UniProtKB - P10833 (RRAS_MOUSE)
Protein
Ras-related protein R-Ras
Gene
Rras
Organism
Mus musculus (Mouse)
Status
Functioni
Regulates the organization of the actin cytoskeleton. With OSPBL3, modulates integrin beta-1 (ITGB1) activity.By similarity
Catalytic activityi
- This reaction proceeds in the forwardBy similarity direction.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 36 – 44 | GTPBy similarity | 9 | |
Nucleotide bindingi | 83 – 87 | GTPBy similarity | 5 | |
Nucleotide bindingi | 142 – 145 | GTPBy similarity | 4 | |
Nucleotide bindingi | 172 – 174 | GTPBy similarity | 3 |
GO - Molecular functioni
- GDP binding Source: UniProtKB
- GTPase activity Source: UniProtKB
- GTP binding Source: GO_Central
- protein-containing complex binding Source: MGI
GO - Biological processi
- face morphogenesis Source: MGI
- leukocyte differentiation Source: MGI
- negative regulation of cell migration Source: MGI
- positive regulation of angiogenesis Source: UniProtKB
- positive regulation of endothelial cell-matrix adhesion via fibronectin Source: MGI
- positive regulation of endothelial cell migration Source: MGI
- positive regulation of vasculogenesis Source: MGI
- Ras protein signal transduction Source: GO_Central
- regulation of ERK1 and ERK2 cascade Source: MGI
- regulation of protein kinase B signaling Source: MGI
Keywordsi
Molecular function | Hydrolase |
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-MMU-416550, Sema4D mediated inhibition of cell attachment and migration |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Rras |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:98179, Rras |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity
Note: Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine (By similarity with RAS).
Cytosol
- cytosol Source: Reactome
Plasma Membrane
- plasma membrane Source: GO_Central
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000082651 | 1 – 215 | Ras-related protein R-RasAdd BLAST | 215 | |
PropeptideiPRO_0000281301 | 216 – 218 | Removed in mature formBy similarity | 3 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 215 | Cysteine methyl esterBy similarity | 1 | |
Lipidationi | 215 | S-geranylgeranyl cysteineBy similarity | 1 |
Post-translational modificationi
S-palmitoylated by ZDHHC19, leading to increased association with membranes and with rafts/caveolae as well as enhanced cell viability.By similarity
Keywords - PTMi
Lipoprotein, Methylation, Palmitate, PrenylationProteomic databases
EPDi | P10833 |
jPOSTi | P10833 |
PaxDbi | P10833 |
PeptideAtlasi | P10833 |
PRIDEi | P10833 |
PTM databases
iPTMneti | P10833 |
PhosphoSitePlusi | P10833 |
SwissPalmi | P10833 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000038387, Expressed in aorta and 295 other tissues |
Genevisiblei | P10833, MM |
Interactioni
Subunit structurei
Interacts with PLCE1 (By similarity).
Interacts (active GTP-bound form preferentially) with RGS14 (By similarity).
Interacts with OSBPL3 (By similarity).
Interacts with ZDHHC19 (By similarity).
By similarityProtein-protein interaction databases
BioGRIDi | 203020, 1 interactor |
IntActi | P10833, 1 interactor |
MINTi | P10833 |
STRINGi | 10090.ENSMUSP00000042150 |
Miscellaneous databases
RNActi | P10833, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 58 – 66 | Effector region | 9 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0395, Eukaryota |
GeneTreei | ENSGT00940000160972 |
HOGENOMi | CLU_041217_9_8_1 |
InParanoidi | P10833 |
OMAi | SGGCPCV |
OrthoDBi | 1259506at2759 |
PhylomeDBi | P10833 |
TreeFami | TF312796 |
Family and domain databases
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase IPR020849, Small_GTPase_Ras-type |
PANTHERi | PTHR24070, PTHR24070, 1 hit |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51421, RAS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
P10833-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSGAASGTG RGRPRGGGPG PRDPPPGETH KLVVVGGGGV GKSALTIQFI
60 70 80 90 100
QSYFVSDYDP TIEDSYTKIC TVDGIPARLD ILDTAGQEEF GAMREQYMRA
110 120 130 140 150
GNGFLLVFAI NDRQSFNEVG KLFTQILRVK DRDDFPIVLV GNKADLENQR
160 170 180 190 200
QVLRSEASSF SASHHMTYFE ASAKLRLNVD EAFEQLVRAV RKYQEQELPP
210
SPPSAPRKKD GGCPCVLL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1B0GRG1 | A0A1B0GRG1_MOUSE | Ras-related protein R-Ras | Rras | 107 | Annotation score: | ||
A0A1B0GSL0 | A0A1B0GSL0_MOUSE | Ras-related protein R-Ras | Rras | 57 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M21019 mRNA Translation: AAA40038.1 BC009105 mRNA Translation: AAH09105.1 |
CCDSi | CCDS21226.1 |
RefSeqi | NP_033127.1, NM_009101.2 |
Genome annotation databases
Ensembli | ENSMUST00000044111; ENSMUSP00000042150; ENSMUSG00000038387 |
GeneIDi | 20130 |
KEGGi | mmu:20130 |
UCSCi | uc009gss.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M21019 mRNA Translation: AAA40038.1 BC009105 mRNA Translation: AAH09105.1 |
CCDSi | CCDS21226.1 |
RefSeqi | NP_033127.1, NM_009101.2 |
3D structure databases
SMRi | P10833 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 203020, 1 interactor |
IntActi | P10833, 1 interactor |
MINTi | P10833 |
STRINGi | 10090.ENSMUSP00000042150 |
PTM databases
iPTMneti | P10833 |
PhosphoSitePlusi | P10833 |
SwissPalmi | P10833 |
Proteomic databases
EPDi | P10833 |
jPOSTi | P10833 |
PaxDbi | P10833 |
PeptideAtlasi | P10833 |
PRIDEi | P10833 |
Protocols and materials databases
Antibodypediai | 32074, 219 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000044111; ENSMUSP00000042150; ENSMUSG00000038387 |
GeneIDi | 20130 |
KEGGi | mmu:20130 |
UCSCi | uc009gss.1, mouse |
Organism-specific databases
CTDi | 6237 |
MGIi | MGI:98179, Rras |
Phylogenomic databases
eggNOGi | KOG0395, Eukaryota |
GeneTreei | ENSGT00940000160972 |
HOGENOMi | CLU_041217_9_8_1 |
InParanoidi | P10833 |
OMAi | SGGCPCV |
OrthoDBi | 1259506at2759 |
PhylomeDBi | P10833 |
TreeFami | TF312796 |
Enzyme and pathway databases
Reactomei | R-MMU-416550, Sema4D mediated inhibition of cell attachment and migration |
Miscellaneous databases
BioGRID-ORCSi | 20130, 1 hit in 20 CRISPR screens |
PROi | PR:P10833 |
RNActi | P10833, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000038387, Expressed in aorta and 295 other tissues |
Genevisiblei | P10833, MM |
Family and domain databases
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase IPR020849, Small_GTPase_Ras-type |
PANTHERi | PTHR24070, PTHR24070, 1 hit |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51421, RAS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RRAS_MOUSE | |
Accessioni | P10833Primary (citable) accession number: P10833 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | July 1, 1989 | |
Last modified: | December 2, 2020 | |
This is version 177 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families