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Protein

Spermatid nuclear transition protein 1

Gene

Tnp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals (PubMed:10781074, PubMed:15163613, PubMed:15189834, PubMed:15083521, PubMed:28366643). In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction (PubMed:28366643). The histone H2AFB1-HIST1H2BA/TH2B dimer is required for loading of TNP1 onto chromatin (PubMed:28366643).5 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Spermatid nuclear transition protein 1
Short name:
STP-1
Short name:
TP-1
Gene namesi
Name:Tnp1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:98784 Tnp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

Pathology & Biotechi

Disruption phenotypei

Reduced fertility in males (PubMed:10781074). Testis weights and sperm production are normal but sperm motility is severely reduced (PubMed:10781074). A significant proportion of Prm2 remains unprocessed (PubMed:10781074, PubMed:15163613, PubMed:15189834, PubMed:15083521). Male mice lacking both Tnp1 and Tnp2 are completely infertile, but protamine alone are capable of histone eviction (PubMed:15163613, PubMed:15189834, PubMed:15083521). Chromatin in mature spermatozoa shows defects in density (PubMed:15189834, PubMed:15083521).4 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001914181 – 55Spermatid nuclear transition protein 1Add BLAST55

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei36PhosphoserineBy similarity1
Modified residuei40PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP10856
PRIDEiP10856

PTM databases

iPTMnetiP10856
PhosphoSitePlusiP10856

Expressioni

Tissue specificityi

Testis-specific.1 Publication

Developmental stagei

Appears in elongating/condensing spermatids when histones are still detectable (PubMed:15163613). Coexpressed with H2afb1 during late spermiogenesis (PubMed:28366643).2 Publications

Gene expression databases

BgeeiENSMUSG00000026182 Expressed in 90 organ(s), highest expression level in testis
CleanExiMM_TNP1
ExpressionAtlasiP10856 baseline and differential
GenevisibleiP10856 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027374

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410JJTU Eukaryota
ENOG4111B50 LUCA
GeneTreeiENSGT00390000000539
HOGENOMiHOG000136637
HOVERGENiHBG094887
InParanoidiP10856
OMAiKRCDDAN
PhylomeDBiP10856
TreeFamiTF338391

Family and domain databases

InterProiView protein in InterPro
IPR001319 Nuclear_transition_prot1
IPR020062 Nuclear_transition_prot1_CS
PANTHERiPTHR17486 PTHR17486, 1 hit
PfamiView protein in Pfam
PF02079 TP1, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD010292 TP1, 1 hit
PROSITEiView protein in PROSITE
PS00541 TP1, 1 hit

Sequencei

Sequence statusi: Complete.

P10856-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTSRKLKTH GMRRGKNRAP HKGVKRGGSK RKYRKSVLKS RKRGDDASRN

YRSHL
Length:55
Mass (Da):6,407
Last modified:January 23, 2007 - v2
Checksum:iC3715E99698A7B92
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12521 mRNA Translation: CAA31039.1
S80846 Genomic DNA Translation: AAB21244.2
BC048494 mRNA Translation: AAH48494.1
BC061170 mRNA Translation: AAH61170.1
CCDSiCCDS35611.1
PIRiA40561 BGMS
RefSeqiNP_033433.1, NM_009407.2
UniGeneiMm.425024

Genome annotation databases

EnsembliENSMUST00000027374; ENSMUSP00000027374; ENSMUSG00000026182
GeneIDi21958
KEGGimmu:21958
UCSCiuc007bkz.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12521 mRNA Translation: CAA31039.1
S80846 Genomic DNA Translation: AAB21244.2
BC048494 mRNA Translation: AAH48494.1
BC061170 mRNA Translation: AAH61170.1
CCDSiCCDS35611.1
PIRiA40561 BGMS
RefSeqiNP_033433.1, NM_009407.2
UniGeneiMm.425024

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027374

PTM databases

iPTMnetiP10856
PhosphoSitePlusiP10856

Proteomic databases

PaxDbiP10856
PRIDEiP10856

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027374; ENSMUSP00000027374; ENSMUSG00000026182
GeneIDi21958
KEGGimmu:21958
UCSCiuc007bkz.2 mouse

Organism-specific databases

CTDi7141
MGIiMGI:98784 Tnp1

Phylogenomic databases

eggNOGiENOG410JJTU Eukaryota
ENOG4111B50 LUCA
GeneTreeiENSGT00390000000539
HOGENOMiHOG000136637
HOVERGENiHBG094887
InParanoidiP10856
OMAiKRCDDAN
PhylomeDBiP10856
TreeFamiTF338391

Miscellaneous databases

ChiTaRSiTnp1 mouse
PROiPR:P10856
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026182 Expressed in 90 organ(s), highest expression level in testis
CleanExiMM_TNP1
ExpressionAtlasiP10856 baseline and differential
GenevisibleiP10856 MM

Family and domain databases

InterProiView protein in InterPro
IPR001319 Nuclear_transition_prot1
IPR020062 Nuclear_transition_prot1_CS
PANTHERiPTHR17486 PTHR17486, 1 hit
PfamiView protein in Pfam
PF02079 TP1, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD010292 TP1, 1 hit
PROSITEiView protein in PROSITE
PS00541 TP1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTP1_MOUSE
AccessioniPrimary (citable) accession number: P10856
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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