthoDBi346239at2759
PhylomeDBiP10912
TreeFamiTF330851

Enzyme and pathway databases

ReactomeiR-HSA-1170546 Prolactin receptor signaling
R-HSA-982772 Growth hormone receptor signaling
SignaLinkiP10912
SIGNORiP10912

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		GHR human
EvolutionaryTraceiP10912

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Growth_hormone_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2690
PharosiP10912 Tclin

Protein Ontology

More...PROi		PR:P10912
RNActiP10912 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000112964 Expressed in adipose tissue and 191 other tissues
ExpressionAtlasiP10912 baseline and differential
GenevisibleiP10912 HS

Family and domain databases

CDDicd00063 FN3, 1 hit
DisProtiDP00033
Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR025871 GHBP
IPR015152 Growth/epo_recpt_lig-bind
IPR013783 Ig-like_fold
IPR003528 Long_hematopoietin_rcpt_CS
PfamiView protein in Pfam
PF09067 EpoR_lig-bind, 1 hit
PF00041 fn3, 1 hit
PF12772 GHBP, 1 hit
SUPFAMiSSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit
PS01352 HEMATOPO_REC_L_F1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGHR_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P10912
Secondary accession number(s): Q9HCX2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: April 22, 2020
This is version 225 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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