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Protein

C-C motif chemokine 3

Gene

Ccl3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Monokine with inflammatory, pyrogenic and chemokinetic properties. Has a potent chemotactic activity for eosinophils. Binding to a high-affinity receptor activates calcium release in neutrophils.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 3
Alternative name(s):
Heparin-binding chemotaxis protein
L2G25B
Macrophage inflammatory protein 1-alpha
Short name:
MIP-1-alpha
SIS-alpha
Small-inducible cytokine A3
TY-5
Gene namesi
Name:Ccl3
Synonyms:Mip1a, Scya3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:98260 Ccl3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000000515824 – 92C-C motif chemokine 3Add BLAST69

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 57By similarity
Disulfide bondi35 ↔ 73By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP10855
PeptideAtlasiP10855
PRIDEiP10855

Expressioni

Tissue specificityi

Expressed in lung, spleen, and pancreas.

Gene expression databases

BgeeiENSMUSG00000000982 Expressed in 36 organ(s), highest expression level in stroma of bone marrow
CleanExiMM_CCL3
ExpressionAtlasiP10855 baseline and differential
GenevisibleiP10855 MM

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
RHVP.R17E9M5R04EBI-16188162,EBI-16188152From Cricetid gammaherpesvirus 2.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203127, 1 interactor
DIPiDIP-61916N
IntActiP10855, 1 interactor
STRINGi10090.ENSMUSP00000001008

Structurei

Secondary structure

192
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP10855
SMRiP10855
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J4I9 Eukaryota
ENOG410YXJU LUCA
GeneTreeiENSGT00900000140870
HOGENOMiHOG000036685
HOVERGENiHBG017871
InParanoidiP10855
KOiK05408
OMAiMALCNQV
OrthoDBiEOG091G14Y2
PhylomeDBiP10855
TreeFamiTF334888

Family and domain databases

InterProiView protein in InterPro
IPR039809 Chemokine_b/g/d
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR12015 PTHR12015, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10855-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKVSTTALAV LLCTMTLCNQ VFSAPYGADT PTACCFSYSR KIPRQFIVDY
60 70 80 90
FETSSLCSQP GVIFLTKRNR QICADSKETW VQEYITDLEL NA
Length:92
Mass (Da):10,345
Last modified:April 1, 1990 - v2
Checksum:i8BFF2DE7C6DEDD38
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22F → L in AAA40146 (PubMed:2521353).Curated1
Sequence conflicti62V → A in AAA40146 (PubMed:2521353).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23447 mRNA Translation: AAA40146.1
X12531 mRNA Translation: CAA31047.1
X53372 Genomic DNA Translation: CAA37452.1
J04491 mRNA Translation: AAA40304.1
M73061 Genomic DNA Translation: AAA39707.1
AF065939 mRNA Translation: AAC17506.1
AF065940 mRNA Translation: AAC17507.1
AF065941 mRNA Translation: AAC17508.1
AF065942 mRNA Translation: AAC17509.1
AF065943 mRNA Translation: AAC17510.1
CCDSiCCDS36255.1
PIRiS11685 A32393
RefSeqiNP_035467.1, NM_011337.2
UniGeneiMm.1282

Genome annotation databases

EnsembliENSMUST00000001008; ENSMUSP00000001008; ENSMUSG00000000982
GeneIDi20302
KEGGimmu:20302
UCSCiuc007kpn.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23447 mRNA Translation: AAA40146.1
X12531 mRNA Translation: CAA31047.1
X53372 Genomic DNA Translation: CAA37452.1
J04491 mRNA Translation: AAA40304.1
M73061 Genomic DNA Translation: AAA39707.1
AF065939 mRNA Translation: AAC17506.1
AF065940 mRNA Translation: AAC17507.1
AF065941 mRNA Translation: AAC17508.1
AF065942 mRNA Translation: AAC17509.1
AF065943 mRNA Translation: AAC17510.1
CCDSiCCDS36255.1
PIRiS11685 A32393
RefSeqiNP_035467.1, NM_011337.2
UniGeneiMm.1282

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4ZLTX-ray3.00F/L24-92[»]
ProteinModelPortaliP10855
SMRiP10855
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203127, 1 interactor
DIPiDIP-61916N
IntActiP10855, 1 interactor
STRINGi10090.ENSMUSP00000001008

Proteomic databases

PaxDbiP10855
PeptideAtlasiP10855
PRIDEiP10855

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001008; ENSMUSP00000001008; ENSMUSG00000000982
GeneIDi20302
KEGGimmu:20302
UCSCiuc007kpn.1 mouse

Organism-specific databases

CTDi6348
MGIiMGI:98260 Ccl3

Phylogenomic databases

eggNOGiENOG410J4I9 Eukaryota
ENOG410YXJU LUCA
GeneTreeiENSGT00900000140870
HOGENOMiHOG000036685
HOVERGENiHBG017871
InParanoidiP10855
KOiK05408
OMAiMALCNQV
OrthoDBiEOG091G14Y2
PhylomeDBiP10855
TreeFamiTF334888

Miscellaneous databases

PROiPR:P10855
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000982 Expressed in 36 organ(s), highest expression level in stroma of bone marrow
CleanExiMM_CCL3
ExpressionAtlasiP10855 baseline and differential
GenevisibleiP10855 MM

Family and domain databases

InterProiView protein in InterPro
IPR039809 Chemokine_b/g/d
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR12015 PTHR12015, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCL3_MOUSE
AccessioniPrimary (citable) accession number: P10855
Secondary accession number(s): P14096
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: April 1, 1990
Last modified: November 7, 2018
This is version 162 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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