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Protein

Ras-related protein R-Ras

Gene

Rras

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates the organization of the actin cytoskeleton. With OSPBL3, modulates integrin beta-1 (ITGB1) activity.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi36 – 44GTPBy similarity9
Nucleotide bindingi83 – 87GTPBy similarity5
Nucleotide bindingi142 – 145GTPBy similarity4
Nucleotide bindingi172 – 174GTPBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-416550 Sema4D mediated inhibition of cell attachment and migration
R-MMU-442742 CREB phosphorylation through the activation of Ras

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein R-Ras
Alternative name(s):
p23
Gene namesi
Name:Rras
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:98179 Rras

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000826511 – 215Ras-related protein R-RasAdd BLAST215
PropeptideiPRO_0000281301216 – 218Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei215Cysteine methyl esterBy similarity1
Lipidationi215S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiP10833
PaxDbiP10833
PeptideAtlasiP10833
PRIDEiP10833

PTM databases

iPTMnetiP10833
PhosphoSitePlusiP10833
SwissPalmiP10833

Expressioni

Gene expression databases

BgeeiENSMUSG00000038387 Expressed in 277 organ(s), highest expression level in aorta
CleanExiMM_RRAS
ExpressionAtlasiP10833 baseline and differential
GenevisibleiP10833 MM

Interactioni

Subunit structurei

Interacts with PLCE1. Interacts (active GTP-bound form preferentially) with RGS14. Interacts with OSBPL3.By similarity

Protein-protein interaction databases

BioGridi203020, 1 interactor
CORUMiP10833
IntActiP10833, 1 interactor
MINTiP10833
STRINGi10090.ENSMUSP00000042150

Structurei

3D structure databases

ProteinModelPortaliP10833
SMRiP10833
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi58 – 66Effector region9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00860000133672
HOGENOMiHOG000233973
HOVERGENiHBG009351
InParanoidiP10833
KOiK07829
OMAiRSEASTF
OrthoDBiEOG091G0UAU
PhylomeDBiP10833
TreeFamiTF312796

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P10833-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSGAASGTG RGRPRGGGPG PRDPPPGETH KLVVVGGGGV GKSALTIQFI
60 70 80 90 100
QSYFVSDYDP TIEDSYTKIC TVDGIPARLD ILDTAGQEEF GAMREQYMRA
110 120 130 140 150
GNGFLLVFAI NDRQSFNEVG KLFTQILRVK DRDDFPIVLV GNKADLENQR
160 170 180 190 200
QVLRSEASSF SASHHMTYFE ASAKLRLNVD EAFEQLVRAV RKYQEQELPP
210
SPPSAPRKKD GGCPCVLL
Length:218
Mass (Da):23,764
Last modified:July 1, 1989 - v1
Checksum:iC1D32CE7904322E5
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GRG1A0A1B0GRG1_MOUSE
Ras-related protein R-Ras
Rras
107Annotation score:
A0A1B0GSL0A0A1B0GSL0_MOUSE
Ras-related protein R-Ras
Rras
57Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21019 mRNA Translation: AAA40038.1
BC009105 mRNA Translation: AAH09105.1
CCDSiCCDS21226.1
RefSeqiNP_033127.1, NM_009101.2
UniGeneiMm.389894

Genome annotation databases

EnsembliENSMUST00000044111; ENSMUSP00000042150; ENSMUSG00000038387
GeneIDi20130
KEGGimmu:20130
UCSCiuc009gss.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21019 mRNA Translation: AAA40038.1
BC009105 mRNA Translation: AAH09105.1
CCDSiCCDS21226.1
RefSeqiNP_033127.1, NM_009101.2
UniGeneiMm.389894

3D structure databases

ProteinModelPortaliP10833
SMRiP10833
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203020, 1 interactor
CORUMiP10833
IntActiP10833, 1 interactor
MINTiP10833
STRINGi10090.ENSMUSP00000042150

PTM databases

iPTMnetiP10833
PhosphoSitePlusiP10833
SwissPalmiP10833

Proteomic databases

EPDiP10833
PaxDbiP10833
PeptideAtlasiP10833
PRIDEiP10833

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044111; ENSMUSP00000042150; ENSMUSG00000038387
GeneIDi20130
KEGGimmu:20130
UCSCiuc009gss.1 mouse

Organism-specific databases

CTDi6237
MGIiMGI:98179 Rras

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00860000133672
HOGENOMiHOG000233973
HOVERGENiHBG009351
InParanoidiP10833
KOiK07829
OMAiRSEASTF
OrthoDBiEOG091G0UAU
PhylomeDBiP10833
TreeFamiTF312796

Enzyme and pathway databases

ReactomeiR-MMU-416550 Sema4D mediated inhibition of cell attachment and migration
R-MMU-442742 CREB phosphorylation through the activation of Ras

Miscellaneous databases

PROiPR:P10833
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038387 Expressed in 277 organ(s), highest expression level in aorta
CleanExiMM_RRAS
ExpressionAtlasiP10833 baseline and differential
GenevisibleiP10833 MM

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRRAS_MOUSE
AccessioniPrimary (citable) accession number: P10833
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: September 12, 2018
This is version 164 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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