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Entry version 232 (16 Oct 2019)
Sequence version 1 (01 Jul 1989)
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Protein

Thyroid hormone receptor alpha

Gene

THRA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Isoform Alpha-1: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.4 Publications
Isoform Alpha-2: Does not bind thyroid hormone and functions as a weak dominant negative inhibitor of thyroid hormone action.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei228Thyroid hormone1
Binding sitei277Thyroid hormone; via amide nitrogen1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi53 – 127Nuclear receptorPROSITE-ProRule annotationAdd BLAST75
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri53 – 73NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri91 – 115NR C4-typePROSITE-ProRule annotationAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-383280 Nuclear Receptor transcription pathway
R-HSA-4090294 SUMOylation of intracellular receptors [P10827-2]

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P10827

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P10827

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Thyroid hormone receptor alpha
Alternative name(s):
Nuclear receptor subfamily 1 group A member 1
V-erbA-related protein 7
Short name:
EAR-7
c-erbA-1
c-erbA-alpha
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:THRA
Synonyms:EAR7, ERBA1, NR1A1, THRA1, THRA2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11796 THRA

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
190120 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P10827

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Hypothyroidism, congenital, non-goitrous, 6 (CHNG6)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by growth retardation, developmental retardation, skeletal dysplasia, borderline low thyroxine levels and high triiodothyronine levels. There is differential sensitivity to thyroid hormone action, with retention of hormone responsiveness in the hypothalamic pituitary axis and liver but skeletal, gastrointestinal, and myocardial resistance.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_074559263A → V in CHNG6; no effect on T3 binding; no effect on thyroid hormone-dependent transcriptional activation. 1 PublicationCorresponds to variant dbSNP:rs1555545033EnsemblClinVar.1
Natural variantiVAR_074560359N → Y in CHNG6; atypical phenotype; weak reduction in transcriptional activation. 1 Publication1
Isoform Alpha-1 (identifier: P10827-2)
Natural varianti263A → V in CHNG6, reduces T3 binding, impairs thyroid hormone-dependent transcriptional activation, no effect on DNA-binding) (Ref.24. 3 Publications1
Natural varianti359N → Y in CHNG6, decreases transcriptional activity, decreases T3 binding) (Ref.25. 3 Publications1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi277S → N: No effect on thyroid hormone binding. 2 Publications1

Keywords - Diseasei

Congenital hypothyroidism, Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
7067

MalaCards human disease database

More...
MalaCardsi
THRA
MIMi614450 phenotype

Open Targets

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OpenTargetsi
ENSG00000126351

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
97927 Peripheral resistance to thyroid hormones

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36507

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P10827

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL1860

Drug and drug target database

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DrugBanki
DB01118 Amiodarone
DB00509 Dextrothyroxine
DB05035 Eprotirome
DB03176 KB-141
DB00451 Levothyroxine
DB00279 Liothyronine
DB01583 Liotrix
DB05235 NRP409

DrugCentral

More...
DrugCentrali
P10827

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
588

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
THRA

Domain mapping of disease mutations (DMDM)

More...
DMDMi
135705

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000534241 – 490Thyroid hormone receptor alphaAdd BLAST490

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P10827

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P10827

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P10827

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P10827

PeptideAtlas

More...
PeptideAtlasi
P10827

PRoteomics IDEntifications database

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PRIDEi
P10827

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
52657 [P10827-1]
52658 [P10827-2]
52659 [P10827-3]
52660 [P10827-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P10827

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P10827

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000126351 Expressed in 221 organ(s), highest expression level in nucleus accumbens

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P10827 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P10827 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB023349
HPA009654

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds DNA as a dimer; homodimer and heterodimer with RXRB.

Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Probably interacts with SFPQ.

Interacts with C1D.

Interacts with AKAP13.

Interacts with TP53INP2.

Interacts with PER2. Isoform alpha-2 and isoform alpha-1 interact with TACC1, but the interaction with alpha-1 is weaker. The interaction with isoform alpha-1, but not alpha-2, is decreased in the presence of thyroid hormone T3 (PubMed:20078863).

9 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
112923, 82 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-662 RXRalpha-TRalpha nuclear hormone receptor complex [P10827-2]

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P10827

Database of interacting proteins

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DIPi
DIP-31452N

Protein interaction database and analysis system

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IntActi
P10827, 30 interactors

Molecular INTeraction database

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MINTi
P10827

STRING: functional protein association networks

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STRINGi
9606.ENSP00000264637

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P10827

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1490
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P10827

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P10827

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini163 – 407NR LBDPROSITE-ProRule annotationAdd BLAST245

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 52ModulatingAdd BLAST52

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri53 – 73NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri91 – 115NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3575 Eukaryota
ENOG410XRZC LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157917

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000010313

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P10827

KEGG Orthology (KO)

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KOi
K05547

Identification of Orthologs from Complete Genome Data

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OMAi
KPSKLEC

Database of Orthologous Groups

More...
OrthoDBi
1018705at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P10827

TreeFam database of animal gene trees

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TreeFami
TF328382

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.565.10, 1 hit
3.30.50.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR035500 NHR-like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001728 ThyrH_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00398 STRDHORMONER
PR00047 STROIDFINGER
PR00546 THYROIDHORMR

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48508 SSF48508, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform Alpha-2 (identifier: P10827-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEQKPSKVEC GSDPEENSAR SPDGKRKRKN GQCSLKTSMS GYIPSYLDKD
60 70 80 90 100
EQCVVCGDKA TGYHYRCITC EGCKGFFRRT IQKNLHPTYS CKYDSCCVID
110 120 130 140 150
KITRNQCQLC RFKKCIAVGM AMDLVLDDSK RVAKRKLIEQ NRERRRKEEM
160 170 180 190 200
IRSLQQRPEP TPEEWDLIHI ATEAHRSTNA QGSHWKQRRK FLPDDIGQSP
210 220 230 240 250
IVSMPDGDKV DLEAFSEFTK IITPAITRVV DFAKKLPMFS ELPCEDQIIL
260 270 280 290 300
LKGCCMEIMS LRAAVRYDPE SDTLTLSGEM AVKREQLKNG GLGVVSDAIF
310 320 330 340 350
ELGKSLSAFN LDDTEVALLQ AVLLMSTDRS GLLCVDKIEK SQEAYLLAFE
360 370 380 390 400
HYVNHRKHNI PHFWPKLLMK EREVQSSILY KGAAAEGRPG GSLGVHPEGQ
410 420 430 440 450
QLLGMHVVQG PQVRQLEQQL GEAGSLQGPV LQHQSPKSPQ QRLLELLHRS
460 470 480 490
GILHARAVCG EDDSSEADSP SSSEEEPEVC EDLAGNAASP
Note: Does not bind thyroid hormone T3.1 Publication
Length:490
Mass (Da):54,816
Last modified:July 1, 1989 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC87C7D2F67B1AE49
GO
Isoform Alpha-1 (identifier: P10827-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     371-490: EREVQSSILY...EDLAGNAASP → VTDLRMIGAC...FLEVFEDQEV

Show »
Length:410
Mass (Da):46,813
Checksum:iB9FD7BFAC16D6882
GO
Isoform Alpha-3 (identifier: P10827-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     371-409: Missing.

Show »
Length:451
Mass (Da):50,747
Checksum:i1495A3F2EE6601DD
GO
Isoform Alpha-4 (identifier: P10827-4) [UniParc]FASTAAdd to basket
Also known as: Alpha3

The sequence of this isoform differs from the canonical sequence as follows:
     371-412: Missing.

Show »
Length:448
Mass (Da):50,465
Checksum:i15FD778790B4D26B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QRA9J3QRA9_HUMAN
Thyroid hormone receptor alpha
THRA
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KTF3J3KTF3_HUMAN
Thyroid hormone receptor alpha
THRA
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QR26J3QR26_HUMAN
Thyroid hormone receptor alpha
THRA
31Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QRW5J3QRW5_HUMAN
Thyroid hormone receptor alpha
THRA
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti37T → S in CAA68539 (PubMed:3684612).Curated1
Sequence conflicti119G → A in CAA68539 (PubMed:3684612).Curated1
Sequence conflicti285E → A in CAB57886 (PubMed:1850510).Curated1
Sequence conflicti285E → A in CAA38899 (PubMed:1850510).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_074559263A → V in CHNG6; no effect on T3 binding; no effect on thyroid hormone-dependent transcriptional activation. 1 PublicationCorresponds to variant dbSNP:rs1555545033EnsemblClinVar.1
Natural variantiVAR_074560359N → Y in CHNG6; atypical phenotype; weak reduction in transcriptional activation. 1 Publication1
Isoform Alpha-1 (identifier: P10827-2)
Natural varianti263A → V in CHNG6, reduces T3 binding, impairs thyroid hormone-dependent transcriptional activation, no effect on DNA-binding) (Ref.24. 3 Publications1
Natural varianti359N → Y in CHNG6, decreases transcriptional activity, decreases T3 binding) (Ref.25. 3 Publications1
Natural varianti398P → R in CHNG6) (Ref.26. 3 Publications1
Natural varianti403E → Q in CHNG6) (Ref.26. 3 Publications1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_003621371 – 490EREVQ…NAASP → VTDLRMIGACHASRFLHMKV ECPTELFPPLFLEVFEDQEV in isoform Alpha-1. 2 PublicationsAdd BLAST120
Alternative sequenceiVSP_003623371 – 412Missing in isoform Alpha-4. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_003622371 – 409Missing in isoform Alpha-3. 1 PublicationAdd BLAST39

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X55074
, X55073, X55070, X55071, X55004, X55069, X55068, X55066 Genomic DNA Translation: CAB57886.1
X55005 mRNA Translation: CAA38749.1
X55074
, X55073, X55070, X55071, X55004, X55069, X55068 Genomic DNA Translation: CAA38899.1
M24899 mRNA Translation: AAA35783.1
M24900 mRNA Translation: AAA52333.1
J03239 mRNA Translation: AAA61176.1
Y00479 mRNA Translation: CAA68539.1
M24748 Genomic DNA Translation: AAA66021.1
AK290530 mRNA Translation: BAF83219.1
CH471152 Genomic DNA Translation: EAW60632.1
BC000261 mRNA Translation: AAH00261.1
BC002728 mRNA Translation: AAH02728.1
BC035137 mRNA Translation: AAH35137.1
AF522368 mRNA Translation: AAM77692.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11360.1 [P10827-1]
CCDS42316.1 [P10827-2]
CCDS58546.1 [P10827-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
A30893
A40917
S06163

NCBI Reference Sequences

More...
RefSeqi
NP_001177847.1, NM_001190918.1 [P10827-3]
NP_001177848.1, NM_001190919.1 [P10827-1]
NP_003241.2, NM_003250.5 [P10827-1]
NP_955366.1, NM_199334.3 [P10827-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000264637; ENSP00000264637; ENSG00000126351 [P10827-1]
ENST00000394121; ENSP00000377679; ENSG00000126351 [P10827-1]
ENST00000450525; ENSP00000395641; ENSG00000126351 [P10827-2]
ENST00000546243; ENSP00000443972; ENSG00000126351 [P10827-2]
ENST00000584985; ENSP00000463466; ENSG00000126351 [P10827-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
7067

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:7067

UCSC genome browser

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UCSCi
uc002htw.4 human [P10827-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55074
, X55073, X55070, X55071, X55004, X55069, X55068, X55066 Genomic DNA Translation: CAB57886.1
X55005 mRNA Translation: CAA38749.1
X55074
, X55073, X55070, X55071, X55004, X55069, X55068 Genomic DNA Translation: CAA38899.1
M24899 mRNA Translation: AAA35783.1
M24900 mRNA Translation: AAA52333.1
J03239 mRNA Translation: AAA61176.1
Y00479 mRNA Translation: CAA68539.1
M24748 Genomic DNA Translation: AAA66021.1
AK290530 mRNA Translation: BAF83219.1
CH471152 Genomic DNA Translation: EAW60632.1
BC000261 mRNA Translation: AAH00261.1
BC002728 mRNA Translation: AAH02728.1
BC035137 mRNA Translation: AAH35137.1
AF522368 mRNA Translation: AAM77692.1
CCDSiCCDS11360.1 [P10827-1]
CCDS42316.1 [P10827-2]
CCDS58546.1 [P10827-3]
PIRiA30893
A40917
S06163
RefSeqiNP_001177847.1, NM_001190918.1 [P10827-3]
NP_001177848.1, NM_001190919.1 [P10827-1]
NP_003241.2, NM_003250.5 [P10827-1]
NP_955366.1, NM_199334.3 [P10827-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NAVX-ray2.50A148-370[»]
2H77X-ray2.33A148-370[»]
2H79X-ray1.87A148-370[»]
3HZFX-ray2.50A148-370[»]
3ILZX-ray1.85A148-370[»]
3JZBX-ray2.01A148-370[»]
4LNWX-ray1.90A148-370[»]
4LNXX-ray2.05A148-370[»]
SMRiP10827
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi112923, 82 interactors
ComplexPortaliCPX-662 RXRalpha-TRalpha nuclear hormone receptor complex [P10827-2]
CORUMiP10827
DIPiDIP-31452N
IntActiP10827, 30 interactors
MINTiP10827
STRINGi9606.ENSP00000264637

Chemistry databases

BindingDBiP10827
ChEMBLiCHEMBL1860
DrugBankiDB01118 Amiodarone
DB00509 Dextrothyroxine
DB05035 Eprotirome
DB03176 KB-141
DB00451 Levothyroxine
DB00279 Liothyronine
DB01583 Liotrix
DB05235 NRP409
DrugCentraliP10827
GuidetoPHARMACOLOGYi588

PTM databases

iPTMnetiP10827
PhosphoSitePlusiP10827

Polymorphism and mutation databases

BioMutaiTHRA
DMDMi135705

Proteomic databases

jPOSTiP10827
MassIVEiP10827
MaxQBiP10827
PaxDbiP10827
PeptideAtlasiP10827
PRIDEiP10827
ProteomicsDBi52657 [P10827-1]
52658 [P10827-2]
52659 [P10827-3]
52660 [P10827-4]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
P10827

The DNASU plasmid repository

More...
DNASUi
7067

Genome annotation databases

EnsembliENST00000264637; ENSP00000264637; ENSG00000126351 [P10827-1]
ENST00000394121; ENSP00000377679; ENSG00000126351 [P10827-1]
ENST00000450525; ENSP00000395641; ENSG00000126351 [P10827-2]
ENST00000546243; ENSP00000443972; ENSG00000126351 [P10827-2]
ENST00000584985; ENSP00000463466; ENSG00000126351 [P10827-3]
GeneIDi7067
KEGGihsa:7067
UCSCiuc002htw.4 human [P10827-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7067
DisGeNETi7067

GeneCards: human genes, protein and diseases

More...
GeneCardsi
THRA
HGNCiHGNC:11796 THRA
HPAiCAB023349
HPA009654
MalaCardsiTHRA
MIMi190120 gene
614450 phenotype
neXtProtiNX_P10827
OpenTargetsiENSG00000126351
Orphaneti97927 Peripheral resistance to thyroid hormones
PharmGKBiPA36507

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00940000157917
HOGENOMiHOG000010313
InParanoidiP10827
KOiK05547
OMAiKPSKLEC
OrthoDBi1018705at2759
PhylomeDBiP10827
TreeFamiTF328382

Enzyme and pathway databases

ReactomeiR-HSA-383280 Nuclear Receptor transcription pathway
R-HSA-4090294 SUMOylation of intracellular receptors [P10827-2]
SignaLinkiP10827
SIGNORiP10827

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
THRA human
EvolutionaryTraceiP10827

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Thyroid_hormone_receptor_alpha

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7067
PharosiP10827

Protein Ontology

More...
PROi
PR:P10827

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000126351 Expressed in 221 organ(s), highest expression level in nucleus accumbens
ExpressionAtlasiP10827 baseline and differential
GenevisibleiP10827 HS

Family and domain databases

Gene3Di1.10.565.10, 1 hit
3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR-like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001728 ThyrH_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR00398 STRDHORMONER
PR00047 STROIDFINGER
PR00546 THYROIDHORMR
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTHA_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P10827
Secondary accession number(s): A8K3B5
, P21205, Q8N6A1, Q96H73
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: October 16, 2019
This is version 232 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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