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Protein

Alcohol dehydrogenase

Gene

Adh

Organism
Drosophila lebanonensis (Fruit fly) (Scaptodrosophila lebanonensis)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.PROSITE-ProRule annotation
A secondary alcohol + NAD+ = a ketone + NADH.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei138Substrate1
Active sitei151Proton acceptor1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 33NAD1 PublicationAdd BLAST24

GO - Molecular functioni

  • alcohol dehydrogenase (NAD) activity Source: UniProtKB
  • identical protein binding Source: IntAct

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

SABIO-RKiP10807

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase (EC:1.1.1.1)
Gene namesi
Name:Adh
OrganismiDrosophila lebanonensis (Fruit fly) (Scaptodrosophila lebanonensis)
Taxonomic identifieri7225 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeScaptodrosophila

Organism-specific databases

FlyBaseiFBgn0012438 Dleb\Adh

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000544711 – 254Alcohol dehydrogenaseAdd BLAST254

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine1 Publication1

Keywords - PTMi

Acetylation

PTM databases

iPTMnetiP10807

Interactioni

Subunit structurei

Homodimer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-7944097,EBI-7944097

GO - Molecular functioni

Protein-protein interaction databases

MINTiP10807

Structurei

Secondary structure

1254
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP10807
SMRiP10807
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10807

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR002425 ADH_Drosophila-type
IPR002424 ADH_insect
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR01168 ALCDHDRGNASE
PR01167 INSADHFAMILY
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequencei

Sequence statusi: Complete.

P10807-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDLTNKNVIF VAALGGIGLD TSRELVKRNL KNFVILDRVE NPTALAELKA
60 70 80 90 100
INPKVNITFH TYDVTVPVAE SKKLLKKIFD QLKTVDILIN GAGILDDHQI
110 120 130 140 150
ERTIAINFTG LVNTTTAILD FWDKRKGGPG GIIANICSVT GFNAIHQVPV
160 170 180 190 200
YSASKAAVVS FTNSLAKLAP ITGVTAYSIN PGITRTPLVH TFNSWLDVEP
210 220 230 240 250
RVAELLLSHP TQTSEQCGQN FVKAIEANKN GAIWKLDLGT LEAIEWTKHW

DSHI
Length:254
Mass (Da):27,792
Last modified:July 1, 1989 - v1
Checksum:i56DA3644E6B9CDCE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53429 Genomic DNA Translation: CAA37520.1 Sequence problems.
X54814 Genomic DNA Translation: CAA38583.1
M97637 Genomic DNA Translation: AAA28355.1
PIRiS12695 DEFFRL

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53429 Genomic DNA Translation: CAA37520.1 Sequence problems.
X54814 Genomic DNA Translation: CAA38583.1
M97637 Genomic DNA Translation: AAA28355.1
PIRiS12695 DEFFRL

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A4UX-ray1.92A/B1-254[»]
1B14X-ray2.40A/B1-254[»]
1B15X-ray2.20A/B1-254[»]
1B16X-ray1.40A/B1-254[»]
1B2LX-ray1.60A1-254[»]
1SBYX-ray1.10A/B1-254[»]
3RJ5X-ray1.45A/B1-254[»]
3RJ9X-ray1.98A/B/C/D/E/F1-254[»]
ProteinModelPortaliP10807
SMRiP10807
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiP10807

PTM databases

iPTMnetiP10807

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

FlyBaseiFBgn0012438 Dleb\Adh

Enzyme and pathway databases

SABIO-RKiP10807

Miscellaneous databases

EvolutionaryTraceiP10807

Family and domain databases

InterProiView protein in InterPro
IPR002425 ADH_Drosophila-type
IPR002424 ADH_insect
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR01168 ALCDHDRGNASE
PR01167 INSADHFAMILY
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADH_DROLE
AccessioniPrimary (citable) accession number: P10807
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: February 28, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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