UniProtKB - P10775 (RINI_PIG)
Protein
Ribonuclease inhibitor
Gene
RNH1
Organism
Sus scrofa (Pig)
Status
Functioni
Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis.1 Publication
Names & Taxonomyi
Protein namesi | Recommended name: Ribonuclease inhibitorAlternative name(s): Ribonuclease/angiogenin inhibitor 1 |
Gene namesi | Name:RNH1 Synonyms:RI, RNH |
Organismi | Sus scrofa (Pig) |
Taxonomic identifieri | 9823 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Suina › Suidae › Sus |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000097346 | 1 – 456 | Ribonuclease inhibitorAdd BLAST | 456 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionine1 Publication | 1 | |
Modified residuei | 86 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
PeptideAtlasi | P10775 |
PRIDEi | P10775 |
PTM databases
iPTMneti | P10775 |
Interactioni
Subunit structurei
Forms high-affinity heterodimers with RNASE1, ANG and RNASE2.
1 PublicationProtein-protein interaction databases
IntActi | P10775, 1 interactor |
MINTi | P10775 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P10775 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P10775 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 15 – 43 | LRR 1Add BLAST | 29 | |
Repeati | 44 – 71 | LRR 2Add BLAST | 28 | |
Repeati | 72 – 100 | LRR 3Add BLAST | 29 | |
Repeati | 101 – 128 | LRR 4Add BLAST | 28 | |
Repeati | 129 – 157 | LRR 5Add BLAST | 29 | |
Repeati | 158 – 185 | LRR 6Add BLAST | 28 | |
Repeati | 186 – 214 | LRR 7Add BLAST | 29 | |
Repeati | 215 – 242 | LRR 8Add BLAST | 28 | |
Repeati | 243 – 271 | LRR 9Add BLAST | 29 | |
Repeati | 272 – 299 | LRR 10Add BLAST | 28 | |
Repeati | 300 – 328 | LRR 11Add BLAST | 29 | |
Repeati | 329 – 356 | LRR 12Add BLAST | 28 | |
Repeati | 357 – 385 | LRR 13Add BLAST | 29 | |
Repeati | 386 – 413 | LRR 14Add BLAST | 28 | |
Repeati | 414 – 442 | LRR 15Add BLAST | 29 |
Domaini
The LRR domain forms a horseshoe-shaped structure that interacts tightly with target RNases via a large protein interaction surface on its interior side.By similarity
Keywords - Domaini
Leucine-rich repeat, RepeatPhylogenomic databases
InParanoidi | P10775 |
OMAi | CQLECLW |
Family and domain databases
Gene3Di | 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR001611, Leu-rich_rpt IPR006553, Leu-rich_rpt_Cys-con_subtyp IPR032675, LRR_dom_sf IPR041302, LRR_RI_cap |
Pfami | View protein in Pfam PF13516, LRR_6, 8 hits PF18779, LRR_RI_capping, 1 hit |
SMARTi | View protein in SMART SM00367, LRR_CC, 6 hits |
PROSITEi | View protein in PROSITE PS51450, LRR, 6 hits |
i Sequence
Sequence statusi: Complete.
P10775-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNLDIHCEQL SDARWTELLP LLQQYEVVRL DDCGLTEEHC KDIGSALRAN
60 70 80 90 100
PSLTELCLRT NELGDAGVHL VLQGLQSPTC KIQKLSLQNC SLTEAGCGVL
110 120 130 140 150
PSTLRSLPTL RELHLSDNPL GDAGLRLLCE GLLDPQCHLE KLQLEYCRLT
160 170 180 190 200
AASCEPLASV LRATRALKEL TVSNNDIGEA GARVLGQGLA DSACQLETLR
210 220 230 240 250
LENCGLTPAN CKDLCGIVAS QASLRELDLG SNGLGDAGIA ELCPGLLSPA
260 270 280 290 300
SRLKTLWLWE CDITASGCRD LCRVLQAKET LKELSLAGNK LGDEGARLLC
310 320 330 340 350
ESLLQPGCQL ESLWVKSCSL TAACCQHVSL MLTQNKHLLE LQLSSNKLGD
360 370 380 390 400
SGIQELCQAL SQPGTTLRVL CLGDCEVTNS GCSSLASLLL ANRSLRELDL
410 420 430 440 450
SNNCVGDPGV LQLLGSLEQP GCALEQLVLY DTYWTEEVED RLQALEGSKP
GLRVIS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M58700 mRNA Translation: AAA63448.1 |
PIRi | A31857 |
RefSeqi | XP_013847653.1, XM_013992199.1 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M58700 mRNA Translation: AAA63448.1 |
PIRi | A31857 |
RefSeqi | XP_013847653.1, XM_013992199.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1DFJ | X-ray | 2.50 | I | 1-456 | [»] | |
2BNH | X-ray | 2.30 | A | 1-456 | [»] | |
SMRi | P10775 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
IntActi | P10775, 1 interactor |
MINTi | P10775 |
PTM databases
iPTMneti | P10775 |
Proteomic databases
PeptideAtlasi | P10775 |
PRIDEi | P10775 |
Genome annotation databases
Phylogenomic databases
InParanoidi | P10775 |
OMAi | CQLECLW |
Miscellaneous databases
EvolutionaryTracei | P10775 |
Gene expression databases
ExpressionAtlasi | P10775, baseline and differential |
Family and domain databases
Gene3Di | 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR001611, Leu-rich_rpt IPR006553, Leu-rich_rpt_Cys-con_subtyp IPR032675, LRR_dom_sf IPR041302, LRR_RI_cap |
Pfami | View protein in Pfam PF13516, LRR_6, 8 hits PF18779, LRR_RI_capping, 1 hit |
SMARTi | View protein in SMART SM00367, LRR_CC, 6 hits |
PROSITEi | View protein in PROSITE PS51450, LRR, 6 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RINI_PIG | |
Accessioni | P10775Primary (citable) accession number: P10775 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | July 1, 1989 | |
Last modified: | April 7, 2021 | |
This is version 135 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references