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Protein

C-X-C motif chemokine 2

Gene

Cxcl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Chemotactic for human polymorphonuclear leukocytes but does not induce chemokinesis or an oxidative burst.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiR-MMU-380108 Chemokine receptors bind chemokines
R-MMU-418594 G alpha (i) signalling events
R-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 2
Alternative name(s):
Macrophage inflammatory protein 2
Short name:
MIP2
Gene namesi
Name:Cxcl2
Synonyms:Mip-2, Mip2, Scyb2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1340094 Cxcl2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 271 PublicationAdd BLAST27
ChainiPRO_000000506128 – 100C-X-C motif chemokine 2Add BLAST73

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 62
Disulfide bondi38 ↔ 78

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP10889
PRIDEiP10889

Miscellaneous databases

PMAP-CutDBiP10889

Expressioni

Gene expression databases

BgeeiENSMUSG00000058427 Expressed in 51 organ(s), highest expression level in epididymal fat pad
CleanExiMM_CXCL2
ExpressionAtlasiP10889 baseline and differential
GenevisibleiP10889 MM

Interactioni

Subunit structurei

Homotetramer.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203135, 1 interactor
DIPiDIP-61570N
IntActiP10889, 1 interactor
STRINGi10090.ENSMUSP00000074885

Structurei

Secondary structure

1100
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP10889
SMRiP10889
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10889

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3WE Eukaryota
ENOG410ZT1C LUCA
GeneTreeiENSGT00530000062901
HOGENOMiHOG000220915
HOVERGENiHBG107789
InParanoidiP10889
KOiK05505
OMAiANSHCEK
OrthoDBiEOG091G14TE
PhylomeDBiP10889
TreeFamiTF333433

Family and domain databases

CDDicd00273 Chemokine_CXC, 1 hit
InterProiView protein in InterPro
IPR001089 Chemokine_CXC
IPR018048 Chemokine_CXC_CS
IPR001811 Chemokine_IL8-like_dom
IPR033899 CXC_Chemokine_domain
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR10179 PTHR10179, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
PRINTSiPR00437 SMALLCYTKCXC
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00471 SMALL_CYTOKINES_CXC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P10889-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPPTCRLLS AALVLLLLLA TNHQATGAVV ASELRCQCLK TLPRVDFKNI
60 70 80 90 100
QSLSVTPPGP HCAQTEVIAT LKGGQKVCLD PEAPLVQKII QKILNKGKAN
Length:100
Mass (Da):10,621
Last modified:February 1, 1991 - v2
Checksum:iB9EF0A3218EE92B5
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3U1L9Q3U1L9_MOUSE
C-X-C motif chemokine
Cxcl2
96Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53798 mRNA Translation: CAA37807.1
CCDSiCCDS39144.1
PIRiJH0200
RefSeqiNP_033166.1, NM_009140.2
UniGeneiMm.4979

Genome annotation databases

EnsembliENSMUST00000075433; ENSMUSP00000074885; ENSMUSG00000058427
GeneIDi20310
KEGGimmu:20310
UCSCiuc008ybm.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53798 mRNA Translation: CAA37807.1
CCDSiCCDS39144.1
PIRiJH0200
RefSeqiNP_033166.1, NM_009140.2
UniGeneiMm.4979

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MI2NMR-A/B28-100[»]
3N52X-ray1.90A/B/C/D28-100[»]
ProteinModelPortaliP10889
SMRiP10889
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203135, 1 interactor
DIPiDIP-61570N
IntActiP10889, 1 interactor
STRINGi10090.ENSMUSP00000074885

Proteomic databases

PaxDbiP10889
PRIDEiP10889

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075433; ENSMUSP00000074885; ENSMUSG00000058427
GeneIDi20310
KEGGimmu:20310
UCSCiuc008ybm.1 mouse

Organism-specific databases

CTDi2920
MGIiMGI:1340094 Cxcl2

Phylogenomic databases

eggNOGiENOG410J3WE Eukaryota
ENOG410ZT1C LUCA
GeneTreeiENSGT00530000062901
HOGENOMiHOG000220915
HOVERGENiHBG107789
InParanoidiP10889
KOiK05505
OMAiANSHCEK
OrthoDBiEOG091G14TE
PhylomeDBiP10889
TreeFamiTF333433

Enzyme and pathway databases

ReactomeiR-MMU-380108 Chemokine receptors bind chemokines
R-MMU-418594 G alpha (i) signalling events
R-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

EvolutionaryTraceiP10889
PMAP-CutDBiP10889
PROiPR:P10889
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000058427 Expressed in 51 organ(s), highest expression level in epididymal fat pad
CleanExiMM_CXCL2
ExpressionAtlasiP10889 baseline and differential
GenevisibleiP10889 MM

Family and domain databases

CDDicd00273 Chemokine_CXC, 1 hit
InterProiView protein in InterPro
IPR001089 Chemokine_CXC
IPR018048 Chemokine_CXC_CS
IPR001811 Chemokine_IL8-like_dom
IPR033899 CXC_Chemokine_domain
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR10179 PTHR10179, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
PRINTSiPR00437 SMALLCYTKCXC
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00471 SMALL_CYTOKINES_CXC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCXCL2_MOUSE
AccessioniPrimary (citable) accession number: P10889
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: February 1, 1991
Last modified: November 7, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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