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Entry version 105 (08 May 2019)
Sequence version 2 (01 Aug 1991)
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Protein

Chymotrypsin inhibitor 3

Gene
N/A
Organism
Psophocarpus tetragonolobus (Winged bean) (Dolichos tetragonolobus)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inhibits alpha-chymotrypsin at the molar ratio of 1:2 in state of 1:1.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei89 – 90Reactive bond for chymotrypsin2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I03.009

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chymotrypsin inhibitor 3
Alternative name(s):
WCI-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPsophocarpus tetragonolobus (Winged bean) (Dolichos tetragonolobus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3891 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideae50 kb inversion cladeNPAAA cladeindigoferoid/millettioid cladePhaseoleaePsophocarpus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 241 PublicationAdd BLAST24
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001689325 – 207Chymotrypsin inhibitor 3Add BLAST183

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi65 ↔ 109
Disulfide bondi159 ↔ 168

Keywords - PTMi

Disulfide bond

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1207
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EYLX-ray1.90A25-207[»]
1FMZX-ray2.05A25-207[»]
1FN0X-ray2.00A25-207[»]
1WBCX-ray2.95A25-207[»]
1XG6X-ray2.15A25-207[»]
2BEAX-ray2.35A/B25-207[»]
2BEBX-ray2.81A/B25-207[»]
2ESUX-ray1.94A25-207[»]
2ET2X-ray2.10A25-207[»]
2QYIX-ray2.60B/D25-207[»]
2WBCX-ray2.30A25-207[»]
3I29X-ray2.40B25-207[»]
3I2AX-ray2.30A/B25-207[»]
3I2XX-ray2.85A/B25-207[»]
3QYDX-ray2.97A/B/C25-201[»]
3VEQX-ray2.25A25-207[»]
4H9WX-ray2.50A25-207[»]
4HA2X-ray2.90A/B25-207[»]
4TLPX-ray1.90A26-200[»]
4WBCX-ray2.14A25-207[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P10822

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P10822

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00178 STI, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011065 Kunitz_inhibitor_STI-like_sf
IPR002160 Prot_inh_Kunz-lg

The PANTHER Classification System

More...
PANTHERi
PTHR33107 PTHR33107, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00197 Kunitz_legume, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00291 KUNITZINHBTR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00452 STI, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50386 SSF50386, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00283 SOYBEAN_KUNITZ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P10822-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKSTTFLALF LLSAIISHLP SSTADDDLVD AEGNLVENGG TYYLLPHIWA
60 70 80 90 100
HGGGIETAKT GNEPCPLTVV RSPNEVSKGE PIRISSQFLS LFIPRGSLVA
110 120 130 140 150
LGFANPPSCA ASPWWTVVDS PQGPAVKLSQ QKLPEKDILV FKFEKVSHSN
160 170 180 190 200
IHVYKLLYCQ HDEEDVKCDQ YIGIHRDRNG NRRLVVTEEN PLELVLLKAK

SETASSH
Length:207
Mass (Da):22,774
Last modified:August 1, 1991 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE8D164DB6D2D616A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
S96732 Genomic DNA Translation: AAC60535.1
D13974 mRNA Translation: BAA03084.1
D13975 Genomic DNA Translation: BAA03085.1
D13976 Genomic DNA Translation: BAA03086.1

Protein sequence database of the Protein Information Resource

More...
PIRi
JX0206

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S96732 Genomic DNA Translation: AAC60535.1
D13974 mRNA Translation: BAA03084.1
D13975 Genomic DNA Translation: BAA03085.1
D13976 Genomic DNA Translation: BAA03086.1
PIRiJX0206

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EYLX-ray1.90A25-207[»]
1FMZX-ray2.05A25-207[»]
1FN0X-ray2.00A25-207[»]
1WBCX-ray2.95A25-207[»]
1XG6X-ray2.15A25-207[»]
2BEAX-ray2.35A/B25-207[»]
2BEBX-ray2.81A/B25-207[»]
2ESUX-ray1.94A25-207[»]
2ET2X-ray2.10A25-207[»]
2QYIX-ray2.60B/D25-207[»]
2WBCX-ray2.30A25-207[»]
3I29X-ray2.40B25-207[»]
3I2AX-ray2.30A/B25-207[»]
3I2XX-ray2.85A/B25-207[»]
3QYDX-ray2.97A/B/C25-201[»]
3VEQX-ray2.25A25-207[»]
4H9WX-ray2.50A25-207[»]
4HA2X-ray2.90A/B25-207[»]
4TLPX-ray1.90A26-200[»]
4WBCX-ray2.14A25-207[»]
SMRiP10822
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiI03.009

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP10822

Family and domain databases

CDDicd00178 STI, 1 hit
InterProiView protein in InterPro
IPR011065 Kunitz_inhibitor_STI-like_sf
IPR002160 Prot_inh_Kunz-lg
PANTHERiPTHR33107 PTHR33107, 1 hit
PfamiView protein in Pfam
PF00197 Kunitz_legume, 1 hit
PRINTSiPR00291 KUNITZINHBTR
SMARTiView protein in SMART
SM00452 STI, 1 hit
SUPFAMiSSF50386 SSF50386, 1 hit
PROSITEiView protein in PROSITE
PS00283 SOYBEAN_KUNITZ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiICW3_PSOTE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P10822
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: August 1, 1991
Last modified: May 8, 2019
This is version 105 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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