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Protein

Fibroblast growth factor 6

Gene

FGF6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is required for normal muscle regeneration.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Growth factor, Mitogen
Biological processAngiogenesis, Differentiation

Enzyme and pathway databases

ReactomeiR-HSA-109704 PI3K Cascade
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1839122 Signaling by activated point mutants of FGFR1
R-HSA-190322 FGFR4 ligand binding and activation
R-HSA-190373 FGFR1c ligand binding and activation
R-HSA-190375 FGFR2c ligand binding and activation
R-HSA-2033519 Activated point mutants of FGFR2
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-5654219 Phospholipase C-mediated cascade: FGFR1
R-HSA-5654221 Phospholipase C-mediated cascade, FGFR2
R-HSA-5654228 Phospholipase C-mediated cascade, FGFR4
R-HSA-5654687 Downstream signaling of activated FGFR1
R-HSA-5654688 SHC-mediated cascade:FGFR1
R-HSA-5654689 PI-3K cascade:FGFR1
R-HSA-5654693 FRS-mediated FGFR1 signaling
R-HSA-5654695 PI-3K cascade:FGFR2
R-HSA-5654699 SHC-mediated cascade:FGFR2
R-HSA-5654700 FRS-mediated FGFR2 signaling
R-HSA-5654712 FRS-mediated FGFR4 signaling
R-HSA-5654719 SHC-mediated cascade:FGFR4
R-HSA-5654720 PI-3K cascade:FGFR4
R-HSA-5654726 Negative regulation of FGFR1 signaling
R-HSA-5654727 Negative regulation of FGFR2 signaling
R-HSA-5654733 Negative regulation of FGFR4 signaling
R-HSA-5655253 Signaling by FGFR2 in disease
R-HSA-5655302 Signaling by FGFR1 in disease
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
SignaLinkiP10767
SIGNORiP10767

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 6
Short name:
FGF-6
Alternative name(s):
Heparin secretory-transforming protein 2
Short name:
HST-2
Short name:
HSTF-2
Heparin-binding growth factor 6
Short name:
HBGF-6
Gene namesi
Name:FGF6
Synonyms:HST2, HSTF2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000111241.2
HGNCiHGNC:3684 FGF6
MIMi134921 gene
neXtProtiNX_P10767

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi2251
OpenTargetsiENSG00000111241
PharmGKBiPA28123

Polymorphism and mutation databases

BioMutaiFGF6
DMDMi1169676

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 37Sequence analysisAdd BLAST37
ChainiPRO_000000896138 – 208Fibroblast growth factor 6Add BLAST171

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi45N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi90 ↔ 157Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP10767
PRIDEiP10767
ProteomicsDBi52651

PTM databases

PhosphoSitePlusiP10767

Expressioni

Tissue specificityi

Leukemia cell lines with platelet/ megakaryocytic differentiation potential.

Gene expression databases

BgeeiENSG00000111241 Expressed in 83 organ(s), highest expression level in muscle of leg
CleanExiHS_FGF6
ExpressionAtlasiP10767 baseline and differential
GenevisibleiP10767 HS

Interactioni

Subunit structurei

Interacts with FGFR1, FGFR2 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108542, 2 interactors
DIPiDIP-6035N
STRINGi9606.ENSP00000228837

Structurei

3D structure databases

ProteinModelPortaliP10767
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3885 Eukaryota
ENOG4111IPH LUCA
GeneTreeiENSGT00760000118859
HOGENOMiHOG000236341
HOVERGENiHBG007580
InParanoidiP10767
KOiK04358
OMAiFVYKGFY
OrthoDBiEOG091G0NAY
PhylomeDBiP10767
TreeFamiTF317805

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR028242 FGF6
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 1 hit
PTHR11486:SF25 PTHR11486:SF25, 1 hit
PfamiView protein in Pfam
PF00167 FGF, 1 hit
PRINTSiPR00263 HBGFFGF
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00247 HBGF_FGF, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P10767-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALGQKLFIT MSRGAGRLQG TLWALVFLGI LVGMVVPSPA GTRANNTLLD
60 70 80 90 100
SRGWGTLLSR SRAGLAGEIA GVNWESGYLV GIKRQRRLYC NVGIGFHLQV
110 120 130 140 150
LPDGRISGTH EENPYSLLEI STVERGVVSL FGVRSALFVA MNSKGRLYAT
160 170 180 190 200
PSFQEECKFR ETLLPNNYNA YESDLYQGTY IALSKYGRVK RGSKVSPIMT

VTHFLPRI
Length:208
Mass (Da):22,905
Last modified:November 1, 1995 - v4
Checksum:i79EF44685B324322
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YGZ9H0YGZ9_HUMAN
Fibroblast growth factor 6
FGF6
31Annotation score:

Sequence cautioni

The sequence CAA40359 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA40360 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti100V → G in CAB37648 (PubMed:2649847).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01888236V → A1 PublicationCorresponds to variant dbSNP:rs11613495Ensembl.1
Natural variantiVAR_01888363A → V1 PublicationCorresponds to variant dbSNP:rs17183529Ensembl.1
Natural variantiVAR_018884174D → V1 PublicationCorresponds to variant dbSNP:rs7961645Ensembl.1
Natural variantiVAR_018885191R → W1 PublicationCorresponds to variant dbSNP:rs17183778Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57075 Genomic DNA Translation: CAA40358.1
X57075 Genomic DNA Translation: CAA40359.1 Different initiation.
X57075 Genomic DNA Translation: CAA40360.1 Different initiation.
AY581424 Genomic DNA Translation: AAS79318.1
BC121097 mRNA Translation: AAI21098.1
BC121098 mRNA Translation: AAI21099.1
X63454 mRNA Translation: CAA45054.1
X14071, X14072, X14073 Genomic DNA Translation: CAB37648.2
CCDSiCCDS8527.1
PIRiS20102
RefSeqiNP_066276.2, NM_020996.2
UniGeneiHs.166015

Genome annotation databases

EnsembliENST00000228837; ENSP00000228837; ENSG00000111241
GeneIDi2251
KEGGihsa:2251
UCSCiuc001qmr.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57075 Genomic DNA Translation: CAA40358.1
X57075 Genomic DNA Translation: CAA40359.1 Different initiation.
X57075 Genomic DNA Translation: CAA40360.1 Different initiation.
AY581424 Genomic DNA Translation: AAS79318.1
BC121097 mRNA Translation: AAI21098.1
BC121098 mRNA Translation: AAI21099.1
X63454 mRNA Translation: CAA45054.1
X14071, X14072, X14073 Genomic DNA Translation: CAB37648.2
CCDSiCCDS8527.1
PIRiS20102
RefSeqiNP_066276.2, NM_020996.2
UniGeneiHs.166015

3D structure databases

ProteinModelPortaliP10767
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108542, 2 interactors
DIPiDIP-6035N
STRINGi9606.ENSP00000228837

PTM databases

PhosphoSitePlusiP10767

Polymorphism and mutation databases

BioMutaiFGF6
DMDMi1169676

Proteomic databases

PaxDbiP10767
PRIDEiP10767
ProteomicsDBi52651

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000228837; ENSP00000228837; ENSG00000111241
GeneIDi2251
KEGGihsa:2251
UCSCiuc001qmr.2 human

Organism-specific databases

CTDi2251
DisGeNETi2251
EuPathDBiHostDB:ENSG00000111241.2
GeneCardsiFGF6
HGNCiHGNC:3684 FGF6
MIMi134921 gene
neXtProtiNX_P10767
OpenTargetsiENSG00000111241
PharmGKBiPA28123
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3885 Eukaryota
ENOG4111IPH LUCA
GeneTreeiENSGT00760000118859
HOGENOMiHOG000236341
HOVERGENiHBG007580
InParanoidiP10767
KOiK04358
OMAiFVYKGFY
OrthoDBiEOG091G0NAY
PhylomeDBiP10767
TreeFamiTF317805

Enzyme and pathway databases

ReactomeiR-HSA-109704 PI3K Cascade
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1839122 Signaling by activated point mutants of FGFR1
R-HSA-190322 FGFR4 ligand binding and activation
R-HSA-190373 FGFR1c ligand binding and activation
R-HSA-190375 FGFR2c ligand binding and activation
R-HSA-2033519 Activated point mutants of FGFR2
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-5654219 Phospholipase C-mediated cascade: FGFR1
R-HSA-5654221 Phospholipase C-mediated cascade, FGFR2
R-HSA-5654228 Phospholipase C-mediated cascade, FGFR4
R-HSA-5654687 Downstream signaling of activated FGFR1
R-HSA-5654688 SHC-mediated cascade:FGFR1
R-HSA-5654689 PI-3K cascade:FGFR1
R-HSA-5654693 FRS-mediated FGFR1 signaling
R-HSA-5654695 PI-3K cascade:FGFR2
R-HSA-5654699 SHC-mediated cascade:FGFR2
R-HSA-5654700 FRS-mediated FGFR2 signaling
R-HSA-5654712 FRS-mediated FGFR4 signaling
R-HSA-5654719 SHC-mediated cascade:FGFR4
R-HSA-5654720 PI-3K cascade:FGFR4
R-HSA-5654726 Negative regulation of FGFR1 signaling
R-HSA-5654727 Negative regulation of FGFR2 signaling
R-HSA-5654733 Negative regulation of FGFR4 signaling
R-HSA-5655253 Signaling by FGFR2 in disease
R-HSA-5655302 Signaling by FGFR1 in disease
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
SignaLinkiP10767
SIGNORiP10767

Miscellaneous databases

GeneWikiiFGF6
GenomeRNAii2251
PROiPR:P10767
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000111241 Expressed in 83 organ(s), highest expression level in muscle of leg
CleanExiHS_FGF6
ExpressionAtlasiP10767 baseline and differential
GenevisibleiP10767 HS

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR028242 FGF6
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 1 hit
PTHR11486:SF25 PTHR11486:SF25, 1 hit
PfamiView protein in Pfam
PF00167 FGF, 1 hit
PRINTSiPR00263 HBGFFGF
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00247 HBGF_FGF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFGF6_HUMAN
AccessioniPrimary (citable) accession number: P10767
Secondary accession number(s): Q0VAE1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 1, 1995
Last modified: November 7, 2018
This is version 172 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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