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UniProtKB - P10905 (UGPA_ECOLI)

Entry version 156 (07 Apr 2021)
Sequence version 1 (01 Jul 1989)
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Protein

sn-glycerol-3-phosphate transport system permease protein UgpA

Gene

ugpA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Part of the binding-protein-dependent transport system for sn-glycerol-3-phosphate; probably responsible for the translocation of the substrate across the membrane.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:UGPA-MONOMER
MetaCyc:UGPA-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.6.3.20, 2026

Protein family/group databases

Transport Classification Database

More...TCDBi		3.A.1.1.3, the atp-binding cassette (abc) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
sn-glycerol-3-phosphate transport system permease protein UgpA
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ugpA
Ordered Locus Names:b3452, JW3417
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei12 – 32HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini33 – 80PeriplasmicSequence analysisAdd BLAST48
Transmembranei81 – 101HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini102 – 109CytoplasmicSequence analysis8
Transmembranei110 – 130HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini131 – 156PeriplasmicSequence analysisAdd BLAST26
Transmembranei157 – 177HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini178 – 207CytoplasmicSequence analysisAdd BLAST30
Transmembranei208 – 228HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini229 – 262PeriplasmicSequence analysisAdd BLAST34
Transmembranei263 – 283HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini284 – 295CytoplasmicSequence analysisAdd BLAST12

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000602321 – 295sn-glycerol-3-phosphate transport system permease protein UgpAAdd BLAST295

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P10905

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The complex is composed of two ATP-binding proteins (UgpC), two transmembrane proteins (UgpA and UgpE) and a solute-binding protein (UgpB).

Curated

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		4263421, 175 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-2150, sn-glycerol-3-phosphate ABC transporter complex

Database of interacting proteins

More...DIPi		DIP-11077N

Protein interaction database and analysis system

More...IntActi		P10905, 1 interactor

STRING: functional protein association networks

More...STRINGi		511145.b3452

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P10905

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini76 – 284ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST209

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the binding-protein-dependent transport system permease family. UgpAE subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG1175, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_016047_0_2_6

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P10905

Database for complete collections of gene phylogenies

More...PhylomeDBi		P10905

Family and domain databases

Conserved Domains Database

More...CDDi		cd06261, TM_PBP2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.3720.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000515, MetI-like
IPR035906, MetI-like_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00528, BPD_transp_1, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF161098, SSF161098, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50928, ABC_TM1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P10905-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSSRPVFRS RWLPYLLVAP QLIITVIFFI WPAGEALWYS LQSVDPFGFS 
        60         70         80         90        100
SQFVGLDNFV TLFHDSYYLD SFWTTIKFST FVTVSGLLVS LFFAALVEYI 
       110        120        130        140        150
VRGSRFYQTL MLLPYAVAPA VAAVLWIFLF NPGRGLITHF LAEFGYDWNH 
       160        170        180        190        200
AQNSGQAMFL VVFASVWKQI SYNFLFFYAA LQSIPRSLIE AAAIDGAGPI 
       210        220        230        240        250
RRFFKIALPL IAPVSFFLLV VNLVYAFFDT FPVIDAATSG GPVQATTTLI 
       260        270        280        290 
YKIYREGFTG LDLASSAAQS VVLMFLVIVL TVVQFRYVES KVRYQ
Length:295
Mass (Da):33,264
Last modified:July 1, 1989 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCC8765DE0FB647A9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X13141 Genomic DNA Translation: CAA31532.1
U00039 Genomic DNA Translation: AAB18427.1
U00096 Genomic DNA Translation: AAC76477.1
AP009048 Genomic DNA Translation: BAE77841.1

Protein sequence database of the Protein Information Resource

More...PIRi		S03781, MMECUA

NCBI Reference Sequences

More...RefSeqi		NP_417909.1, NC_000913.3
WP_000099289.1, NZ_SSZK01000008.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC76477; AAC76477; b3452
BAE77841; BAE77841; BAE77841

Database of genes from NCBI RefSeq genomes

More...GeneIDi		57729285
947957

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW3417
eco:b3452

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|1411691.4.peg.3275

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13141 Genomic DNA Translation: CAA31532.1
U00039 Genomic DNA Translation: AAB18427.1
U00096 Genomic DNA Translation: AAC76477.1
AP009048 Genomic DNA Translation: BAE77841.1
PIRiS03781, MMECUA
RefSeqiNP_417909.1, NC_000913.3
WP_000099289.1, NZ_SSZK01000008.1

3D structure databases

SMRiP10905
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi4263421, 175 interactors
ComplexPortaliCPX-2150, sn-glycerol-3-phosphate ABC transporter complex
DIPiDIP-11077N
IntActiP10905, 1 interactor
STRINGi511145.b3452

Protein family/group databases

TCDBi3.A.1.1.3, the atp-binding cassette (abc) superfamily

Proteomic databases

PaxDbiP10905

Genome annotation databases

EnsemblBacteriaiAAC76477; AAC76477; b3452
BAE77841; BAE77841; BAE77841
GeneIDi57729285
947957
KEGGiecj:JW3417
eco:b3452
PATRICifig|1411691.4.peg.3275

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB1039

Phylogenomic databases

eggNOGiCOG1175, Bacteria
HOGENOMiCLU_016047_0_2_6
InParanoidiP10905
PhylomeDBiP10905

Enzyme and pathway databases

BioCyciEcoCyc:UGPA-MONOMER
MetaCyc:UGPA-MONOMER
BRENDAi3.6.3.20, 2026

Miscellaneous databases

Protein Ontology

More...PROi		PR:P10905

Family and domain databases

CDDicd06261, TM_PBP2, 1 hit
Gene3Di1.10.3720.10, 1 hit
InterProiView protein in InterPro
IPR000515, MetI-like
IPR035906, MetI-like_sf
PfamiView protein in Pfam
PF00528, BPD_transp_1, 1 hit
SUPFAMiSSF161098, SSF161098, 1 hit
PROSITEiView protein in PROSITE
PS50928, ABC_TM1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUGPA_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P10905
Secondary accession number(s): Q2M7B5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: April 7, 2021
This is version 156 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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