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Protein

Proto-oncogene DBL

Gene

MCF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Guanine nucleotide exchange factor (GEF) that modulates the Rho family of GTPases. Promotes the conversion of some member of the Rho family GTPase from the GDP-bound to the GTP-bound form. Isoform 1 exhibits no activity toward RHOA, RAC1 or CDC42. Isoform 2 exhibits decreased GEF activity toward CDC42. Isoform 3 exhibits a weak but significant activity toward RAC1 and CDC42. Isoform 4 exhibits significant activity toward RHOA and CDC42. The truncated DBL oncogene is active toward RHOA, RAC1 and CDC42.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-193634 Axonal growth inhibition (RHOA activation)
R-HSA-193648 NRAGE signals death through JNK
R-HSA-194840 Rho GTPase cycle
R-HSA-416482 G alpha (12/13) signalling events

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001545

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Proto-oncogene DBL
Alternative name(s):
Proto-oncogene MCF-2
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MCF2
Synonyms:DBL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000101977.19

Human Gene Nomenclature Database

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HGNCi
HGNC:6940 MCF2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
311030 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P10911

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

MCF2 and DBL represent two activated versions of the same proto-oncogene.Curated

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi640 – 646LLLKELL → IIIRDII: Transformation capability reduced; no stimulation of GDP dissociation. 1 Publication7

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNET

More...
DisGeNETi
4168

Open Targets

More...
OpenTargetsi
ENSG00000101977

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30684

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MCF2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
92087039

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000304321 – 925Proto-oncogene DBLAdd BLAST925
ChainiPRO_0000030433398 – 925MCF2-transforming proteinAdd BLAST528
ChainiPRO_0000030434498 – 925DBL-transforming proteinAdd BLAST428

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation by TNK2 enhances guanine nucleotide exchange factor (GEF) activity toward Rho family proteins.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P10911

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P10911

PeptideAtlas

More...
PeptideAtlasi
P10911

PRoteomics IDEntifications database

More...
PRIDEi
P10911

ProteomicsDB human proteome resource

More...
ProteomicsDBi
52668
52669 [P10911-2]
52670 [P10911-3]
52671 [P10911-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P10911

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P10911

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 is expressed only in brain. Isoform 3 is expressed in heart, kidney, spleen, liver and testis. Isoform 4 is expressed in brain, heart, kidney, testis, placenta, stomach and peripheral blood. The protein is detectable in brain, heart, kidney, intestine, muscle, lung and testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000101977 Expressed in 135 organ(s), highest expression level in left adrenal gland

CleanEx database of gene expression profiles

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CleanExi
HS_MCF2

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P10911 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P10911 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with an array of inositol phospholipids such as phosphatidylinositol 3-phosphate (PI3P), phosphatidylinositol 4-phosphate (PI4P) and phosphatidylinositol 5-phosphate (PI5P). May interact with CCPG1.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
NME1P155314EBI-1914514,EBI-741141

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
110336, 10 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P10911

Protein interaction database and analysis system

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IntActi
P10911, 1 interactor

Molecular INTeraction database

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MINTi
P10911

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000430276

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P10911

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P10911

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 88CRAL-TRIOPROSITE-ProRule annotationAdd BLAST88
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati221 – 322SpectrinAdd BLAST102
Domaini495 – 675DHPROSITE-ProRule annotationAdd BLAST181
Domaini687 – 809PHPROSITE-ProRule annotationAdd BLAST123

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The CRAL-TRIO domain is involved in interaction with inositol phospholipids.
The DH domain is essential for transforming activity and directly catalyzes GDP-GTP exchange activity. It may interact with CCPG1.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MCF2 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4240 Eukaryota
ENOG410XPCA LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156974

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231361

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG062385

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P10911

KEGG Orthology (KO)

More...
KOi
K20685

Identification of Orthologs from Complete Genome Data

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OMAi
VMHDYQE

Database of Orthologous Groups

More...
OrthoDBi
118479at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P10911

TreeFam database of animal gene trees

More...
TreeFami
TF318080

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00160 RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.900.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001251 CRAL-TRIO_dom
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR018159 Spectrin/alpha-actinin

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13716 CRAL_TRIO_2, 1 hit
PF00169 PH, 1 hit
PF00621 RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SM00150 SPEC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48065 SSF48065, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50191 CRAL_TRIO, 1 hit
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P10911-1) [UniParc]FASTAAdd to basket
Also known as: Var.1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEANPRRGK MRFRRNAASF PGNLHLVLVL RPTSFLQRTF TDIGFWFSQE
60 70 80 90 100
DFMLKLPVVM LSSVSDLLTY IDDKQLTPEL GGTLQYCHSE WIIFRNAIEN
110 120 130 140 150
FALTVKEMAQ MLQSFGTELA ETELPDDIPS IEEILAIRAE RYHLLKNDIT
160 170 180 190 200
AVTKEGKILL TNLEVPDTEG AVSSRLECHR QISGDWQTIN KLLTQVHDME
210 220 230 240 250
TAFDGFWEKH QLKMEQYLQL WKFEQDFQQL VTEVEFLLNQ QAELADVTGT
260 270 280 290 300
IAQVKQKIKK LENLDENSQE LLSKAQFVIL HGHKLAANHH YALDLICQRC
310 320 330 340 350
NELRYLSDIL VNEIKAKRIQ LSRTFKMHKL LQQARQCCDE GECLLANQEI
360 370 380 390 400
DKFQSKEDAQ KALQDIENFL EMALPFINYE PETLQYEFDV ILSPELKVQM
410 420 430 440 450
KTIQLKLENI RSIFENQQAG FRNLADKHVR PIQFVVPTPE NLVTSGTPFF
460 470 480 490 500
SSKQGKKTWR QNQSNLKIEV VPDCQEKRSS GPSSSLDNGN SLDVLKNHVL
510 520 530 540 550
NELIQTERVY VRELYTVLLG YRAEMDNPEM FDLMPPLLRN KKDILFGNMA
560 570 580 590 600
EIYEFHNDIF LSSLENCAHA PERVGPCFLE RKDDFQMYAK YCQNKPRSET
610 620 630 640 650
IWRKYSECAF FQECQRKLKH RLRLDSYLLK PVQRITKYQL LLKELLKYSK
660 670 680 690 700
DCEGSALLKK ALDAMLDLLK SVNDSMHQIA INGYIGNLNE LGKMIMQGGF
710 720 730 740 750
SVWIGHKKGA TKMKDLARFK PMQRHLFLYE KAIVFCKRRV ESGEGSDRYP
760 770 780 790 800
SYSFKHCWKM DEVGITEYVK GDNRKFEIWY GEKEEVYIVQ ASNVDVKMTW
810 820 830 840 850
LKEIRNILLK QQELLTVKKR KQQDQLTERD KFQISLQQND EKQQGAFIST
860 870 880 890 900
EETELEHTST VVEVCEAIAS VQAEANTVWT EASQSAEISE EPAEWSSNYF
910 920
YPTYDENEEE NRPLMRPVSE MALLY
Length:925
Mass (Da):107,673
Last modified:March 7, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i96233C7AFC85D637
GO
Isoform 2 (identifier: P10911-2) [UniParc]FASTAAdd to basket
Also known as: Var.2

The sequence of this isoform differs from the canonical sequence as follows:
     842-860: KQQGAFISTEETELEHTST → DLCRRWLSYIDEATMSNGK
     861-925: Missing.

Show »
Length:860
Mass (Da):100,409
Checksum:iCCD14CA833425027
GO
Isoform 3 (identifier: P10911-3) [UniParc]FASTAAdd to basket
Also known as: Var.3

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MAEANPRRGKMRFRRNA → MQDIAFLSGG...SLKISLQKIS

Show »
Length:985
Mass (Da):114,376
Checksum:i8D0C81505593C040
GO
Isoform 4 (identifier: P10911-4) [UniParc]FASTAAdd to basket
Also known as: Var.4

The sequence of this isoform differs from the canonical sequence as follows:
     454-454: Q → QVGVGYSFFQACKLFSK

Show »
Length:941
Mass (Da):109,436
Checksum:iC5B1B4F9F368AC16
GO
Isoform 5 (identifier: P10911-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MAEANPRRGKMRFRRNA → MQDIAFLSGG...SLKISLQKIS
     454-454: Q → QVGVGYSFFQACKLFSK

Show »
Length:1,001
Mass (Da):116,139
Checksum:i8D7277D0703671B3
GO
Isoform 6 (identifier: P10911-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     58-96: Missing.
     842-860: KQQGAFISTEETELEHTST → DLCRRWLSYIDEATMSNGK
     861-925: Missing.

Note: No experimental confirmation available.
Show »
Length:821
Mass (Da):95,940
Checksum:i4FAD1AAA126237A8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2U3TZL4A0A2U3TZL4_HUMAN
Proto-oncogene DBL
MCF2
1,028Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JYJ5Q5JYJ5_HUMAN
Proto-oncogene DBL
MCF2
528Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y662H0Y662_HUMAN
Proto-oncogene DBL
MCF2
429Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA52172 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti54L → P (PubMed:3056717).Curated1
Sequence conflicti54L → P (PubMed:12445822).Curated1
Sequence conflicti178C → S in BAH12371 (PubMed:14702039).Curated1
Sequence conflicti330L → F in BAH14787 (PubMed:14702039).Curated1
Sequence conflicti358D → Y in BAH12371 (PubMed:14702039).Curated1
Sequence conflicti634R → Q (PubMed:3281159).Curated1
Sequence conflicti687N → I in BAH14787 (PubMed:14702039).Curated1
Sequence conflicti886A → V (PubMed:2577874).Curated1
Sequence conflicti900F → S in BAH13855 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0081501 – 17MAEAN…FRRNA → MQDIAFLSGGRGKDNAWIIT FPENCNFRCIPEEVIAKVLT YLTSIARQNGSDSRFTIILD RRLDTWSSLKISLQKIS in isoform 3 and isoform 5. 3 PublicationsAdd BLAST17
Alternative sequenceiVSP_04611858 – 96Missing in isoform 6. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_008153454Q → QVGVGYSFFQACKLFSK in isoform 4 and isoform 5. 2 Publications1
Alternative sequenceiVSP_008151842 – 860KQQGA…EHTST → DLCRRWLSYIDEATMSNGK in isoform 2 and isoform 6. 2 PublicationsAdd BLAST19
Alternative sequenceiVSP_008152861 – 925Missing in isoform 2 and isoform 6. 2 PublicationsAdd BLAST65

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X12556 mRNA Translation: CAA31069.1
AB085901 mRNA Translation: BAC41200.1
AB085902 mRNA Translation: BAC41201.1
AL117234 mRNA Translation: CAB55301.1
AK296488 mRNA Translation: BAH12371.1
AK302957 mRNA Translation: BAH13855.1
AK316416 mRNA Translation: BAH14787.1
AL033403 Genomic DNA No translation available.
AL161777 Genomic DNA No translation available.
CH471150 Genomic DNA Translation: EAW88427.1
CH471150 Genomic DNA Translation: EAW88430.1
J03639 mRNA Translation: AAA52172.1 Different initiation.
X13230 mRNA Translation: CAA31617.1 Sequence problems.

The Consensus CDS (CCDS) project

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CCDSi
CCDS14667.1 [P10911-1]
CCDS48175.1 [P10911-3]
CCDS55514.1 [P10911-6]
CCDS55515.1 [P10911-2]
CCDS55516.1 [P10911-4]
CCDS55517.1 [P10911-5]

Protein sequence database of the Protein Information Resource

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PIRi
A28051 TVHUBD
A30040 TVHUDB
S10138

NCBI Reference Sequences

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RefSeqi
NP_001093325.1, NM_001099855.1 [P10911-3]
NP_001165347.1, NM_001171876.1 [P10911-5]
NP_001165348.1, NM_001171877.1 [P10911-6]
NP_001165349.1, NM_001171878.1 [P10911-2]
NP_001165350.1, NM_001171879.1 [P10911-4]
NP_005360.3, NM_005369.4 [P10911-1]
XP_011529641.1, XM_011531339.2 [P10911-5]
XP_016885020.1, XM_017029531.1 [P10911-5]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.387262

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000338585; ENSP00000342204; ENSG00000101977 [P10911-4]
ENST00000370573; ENSP00000359605; ENSG00000101977 [P10911-2]
ENST00000370576; ENSP00000359608; ENSG00000101977 [P10911-1]
ENST00000414978; ENSP00000397055; ENSG00000101977 [P10911-3]
ENST00000519895; ENSP00000430276; ENSG00000101977 [P10911-5]
ENST00000536274; ENSP00000438155; ENSG00000101977 [P10911-6]

Database of genes from NCBI RefSeq genomes

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GeneIDi
4168

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:4168

UCSC genome browser

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UCSCi
uc004fau.4 human [P10911-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12556 mRNA Translation: CAA31069.1
AB085901 mRNA Translation: BAC41200.1
AB085902 mRNA Translation: BAC41201.1
AL117234 mRNA Translation: CAB55301.1
AK296488 mRNA Translation: BAH12371.1
AK302957 mRNA Translation: BAH13855.1
AK316416 mRNA Translation: BAH14787.1
AL033403 Genomic DNA No translation available.
AL161777 Genomic DNA No translation available.
CH471150 Genomic DNA Translation: EAW88427.1
CH471150 Genomic DNA Translation: EAW88430.1
J03639 mRNA Translation: AAA52172.1 Different initiation.
X13230 mRNA Translation: CAA31617.1 Sequence problems.
CCDSiCCDS14667.1 [P10911-1]
CCDS48175.1 [P10911-3]
CCDS55514.1 [P10911-6]
CCDS55515.1 [P10911-2]
CCDS55516.1 [P10911-4]
CCDS55517.1 [P10911-5]
PIRiA28051 TVHUBD
A30040 TVHUDB
S10138
RefSeqiNP_001093325.1, NM_001099855.1 [P10911-3]
NP_001165347.1, NM_001171876.1 [P10911-5]
NP_001165348.1, NM_001171877.1 [P10911-6]
NP_001165349.1, NM_001171878.1 [P10911-2]
NP_001165350.1, NM_001171879.1 [P10911-4]
NP_005360.3, NM_005369.4 [P10911-1]
XP_011529641.1, XM_011531339.2 [P10911-5]
XP_016885020.1, XM_017029531.1 [P10911-5]
UniGeneiHs.387262

3D structure databases

ProteinModelPortaliP10911
SMRiP10911
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110336, 10 interactors
CORUMiP10911
IntActiP10911, 1 interactor
MINTiP10911
STRINGi9606.ENSP00000430276

Chemistry databases

SwissLipidsiSLP:000001545

PTM databases

iPTMnetiP10911
PhosphoSitePlusiP10911

Polymorphism and mutation databases

BioMutaiMCF2
DMDMi92087039

Proteomic databases

jPOSTiP10911
PaxDbiP10911
PeptideAtlasiP10911
PRIDEiP10911
ProteomicsDBi52668
52669 [P10911-2]
52670 [P10911-3]
52671 [P10911-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
4168
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338585; ENSP00000342204; ENSG00000101977 [P10911-4]
ENST00000370573; ENSP00000359605; ENSG00000101977 [P10911-2]
ENST00000370576; ENSP00000359608; ENSG00000101977 [P10911-1]
ENST00000414978; ENSP00000397055; ENSG00000101977 [P10911-3]
ENST00000519895; ENSP00000430276; ENSG00000101977 [P10911-5]
ENST00000536274; ENSP00000438155; ENSG00000101977 [P10911-6]
GeneIDi4168
KEGGihsa:4168
UCSCiuc004fau.4 human [P10911-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4168
DisGeNETi4168
EuPathDBiHostDB:ENSG00000101977.19

GeneCards: human genes, protein and diseases

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GeneCardsi
MCF2
HGNCiHGNC:6940 MCF2
MIMi311030 gene
neXtProtiNX_P10911
OpenTargetsiENSG00000101977
PharmGKBiPA30684

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4240 Eukaryota
ENOG410XPCA LUCA
GeneTreeiENSGT00940000156974
HOGENOMiHOG000231361
HOVERGENiHBG062385
InParanoidiP10911
KOiK20685
OMAiVMHDYQE
OrthoDBi118479at2759
PhylomeDBiP10911
TreeFamiTF318080

Enzyme and pathway databases

ReactomeiR-HSA-193634 Axonal growth inhibition (RHOA activation)
R-HSA-193648 NRAGE signals death through JNK
R-HSA-194840 Rho GTPase cycle
R-HSA-416482 G alpha (12/13) signalling events

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MCF2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MCF2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4168

Protein Ontology

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PROi
PR:P10911

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000101977 Expressed in 135 organ(s), highest expression level in left adrenal gland
CleanExiHS_MCF2
ExpressionAtlasiP10911 baseline and differential
GenevisibleiP10911 HS

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR001251 CRAL-TRIO_dom
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR018159 Spectrin/alpha-actinin
PfamiView protein in Pfam
PF13716 CRAL_TRIO_2, 1 hit
PF00169 PH, 1 hit
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SM00150 SPEC, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
PROSITEiView protein in PROSITE
PS50191 CRAL_TRIO, 1 hit
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMCF2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P10911
Secondary accession number(s): B7Z3Y5
, B7Z869, B7ZAV1, E9PH77, F5H091, P14919, Q5JYJ2, Q5JYJ3, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: March 7, 2006
Last modified: January 16, 2019
This is version 198 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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