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Protein

Thyroid hormone receptor beta

Gene

THRB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.7 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei282Thyroid hormone1
Binding sitei320Thyroid hormone1
Binding sitei331Thyroid hormone; via amide nitrogen1
Binding sitei435Thyroid hormone1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi107 – 181Nuclear receptorPROSITE-ProRule annotationAdd BLAST75
Zinc fingeri107 – 127NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri145 – 169NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

  • chromatin DNA binding Source: Ensembl
  • DNA binding Source: ProtInc
  • DNA-binding transcription factor activity Source: ProtInc
  • enzyme binding Source: UniProtKB
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
  • sequence-specific DNA binding Source: InterPro
  • steroid hormone receptor activity Source: InterPro
  • thyroid hormone binding Source: UniProtKB
  • thyroid hormone receptor activity Source: UniProtKB
  • transcription corepressor activity Source: ProtInc
  • zinc ion binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-383280 Nuclear Receptor transcription pathway
R-HSA-4090294 SUMOylation of intracellular receptors
SignaLinkiP10828
SIGNORiP10828

Names & Taxonomyi

Protein namesi
Recommended name:
Thyroid hormone receptor beta
Alternative name(s):
Nuclear receptor subfamily 1 group A member 2
c-erbA-2
c-erbA-beta
Gene namesi
Name:THRB
Synonyms:ERBA2, NR1A2, THR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000151090.17
HGNCiHGNC:11799 THRB
MIMi190160 gene
neXtProtiNX_P10828

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Generalized thyroid hormone resistance (GTHR)19 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by goiter, abnormal mental functions, increased susceptibility to infections, abnormal growth and bone maturation, tachycardia and deafness. Affected individuals may also have attention deficit-hyperactivity disorders (ADHD) and language difficulties. GTHR patients also have high levels of circulating thyroid hormones (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH).
See also OMIM:188570
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_004632234A → T in GTHR; impairs hormone binding and ligand-dependent conformational changes. 2 PublicationsCorresponds to variant dbSNP:rs121918694EnsemblClinVar.1
Natural variantiVAR_004633243R → W in GTHR. 1 PublicationCorresponds to variant dbSNP:rs121918707EnsemblClinVar.1
Natural variantiVAR_059041268A → G in GTHR. 1 Publication1
Natural variantiVAR_004635317A → T in GTHR; impairs hormone binding. 4 PublicationsCorresponds to variant dbSNP:rs121918690EnsemblClinVar.1
Natural variantiVAR_004636320R → C in GTHR. 1 PublicationCorresponds to variant dbSNP:rs121918696EnsemblClinVar.1
Natural variantiVAR_004637320R → H in GTHR. 2 PublicationsCorresponds to variant dbSNP:rs121918693EnsemblClinVar.1
Natural variantiVAR_059042331N → D in GTHR. 1 Publication1
Natural variantiVAR_004638332G → R in GTHR. 1 PublicationCorresponds to variant dbSNP:rs28999969EnsemblClinVar.1
Natural variantiVAR_059043335A → P in GTHR. 1 Publication1
Natural variantiVAR_004640338R → W in GTHR. 3 PublicationsCorresponds to variant dbSNP:rs121918697EnsemblClinVar.1
Natural variantiVAR_004641340Q → H in GTHR. 1 PublicationCorresponds to variant dbSNP:rs121918688EnsemblClinVar.1
Natural variantiVAR_059044341L → P in GTHR. 1 Publication1
Natural variantiVAR_004642342K → I in GTHR. 1 Publication1
Natural variantiVAR_004645345G → R in GTHR. 1 PublicationCorresponds to variant dbSNP:rs121918686EnsemblClinVar.1
Natural variantiVAR_004644345G → S in GTHR. 1 PublicationCorresponds to variant dbSNP:rs121918686EnsemblClinVar.1
Natural variantiVAR_004643345G → V in GTHR. 1 PublicationCorresponds to variant dbSNP:rs28999970EnsemblClinVar.1
Natural variantiVAR_059045346L → F in GTHR. 1 Publication1
Natural variantiVAR_004646347G → E in GTHR. 1 PublicationCorresponds to variant dbSNP:rs28999971EnsemblClinVar.1
Natural variantiVAR_004647348V → E in GTHR. 1 Publication1
Natural variantiVAR_004648426T → I in GTHR. 1 Publication1
Natural variantiVAR_059046431I → M in GTHR. 1 Publication1
Natural variantiVAR_004649438R → H in GTHR. 1 PublicationCorresponds to variant dbSNP:rs121918698EnsemblClinVar.1
Natural variantiVAR_004650442M → V in GTHR. 1 PublicationCorresponds to variant dbSNP:rs121918691EnsemblClinVar.1
Natural variantiVAR_004651443K → E in GTHR. 1 PublicationCorresponds to variant dbSNP:rs121918692EnsemblClinVar.1
Natural variantiVAR_004652446C → R in GTHR. 1 PublicationCorresponds to variant dbSNP:rs121918703EnsemblClinVar.1
Natural variantiVAR_059047447P → T in GTHR. 1 Publication1
Natural variantiVAR_004653453P → H in GTHR. 1 PublicationCorresponds to variant dbSNP:rs121918687EnsemblClinVar.1
Natural variantiVAR_059048453P → L in GTHR. 1 Publication1
Natural variantiVAR_004654453P → S in GTHR. 1 Publication1
Natural variantiVAR_004655453P → T in GTHR. 4 PublicationsCorresponds to variant dbSNP:rs28933408EnsemblClinVar.1
Natural variantiVAR_059049459F → C in GTHR. 1 PublicationCorresponds to variant dbSNP:rs121918702EnsemblClinVar.1
Generalized thyroid hormone resistance autosomal recessive (GTHRAR)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by goiter, clinical euthyroidism, end-organ unresponsiveness to thyroid hormone, abnormal growth and bone maturation, and deafness. Patients also have high levels of circulating thyroid hormones, with elevated thyroid stimulating hormone.
See also OMIM:274300
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_004639337Missing in GTHRAR. 1 Publication1
Selective pituitary thyroid hormone resistance (PRTH)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionVariant form of thyroid hormone resistance and is characterized by clinical hyperthyroidism, with elevated free thyroid hormones, but inappropriately normal serum TSH. Unlike GRTH, where the syndrome usually segregates with a dominant allele, the mode of inheritance in PRTH has not been established.
See also OMIM:145650
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_004634316R → H in PRTH; impairs hormone binding. 2 PublicationsCorresponds to variant dbSNP:rs121918695EnsemblClinVar.1
Natural variantiVAR_058508429R → Q in PRTH. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi207 – 208SI → AA: Modestly inhibits homodimer formation on a minimal response element (in vitro). 1 Publication2
Mutagenesisi207 – 208SI → KK: Inhibits homodimer formation on a minimal response element (in vitro). 1 Publication2
Mutagenesisi243R → Q: Impairs hormone binding and ligand-dependent conformational changes. 1 Publication1
Mutagenesisi331N → S: No effect on thyroid hormone binding. 2 Publications1
Mutagenesisi355D → R: Stabilizes homodimer. 1 Publication1

Keywords - Diseasei

Deafness, Disease mutation

Organism-specific databases

DisGeNETi7068
MalaCardsiTHRB
MIMi145650 phenotype
188570 phenotype
274300 phenotype
OpenTargetsiENSG00000151090
Orphaneti3221 Generalized resistance to thyroid hormone
97927 Peripheral resistance to thyroid hormones
165994 Selective pituitary resistance to thyroid hormone
PharmGKBiPA36508

Chemistry databases

ChEMBLiCHEMBL1947
DrugBankiDB08085 1-(4-HEXYLPHENYL)PROP-2-EN-1-ONE
DB00509 Dextrothyroxine
DB03788 GC-24
DB05035 KB2115
DB00451 Levothyroxine
DB00279 Liothyronine
DB01583 Liotrix
DB05192 MB07811
GuidetoPHARMACOLOGYi589

Polymorphism and mutation databases

BioMutaiTHRB
DMDMi586092

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000534461 – 461Thyroid hormone receptor betaAdd BLAST461

Proteomic databases

MaxQBiP10828
PaxDbiP10828
PeptideAtlasiP10828
PRIDEiP10828
ProteomicsDBi52661
52662 [P10828-2]

PTM databases

iPTMnetiP10828
PhosphoSitePlusiP10828

Expressioni

Gene expression databases

BgeeiENSG00000151090 Expressed in 196 organ(s), highest expression level in Brodmann (1909) area 23
CleanExiHS_THRB
ExpressionAtlasiP10828 baseline and differential
GenevisibleiP10828 HS

Organism-specific databases

HPAiCAB002008
CAB002009
HPA061035

Interactioni

Subunit structurei

Binds DNA as a dimer; homodimer and heterodimer with RXRA. Interacts with the coactivators NCOA1/SRC1, NCOA2/GRIP1, NCOA7 and MED1/TRAP220 in a ligand-inducible manner. Interacts with the corepressor NCOR1 in absence of ligand. Interacts with C1D (By similarity). Interacts with NR2F6; the interaction impairs the binding of the THRB homodimer and THRB:RXRB heterodimer to T3 response elements. Interacts with PRMT2 and THRSP.By similarity11 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112924, 56 interactors
ComplexPortaliCPX-654 RXRalpha-TRbeta nuclear hormone receptor complex
CORUMiP10828
DIPiDIP-5991N
IntActiP10828, 12 interactors
MINTiP10828
STRINGi9606.ENSP00000348827

Chemistry databases

BindingDBiP10828

Structurei

Secondary structure

1461
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP10828
SMRiP10828
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10828

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini217 – 461NR LBDPROSITE-ProRule annotationAdd BLAST245

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 106ModulatingAdd BLAST106
Regioni244 – 461Interaction with NR2F61 PublicationAdd BLAST218

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri107 – 127NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri145 – 169NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00870000136372
HOGENOMiHOG000010313
HOVERGENiHBG005606
InParanoidiP10828
KOiK08362
OMAiQEWELIK
OrthoDBiEOG091G0GC1
PhylomeDBiP10828
TreeFamiTF328382

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001728 ThyrH_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR00398 STRDHORMONER
PR00047 STROIDFINGER
PR00546 THYROIDHORMR
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform Beta-1 (identifier: P10828-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTPNSMTENG LTAWDKPKHC PDREHDWKLV GMSEACLHRK SHSERRSTLK
60 70 80 90 100
NEQSSPHLIQ TTWTSSIFHL DHDDVNDQSV SSAQTFQTEE KKCKGYIPSY
110 120 130 140 150
LDKDELCVVC GDKATGYHYR CITCEGCKGF FRRTIQKNLH PSYSCKYEGK
160 170 180 190 200
CVIDKVTRNQ CQECRFKKCI YVGMATDLVL DDSKRLAKRK LIEENREKRR
210 220 230 240 250
REELQKSIGH KPEPTDEEWE LIKTVTEAHV ATNAQGSHWK QKRKFLPEDI
260 270 280 290 300
GQAPIVNAPE GGKVDLEAFS HFTKIITPAI TRVVDFAKKL PMFCELPCED
310 320 330 340 350
QIILLKGCCM EIMSLRAAVR YDPESETLTL NGEMAVTRGQ LKNGGLGVVS
360 370 380 390 400
DAIFDLGMSL SSFNLDDTEV ALLQAVLLMS SDRPGLACVE RIEKYQDSFL
410 420 430 440 450
LAFEHYINYR KHHVTHFWPK LLMKVTDLRM IGACHASRFL HMKVECPTEL
460
FPPLFLEVFE D
Length:461
Mass (Da):52,788
Last modified:October 1, 1994 - v2
Checksum:i6770BB0D372A7CAA
GO
Isoform Beta-2 (identifier: P10828-2) [UniParc] [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-93: MTPNSMTENG...QTFQTEEKKC → MNYCMQEIYE...QVQSPSYSQK

Show »
Length:476
Mass (Da):54,449
Checksum:i21755292507335D8
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JNQ4C9JNQ4_HUMAN
Thyroid hormone receptor beta
THRB
132Annotation score:
A0A2R8YF24A0A2R8YF24_HUMAN
Thyroid hormone receptor beta
THRB
186Annotation score:
C9JJM3C9JJM3_HUMAN
Thyroid hormone receptor beta
THRB
114Annotation score:
J3KR21J3KR21_HUMAN
Thyroid hormone receptor beta
THRB
121Annotation score:
C9JTN1C9JTN1_HUMAN
Thyroid hormone receptor beta
THRB
103Annotation score:
C9JHC2C9JHC2_HUMAN
Thyroid hormone receptor beta
THRB
67Annotation score:
C9JZS5C9JZS5_HUMAN
Thyroid hormone receptor beta
THRB
63Annotation score:
A0A0C4DG57A0A0C4DG57_HUMAN
Thyroid hormone receptor beta
THRB
122Annotation score:

Sequence cautioni

The sequence AAA35677 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA28412 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti243R → P in AAA35677 (PubMed:3034496).Curated1
Sequence conflicti243R → P in CAA28412 (PubMed:2879243).Curated1
Sequence conflicti451F → L in AAA35677 (PubMed:3034496).Curated1
Sequence conflicti451F → L in CAA28412 (PubMed:2879243).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050577216D → G. Corresponds to variant dbSNP:rs9865746Ensembl.1
Natural variantiVAR_004632234A → T in GTHR; impairs hormone binding and ligand-dependent conformational changes. 2 PublicationsCorresponds to variant dbSNP:rs121918694EnsemblClinVar.1
Natural variantiVAR_004633243R → W in GTHR. 1 PublicationCorresponds to variant dbSNP:rs121918707EnsemblClinVar.1
Natural variantiVAR_059041268A → G in GTHR. 1 Publication1
Natural variantiVAR_004634316R → H in PRTH; impairs hormone binding. 2 PublicationsCorresponds to variant dbSNP:rs121918695EnsemblClinVar.1
Natural variantiVAR_004635317A → T in GTHR; impairs hormone binding. 4 PublicationsCorresponds to variant dbSNP:rs121918690EnsemblClinVar.1
Natural variantiVAR_004636320R → C in GTHR. 1 PublicationCorresponds to variant dbSNP:rs121918696EnsemblClinVar.1
Natural variantiVAR_004637320R → H in GTHR. 2 PublicationsCorresponds to variant dbSNP:rs121918693EnsemblClinVar.1
Natural variantiVAR_059042331N → D in GTHR. 1 Publication1
Natural variantiVAR_004638332G → R in GTHR. 1 PublicationCorresponds to variant dbSNP:rs28999969EnsemblClinVar.1
Natural variantiVAR_059043335A → P in GTHR. 1 Publication1
Natural variantiVAR_011784337T → I2 PublicationsCorresponds to variant dbSNP:rs1054624Ensembl.1
Natural variantiVAR_004639337Missing in GTHRAR. 1 Publication1
Natural variantiVAR_004640338R → W in GTHR. 3 PublicationsCorresponds to variant dbSNP:rs121918697EnsemblClinVar.1
Natural variantiVAR_004641340Q → H in GTHR. 1 PublicationCorresponds to variant dbSNP:rs121918688EnsemblClinVar.1
Natural variantiVAR_059044341L → P in GTHR. 1 Publication1
Natural variantiVAR_004642342K → I in GTHR. 1 Publication1
Natural variantiVAR_004645345G → R in GTHR. 1 PublicationCorresponds to variant dbSNP:rs121918686EnsemblClinVar.1
Natural variantiVAR_004644345G → S in GTHR. 1 PublicationCorresponds to variant dbSNP:rs121918686EnsemblClinVar.1
Natural variantiVAR_004643345G → V in GTHR. 1 PublicationCorresponds to variant dbSNP:rs28999970EnsemblClinVar.1
Natural variantiVAR_059045346L → F in GTHR. 1 Publication1
Natural variantiVAR_004646347G → E in GTHR. 1 PublicationCorresponds to variant dbSNP:rs28999971EnsemblClinVar.1
Natural variantiVAR_004647348V → E in GTHR. 1 Publication1
Natural variantiVAR_004648426T → I in GTHR. 1 Publication1
Natural variantiVAR_058508429R → Q in PRTH. 1 Publication1
Natural variantiVAR_059046431I → M in GTHR. 1 Publication1
Natural variantiVAR_004649438R → H in GTHR. 1 PublicationCorresponds to variant dbSNP:rs121918698EnsemblClinVar.1
Natural variantiVAR_004650442M → V in GTHR. 1 PublicationCorresponds to variant dbSNP:rs121918691EnsemblClinVar.1
Natural variantiVAR_004651443K → E in GTHR. 1 PublicationCorresponds to variant dbSNP:rs121918692EnsemblClinVar.1
Natural variantiVAR_004652446C → R in GTHR. 1 PublicationCorresponds to variant dbSNP:rs121918703EnsemblClinVar.1
Natural variantiVAR_059047447P → T in GTHR. 1 Publication1
Natural variantiVAR_004653453P → H in GTHR. 1 PublicationCorresponds to variant dbSNP:rs121918687EnsemblClinVar.1
Natural variantiVAR_059048453P → L in GTHR. 1 Publication1
Natural variantiVAR_004654453P → S in GTHR. 1 Publication1
Natural variantiVAR_004655453P → T in GTHR. 4 PublicationsCorresponds to variant dbSNP:rs28933408EnsemblClinVar.1
Natural variantiVAR_059049459F → C in GTHR. 1 PublicationCorresponds to variant dbSNP:rs121918702EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0310771 – 93MTPNS…EEKKC → MNYCMQEIYEVHPAAGSNCY MQSTDYYAYFEDSPGYSGCD AQAVPSNNIYMEQAWAVNQP YTCSYPGNMFKSKDSDLDMA LNQYSQPEYFTEEKPTFSQV QSPSYSQK in isoform Beta-2. 1 PublicationAdd BLAST93

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26747 mRNA Translation: AAA35677.1 Different initiation.
X04707 mRNA Translation: CAA28412.1 Different initiation.
AK096628 mRNA Translation: BAG53341.1
AC012087 Genomic DNA No translation available.
AC093927 Genomic DNA No translation available.
AC098971 Genomic DNA No translation available.
AC099054 Genomic DNA No translation available.
AC112217 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64345.1
BC106929 mRNA Translation: AAI06930.1
BC106930 mRNA Translation: AAI06931.1
AY286465 mRNA Translation: AAQ23704.1
AY286466 mRNA Translation: AAQ23705.1
AY286467 mRNA Translation: AAQ23706.1
AY286468 mRNA Translation: AAQ23707.1
AY286469 mRNA Translation: AAQ23708.1
AY286470 mRNA Translation: AAQ23709.1
AY286471 mRNA Translation: AAQ23710.1
X74497 mRNA Translation: CAA52606.1
CCDSiCCDS2641.1 [P10828-1]
PIRiA25237 TVHUAR
S40152
RefSeqiNP_000452.2, NM_000461.4 [P10828-1]
NP_001121648.1, NM_001128176.2 [P10828-1]
NP_001121649.1, NM_001128177.1 [P10828-1]
NP_001239563.1, NM_001252634.1 [P10828-1]
XP_005265478.1, XM_005265421.4
XP_005265480.1, XM_005265423.4
XP_005265481.1, XM_005265424.3
XP_006713380.1, XM_006713317.3
XP_006713381.1, XM_006713318.3 [P10828-1]
XP_011532348.1, XM_011534046.2
XP_011532349.1, XM_011534047.2 [P10828-1]
XP_011532350.1, XM_011534048.2
XP_011532351.1, XM_011534049.2
XP_011532352.1, XM_011534050.2 [P10828-1]
XP_011532353.1, XM_011534051.2
XP_011532354.1, XM_011534052.2 [P10828-1]
XP_016862597.1, XM_017007108.1
XP_016862598.1, XM_017007109.1 [P10828-1]
XP_016862599.1, XM_017007110.1
XP_016862600.1, XM_017007111.1 [P10828-1]
XP_016862601.1, XM_017007112.1 [P10828-1]
UniGeneiHs.187861
Hs.713754

Genome annotation databases

EnsembliENST00000280696; ENSP00000280696; ENSG00000151090 [P10828-2]
ENST00000356447; ENSP00000348827; ENSG00000151090 [P10828-1]
ENST00000396671; ENSP00000379904; ENSG00000151090 [P10828-1]
ENST00000415021; ENSP00000404898; ENSG00000151090 [P10828-1]
ENST00000416420; ENSP00000414444; ENSG00000151090 [P10828-1]
ENST00000642307; ENSP00000494618; ENSG00000151090 [P10828-1]
ENST00000643772; ENSP00000496029; ENSG00000151090 [P10828-1]
ENST00000644321; ENSP00000496616; ENSG00000151090 [P10828-1]
ENST00000645139; ENSP00000493709; ENSG00000151090 [P10828-1]
ENST00000646209; ENSP00000496686; ENSG00000151090 [P10828-1]
ENST00000646432; ENSP00000496509; ENSG00000151090 [P10828-1]
GeneIDi7068
KEGGihsa:7068
UCSCiuc003ccx.5 human [P10828-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26747 mRNA Translation: AAA35677.1 Different initiation.
X04707 mRNA Translation: CAA28412.1 Different initiation.
AK096628 mRNA Translation: BAG53341.1
AC012087 Genomic DNA No translation available.
AC093927 Genomic DNA No translation available.
AC098971 Genomic DNA No translation available.
AC099054 Genomic DNA No translation available.
AC112217 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64345.1
BC106929 mRNA Translation: AAI06930.1
BC106930 mRNA Translation: AAI06931.1
AY286465 mRNA Translation: AAQ23704.1
AY286466 mRNA Translation: AAQ23705.1
AY286467 mRNA Translation: AAQ23706.1
AY286468 mRNA Translation: AAQ23707.1
AY286469 mRNA Translation: AAQ23708.1
AY286470 mRNA Translation: AAQ23709.1
AY286471 mRNA Translation: AAQ23710.1
X74497 mRNA Translation: CAA52606.1
CCDSiCCDS2641.1 [P10828-1]
PIRiA25237 TVHUAR
S40152
RefSeqiNP_000452.2, NM_000461.4 [P10828-1]
NP_001121648.1, NM_001128176.2 [P10828-1]
NP_001121649.1, NM_001128177.1 [P10828-1]
NP_001239563.1, NM_001252634.1 [P10828-1]
XP_005265478.1, XM_005265421.4
XP_005265480.1, XM_005265423.4
XP_005265481.1, XM_005265424.3
XP_006713380.1, XM_006713317.3
XP_006713381.1, XM_006713318.3 [P10828-1]
XP_011532348.1, XM_011534046.2
XP_011532349.1, XM_011534047.2 [P10828-1]
XP_011532350.1, XM_011534048.2
XP_011532351.1, XM_011534049.2
XP_011532352.1, XM_011534050.2 [P10828-1]
XP_011532353.1, XM_011534051.2
XP_011532354.1, XM_011534052.2 [P10828-1]
XP_016862597.1, XM_017007108.1
XP_016862598.1, XM_017007109.1 [P10828-1]
XP_016862599.1, XM_017007110.1
XP_016862600.1, XM_017007111.1 [P10828-1]
XP_016862601.1, XM_017007112.1 [P10828-1]
UniGeneiHs.187861
Hs.713754

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BSXX-ray3.70A/B202-461[»]
1N46X-ray2.20A/B204-461[»]
1NAXX-ray2.70A209-460[»]
1NQ0X-ray2.40A202-461[»]
1NQ1X-ray2.90A202-461[»]
1NQ2X-ray2.40A202-461[»]
1NUOX-ray3.10A202-461[»]
1Q4XX-ray2.80A209-461[»]
1R6GX-ray3.00A203-461[»]
1XZXX-ray2.50X202-461[»]
1Y0XX-ray3.10X202-461[»]
2J4AX-ray2.20A209-461[»]
2NLLX-ray1.90B104-204[»]
2PINX-ray2.30A/B209-461[»]
3D57X-ray2.20A/B209-460[»]
3GWSX-ray2.20X202-460[»]
3IMYX-ray2.55A202-461[»]
3JZCX-ray2.50A202-461[»]
4ZO1X-ray3.22X210-461[»]
ProteinModelPortaliP10828
SMRiP10828
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112924, 56 interactors
ComplexPortaliCPX-654 RXRalpha-TRbeta nuclear hormone receptor complex
CORUMiP10828
DIPiDIP-5991N
IntActiP10828, 12 interactors
MINTiP10828
STRINGi9606.ENSP00000348827

Chemistry databases

BindingDBiP10828
ChEMBLiCHEMBL1947
DrugBankiDB08085 1-(4-HEXYLPHENYL)PROP-2-EN-1-ONE
DB00509 Dextrothyroxine
DB03788 GC-24
DB05035 KB2115
DB00451 Levothyroxine
DB00279 Liothyronine
DB01583 Liotrix
DB05192 MB07811
GuidetoPHARMACOLOGYi589

PTM databases

iPTMnetiP10828
PhosphoSitePlusiP10828

Polymorphism and mutation databases

BioMutaiTHRB
DMDMi586092

Proteomic databases

MaxQBiP10828
PaxDbiP10828
PeptideAtlasiP10828
PRIDEiP10828
ProteomicsDBi52661
52662 [P10828-2]

Protocols and materials databases

DNASUi7068
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000280696; ENSP00000280696; ENSG00000151090 [P10828-2]
ENST00000356447; ENSP00000348827; ENSG00000151090 [P10828-1]
ENST00000396671; ENSP00000379904; ENSG00000151090 [P10828-1]
ENST00000415021; ENSP00000404898; ENSG00000151090 [P10828-1]
ENST00000416420; ENSP00000414444; ENSG00000151090 [P10828-1]
ENST00000642307; ENSP00000494618; ENSG00000151090 [P10828-1]
ENST00000643772; ENSP00000496029; ENSG00000151090 [P10828-1]
ENST00000644321; ENSP00000496616; ENSG00000151090 [P10828-1]
ENST00000645139; ENSP00000493709; ENSG00000151090 [P10828-1]
ENST00000646209; ENSP00000496686; ENSG00000151090 [P10828-1]
ENST00000646432; ENSP00000496509; ENSG00000151090 [P10828-1]
GeneIDi7068
KEGGihsa:7068
UCSCiuc003ccx.5 human [P10828-1]

Organism-specific databases

CTDi7068
DisGeNETi7068
EuPathDBiHostDB:ENSG00000151090.17
GeneCardsiTHRB
HGNCiHGNC:11799 THRB
HPAiCAB002008
CAB002009
HPA061035
MalaCardsiTHRB
MIMi145650 phenotype
188570 phenotype
190160 gene
274300 phenotype
neXtProtiNX_P10828
OpenTargetsiENSG00000151090
Orphaneti3221 Generalized resistance to thyroid hormone
97927 Peripheral resistance to thyroid hormones
165994 Selective pituitary resistance to thyroid hormone
PharmGKBiPA36508
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00870000136372
HOGENOMiHOG000010313
HOVERGENiHBG005606
InParanoidiP10828
KOiK08362
OMAiQEWELIK
OrthoDBiEOG091G0GC1
PhylomeDBiP10828
TreeFamiTF328382

Enzyme and pathway databases

ReactomeiR-HSA-383280 Nuclear Receptor transcription pathway
R-HSA-4090294 SUMOylation of intracellular receptors
SignaLinkiP10828
SIGNORiP10828

Miscellaneous databases

ChiTaRSiTHRB human
EvolutionaryTraceiP10828
GeneWikiiThyroid_hormone_receptor_beta
GenomeRNAii7068
PROiPR:P10828
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000151090 Expressed in 196 organ(s), highest expression level in Brodmann (1909) area 23
CleanExiHS_THRB
ExpressionAtlasiP10828 baseline and differential
GenevisibleiP10828 HS

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001728 ThyrH_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR00398 STRDHORMONER
PR00047 STROIDFINGER
PR00546 THYROIDHORMR
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTHB_HUMAN
AccessioniPrimary (citable) accession number: P10828
Secondary accession number(s): B3KU79
, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: October 1, 1994
Last modified: October 10, 2018
This is version 225 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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