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Entry version 230 (10 Apr 2019)
Sequence version 2 (01 Oct 1994)
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Protein

Thyroid hormone receptor beta

Gene

THRB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.7 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei282Thyroid hormone1
Binding sitei320Thyroid hormone1
Binding sitei331Thyroid hormone; via amide nitrogen1
Binding sitei435Thyroid hormone1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi107 – 181Nuclear receptorPROSITE-ProRule annotationAdd BLAST75
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri107 – 127NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri145 – 169NR C4-typePROSITE-ProRule annotationAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-383280 Nuclear Receptor transcription pathway
R-HSA-4090294 SUMOylation of intracellular receptors

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P10828

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P10828

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Thyroid hormone receptor beta
Alternative name(s):
Nuclear receptor subfamily 1 group A member 2
c-erbA-2
c-erbA-beta
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:THRB
Synonyms:ERBA2, NR1A2, THR1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000151090.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11799 THRB

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
190160 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P10828

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Generalized thyroid hormone resistance (GTHR)19 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by goiter, abnormal mental functions, increased susceptibility to infections, abnormal growth and bone maturation, tachycardia and deafness. Affected individuals may also have attention deficit-hyperactivity disorders (ADHD) and language difficulties. GTHR patients also have high levels of circulating thyroid hormones (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH).
See also OMIM:188570
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_004632234A → T in GTHR; impairs hormone binding and ligand-dependent conformational changes. 2 PublicationsCorresponds to variant dbSNP:rs121918694EnsemblClinVar.1
Natural variantiVAR_004633243R → W in GTHR. 1 PublicationCorresponds to variant dbSNP:rs121918707EnsemblClinVar.1
Natural variantiVAR_059041268A → G in GTHR. 1 Publication1
Natural variantiVAR_004635317A → T in GTHR; impairs hormone binding. 4 PublicationsCorresponds to variant dbSNP:rs121918690EnsemblClinVar.1
Natural variantiVAR_004636320R → C in GTHR. 1 PublicationCorresponds to variant dbSNP:rs121918696EnsemblClinVar.1
Natural variantiVAR_004637320R → H in GTHR. 2 PublicationsCorresponds to variant dbSNP:rs121918693EnsemblClinVar.1
Natural variantiVAR_059042331N → D in GTHR. 1 Publication1
Natural variantiVAR_004638332G → R in GTHR. 1 PublicationCorresponds to variant dbSNP:rs28999969EnsemblClinVar.1
Natural variantiVAR_059043335A → P in GTHR. 1 Publication1
Natural variantiVAR_004640338R → W in GTHR. 3 PublicationsCorresponds to variant dbSNP:rs121918697EnsemblClinVar.1
Natural variantiVAR_004641340Q → H in GTHR. 1 PublicationCorresponds to variant dbSNP:rs121918688EnsemblClinVar.1
Natural variantiVAR_059044341L → P in GTHR. 1 Publication1
Natural variantiVAR_004642342K → I in GTHR. 1 Publication1
Natural variantiVAR_004645345G → R in GTHR. 1 PublicationCorresponds to variant dbSNP:rs121918686EnsemblClinVar.1
Natural variantiVAR_004644345G → S in GTHR. 1 PublicationCorresponds to variant dbSNP:rs121918686EnsemblClinVar.1
Natural variantiVAR_004643345G → V in GTHR. 1 PublicationCorresponds to variant dbSNP:rs28999970EnsemblClinVar.1
Natural variantiVAR_059045346L → F in GTHR. 1 Publication1
Natural variantiVAR_004646347G → E in GTHR. 1 PublicationCorresponds to variant dbSNP:rs28999971EnsemblClinVar.1
Natural variantiVAR_004647348V → E in GTHR. 1 Publication1
Natural variantiVAR_004648426T → I in GTHR. 1 Publication1
Natural variantiVAR_059046431I → M in GTHR. 1 Publication1
Natural variantiVAR_004649438R → H in GTHR. 1 PublicationCorresponds to variant dbSNP:rs121918698EnsemblClinVar.1
Natural variantiVAR_004650442M → V in GTHR. 1 PublicationCorresponds to variant dbSNP:rs121918691EnsemblClinVar.1
Natural variantiVAR_004651443K → E in GTHR. 1 PublicationCorresponds to variant dbSNP:rs121918692EnsemblClinVar.1
Natural variantiVAR_004652446C → R in GTHR. 1 PublicationCorresponds to variant dbSNP:rs121918703EnsemblClinVar.1
Natural variantiVAR_059047447P → T in GTHR. 1 Publication1
Natural variantiVAR_004653453P → H in GTHR. 1 PublicationCorresponds to variant dbSNP:rs121918687EnsemblClinVar.1
Natural variantiVAR_059048453P → L in GTHR. 1 Publication1
Natural variantiVAR_004654453P → S in GTHR. 1 PublicationCorresponds to variant dbSNP:rs28933408EnsemblClinVar.1
Natural variantiVAR_004655453P → T in GTHR. 4 PublicationsCorresponds to variant dbSNP:rs28933408EnsemblClinVar.1
Natural variantiVAR_059049459F → C in GTHR. 1 PublicationCorresponds to variant dbSNP:rs121918702EnsemblClinVar.1
Generalized thyroid hormone resistance autosomal recessive (GTHRAR)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by goiter, clinical euthyroidism, end-organ unresponsiveness to thyroid hormone, abnormal growth and bone maturation, and deafness. Patients also have high levels of circulating thyroid hormones, with elevated thyroid stimulating hormone.
See also OMIM:274300
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_004639337Missing in GTHRAR. 1 Publication1
Selective pituitary thyroid hormone resistance (PRTH)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionVariant form of thyroid hormone resistance and is characterized by clinical hyperthyroidism, with elevated free thyroid hormones, but inappropriately normal serum TSH. Unlike GRTH, where the syndrome usually segregates with a dominant allele, the mode of inheritance in PRTH has not been established.
See also OMIM:145650
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_004634316R → H in PRTH; impairs hormone binding. 2 PublicationsCorresponds to variant dbSNP:rs121918695EnsemblClinVar.1
Natural variantiVAR_058508429R → Q in PRTH. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi207 – 208SI → AA: Modestly inhibits homodimer formation on a minimal response element (in vitro). 1 Publication2
Mutagenesisi207 – 208SI → KK: Inhibits homodimer formation on a minimal response element (in vitro). 1 Publication2
Mutagenesisi243R → Q: Impairs hormone binding and ligand-dependent conformational changes. 1 Publication1
Mutagenesisi331N → S: No effect on thyroid hormone binding. 2 Publications1
Mutagenesisi355D → R: Stabilizes homodimer. 1 Publication1

Keywords - Diseasei

Deafness, Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
7068

MalaCards human disease database

More...
MalaCardsi
THRB
MIMi145650 phenotype
188570 phenotype
274300 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000151090

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
3221 Generalized resistance to thyroid hormone
97927 Peripheral resistance to thyroid hormones
165994 Pituitary resistance to thyroid hormone

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA36508

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1947

Drug and drug target database

More...
DrugBanki
DB08085 1-(4-HEXYLPHENYL)PROP-2-EN-1-ONE
DB00509 Dextrothyroxine
DB03788 GC-24
DB05035 KB2115
DB00451 Levothyroxine
DB00279 Liothyronine
DB01583 Liotrix
DB05192 MB07811

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
589

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
THRB

Domain mapping of disease mutations (DMDM)

More...
DMDMi
586092

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000534461 – 461Thyroid hormone receptor betaAdd BLAST461

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P10828

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P10828

PeptideAtlas

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PeptideAtlasi
P10828

PRoteomics IDEntifications database

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PRIDEi
P10828

ProteomicsDB human proteome resource

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ProteomicsDBi
52661
52662 [P10828-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P10828

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P10828

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000151090 Expressed in 196 organ(s), highest expression level in Brodmann (1909) area 23

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P10828 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P10828 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB002008
CAB002009
HPA061035

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds DNA as a dimer; homodimer and heterodimer with RXRA. Interacts with the coactivators NCOA1/SRC1, NCOA2/GRIP1, NCOA7 and MED1/TRAP220 in a ligand-inducible manner. Interacts with the corepressor NCOR1 in absence of ligand. Interacts with C1D (By similarity). Interacts with NR2F6; the interaction impairs the binding of the THRB homodimer and THRB:RXRB heterodimer to T3 response elements. Interacts with PRMT2 and THRSP.By similarity11 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112924, 56 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-654 RXRalpha-TRbeta nuclear hormone receptor complex

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P10828

Database of interacting proteins

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DIPi
DIP-5991N

Protein interaction database and analysis system

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IntActi
P10828, 13 interactors

Molecular INTeraction database

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MINTi
P10828

STRING: functional protein association networks

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STRINGi
9606.ENSP00000379904

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P10828

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1461
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BSXX-ray3.70A/B202-461[»]
1N46X-ray2.20A/B204-461[»]
1NAXX-ray2.70A209-460[»]
1NQ0X-ray2.40A202-461[»]
1NQ1X-ray2.90A202-461[»]
1NQ2X-ray2.40A202-461[»]
1NUOX-ray3.10A202-461[»]
1Q4XX-ray2.80A209-461[»]
1R6GX-ray3.00A203-461[»]
1XZXX-ray2.50X202-461[»]
1Y0XX-ray3.10X202-461[»]
2J4AX-ray2.20A209-461[»]
2NLLX-ray1.90B104-204[»]
2PINX-ray2.30A/B209-461[»]
3D57X-ray2.20A/B209-460[»]
3GWSX-ray2.20X202-460[»]
3IMYX-ray2.55A202-461[»]
3JZCX-ray2.50A202-461[»]
4ZO1X-ray3.22X210-461[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P10828

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P10828

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P10828

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini217 – 461NR LBDPROSITE-ProRule annotationAdd BLAST245

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 106ModulatingAdd BLAST106
Regioni244 – 461Interaction with NR2F61 PublicationAdd BLAST218

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri107 – 127NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri145 – 169NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3575 Eukaryota
ENOG410XRZC LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156809

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000010313

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG005606

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P10828

KEGG Orthology (KO)

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KOi
K08362

Identification of Orthologs from Complete Genome Data

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OMAi
QEWELIK

Database of Orthologous Groups

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OrthoDBi
1112927at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P10828

TreeFam database of animal gene trees

More...
TreeFami
TF328382

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.50.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001728 ThyrH_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00398 STRDHORMONER
PR00047 STROIDFINGER
PR00546 THYROIDHORMR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48508 SSF48508, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform Beta-1 (identifier: P10828-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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MTPNSMTENG LTAWDKPKHC PDREHDWKLV GMSEACLHRK SHSERRSTLK
60 70 80 90 100
NEQSSPHLIQ TTWTSSIFHL DHDDVNDQSV SSAQTFQTEE KKCKGYIPSY
110 120 130 140 150
LDKDELCVVC GDKATGYHYR CITCEGCKGF FRRTIQKNLH PSYSCKYEGK
160 170 180 190 200
CVIDKVTRNQ CQECRFKKCI YVGMATDLVL DDSKRLAKRK LIEENREKRR
210 220 230 240 250
REELQKSIGH KPEPTDEEWE LIKTVTEAHV ATNAQGSHWK QKRKFLPEDI
260 270 280 290 300
GQAPIVNAPE GGKVDLEAFS HFTKIITPAI TRVVDFAKKL PMFCELPCED
310 320 330 340 350
QIILLKGCCM EIMSLRAAVR YDPESETLTL NGEMAVTRGQ LKNGGLGVVS
360 370 380 390 400
DAIFDLGMSL SSFNLDDTEV ALLQAVLLMS SDRPGLACVE RIEKYQDSFL
410 420 430 440 450
LAFEHYINYR KHHVTHFWPK LLMKVTDLRM IGACHASRFL HMKVECPTEL
460
FPPLFLEVFE D
Length:461
Mass (Da):52,788
Last modified:October 1, 1994 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6770BB0D372A7CAA
GO
Isoform Beta-2 (identifier: P10828-2) [UniParc] [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-93: MTPNSMTENG...QTFQTEEKKC → MNYCMQEIYE...QVQSPSYSQK

Show »
Length:476
Mass (Da):54,449
Checksum:i21755292507335D8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JNQ4C9JNQ4_HUMAN
Thyroid hormone receptor beta
THRB
132Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YF24A0A2R8YF24_HUMAN
Thyroid hormone receptor beta
THRB
186Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JJM3C9JJM3_HUMAN
Thyroid hormone receptor beta
THRB
114Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KR21J3KR21_HUMAN
Thyroid hormone receptor beta
THRB
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JTN1C9JTN1_HUMAN
Thyroid hormone receptor beta
THRB
103Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JHC2C9JHC2_HUMAN
Thyroid hormone receptor beta
THRB
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JZS5C9JZS5_HUMAN
Thyroid hormone receptor beta
THRB
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DG57A0A0C4DG57_HUMAN
Thyroid hormone receptor beta
THRB
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA35677 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA28412 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti243R → P in AAA35677 (PubMed:3034496).Curated1
Sequence conflicti243R → P in CAA28412 (PubMed:2879243).Curated1
Sequence conflicti451F → L in AAA35677 (PubMed:3034496).Curated1
Sequence conflicti451F → L in CAA28412 (PubMed:2879243).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050577216D → G. Corresponds to variant dbSNP:rs9865746Ensembl.1
Natural variantiVAR_004632234A → T in GTHR; impairs hormone binding and ligand-dependent conformational changes. 2 PublicationsCorresponds to variant dbSNP:rs121918694EnsemblClinVar.1
Natural variantiVAR_004633243R → W in GTHR. 1 PublicationCorresponds to variant dbSNP:rs121918707EnsemblClinVar.1
Natural variantiVAR_059041268A → G in GTHR. 1 Publication1
Natural variantiVAR_004634316R → H in PRTH; impairs hormone binding. 2 PublicationsCorresponds to variant dbSNP:rs121918695EnsemblClinVar.1
Natural variantiVAR_004635317A → T in GTHR; impairs hormone binding. 4 PublicationsCorresponds to variant dbSNP:rs121918690EnsemblClinVar.1
Natural variantiVAR_004636320R → C in GTHR. 1 PublicationCorresponds to variant dbSNP:rs121918696EnsemblClinVar.1
Natural variantiVAR_004637320R → H in GTHR. 2 PublicationsCorresponds to variant dbSNP:rs121918693EnsemblClinVar.1
Natural variantiVAR_059042331N → D in GTHR. 1 Publication1
Natural variantiVAR_004638332G → R in GTHR. 1 PublicationCorresponds to variant dbSNP:rs28999969EnsemblClinVar.1
Natural variantiVAR_059043335A → P in GTHR. 1 Publication1
Natural variantiVAR_011784337T → I2 PublicationsCorresponds to variant dbSNP:rs1054624Ensembl.1
Natural variantiVAR_004639337Missing in GTHRAR. 1 Publication1
Natural variantiVAR_004640338R → W in GTHR. 3 PublicationsCorresponds to variant dbSNP:rs121918697EnsemblClinVar.1
Natural variantiVAR_004641340Q → H in GTHR. 1 PublicationCorresponds to variant dbSNP:rs121918688EnsemblClinVar.1
Natural variantiVAR_059044341L → P in GTHR. 1 Publication1
Natural variantiVAR_004642342K → I in GTHR. 1 Publication1
Natural variantiVAR_004645345G → R in GTHR. 1 PublicationCorresponds to variant dbSNP:rs121918686EnsemblClinVar.1
Natural variantiVAR_004644345G → S in GTHR. 1 PublicationCorresponds to variant dbSNP:rs121918686EnsemblClinVar.1
Natural variantiVAR_004643345G → V in GTHR. 1 PublicationCorresponds to variant dbSNP:rs28999970EnsemblClinVar.1
Natural variantiVAR_059045346L → F in GTHR. 1 Publication1
Natural variantiVAR_004646347G → E in GTHR. 1 PublicationCorresponds to variant dbSNP:rs28999971EnsemblClinVar.1
Natural variantiVAR_004647348V → E in GTHR. 1 Publication1
Natural variantiVAR_004648426T → I in GTHR. 1 Publication1
Natural variantiVAR_058508429R → Q in PRTH. 1 Publication1
Natural variantiVAR_059046431I → M in GTHR. 1 Publication1
Natural variantiVAR_004649438R → H in GTHR. 1 PublicationCorresponds to variant dbSNP:rs121918698EnsemblClinVar.1
Natural variantiVAR_004650442M → V in GTHR. 1 PublicationCorresponds to variant dbSNP:rs121918691EnsemblClinVar.1
Natural variantiVAR_004651443K → E in GTHR. 1 PublicationCorresponds to variant dbSNP:rs121918692EnsemblClinVar.1
Natural variantiVAR_004652446C → R in GTHR. 1 PublicationCorresponds to variant dbSNP:rs121918703EnsemblClinVar.1
Natural variantiVAR_059047447P → T in GTHR. 1 Publication1
Natural variantiVAR_004653453P → H in GTHR. 1 PublicationCorresponds to variant dbSNP:rs121918687EnsemblClinVar.1
Natural variantiVAR_059048453P → L in GTHR. 1 Publication1
Natural variantiVAR_004654453P → S in GTHR. 1 PublicationCorresponds to variant dbSNP:rs28933408EnsemblClinVar.1
Natural variantiVAR_004655453P → T in GTHR. 4 PublicationsCorresponds to variant dbSNP:rs28933408EnsemblClinVar.1
Natural variantiVAR_059049459F → C in GTHR. 1 PublicationCorresponds to variant dbSNP:rs121918702EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0310771 – 93MTPNS…EEKKC → MNYCMQEIYEVHPAAGSNCY MQSTDYYAYFEDSPGYSGCD AQAVPSNNIYMEQAWAVNQP YTCSYPGNMFKSKDSDLDMA LNQYSQPEYFTEEKPTFSQV QSPSYSQK in isoform Beta-2. 1 PublicationAdd BLAST93

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M26747 mRNA Translation: AAA35677.1 Different initiation.
X04707 mRNA Translation: CAA28412.1 Different initiation.
AK096628 mRNA Translation: BAG53341.1
AC012087 Genomic DNA No translation available.
AC093927 Genomic DNA No translation available.
AC098971 Genomic DNA No translation available.
AC099054 Genomic DNA No translation available.
AC112217 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64345.1
BC106929 mRNA Translation: AAI06930.1
BC106930 mRNA Translation: AAI06931.1
AY286465 mRNA Translation: AAQ23704.1
AY286466 mRNA Translation: AAQ23705.1
AY286467 mRNA Translation: AAQ23706.1
AY286468 mRNA Translation: AAQ23707.1
AY286469 mRNA Translation: AAQ23708.1
AY286470 mRNA Translation: AAQ23709.1
AY286471 mRNA Translation: AAQ23710.1
X74497 mRNA Translation: CAA52606.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2641.1 [P10828-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
A25237 TVHUAR
S40152

NCBI Reference Sequences

More...
RefSeqi
NP_000452.2, NM_000461.4 [P10828-1]
NP_001121648.1, NM_001128176.2 [P10828-1]
NP_001121649.1, NM_001128177.1 [P10828-1]
NP_001239563.1, NM_001252634.1 [P10828-1]
XP_005265478.1, XM_005265421.4
XP_005265480.1, XM_005265423.4
XP_005265481.1, XM_005265424.3
XP_006713380.1, XM_006713317.3
XP_006713381.1, XM_006713318.3 [P10828-1]
XP_011532348.1, XM_011534046.2
XP_011532349.1, XM_011534047.2 [P10828-1]
XP_011532350.1, XM_011534048.2
XP_011532351.1, XM_011534049.2
XP_011532352.1, XM_011534050.2 [P10828-1]
XP_011532353.1, XM_011534051.2
XP_011532354.1, XM_011534052.2 [P10828-1]
XP_016862597.1, XM_017007108.1
XP_016862598.1, XM_017007109.1 [P10828-1]
XP_016862599.1, XM_017007110.1
XP_016862600.1, XM_017007111.1 [P10828-1]
XP_016862601.1, XM_017007112.1 [P10828-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.187861
Hs.713754

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000280696; ENSP00000280696; ENSG00000151090 [P10828-2]
ENST00000356447; ENSP00000348827; ENSG00000151090 [P10828-1]
ENST00000396671; ENSP00000379904; ENSG00000151090 [P10828-1]
ENST00000415021; ENSP00000404898; ENSG00000151090 [P10828-1]
ENST00000416420; ENSP00000414444; ENSG00000151090 [P10828-1]
ENST00000642307; ENSP00000494618; ENSG00000151090 [P10828-1]
ENST00000643772; ENSP00000496029; ENSG00000151090 [P10828-1]
ENST00000644321; ENSP00000496616; ENSG00000151090 [P10828-1]
ENST00000645139; ENSP00000493709; ENSG00000151090 [P10828-1]
ENST00000646209; ENSP00000496686; ENSG00000151090 [P10828-1]
ENST00000646432; ENSP00000496509; ENSG00000151090 [P10828-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7068

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7068

UCSC genome browser

More...
UCSCi
uc003ccx.5 human [P10828-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26747 mRNA Translation: AAA35677.1 Different initiation.
X04707 mRNA Translation: CAA28412.1 Different initiation.
AK096628 mRNA Translation: BAG53341.1
AC012087 Genomic DNA No translation available.
AC093927 Genomic DNA No translation available.
AC098971 Genomic DNA No translation available.
AC099054 Genomic DNA No translation available.
AC112217 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64345.1
BC106929 mRNA Translation: AAI06930.1
BC106930 mRNA Translation: AAI06931.1
AY286465 mRNA Translation: AAQ23704.1
AY286466 mRNA Translation: AAQ23705.1
AY286467 mRNA Translation: AAQ23706.1
AY286468 mRNA Translation: AAQ23707.1
AY286469 mRNA Translation: AAQ23708.1
AY286470 mRNA Translation: AAQ23709.1
AY286471 mRNA Translation: AAQ23710.1
X74497 mRNA Translation: CAA52606.1
CCDSiCCDS2641.1 [P10828-1]
PIRiA25237 TVHUAR
S40152
RefSeqiNP_000452.2, NM_000461.4 [P10828-1]
NP_001121648.1, NM_001128176.2 [P10828-1]
NP_001121649.1, NM_001128177.1 [P10828-1]
NP_001239563.1, NM_001252634.1 [P10828-1]
XP_005265478.1, XM_005265421.4
XP_005265480.1, XM_005265423.4
XP_005265481.1, XM_005265424.3
XP_006713380.1, XM_006713317.3
XP_006713381.1, XM_006713318.3 [P10828-1]
XP_011532348.1, XM_011534046.2
XP_011532349.1, XM_011534047.2 [P10828-1]
XP_011532350.1, XM_011534048.2
XP_011532351.1, XM_011534049.2
XP_011532352.1, XM_011534050.2 [P10828-1]
XP_011532353.1, XM_011534051.2
XP_011532354.1, XM_011534052.2 [P10828-1]
XP_016862597.1, XM_017007108.1
XP_016862598.1, XM_017007109.1 [P10828-1]
XP_016862599.1, XM_017007110.1
XP_016862600.1, XM_017007111.1 [P10828-1]
XP_016862601.1, XM_017007112.1 [P10828-1]
UniGeneiHs.187861
Hs.713754

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BSXX-ray3.70A/B202-461[»]
1N46X-ray2.20A/B204-461[»]
1NAXX-ray2.70A209-460[»]
1NQ0X-ray2.40A202-461[»]
1NQ1X-ray2.90A202-461[»]
1NQ2X-ray2.40A202-461[»]
1NUOX-ray3.10A202-461[»]
1Q4XX-ray2.80A209-461[»]
1R6GX-ray3.00A203-461[»]
1XZXX-ray2.50X202-461[»]
1Y0XX-ray3.10X202-461[»]
2J4AX-ray2.20A209-461[»]
2NLLX-ray1.90B104-204[»]
2PINX-ray2.30A/B209-461[»]
3D57X-ray2.20A/B209-460[»]
3GWSX-ray2.20X202-460[»]
3IMYX-ray2.55A202-461[»]
3JZCX-ray2.50A202-461[»]
4ZO1X-ray3.22X210-461[»]
ProteinModelPortaliP10828
SMRiP10828
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112924, 56 interactors
ComplexPortaliCPX-654 RXRalpha-TRbeta nuclear hormone receptor complex
CORUMiP10828
DIPiDIP-5991N
IntActiP10828, 13 interactors
MINTiP10828
STRINGi9606.ENSP00000379904

Chemistry databases

BindingDBiP10828
ChEMBLiCHEMBL1947
DrugBankiDB08085 1-(4-HEXYLPHENYL)PROP-2-EN-1-ONE
DB00509 Dextrothyroxine
DB03788 GC-24
DB05035 KB2115
DB00451 Levothyroxine
DB00279 Liothyronine
DB01583 Liotrix
DB05192 MB07811
GuidetoPHARMACOLOGYi589

PTM databases

iPTMnetiP10828
PhosphoSitePlusiP10828

Polymorphism and mutation databases

BioMutaiTHRB
DMDMi586092

Proteomic databases

MaxQBiP10828
PaxDbiP10828
PeptideAtlasiP10828
PRIDEiP10828
ProteomicsDBi52661
52662 [P10828-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
7068
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000280696; ENSP00000280696; ENSG00000151090 [P10828-2]
ENST00000356447; ENSP00000348827; ENSG00000151090 [P10828-1]
ENST00000396671; ENSP00000379904; ENSG00000151090 [P10828-1]
ENST00000415021; ENSP00000404898; ENSG00000151090 [P10828-1]
ENST00000416420; ENSP00000414444; ENSG00000151090 [P10828-1]
ENST00000642307; ENSP00000494618; ENSG00000151090 [P10828-1]
ENST00000643772; ENSP00000496029; ENSG00000151090 [P10828-1]
ENST00000644321; ENSP00000496616; ENSG00000151090 [P10828-1]
ENST00000645139; ENSP00000493709; ENSG00000151090 [P10828-1]
ENST00000646209; ENSP00000496686; ENSG00000151090 [P10828-1]
ENST00000646432; ENSP00000496509; ENSG00000151090 [P10828-1]
GeneIDi7068
KEGGihsa:7068
UCSCiuc003ccx.5 human [P10828-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7068
DisGeNETi7068
EuPathDBiHostDB:ENSG00000151090.17

GeneCards: human genes, protein and diseases

More...
GeneCardsi
THRB
HGNCiHGNC:11799 THRB
HPAiCAB002008
CAB002009
HPA061035
MalaCardsiTHRB
MIMi145650 phenotype
188570 phenotype
190160 gene
274300 phenotype
neXtProtiNX_P10828
OpenTargetsiENSG00000151090
Orphaneti3221 Generalized resistance to thyroid hormone
97927 Peripheral resistance to thyroid hormones
165994 Pituitary resistance to thyroid hormone
PharmGKBiPA36508

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00940000156809
HOGENOMiHOG000010313
HOVERGENiHBG005606
InParanoidiP10828
KOiK08362
OMAiQEWELIK
OrthoDBi1112927at2759
PhylomeDBiP10828
TreeFamiTF328382

Enzyme and pathway databases

ReactomeiR-HSA-383280 Nuclear Receptor transcription pathway
R-HSA-4090294 SUMOylation of intracellular receptors
SignaLinkiP10828
SIGNORiP10828

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
THRB human
EvolutionaryTraceiP10828

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Thyroid_hormone_receptor_beta

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7068

Protein Ontology

More...
PROi
PR:P10828

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000151090 Expressed in 196 organ(s), highest expression level in Brodmann (1909) area 23
ExpressionAtlasiP10828 baseline and differential
GenevisibleiP10828 HS

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001728 ThyrH_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR00398 STRDHORMONER
PR00047 STROIDFINGER
PR00546 THYROIDHORMR
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTHB_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P10828
Secondary accession number(s): B3KU79
, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: October 1, 1994
Last modified: April 10, 2019
This is version 230 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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