UniProtKB - P10820 (PERF_MOUSE)

BLAST

>sp|P10820|PERF_MOUSE Perforin-1 OS=Mus musculus OX=10090 GN=Prf1 PE=1 SV=2
MATCLFLLGLFLLLPRPVPAPCYTATRSECKQKHKFVPGVWMAGEGMDVTTLRRSGSFPV
NTQRFLRPDRTCTLCKNSLMRDATQRLPVAITHWRPHSSHCQRNVAAAKVHSTEGVAREA
AANINNDWRVGLDVNPRPEANMRASVAGSHSKVANFAAEKTYQDQYNFNSDTVECRMYSF
RLVQKPPLHLDFKKALRALPRNFNSSTEHAYHRLISSYGTHFITAVDLGGRISVLTALRT
CQLTLNGLTADEVGDCLNVEAQVSIGAQASVSSEYKACEEKKKQHKMATSFHQTYRERHV
EVLGGPLDSTHDLLFGNQATPEQFSTWTASLPSNPGLVDYSLEPLHTLLEEQNPKREALR
QAISHYIMSRARWQNCSRPCRSGQHKSSHDSCQCECQDSKVTNQDCCPRQRGLAHLVVSN
FRAEHLWGDYTTATDAYLKVFFGGQEFRTGVVWNNNNPRWTDKMDFENVLLSTGGPLRVQ
VWDADYGWDDDLLGSCDRSPHSGFHEVTCELNHGRVKFSYHAKCLPHLTGGTCLEYAPQG
LLGDPPGNRSGAVW

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History
Entry version 173 (10 Oct 2018)
Sequence version 2 (01 Apr 1990)
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Protein

Perforin-1

Gene

Prf1

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes.5 Publications

Sites

Feature key	Position(s)	DescriptionActions	Length
Siteⁱ	213	Important for oligomerization	1
Siteⁱ	343	Important for oligomerization	1
Metal bindingⁱ	435	Calcium 11 Publication	1
Metal bindingⁱ	483	Calcium 11 Publication	1
Metal bindingⁱ	484	Calcium 1; via carbonyl oxygen1 Publication	1
Metal bindingⁱ	485	Calcium 2; via carbonyl oxygen1 Publication	1
Metal bindingⁱ	488	Calcium 2; via carbonyl oxygen1 Publication	1
Metal bindingⁱ	490	Calcium 21 Publication	1

GO - Molecular functionⁱ

calcium ion binding
Source: UniProtKB
Inferred from direct assayⁱ
- 21037563
identical protein binding Source: MGI
wide pore channel activity
Source: UniProtKB
Inferred from direct assayⁱ
- 21037563

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

apoptotic process Source: MGI
circadian rhythm Source: MGI
cytolysis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 8164737
defense response to tumor cell
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 8164737
defense response to virus
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 8164737
immune response to tumor cell
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 8164737
immunological synapse formation Source: MGI
positive regulation of killing of cells of other organism Source: MGI
protein homooligomerization
Source: UniProtKB
Inferred from direct assayⁱ
- 21037563
T cell mediated cytotoxicity
Source: MGI
Inferred from direct assayⁱ
- 15454490

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cytolysis
Ligand	Calcium, Metal-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Perforin-1 Short name: P1 Alternative name(s): Cytolysin Lymphocyte pore-forming protein
Gene namesⁱ	Name:Prf1 Synonyms:Pfp
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 10

Organism-specific databases

MGIⁱ	MGI:97551 Prf1

Keywords - Cellular componentⁱ

Cell membrane, Endosome, Membrane, Secreted

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Mice are viable and fertile, but die of virus infections that are normally efficiently dealt with by the immune system. They cannot eliminate lymphocytic choriomeningitis virus, but die of the infection. Young mice are abnormally susceptible to mouse hepatitis virus. Cytolytic activity towards tumor cells and transplants is also severely reduced.2 Publications

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	191	D → K or V: Loss of cytotoxicity. 1 Publication	1
Mutagenesisⁱ	191	D → S: Strongly decreased cytotoxicity. 1 Publication	1
Mutagenesisⁱ	213	R → E or L: Strongly decreased cytotoxicity. 1 Publication	1
Mutagenesisⁱ	343	E → R: Strongly decreased cytotoxicity. 1 Publication	1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 20	2 PublicationsAdd BLAST		20
ChainⁱPRO_0000023610	21 – 554	Perforin-1Add BLAST		534

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	22 ↔ 75	1 Publication
Disulfide bondⁱ	30 ↔ 72	1 Publication
Disulfide bondⁱ	101 ↔ 175	1 Publication
Glycosylationⁱ	204	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	241 ↔ 407	1 Publication
Glycosylationⁱ	375	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	376 ↔ 392	1 Publication
Disulfide bondⁱ	380 ↔ 394	1 Publication
Disulfide bondⁱ	396 ↔ 406	1 Publication
Disulfide bondⁱ	496 ↔ 509	1 Publication
Disulfide bondⁱ	524 ↔ 533	1 Publication
Glycosylationⁱ	548	N-linked (GlcNAc...) asparagineSequence analysis	1

Post-translational modificationⁱ

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

EPDⁱ	P10820
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P10820
PaxDbⁱ	P10820
PRIDEⁱ	P10820

PTM databases

iPTMnetⁱ	P10820
PhosphoSitePlusⁱ	P10820
SwissPalmⁱ	P10820

Expressionⁱ

Tissue specificityⁱ

Detected in cytotoxic T-lymphocytes and natural killer cells.3 Publications

Gene expression databases

Bgeeⁱ	ENSMUSG00000037202 Expressed in 46 organ(s), highest expression level in decidua
CleanExⁱ	MM_PRF1
ExpressionAtlasⁱ	P10820 baseline and differential
Genevisibleⁱ	P10820 MM

Interactionⁱ

Subunit structureⁱ

Monomer, as soluble protein. Homooligomer. Oligomerization is required for pore formation.2 Publications

GO - Molecular functionⁱ

identical protein binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	202128, 1 interactor
Database of interacting proteins More...DIPⁱ	DIP-59218N
IntActⁱ	P10820, 1 interactor
Molecular INTeraction database More...MINTⁱ	P10820
STRINGⁱ	10090.ENSMUSP00000041483

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	22 – 25	Combined sources	4
Helixⁱ	27 – 31	Combined sources	5
Helixⁱ	40 – 42	Combined sources	3
Turnⁱ	49 – 51	Combined sources	3
Beta strandⁱ	72 – 76	Combined sources	5
Turnⁱ	78 – 82	Combined sources	5
Beta strandⁱ	84 – 87	Combined sources	4
Beta strandⁱ	91 – 96	Combined sources	6
Beta strandⁱ	106 – 110	Combined sources	5
Helixⁱ	113 – 121	Combined sources	9
Turnⁱ	128 – 131	Combined sources	4
Turnⁱ	140 – 143	Combined sources	4
Turnⁱ	147 – 150	Combined sources	4
Helixⁱ	152 – 163	Combined sources	12
Beta strandⁱ	166 – 182	Combined sources	17
Helixⁱ	190 – 197	Combined sources	8
Helixⁱ	208 – 218	Combined sources	11
Beta strandⁱ	220 – 239	Combined sources	20
Helixⁱ	240 – 245	Combined sources	6
Helixⁱ	250 – 264	Combined sources	15
Helixⁱ	273 – 284	Combined sources	12
Helixⁱ	291 – 294	Combined sources	4
Beta strandⁱ	298 – 305	Combined sources	8
Helixⁱ	307 – 309	Combined sources	3
Beta strandⁱ	313 – 315	Combined sources	3
Helixⁱ	321 – 330	Combined sources	10
Turnⁱ	331 – 333	Combined sources	3
Beta strandⁱ	336 – 344	Combined sources	9
Helixⁱ	345 – 348	Combined sources	4
Helixⁱ	355 – 369	Combined sources	15
Beta strandⁱ	384 – 386	Combined sources	3
Beta strandⁱ	394 – 397	Combined sources	4
Turnⁱ	399 – 401	Combined sources	3
Helixⁱ	404 – 406	Combined sources	3
Beta strandⁱ	408 – 410	Combined sources	3
Beta strandⁱ	412 – 424	Combined sources	13
Beta strandⁱ	430 – 432	Combined sources	3
Beta strandⁱ	436 – 442	Combined sources	7
Beta strandⁱ	445 – 448	Combined sources	4
Beta strandⁱ	464 – 470	Combined sources	7
Turnⁱ	471 – 473	Combined sources	3
Beta strandⁱ	477 – 483	Combined sources	7
Beta strandⁱ	485 – 487	Combined sources	3
Beta strandⁱ	491 – 498	Combined sources	8
Beta strandⁱ	502 – 510	Combined sources	9
Beta strandⁱ	512 – 524	Combined sources	13
Beta strandⁱ	528 – 530	Combined sources	3
Beta strandⁱ	541 – 543	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	P10820
SMRⁱ	P10820
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P10820

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	26 – 374	MACPFPROSITE-ProRule annotationAdd BLAST	349
Domainⁱ	375 – 407	EGF-likeAdd BLAST	33
Domainⁱ	416 – 497	C2PROSITE-ProRule annotationAdd BLAST	82

Domainⁱ

The C2 domain mediates calcium-dependent binding to lipid membranes. A subsequent conformation change leads to membrane insertion of beta-hairpin structures and pore formation. The pore is formed by transmembrane beta-strands.

Sequence similaritiesⁱ

Belongs to the complement C6/C7/C8/C9 family.Curated

Keywords - Domainⁱ

EGF-like domain, Signal, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGⁱ	ENOG410IGJ0 Eukaryota ENOG410XSHK LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063725
HOGENOMⁱ	HOG000236309
HOVERGENⁱ	HBG008168
InParanoidⁱ	P10820
KEGG Orthology (KO) More...KOⁱ	K07818
OMAⁱ	NYGTHFI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03LE
PhylomeDBⁱ	P10820
TreeFamⁱ	TF330498

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd04032 C2_Perforin, 1 hit
Gene3Dⁱ	2.60.40.150, 1 hit
InterProⁱ	View protein in InterPro IPR000008 C2_dom IPR035892 C2_domain_sf IPR020864 MACPF IPR020863 MACPF_CS IPR037300 Perforin-1_C2
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00168 C2, 1 hit PF01823 MACPF, 1 hit
SMARTⁱ	View protein in SMART SM00239 C2, 1 hit SM00457 MACPF, 1 hit
PROSITEⁱ	View protein in PROSITE PS50004 C2, 1 hit PS00279 MACPF_1, 1 hit PS51412 MACPF_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P10820-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MATCLFLLGL FLLLPRPVPA PCYTATRSEC KQKHKFVPGV WMAGEGMDVT 
        60         70         80         90        100
TLRRSGSFPV NTQRFLRPDR TCTLCKNSLM RDATQRLPVA ITHWRPHSSH 
       110        120        130        140        150
CQRNVAAAKV HSTEGVAREA AANINNDWRV GLDVNPRPEA NMRASVAGSH 
       160        170        180        190        200
SKVANFAAEK TYQDQYNFNS DTVECRMYSF RLVQKPPLHL DFKKALRALP 
       210        220        230        240        250
RNFNSSTEHA YHRLISSYGT HFITAVDLGG RISVLTALRT CQLTLNGLTA 
       260        270        280        290        300
DEVGDCLNVE AQVSIGAQAS VSSEYKACEE KKKQHKMATS FHQTYRERHV 
       310        320        330        340        350
EVLGGPLDST HDLLFGNQAT PEQFSTWTAS LPSNPGLVDY SLEPLHTLLE 
       360        370        380        390        400
EQNPKREALR QAISHYIMSR ARWQNCSRPC RSGQHKSSHD SCQCECQDSK 
       410        420        430        440        450
VTNQDCCPRQ RGLAHLVVSN FRAEHLWGDY TTATDAYLKV FFGGQEFRTG 
       460        470        480        490        500
VVWNNNNPRW TDKMDFENVL LSTGGPLRVQ VWDADYGWDD DLLGSCDRSP 
       510        520        530        540        550
HSGFHEVTCE LNHGRVKFSY HAKCLPHLTG GTCLEYAPQG LLGDPPGNRS 

GAVW

Length:554

Mass (Da):62,081

Last modified:April 1, 1990 - v2

Checksum:ⁱ9E5964CE9FE8A0D8

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	3	T → M in CAA31251 (PubMed:3261391).Curated	1
Sequence conflictⁱ	176	R → P in AAA39909 (PubMed:2783486).Curated	1
Sequence conflictⁱ	229	G → A in CAA31251 (PubMed:3261391).Curated	1
Sequence conflictⁱ	229	G → A in CAA42731 (Ref. 5) Curated	1
Sequence conflictⁱ	435	D → E in AAA39909 (PubMed:2783486).Curated	1
Sequence conflictⁱ	543 – 550	GDPPGNRS → EILQETAC in AAA39909 (PubMed:2783486).Curated	8

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M23182 mRNA Translation: AAA39910.1 X51340, X51446 Genomic DNA Translation: CAA35721.1 X12760 mRNA Translation: CAA31251.1 J04148 mRNA Translation: AAA39909.1 X60165 mRNA Translation: CAA42731.1 M95527 Genomic DNA Translation: AAB01574.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS23875.1
PIRⁱ	JL0146 A31300
NCBI Reference Sequences More...RefSeqⁱ	NP_035203.3, NM_011073.3 XP_006513433.1, XM_006513370.3
UniGeneⁱ	Mm.240313

Genome annotation databases

Ensemblⁱ	ENSMUST00000035419; ENSMUSP00000041483; ENSMUSG00000037202 ENSMUST00000219375; ENSMUSP00000151354; ENSMUSG00000037202
GeneIDⁱ	18646
KEGGⁱ	mmu:18646
UCSC genome browser More...UCSCⁱ	uc007ffv.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P10820	Perforin 1 (Pore forming protein)		MOUSE		554	UniRef100_P10820

Protein	Similar proteins		Species	Score	Length	Source
P10820	Perforin 1 (Pore forming protein)		MOUSE		554	UniRef90_P10820
UPI000A306CE9		MUSPA		554
UPI000A31AE56		MUSCR		554
UPI0001E7A94E		MOUSE		540

Protein	Similar proteins		Species	Score	Length	Source
P10820	Perforin-1		RAT		554	UniRef50_P10820
Perforin-1		HUMAN		555
Perforin 1 (Pore forming protein)		MOUSE		554
Uncharacterized protein		ICTTR		556
Perforin-1		CASCN		554
+153

Cross-referencesⁱ

Web resourcesⁱ

Protein Spotlight

Our hollow architecture - Issue 126 of February 2011

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M23182 mRNA Translation: AAA39910.1 X51340, X51446 Genomic DNA Translation: CAA35721.1 X12760 mRNA Translation: CAA31251.1 J04148 mRNA Translation: AAA39909.1 X60165 mRNA Translation: CAA42731.1 M95527 Genomic DNA Translation: AAB01574.1
CCDSⁱ	CCDS23875.1
PIRⁱ	JL0146 A31300
RefSeqⁱ	NP_035203.3, NM_011073.3 XP_006513433.1, XM_006513370.3
UniGeneⁱ	Mm.240313

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3NSJ	X-ray	2.75	A	21-554	[»]
	4Y1S	X-ray	1.61	A	410-535	[»]
	4Y1T	X-ray	2.67	A	410-535	[»]
	5UG6	X-ray	2.00	A	410-535	[»]
	5UG7	X-ray	1.80	A	410-535	[»]
ProteinModelPortalⁱ	P10820
SMRⁱ	P10820
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	202128, 1 interactor
DIPⁱ	DIP-59218N
IntActⁱ	P10820, 1 interactor
MINTⁱ	P10820
STRINGⁱ	10090.ENSMUSP00000041483

PTM databases

iPTMnetⁱ	P10820
PhosphoSitePlusⁱ	P10820
SwissPalmⁱ	P10820

Proteomic databases

EPDⁱ	P10820
MaxQBⁱ	P10820
PaxDbⁱ	P10820
PRIDEⁱ	P10820

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000035419; ENSMUSP00000041483; ENSMUSG00000037202 ENSMUST00000219375; ENSMUSP00000151354; ENSMUSG00000037202
GeneIDⁱ	18646
KEGGⁱ	mmu:18646
UCSCⁱ	uc007ffv.2 mouse

Organism-specific databases

CTDⁱ	5551
MGIⁱ	MGI:97551 Prf1

Phylogenomic databases

eggNOGⁱ	ENOG410IGJ0 Eukaryota ENOG410XSHK LUCA
GeneTreeⁱ	ENSGT00530000063725
HOGENOMⁱ	HOG000236309
HOVERGENⁱ	HBG008168
InParanoidⁱ	P10820
KOⁱ	K07818
OMAⁱ	NYGTHFI
OrthoDBⁱ	EOG091G03LE
PhylomeDBⁱ	P10820
TreeFamⁱ	TF330498

Miscellaneous databases

EvolutionaryTraceⁱ	P10820
Protein Ontology More...PROⁱ	PR:P10820
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000037202 Expressed in 46 organ(s), highest expression level in decidua
CleanExⁱ	MM_PRF1
ExpressionAtlasⁱ	P10820 baseline and differential
Genevisibleⁱ	P10820 MM

Family and domain databases

CDDⁱ	cd04032 C2_Perforin, 1 hit
Gene3Dⁱ	2.60.40.150, 1 hit
InterProⁱ	View protein in InterPro IPR000008 C2_dom IPR035892 C2_domain_sf IPR020864 MACPF IPR020863 MACPF_CS IPR037300 Perforin-1_C2
Pfamⁱ	View protein in Pfam PF00168 C2, 1 hit PF01823 MACPF, 1 hit
SMARTⁱ	View protein in SMART SM00239 C2, 1 hit SM00457 MACPF, 1 hit
PROSITEⁱ	View protein in PROSITE PS50004 C2, 1 hit PS00279 MACPF_1, 1 hit PS51412 MACPF_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PERF_MOUSE
Accessionⁱ	P10820Primary (citable) accession number: P10820
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
	Last sequence update:	April 1, 1990
	Last modified:	October 10, 2018
	This is version 173 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Protein Spotlight
Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

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UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P10820 (PERF_MOUSE)

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Perforin-1

Prf1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Plasma membrane

Endosome

Other locations

Cytosol

Endosome

Extracellular region or secreted

Lysosome

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ