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UniProtKB - P10908 (UGPQ_ECOLI)
Protein
Glycerophosphodiester phosphodiesterase, cytoplasmic
Gene
ugpQ
Organism
Escherichia coli (strain K12)
Status
Functioni
Glycerophosphoryl diester phosphodiesterase hydrolyzes deacylated phospholipids to G3P and the corresponding alcohols.
Miscellaneous
There are 2 isozymes of glycerophosphoryl diester phosphodiesterase in E.coli: a periplasmic isozyme (GlpQ) and a cytosolic isozyme (UgpQ).
Catalytic activityi
- EC:3.1.4.461 Publication
Cofactori
Kineticsi
- KM=0.22 mM for glycerophosphoethanolamine1 Publication
- KM=0.66 mM for glycerophosphoserine1 Publication
- KM=0.62 mM for glycerophosphoglycerol1 Publication
- KM=0.39 mM for glycerophosphoinositol1 Publication
- KM=2.0 mM for glycerophosphocholine1 Publication
pH dependencei
Optimum pH is 7.5.1 Publication
GO - Molecular functioni
- glycerophosphocholine phosphodiesterase activity Source: EcoCyc
- glycerophosphodiester phosphodiesterase activity Source: EcoCyc
- glycerophosphoinositol glycerophosphodiesterase activity Source: EcoCyc
- magnesium ion binding Source: EcoCyc
GO - Biological processi
- glycerol metabolic process Source: UniProtKB-KW
- lipid metabolic process Source: InterPro
Keywordsi
Molecular function | Hydrolase |
Biological process | Glycerol metabolism |
Ligand | Magnesium, Metal-binding |
Enzyme and pathway databases
BioCyci | EcoCyc:GLYCPDIESTER-CYTO-MONOMER |
BRENDAi | 3.1.4.46, 2026 |
Names & Taxonomyi
Protein namesi | Recommended name: Glycerophosphodiester phosphodiesterase, cytoplasmic (EC:3.1.4.46)Short name: Glycerophosphoryl diester phosphodiesterase, cytoplasmic |
Gene namesi | Name:ugpQ Ordered Locus Names:b3449, JW3414 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000200574 | 1 – 247 | Glycerophosphodiester phosphodiesterase, cytoplasmicAdd BLAST | 247 |
Proteomic databases
jPOSTi | P10908 |
PaxDbi | P10908 |
PRIDEi | P10908 |
Expressioni
Inductioni
Up-regulated by low levels of phosphate in the medium.1 Publication
Interactioni
Protein-protein interaction databases
BioGRIDi | 4261665, 14 interactors 852264, 3 interactors |
IntActi | P10908, 10 interactors |
STRINGi | 511145.b3449 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 7 – 244 | GP-PDEAdd BLAST | 238 |
Sequence similaritiesi
Belongs to the glycerophosphoryl diester phosphodiesterase family.Curated
Phylogenomic databases
eggNOGi | COG0584, Bacteria |
HOGENOMi | CLU_030006_3_2_6 |
InParanoidi | P10908 |
OMAi | YRMFECD |
PhylomeDBi | P10908 |
Family and domain databases
Gene3Di | 3.20.20.190, 1 hit |
InterProi | View protein in InterPro IPR030395, GP_PDE_dom IPR017946, PLC-like_Pdiesterase_TIM-brl |
Pfami | View protein in Pfam PF03009, GDPD, 1 hit |
SUPFAMi | SSF51695, SSF51695, 1 hit |
PROSITEi | View protein in PROSITE PS51704, GP_PDE, 1 hit |
i Sequence
Sequence statusi: Complete.
P10908-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSNWPYPRIV AHRGGGKLAP ENTLASIDVG AKYGHKMIEF DAKLSKDGEI
60 70 80 90 100
FLLHDDNLER TSNGWGVAGE LNWQDLLRVD AGSWYSKMFK GEPLPLLSQV
110 120 130 140 150
AERCREHGMM ANIEIKPTTG TGPLTGKMVA LAARELWAGM TPPLLSSFEI
160 170 180 190 200
DALEAAQQAA PELPRGLLLD EWRDDWRELT ARLGCVSIHL NHKLLNKARV
210 220 230 240
MQLKDAGLRI LVYTVNKPQR AAELLRWGVD CICTDAIDVI GPNFTAQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X14437 Genomic DNA Translation: CAA32609.1 X13141 Genomic DNA Translation: CAA31535.1 X56908 Genomic DNA Translation: CAA40224.1 U00039 Genomic DNA Translation: AAB18424.1 U00096 Genomic DNA Translation: AAC76474.1 AP009048 Genomic DNA Translation: BAE77844.1 |
PIRi | JV0024, ESECGD |
RefSeqi | NP_417906.1, NC_000913.3 WP_000073623.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC76474; AAC76474; b3449 BAE77844; BAE77844; BAE77844 |
GeneIDi | 947955 |
KEGGi | ecj:JW3414 eco:b3449 |
PATRICi | fig|1411691.4.peg.3278 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X14437 Genomic DNA Translation: CAA32609.1 X13141 Genomic DNA Translation: CAA31535.1 X56908 Genomic DNA Translation: CAA40224.1 U00039 Genomic DNA Translation: AAB18424.1 U00096 Genomic DNA Translation: AAC76474.1 AP009048 Genomic DNA Translation: BAE77844.1 |
PIRi | JV0024, ESECGD |
RefSeqi | NP_417906.1, NC_000913.3 WP_000073623.1, NZ_LN832404.1 |
3D structure databases
AlphaFoldDBi | P10908 |
SMRi | P10908 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4261665, 14 interactors 852264, 3 interactors |
IntActi | P10908, 10 interactors |
STRINGi | 511145.b3449 |
Proteomic databases
jPOSTi | P10908 |
PaxDbi | P10908 |
PRIDEi | P10908 |
Protocols and materials databases
DNASUi | 947955 |
Genome annotation databases
EnsemblBacteriai | AAC76474; AAC76474; b3449 BAE77844; BAE77844; BAE77844 |
GeneIDi | 947955 |
KEGGi | ecj:JW3414 eco:b3449 |
PATRICi | fig|1411691.4.peg.3278 |
Organism-specific databases
EchoBASEi | EB1043 |
Phylogenomic databases
eggNOGi | COG0584, Bacteria |
HOGENOMi | CLU_030006_3_2_6 |
InParanoidi | P10908 |
OMAi | YRMFECD |
PhylomeDBi | P10908 |
Enzyme and pathway databases
BioCyci | EcoCyc:GLYCPDIESTER-CYTO-MONOMER |
BRENDAi | 3.1.4.46, 2026 |
Miscellaneous databases
PROi | PR:P10908 |
Family and domain databases
Gene3Di | 3.20.20.190, 1 hit |
InterProi | View protein in InterPro IPR030395, GP_PDE_dom IPR017946, PLC-like_Pdiesterase_TIM-brl |
Pfami | View protein in Pfam PF03009, GDPD, 1 hit |
SUPFAMi | SSF51695, SSF51695, 1 hit |
PROSITEi | View protein in PROSITE PS51704, GP_PDE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | UGPQ_ECOLI | |
Accessioni | P10908Primary (citable) accession number: P10908 Secondary accession number(s): P22633, Q2M7B2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | July 1, 1989 | |
Last modified: | May 25, 2022 | |
This is version 149 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families