HOM3

Functionⁱ

Miscellaneous

Present with 48100 molecules/cell in log phase SD medium.1 Publication

Catalytic activityⁱ

ATP + L-aspartate = ADP + 4-phospho-L-aspartate.

Pathwayⁱ: L-lysine biosynthesis via DAP pathway

This protein is involved in step 1 of the subpathway that synthesizes (S)-tetrahydrodipicolinate from L-aspartate.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:

Aspartokinase (HOM3)
Aspartate-semialdehyde dehydrogenase (HOM2)
no protein annotated in this organism
no protein annotated in this organism

This subpathway is part of the pathway L-lysine biosynthesis via DAP pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-tetrahydrodipicolinate from L-aspartate, the pathway L-lysine biosynthesis via DAP pathway and in Amino-acid biosynthesis.

Pathwayⁱ: L-methionine biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes L-homoserine from L-aspartate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:

Aspartokinase (HOM3)
Aspartate-semialdehyde dehydrogenase (HOM2)
Homoserine dehydrogenase (HOM6)

This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homoserine from L-aspartate, the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

Pathwayⁱ: L-threonine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-threonine from L-aspartate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:

Aspartokinase (HOM3)
Aspartate-semialdehyde dehydrogenase (HOM2)
Homoserine dehydrogenase (HOM6)
Homoserine kinase (THR1)
Threonine synthase (THR4)

This subpathway is part of the pathway L-threonine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-threonine from L-aspartate, the pathway L-threonine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functionⁱ

aspartate kinase activity
Source: SGD
Inferred from direct assayⁱ
- 18626862
ATP binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

homoserine biosynthetic process
Source: SGD
Inferred from mutant phenotypeⁱ
- 4380684
lysine biosynthetic process via diaminopimelate Source: GO_Central
methionine biosynthetic process
Source: SGD
Inferred from mutant phenotypeⁱ
- 4380684
threonine biosynthetic process
Source: SGD
Inferred from direct assayⁱ
- 18626862

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Transferase
Biological process	Amino-acid biosynthesis, Threonine biosynthesis
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCycⁱ	YEAST:YER052C-MONOMER
BRENDAⁱ	2.7.2.4 984
SABIO-RKⁱ	P10869
UniPathwayⁱ	UPA00034; UER00015 UPA00050; UER00461 UPA00051; UER00462

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Aspartokinase (EC:2.7.2.4) Alternative name(s): Aspartate kinase
Gene namesⁱ	Name:HOM3 Ordered Locus Names:YER052C
Organismⁱ	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifierⁱ	559292 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae
Proteomesⁱ	UP000002311 Componentⁱ: Chromosome V

Organism-specific databases

EuPathDBⁱ	FungiDB:YER052C
Saccharomyces Genome Database More...SGDⁱ	S000000854 HOM3

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000066690	1 – 527	AspartokinaseAdd BLAST		527

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	333	PhosphothreonineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P10869
PaxDbⁱ	P10869
PRIDEⁱ	P10869

PTM databases

iPTMnetⁱ	P10869

iPTMnetⁱ

P10869

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
FPR1	P20081	3	EBI-2430,EBI-6961

With

Entry

#Exp.

IntAct

Notes

FPR1

P20081

3

EBI-2430,EBI-6961

Protein-protein interaction databases

BioGridⁱ	36791, 290 interactors
Database of interacting proteins More...DIPⁱ	DIP-1319N
IntActⁱ	P10869, 12 interactors
Molecular INTeraction database More...MINTⁱ	P10869
STRINGⁱ	4932.YER052C

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P10869
SMRⁱ	P10869
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	367 – 440	ACT 1PROSITE-ProRule annotationAdd BLAST		74
Domainⁱ	442 – 527	ACT 2PROSITE-ProRule annotationAdd BLAST		86

Sequence similaritiesⁱ

Belongs to the aspartokinase family.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

HOGENOMⁱ	HOG000293094
InParanoidⁱ	P10869
KEGG Orthology (KO) More...KOⁱ	K00928
OMAⁱ	INIMMIS
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C1PG8

Family and domain databases

Gene3Dⁱ	3.40.1160.10, 1 hit
InterProⁱ	View protein in InterPro IPR036393 AceGlu_kinase-like_sf IPR002912 ACT_dom IPR001048 Asp/Glu/Uridylate_kinase IPR001341 Asp_kinase IPR018042 Aspartate_kinase_CS IPR027795 CASTOR_ACT_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00696 AA_kinase, 1 hit PF13840 ACT_7, 1 hit
SUPFAMⁱ	SSF53633 SSF53633, 1 hit
TIGRFAMsⁱ	TIGR00657 asp_kinases, 1 hit
PROSITEⁱ	View protein in PROSITE PS51671 ACT, 1 hit PS00324 ASPARTOKINASE, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P10869-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPMDFQPTSS HSNWVVQKFG GTSVGKFPVQ IVDDIVKHYS KPDGPNNNVA 
        60         70         80         90        100
VVCSARSSYT KAEGTTSRLL KCCDLASQES EFQDIIEVIR QDHIDNADRF 
       110        120        130        140        150
ILNPALQAKL VDDTNKELEL VKKYLNASKV LGEVSSRTVD LVMSCGEKLS 
       160        170        180        190        200
CLFMTALCND RGCKAKYVDL SHIVPSDFSA SALDNSFYTF LVQALKEKLA 
       210        220        230        240        250
PFVSAKERIV PVFTGFFGLV PTGLLNGVGR GYTDLCAALI AVAVNADELQ 
       260        270        280        290        300
VWKEVDGIFT ADPRKVPEAR LLDSVTPEEA SELTYYGSEV IHPFTMEQVI 
       310        320        330        340        350
RAKIPIRIKN VQNPLGNGTI IYPDNVAKKG ESTPPHPPEN LSSSFYEKRK 
       360        370        380        390        400
RGATAITTKN DIFVINIHSN KKTLSHGFLA QIFTILDKYK LVVDLISTSE 
       410        420        430        440        450
VHVSMALPIP DADSLKSLRQ AEEKLRILGS VDITKKLSIV SLVGKHMKQY 
       460        470        480        490        500
IGIAGTMFTT LAEEGINIEM ISQGANEINI SCVINESDSI KALQCIHAKL 
       510        520 
LSERTNTSNQ FEHAIDERLE QLKRLGI

Length:527

Mass (Da):58,110

Last modified:August 1, 1990 - v2

Checksum:ⁱD4D28FB8D4374898

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J03526 Genomic DNA Translation: AAA34681.1 U18796 Genomic DNA Translation: AAB64587.1 BK006939 Genomic DNA Translation: DAA07708.1
PIRⁱ	A35888 KIBYD
NCBI Reference Sequences More...RefSeqⁱ	NP_010972.1, NM_001178943.1

Genome annotation databases

EnsemblFungiⁱ	YER052C; YER052C; YER052C
GeneIDⁱ	856778
KEGGⁱ	sce:YER052C

Protein	Similar proteins		Species	Score	Length
P10869	Aspartokinase		YEASK		527
Aspartokinase		YEASO		527
Aspartokinase		YEASC		527

Protein	Similar proteins		Species	Score	Length
P10869	Aspartokinase		YEASK		527
Aspartokinase		YEASO		527
Aspartokinase		YEASC		527
Aspartokinase		YEASB		527
Aspartokinase		YEAS1		527
+13

Protein	Similar proteins		Species	Score	Length
P10869	Aspartokinase		YEASK		527
Aspartokinase		YEASO		527
Aspartokinase		YEASC		527
Aspartokinase		SACCK		527
Aspartokinase		YEASL		527
+374

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J03526 Genomic DNA Translation: AAA34681.1 U18796 Genomic DNA Translation: AAB64587.1 BK006939 Genomic DNA Translation: DAA07708.1
PIRⁱ	A35888 KIBYD
NCBI Reference Sequences More...RefSeqⁱ	NP_010972.1, NM_001178943.1

3D structure databases

ProteinModelPortalⁱ	P10869
SMRⁱ	P10869
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	36791, 290 interactors
Database of interacting proteins More...DIPⁱ	DIP-1319N
IntActⁱ	P10869, 12 interactors
Molecular INTeraction database More...MINTⁱ	P10869
STRINGⁱ	4932.YER052C

PTM databases

iPTMnetⁱ	P10869

iPTMnetⁱ

P10869

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P10869
PaxDbⁱ	P10869
PRIDEⁱ	P10869

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	YER052C; YER052C; YER052C
GeneIDⁱ	856778
KEGGⁱ	sce:YER052C

Organism-specific databases

EuPathDBⁱ	FungiDB:YER052C
Saccharomyces Genome Database More...SGDⁱ	S000000854 HOM3

Phylogenomic databases

HOGENOMⁱ	HOG000293094
InParanoidⁱ	P10869
KEGG Orthology (KO) More...KOⁱ	K00928
OMAⁱ	INIMMIS
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C1PG8

Enzyme and pathway databases

UniPathwayⁱ	UPA00034; UER00015 UPA00050; UER00461 UPA00051; UER00462
BioCycⁱ	YEAST:YER052C-MONOMER
BRENDAⁱ	2.7.2.4 984
SABIO-RKⁱ	P10869

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P10869

PROⁱ

PR:P10869

Family and domain databases

Gene3Dⁱ	3.40.1160.10, 1 hit
InterProⁱ	View protein in InterPro IPR036393 AceGlu_kinase-like_sf IPR002912 ACT_dom IPR001048 Asp/Glu/Uridylate_kinase IPR001341 Asp_kinase IPR018042 Aspartate_kinase_CS IPR027795 CASTOR_ACT_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00696 AA_kinase, 1 hit PF13840 ACT_7, 1 hit
SUPFAMⁱ	SSF53633 SSF53633, 1 hit
TIGRFAMsⁱ	TIGR00657 asp_kinases, 1 hit
PROSITEⁱ	View protein in PROSITE PS51671 ACT, 1 hit PS00324 ASPARTOKINASE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AK_YEAST
Accessionⁱ	P10869Primary (citable) accession number: P10869 Secondary accession number(s): D3DLV4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
	Last sequence update:	August 1, 1990
	Last modified:	July 18, 2018
	This is version 167 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

PATHWAY comments
Index of metabolic and biosynthesis pathways
SIMILARITY comments
Index of protein domains and families
Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
Yeast chromosome V
Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P10869 (AK_YEAST)

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Aspartokinase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-lysine biosynthesis via DAP pathway

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-methionine biosynthesis via de novo pathway

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-threonine biosynthesis

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

Pathwayⁱ: L-lysine biosynthesis via DAP pathway

Pathwayⁱ: L-methionine biosynthesis via de novo pathway

Pathwayⁱ: L-threonine biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ