UniProtKB - P10881 (LA_BOVIN)
Protein
Lupus La protein homolog
Gene
SSB
Organism
Bos taurus (Bovine)
Status
Functioni
Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation.
GO - Molecular functioni
- poly(U) RNA binding Source: Ensembl
- sequence-specific mRNA binding Source: Ensembl
- tRNA binding Source: Ensembl
GO - Biological processi
- IRES-dependent viral translational initiation Source: Ensembl
- nuclear histone mRNA catabolic process Source: Ensembl
- protein localization to cytoplasmic stress granule Source: Ensembl
- tRNA 3'-end processing Source: Ensembl
- tRNA 5'-leader removal Source: Ensembl
- tRNA export from nucleus Source: Ensembl
Keywordsi
Molecular function | RNA-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Lupus La protein homologAlternative name(s): La autoantigen homolog La ribonucleoprotein |
Gene namesi | Name:SSB |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:58554, SSB |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: Ensembl
- ribonucleoprotein complex Source: InterPro
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000207598 | 1 – 404 | Lupus La protein homologAdd BLAST | 404 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 92 | PhosphoserineBy similarity | 1 | |
Modified residuei | 94 | PhosphoserineBy similarity | 1 | |
Modified residuei | 116 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 120 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 128 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 225 | PhosphoserineBy similarity | 1 | |
Modified residuei | 328 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 341 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 360 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 362 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 366 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Phosphorylated in the C-terminal part of the protein.
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
PaxDbi | P10881 |
PeptideAtlasi | P10881 |
PRIDEi | P10881 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000008716, Expressed in spermatocyte and 19 other tissues |
Interactioni
Subunit structurei
Interacts with DDX15. May interact with RUFY1 (By similarity).
By similarityProtein-protein interaction databases
STRINGi | 9913.ENSBTAP00000011484 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 7 – 99 | HTH La-type RNA-bindingPROSITE-ProRule annotationAdd BLAST | 93 | |
Domaini | 111 – 187 | RRMPROSITE-ProRule annotationAdd BLAST | 77 | |
Domaini | 227 – 348 | xRRMPROSITE-ProRule annotationAdd BLAST | 122 |
Phylogenomic databases
eggNOGi | KOG4213, Eukaryota |
GeneTreei | ENSGT00830000128380 |
HOGENOMi | CLU_042341_0_0_1 |
InParanoidi | P10881 |
OMAi | EYYFGNH |
OrthoDBi | 882725at2759 |
TreeFami | TF314476 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit 3.30.70.330, 2 hits |
InterProi | View protein in InterPro IPR006630, La_HTH IPR014886, La_RRM IPR002344, Lupus_La IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF05383, La, 1 hit PF00076, RRM_1, 1 hit PF08777, RRM_3, 1 hit |
PRINTSi | PR00302, LUPUSLA |
SMARTi | View protein in SMART SM00715, LA, 1 hit SM00360, RRM, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF54928, SSF54928, 2 hits |
PROSITEi | View protein in PROSITE PS50961, HTH_LA, 1 hit PS50102, RRM, 1 hit PS51939, XRRM, 1 hit |
i Sequence
Sequence statusi: Complete.
P10881-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAENGDNEKM AALEAKICHQ IEYYFGDFNL PRDKFLKEQI KLDEGWVPLE
60 70 80 90 100
IMIKFNRLNR LTTDFNVIVE ALSKSKAELM EISEDKTKIR RSPSKPLPEV
110 120 130 140 150
TDEYKNDVKN RSVYIKGFPT DAALDDIKEW LEDKGQVLNI QMRRTLHKAF
160 170 180 190 200
KGSIFAVFDS IESAKKFVET PGQKYKDTDL LILFKEDYFT KKNEERKQNK
210 220 230 240 250
MEAKLRAKQE QEEKQKLAEN AEMKSLEEKI GCLLKFSGDL DDQTCREDLH
260 270 280 290 300
TLFSNHGEIK WIHFVRGAKE GIILFKEKAK EALDKAKEAN NGNLQLRNKE
310 320 330 340 350
VTWEVLEGDV EKEALKKIIE DQQESLNKWK SKGRRFKGKG KGNKAAQAGS
360 370 380 390 400
AKGKVQFQGK KTKFDSDDER DENGASRAVK RAREETDKEP PSKQQKTENG
AGDQ
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 76 | K → E in CAA31986 (PubMed:2468131).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X13698 mRNA Translation: CAA31986.1 BC103234 mRNA Translation: AAI03235.1 |
PIRi | S03849 |
RefSeqi | NP_788838.1, NM_176665.2 |
Genome annotation databases
Ensembli | ENSBTAT00000011484; ENSBTAP00000011484; ENSBTAG00000008716 |
GeneIDi | 338071 |
KEGGi | bta:338071 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X13698 mRNA Translation: CAA31986.1 BC103234 mRNA Translation: AAI03235.1 |
PIRi | S03849 |
RefSeqi | NP_788838.1, NM_176665.2 |
3D structure databases
BMRBi | P10881 |
SMRi | P10881 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000011484 |
Proteomic databases
PaxDbi | P10881 |
PeptideAtlasi | P10881 |
PRIDEi | P10881 |
Genome annotation databases
Ensembli | ENSBTAT00000011484; ENSBTAP00000011484; ENSBTAG00000008716 |
GeneIDi | 338071 |
KEGGi | bta:338071 |
Organism-specific databases
CTDi | 6741 |
VGNCi | VGNC:58554, SSB |
Phylogenomic databases
eggNOGi | KOG4213, Eukaryota |
GeneTreei | ENSGT00830000128380 |
HOGENOMi | CLU_042341_0_0_1 |
InParanoidi | P10881 |
OMAi | EYYFGNH |
OrthoDBi | 882725at2759 |
TreeFami | TF314476 |
Gene expression databases
Bgeei | ENSBTAG00000008716, Expressed in spermatocyte and 19 other tissues |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit 3.30.70.330, 2 hits |
InterProi | View protein in InterPro IPR006630, La_HTH IPR014886, La_RRM IPR002344, Lupus_La IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF05383, La, 1 hit PF00076, RRM_1, 1 hit PF08777, RRM_3, 1 hit |
PRINTSi | PR00302, LUPUSLA |
SMARTi | View protein in SMART SM00715, LA, 1 hit SM00360, RRM, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF54928, SSF54928, 2 hits |
PROSITEi | View protein in PROSITE PS50961, HTH_LA, 1 hit PS50102, RRM, 1 hit PS51939, XRRM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LA_BOVIN | |
Accessioni | P10881Primary (citable) accession number: P10881 Secondary accession number(s): Q3ZBL2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | April 3, 2007 | |
Last modified: | December 2, 2020 | |
This is version 143 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |