ESD

Functionⁱ

Serine hydrolase involved in the detoxification of formaldehyde.

2 Publications

Catalytic activityⁱ

H₂O
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Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
S-formylglutathione
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See the description of this molecule in ChEBI.
=
formate
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+
glutathione
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See the description of this molecule in ChEBI.
+
H⁺
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Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.10
  "Esterase D: a new human polymorphism."
  Hopkinson D.A., Mestriner M.A., Cortner J., Harris H.
  Ann. Hum. Genet. 37:119-137(1973) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION AS METHYLUMBELLIFERYL-ACETATE DEACETYLASE, CATALYTIC ACTIVITY.
EC:
3.1.2.12
- Search proteins in UniProtKB for this EC number.
- See the description of this EC number in ENZYME.
- Search reactions for this EC number in Rhea.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.10
  "Esterase D: a new human polymorphism."
  Hopkinson D.A., Mestriner M.A., Cortner J., Harris H.
  Ann. Hum. Genet. 37:119-137(1973) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION AS METHYLUMBELLIFERYL-ACETATE DEACETYLASE, CATALYTIC ACTIVITY.
Source:
Rhea
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
. Show »« Hide
H₂O
+
S-formylglutathione
zoom
=
formate
zoom
+
glutathione
zoom
+
H⁺
4-methylumbelliferyl acetate
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Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
H₂O
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Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
=
4-methylumbelliferone
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
acetate
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
H⁺
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.10
  "Esterase D: a new human polymorphism."
  Hopkinson D.A., Mestriner M.A., Cortner J., Harris H.
  Ann. Hum. Genet. 37:119-137(1973) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION AS METHYLUMBELLIFERYL-ACETATE DEACETYLASE, CATALYTIC ACTIVITY.
EC:
3.1.1.56
- Search proteins in UniProtKB for this EC number.
- See the description of this EC number in ENZYME.
- Search reactions for this EC number in Rhea.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.10
  "Esterase D: a new human polymorphism."
  Hopkinson D.A., Mestriner M.A., Cortner J., Harris H.
  Ann. Hum. Genet. 37:119-137(1973) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION AS METHYLUMBELLIFERYL-ACETATE DEACETYLASE, CATALYTIC ACTIVITY.
Source:
Rhea
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
. Show »« Hide
4-methylumbelliferyl acetate
zoom
+
H₂O
=
4-methylumbelliferone
zoom
+
acetate
zoom
+
H⁺

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	149	Charge relay system1 Publication	1
Active siteⁱ	226	Charge relay system1 Publication	1
Active siteⁱ	260	Charge relay system1 Publication	1

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

formaldehyde catabolic process Source: InterPro

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Serine esterase

Molecular function

Hydrolase, Serine esterase

Enzyme and pathway databases

PathwayCommonsⁱ	P10768
Reactomeⁱ	R-HSA-156590, Glutathione conjugation

Protein family/group databases

ESTHERⁱ	human-ESD, A85-EsteraseD-FGH
MEROPS protease database More...MEROPSⁱ	S09.990

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: S-formylglutathione hydrolase (EC:3.1.2.12) Short name: FGH Alternative name(s): Esterase D Methylumbelliferyl-acetate deacetylase (EC:3.1.1.56)
Gene namesⁱ	Name:ESD
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3465, ESD
MIMⁱ	133280, gene
neXtProtⁱ	NX_P10768
VEuPathDBⁱ	HostDB:ENSG00000139684

Keywords - Cellular componentⁱ

Cytoplasm, Cytoplasmic vesicle

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	54	L → A: 83% of wild-type activity. 1 Publication	1
Mutagenesisⁱ	149	S → A: Loss of activity. 1 Publication	1
Mutagenesisⁱ	149	S → T: 1.3% of wild-type activity. 1 Publication	1
Mutagenesisⁱ	150	M → A: 62% increase in activity. 1 Publication	1
Mutagenesisⁱ	226	D → A: 4.3% of wild-type activity. 1 Publication	1
Mutagenesisⁱ	226	D → N: 9% of wild-type activity. 1 Publication	1
Mutagenesisⁱ	260	H → A: 3% of wild-type activity. 1 Publication	1
Mutagenesisⁱ	260	H → Q: 1.3% of wild-type activity. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2098
Open Targets More...OpenTargetsⁱ	ENSG00000139684
PharmGKBⁱ	PA27882

Miscellaneous databases

Pharosⁱ	P10768, Tbio

Pharosⁱ

P10768, Tbio

Chemistry databases

ChEMBLⁱ	CHEMBL2189130
Drug and drug target database More...DrugBankⁱ	DB00143, Glutathione

Genetic variation databases

BioMutaⁱ	ESD
DMDMⁱ	544254

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedBy similarity
ChainⁱPRO_0000210339	2 – 282	S-formylglutathione hydrolaseAdd BLAST		281

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineBy similarity	1
Modified residueⁱ	4	N6-succinyllysineBy similarity	1
Modified residueⁱ	200	N6-acetyllysineCombined sources	1

Keywords - PTMⁱ

Acetylation

Proteomic databases

The CPTAC Assay portal More...CPTACⁱ	CPTAC-73 CPTAC-74
EPDⁱ	P10768
jPOSTⁱ	P10768
MassIVEⁱ	P10768
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P10768
PaxDbⁱ	P10768
PeptideAtlas More...PeptideAtlasⁱ	P10768
PRIDEⁱ	P10768
ProteomicsDBⁱ	52652
TopDownProteomicsⁱ	P10768

2D gel databases

DOSAC-COBS 2D-PAGE database More...DOSAC-COBS-2DPAGEⁱ	P10768
USC-OGP 2-DE database More...OGPⁱ	P10768
REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	IPI00411706
UCD-2DPAGEⁱ	P10768

PTM databases

GlyGenⁱ	P10768, 1 site, 1 O-linked glycan (1 site)
iPTMnetⁱ	P10768
MetOSiteⁱ	P10768
PhosphoSitePlusⁱ	P10768
SwissPalmⁱ	P10768

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000139684, Expressed in thoracic mammary gland and 251 other tissues
ExpressionAtlasⁱ	P10768, baseline and differential
Genevisibleⁱ	P10768, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000139684, Low tissue specificity

HPAⁱ

ENSG00000139684, Low tissue specificity

Interactionⁱ

Subunit structureⁱ

Homodimer.

Binary interactionsⁱ

Hide details

P10768

With	#Exp.	IntAct
itself	5	EBI-1052334,EBI-1052334
FSD2 [A1L4K1]	7	EBI-1052334,EBI-5661036

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	108402, 37 interactors
IntActⁱ	P10768, 11 interactors
STRINGⁱ	9606.ENSP00000367992

Miscellaneous databases

RNActⁱ	P10768, protein

RNActⁱ

P10768, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	4 – 11	Combined sources	8
Beta strandⁱ	14 – 23	Combined sources	10
Turnⁱ	24 – 27	Combined sources	4
Beta strandⁱ	28 – 36	Combined sources	9
Helixⁱ	38 – 41	Combined sources	4
Beta strandⁱ	45 – 51	Combined sources	7
Helixⁱ	59 – 64	Combined sources	6
Helixⁱ	68 – 74	Combined sources	7
Beta strandⁱ	77 – 81	Combined sources	5
Beta strandⁱ	93 – 95	Combined sources	3
Helixⁱ	114 – 117	Combined sources	4
Helixⁱ	120 – 125	Combined sources	6
Helixⁱ	127 – 135	Combined sources	9
Beta strandⁱ	136 – 148	Combined sources	13
Helixⁱ	150 – 160	Combined sources	11
Turnⁱ	163 – 165	Combined sources	3
Beta strandⁱ	169 – 173	Combined sources	5
Helixⁱ	178 – 180	Combined sources	3
Helixⁱ	182 – 192	Combined sources	11
Helixⁱ	199 – 202	Combined sources	4
Helixⁱ	204 – 208	Combined sources	5
Beta strandⁱ	218 – 223	Combined sources	6
Helixⁱ	227 – 230	Combined sources	4
Helixⁱ	236 – 245	Combined sources	10
Beta strandⁱ	250 – 255	Combined sources	6
Helixⁱ	262 – 279	Combined sources	18

Show more details

3D structure databases

SMRⁱ	P10768
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P10768

EvolutionaryTraceⁱ

P10768

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the esterase D family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3101, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000011864
InParanoidⁱ	P10768
OMAⁱ	QKAFAGY
Database of Orthologous Groups More...OrthoDBⁱ	942551at2759
PhylomeDBⁱ	P10768
TreeFamⁱ	TF300793

Family and domain databases

Gene3Dⁱ	3.40.50.1820, 1 hit
InterProⁱ	View protein in InterPro IPR029058, AB_hydrolase IPR000801, Esterase-like IPR014186, S-formylglutathione_hydrol
PANTHERⁱ	PTHR10061, PTHR10061, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00756, Esterase, 1 hit
SUPFAMⁱ	SSF53474, SSF53474, 1 hit
TIGRFAMsⁱ	TIGR02821, fghA_ester_D, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

P10768-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MALKQISSNK CFGGLQKVFE HDSVELNCKM KFAVYLPPKA ETGKCPALYW 
        60         70         80         90        100
LSGLTCTEQN FISKSGYHQS ASEHGLVVIA PDTSPRGCNI KGEDESWDFG 
       110        120        130        140        150
TGAGFYVDAT EDPWKTNYRM YSYVTEELPQ LINANFPVDP QRMSIFGHSM 
       160        170        180        190        200
GGHGALICAL KNPGKYKSVS AFAPICNPVL CPWGKKAFSG YLGTDQSKWK 
       210        220        230        240        250
AYDATHLVKS YPGSQLDILI DQGKDDQFLL DGQLLPDNFI AACTEKKIPV 
       260        270        280 
VFRLQEGYDH SYYFIATFIT DHIRHHAKYL NA

Length:282

Mass (Da):31,463

Last modified:June 1, 1994 - v2

Checksum:ⁱBFC20D5FA2BB0DCE

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

X6RA14	X6RA14_HUMAN	S-formylglutathione hydrolase S-formylglutathione hydrolase, EC 3.1.2.12	ESD	253	Annotation score:
H7BZT7	H7BZT7_HUMAN	S-formylglutathione hydrolase S-formylglutathione hydrolase, EC 3.1.2.12	ESD	230	Annotation score:
U3KQT1	U3KQT1_HUMAN	S-formylglutathione hydrolase S-formylglutathione hydrolase, EC 3.1.2.12	ESD hCG_29992	262	Annotation score:

Polymorphismⁱ

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_005202	190	G → E in allele ESD*2. 2 PublicationsCorresponds to variant dbSNP:rs9778Ensembl.		1
Natural variantⁱVAR_022275	257	G → D2 PublicationsCorresponds to variant dbSNP:rs15303Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M13450 mRNA Translation: AAA52408.1 Sequence problems. AF112219 mRNA Translation: AAC99788.1 BT007059 mRNA Translation: AAP35708.1 AL136958 Genomic DNA No translation available. BC001169 mRNA Translation: AAH01169.1 AF052509 Genomic DNA Translation: AAC06298.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS9404.1
PIRⁱ	A23543
NCBI Reference Sequences More...RefSeqⁱ	NP_001975.1, NM_001984.1 XP_005266335.1, XM_005266278.2 XP_011533256.1, XM_011534954.1

Genome annotation databases

Ensemblⁱ	ENST00000378720; ENSP00000367992; ENSG00000139684
GeneIDⁱ	2098
KEGGⁱ	hsa:2098
UCSC genome browser More...UCSCⁱ	uc001vbn.3, human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P10768	S-formylglutathione hydrolase		HUMAN		282	UniRef100_P10768
S-formylglutathione hydrolase		GORGO		253
S-formylglutathione hydrolase		HUMAN		253
+1

Protein	Similar proteins		Species	Score	Length	Source
P10768	S-formylglutathione hydrolase		HUMAN		282	UniRef90_P10768
S-formylglutathione hydrolase		GORGO		253
S-formylglutathione hydrolase		TURTR		313
S-formylglutathione hydrolase		DELLE		311
S-formylglutathione hydrolase		CRIGR		282
+53

Protein	Similar proteins		Species	Score	Length	Source
P10768	S-formylglutathione hydrolase		HUMAN		282	UniRef50_P10768
S-formylglutathione hydrolase		GORGO		253
S-formylglutathione hydrolase		TURTR		313
S-formylglutathione hydrolase		DELLE		311
S-formylglutathione hydrolase		CASCN		282
+70

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M13450 mRNA Translation: AAA52408.1 Sequence problems. AF112219 mRNA Translation: AAC99788.1 BT007059 mRNA Translation: AAP35708.1 AL136958 Genomic DNA No translation available. BC001169 mRNA Translation: AAH01169.1 AF052509 Genomic DNA Translation: AAC06298.1
CCDSⁱ	CCDS9404.1
PIRⁱ	A23543
RefSeqⁱ	NP_001975.1, NM_001984.1 XP_005266335.1, XM_005266278.2 XP_011533256.1, XM_011534954.1

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3FCX	X-ray	1.50	A/B	1-282	[»]
SMRⁱ	P10768
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	108402, 37 interactors
IntActⁱ	P10768, 11 interactors
STRINGⁱ	9606.ENSP00000367992

Chemistry databases

ChEMBLⁱ	CHEMBL2189130
DrugBankⁱ	DB00143, Glutathione

Protein family/group databases

ESTHERⁱ	human-ESD, A85-EsteraseD-FGH
MEROPSⁱ	S09.990

PTM databases

GlyGenⁱ	P10768, 1 site, 1 O-linked glycan (1 site)
iPTMnetⁱ	P10768
MetOSiteⁱ	P10768
PhosphoSitePlusⁱ	P10768
SwissPalmⁱ	P10768

Genetic variation databases

BioMutaⁱ	ESD
DMDMⁱ	544254

2D gel databases

DOSAC-COBS-2DPAGEⁱ	P10768
OGPⁱ	P10768
REPRODUCTION-2DPAGEⁱ	IPI00411706
UCD-2DPAGEⁱ	P10768

Proteomic databases

CPTACⁱ	CPTAC-73 CPTAC-74
EPDⁱ	P10768
jPOSTⁱ	P10768
MassIVEⁱ	P10768
MaxQBⁱ	P10768
PaxDbⁱ	P10768
PeptideAtlasⁱ	P10768
PRIDEⁱ	P10768
ProteomicsDBⁱ	52652
TopDownProteomicsⁱ	P10768

Protocols and materials databases

Antibodypediaⁱ	23747, 221 antibodies
The DNASU plasmid repository More...DNASUⁱ	2098

Genome annotation databases

Ensemblⁱ	ENST00000378720; ENSP00000367992; ENSG00000139684
GeneIDⁱ	2098
KEGGⁱ	hsa:2098
UCSCⁱ	uc001vbn.3, human

Organism-specific databases

CTDⁱ	2098
DisGeNETⁱ	2098
GeneCardsⁱ	ESD
HGNCⁱ	HGNC:3465, ESD
HPAⁱ	ENSG00000139684, Low tissue specificity
MIMⁱ	133280, gene
neXtProtⁱ	NX_P10768
OpenTargetsⁱ	ENSG00000139684
PharmGKBⁱ	PA27882
VEuPathDBⁱ	HostDB:ENSG00000139684
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3101, Eukaryota
GeneTreeⁱ	ENSGT00390000011864
InParanoidⁱ	P10768
OMAⁱ	QKAFAGY
OrthoDBⁱ	942551at2759
PhylomeDBⁱ	P10768
TreeFamⁱ	TF300793

Enzyme and pathway databases

PathwayCommonsⁱ	P10768
Reactomeⁱ	R-HSA-156590, Glutathione conjugation

Miscellaneous databases

BioGRID-ORCSⁱ	2098, 8 hits in 1020 CRISPR screens
ChiTaRSⁱ	ESD, human
EvolutionaryTraceⁱ	P10768
GeneWikiⁱ	ESD_(gene)
GenomeRNAiⁱ	2098
Pharosⁱ	P10768, Tbio
Protein Ontology More...PROⁱ	PR:P10768
RNActⁱ	P10768, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000139684, Expressed in thoracic mammary gland and 251 other tissues
ExpressionAtlasⁱ	P10768, baseline and differential
Genevisibleⁱ	P10768, HS

Family and domain databases

Gene3Dⁱ	3.40.50.1820, 1 hit
InterProⁱ	View protein in InterPro IPR029058, AB_hydrolase IPR000801, Esterase-like IPR014186, S-formylglutathione_hydrol
PANTHERⁱ	PTHR10061, PTHR10061, 1 hit
Pfamⁱ	View protein in Pfam PF00756, Esterase, 1 hit
SUPFAMⁱ	SSF53474, SSF53474, 1 hit
TIGRFAMsⁱ	TIGR02821, fghA_ester_D, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ESTD_HUMAN
Accessionⁱ	P10768Primary (citable) accession number: P10768 Secondary accession number(s): Q5TBU8 , Q5TBV0, Q5TBV2, Q9BVJ2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
	Last sequence update:	June 1, 1994
	Last modified:	September 29, 2021
	This is version 200 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Direct protein sequencing, Reference proteome

Documents

Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P10768 (ESTD_HUMAN)

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S-formylglutathione hydrolase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoplasm and Cytosol

Other locations

Cytosol

Endoplasmic reticulum

Extracellular region or secreted

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Miscellaneous databases

Chemistry databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

P10768

GO - Molecular functioni

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Genetic variation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ