UniProtKB - P10905 (UGPA_ECOLI)
Protein
sn-glycerol-3-phosphate transport system permease protein UgpA
Gene
ugpA
Organism
Escherichia coli (strain K12)
Status
Functioni
Part of the binding-protein-dependent transport system for sn-glycerol-3-phosphate; probably responsible for the translocation of the substrate across the membrane.
GO - Molecular functioni
- glycerol-3-phosphate transmembrane transporter activity Source: EcoCyc
- glycerophosphodiester transmembrane transporter activity Source: EcoCyc
GO - Biological processi
- glycerol-3-phosphate transmembrane transport Source: EcoCyc
- glycerophosphodiester transmembrane transport Source: EcoCyc
Keywordsi
Biological process | Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:UGPA-MONOMER MetaCyc:UGPA-MONOMER |
BRENDAi | 3.6.3.20, 2026 |
Protein family/group databases
TCDBi | 3.A.1.1.3, the atp-binding cassette (abc) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: sn-glycerol-3-phosphate transport system permease protein UgpA |
Gene namesi | Name:ugpA Ordered Locus Names:b3452, JW3417 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
Plasma Membrane
- ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing Source: EcoCyc
- plasma membrane Source: EcoCyc
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 11 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 12 – 32 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 33 – 80 | PeriplasmicSequence analysisAdd BLAST | 48 | |
Transmembranei | 81 – 101 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 102 – 109 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 110 – 130 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 131 – 156 | PeriplasmicSequence analysisAdd BLAST | 26 | |
Transmembranei | 157 – 177 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 178 – 207 | CytoplasmicSequence analysisAdd BLAST | 30 | |
Transmembranei | 208 – 228 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 229 – 262 | PeriplasmicSequence analysisAdd BLAST | 34 | |
Transmembranei | 263 – 283 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 284 – 295 | CytoplasmicSequence analysisAdd BLAST | 12 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000060232 | 1 – 295 | sn-glycerol-3-phosphate transport system permease protein UgpAAdd BLAST | 295 |
Proteomic databases
PaxDbi | P10905 |
Interactioni
Subunit structurei
The complex is composed of two ATP-binding proteins (UgpC), two transmembrane proteins (UgpA and UgpE) and a solute-binding protein (UgpB).
CuratedProtein-protein interaction databases
BioGRIDi | 4263421, 175 interactors |
ComplexPortali | CPX-2150, sn-glycerol-3-phosphate ABC transporter complex |
DIPi | DIP-11077N |
IntActi | P10905, 1 interactor |
STRINGi | 511145.b3452 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 76 – 284 | ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST | 209 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG1175, Bacteria |
HOGENOMi | CLU_016047_0_2_6 |
InParanoidi | P10905 |
PhylomeDBi | P10905 |
Family and domain databases
CDDi | cd06261, TM_PBP2, 1 hit |
Gene3Di | 1.10.3720.10, 1 hit |
InterProi | View protein in InterPro IPR000515, MetI-like IPR035906, MetI-like_sf |
Pfami | View protein in Pfam PF00528, BPD_transp_1, 1 hit |
SUPFAMi | SSF161098, SSF161098, 1 hit |
PROSITEi | View protein in PROSITE PS50928, ABC_TM1, 1 hit |
i Sequence
Sequence statusi: Complete.
P10905-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSSRPVFRS RWLPYLLVAP QLIITVIFFI WPAGEALWYS LQSVDPFGFS
60 70 80 90 100
SQFVGLDNFV TLFHDSYYLD SFWTTIKFST FVTVSGLLVS LFFAALVEYI
110 120 130 140 150
VRGSRFYQTL MLLPYAVAPA VAAVLWIFLF NPGRGLITHF LAEFGYDWNH
160 170 180 190 200
AQNSGQAMFL VVFASVWKQI SYNFLFFYAA LQSIPRSLIE AAAIDGAGPI
210 220 230 240 250
RRFFKIALPL IAPVSFFLLV VNLVYAFFDT FPVIDAATSG GPVQATTTLI
260 270 280 290
YKIYREGFTG LDLASSAAQS VVLMFLVIVL TVVQFRYVES KVRYQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X13141 Genomic DNA Translation: CAA31532.1 U00039 Genomic DNA Translation: AAB18427.1 U00096 Genomic DNA Translation: AAC76477.1 AP009048 Genomic DNA Translation: BAE77841.1 |
PIRi | S03781, MMECUA |
RefSeqi | NP_417909.1, NC_000913.3 WP_000099289.1, NZ_SSZK01000008.1 |
Genome annotation databases
EnsemblBacteriai | AAC76477; AAC76477; b3452 BAE77841; BAE77841; BAE77841 |
GeneIDi | 57729285 947957 |
KEGGi | ecj:JW3417 eco:b3452 |
PATRICi | fig|1411691.4.peg.3275 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X13141 Genomic DNA Translation: CAA31532.1 U00039 Genomic DNA Translation: AAB18427.1 U00096 Genomic DNA Translation: AAC76477.1 AP009048 Genomic DNA Translation: BAE77841.1 |
PIRi | S03781, MMECUA |
RefSeqi | NP_417909.1, NC_000913.3 WP_000099289.1, NZ_SSZK01000008.1 |
3D structure databases
SMRi | P10905 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4263421, 175 interactors |
ComplexPortali | CPX-2150, sn-glycerol-3-phosphate ABC transporter complex |
DIPi | DIP-11077N |
IntActi | P10905, 1 interactor |
STRINGi | 511145.b3452 |
Protein family/group databases
TCDBi | 3.A.1.1.3, the atp-binding cassette (abc) superfamily |
Proteomic databases
PaxDbi | P10905 |
Genome annotation databases
EnsemblBacteriai | AAC76477; AAC76477; b3452 BAE77841; BAE77841; BAE77841 |
GeneIDi | 57729285 947957 |
KEGGi | ecj:JW3417 eco:b3452 |
PATRICi | fig|1411691.4.peg.3275 |
Organism-specific databases
EchoBASEi | EB1039 |
Phylogenomic databases
eggNOGi | COG1175, Bacteria |
HOGENOMi | CLU_016047_0_2_6 |
InParanoidi | P10905 |
PhylomeDBi | P10905 |
Enzyme and pathway databases
BioCyci | EcoCyc:UGPA-MONOMER MetaCyc:UGPA-MONOMER |
BRENDAi | 3.6.3.20, 2026 |
Miscellaneous databases
PROi | PR:P10905 |
Family and domain databases
CDDi | cd06261, TM_PBP2, 1 hit |
Gene3Di | 1.10.3720.10, 1 hit |
InterProi | View protein in InterPro IPR000515, MetI-like IPR035906, MetI-like_sf |
Pfami | View protein in Pfam PF00528, BPD_transp_1, 1 hit |
SUPFAMi | SSF161098, SSF161098, 1 hit |
PROSITEi | View protein in PROSITE PS50928, ABC_TM1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UGPA_ECOLI | |
Accessioni | P10905Primary (citable) accession number: P10905 Secondary accession number(s): Q2M7B5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | July 1, 1989 | |
Last modified: | April 7, 2021 | |
This is version 156 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families