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Protein

AMP deaminase 1

Gene

Ampd1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

AMP deaminase plays a critical role in energy metabolism.

Catalytic activityi

AMP + H2O = IMP + NH3.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Pathwayi: IMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes IMP from AMP.
Proteins known to be involved in this subpathway in this organism are:
  1. AMP deaminase 1 (Ampd1), AMP deaminase 2 (Ampd2), AMP deaminase 3 (Ampd3)
This subpathway is part of the pathway IMP biosynthesis via salvage pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes IMP from AMP, the pathway IMP biosynthesis via salvage pathway and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi303Zinc; catalyticBy similarity1
Metal bindingi305Zinc; catalyticBy similarity1
Binding sitei305SubstrateBy similarity1
Metal bindingi572Zinc; catalyticBy similarity1
Binding sitei575SubstrateBy similarity1
Active sitei594Proton acceptorPROSITE-ProRule annotation1
Metal bindingi649Zinc; catalyticBy similarity1

GO - Molecular functioni

  • AMP deaminase activity Source: UniProtKB-EC
  • metal ion binding Source: UniProtKB-KW
  • myosin heavy chain binding Source: RGD

GO - Biological processi

  • IMP salvage Source: UniProtKB-UniPathway
  • response to organic substance Source: RGD

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-74217 Purine salvage
UniPathwayiUPA00591; UER00663

Names & Taxonomyi

Protein namesi
Recommended name:
AMP deaminase 1 (EC:3.5.4.6)
Alternative name(s):
AMP deaminase isoform M
Myoadenylate deaminase
Gene namesi
Name:Ampd1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi2109 Ampd1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001944051 – 747AMP deaminase 1Add BLAST747

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei81PhosphothreonineCombined sources1
Modified residuei85PhosphoserineCombined sources1
Modified residuei216PhosphotyrosineCombined sources1
Modified residuei441PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP10759
PRIDEiP10759

PTM databases

iPTMnetiP10759
PhosphoSitePlusiP10759

Expressioni

Gene expression databases

BgeeiENSRNOG00000018656
GenevisibleiP10759 RN

Interactioni

Subunit structurei

Homotetramer.

GO - Molecular functioni

  • myosin heavy chain binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025248

Chemistry databases

BindingDBiP10759

Structurei

3D structure databases

ProteinModelPortaliP10759
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni374 – 379Substrate bindingBy similarity6
Regioni650 – 653Substrate bindingBy similarity4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1096 Eukaryota
COG1816 LUCA
GeneTreeiENSGT00390000008190
HOGENOMiHOG000092200
HOVERGENiHBG050494
InParanoidiP10759
KOiK01490
OMAiNMTWMIQ
OrthoDBiEOG091G01OU
PhylomeDBiP10759
TreeFamiTF300439

Family and domain databases

CDDicd01319 AMPD, 1 hit
InterProiView protein in InterPro
IPR006650 A/AMP_deam_AS
IPR001365 A/AMP_deaminase_dom
IPR006329 AMPD
IPR029770 AMPD1
IPR032466 Metal_Hydrolase
PANTHERiPTHR11359 PTHR11359, 1 hit
PTHR11359:SF1 PTHR11359:SF1, 1 hit
PfamiView protein in Pfam
PF00962 A_deaminase, 1 hit
PIRSFiPIRSF001251 AMP_deaminase_met, 1 hit
SUPFAMiSSF51556 SSF51556, 1 hit
TIGRFAMsiTIGR01429 AMP_deaminase, 1 hit
PROSITEiView protein in PROSITE
PS00485 A_DEAMINASE, 1 hit

Sequencei

Sequence statusi: Complete.

P10759-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLFKLTGQG KQIDDAMRSF AEKVFASEVK DEGGRHEISP FDVDEICPIS
60 70 80 90 100
LREMQAHIFH MENLSMSMDG RRKRRFQGRK TVNLSIPQSE TSSTKLSHIE
110 120 130 140 150
EFISSSPTYE SVPDFQRVQI TGDYASGVTV EDFEVVCKGL YRALCIREKY
160 170 180 190 200
MQKSFQRFPK TPSKYLRNID GEALVAIESF YPVFTPPPKK GEDPFRREDL
210 220 230 240 250
PANLGYHLKM KGGVIYIYPD EAAASRDEPK PYPYPNLDDF LDDMNFLLAL
260 270 280 290 300
IAQGPVKTYT HRRLKFLSSK FQVHQMLNEM DELKELKNNP HRDFYNCRKV
310 320 330 340 350
DTHIHAAACM NQKHLLRFIK KSYHIDADRV VYSTKEKNLT LKELFAQLNM
360 370 380 390 400
HPYDLTVDSL DVHAGRQTFQ RFDKFNDKYN PVGASELRDL YLKTDNYING
410 420 430 440 450
EYFATIIKEV GADLVDAKYQ HAEPRLSIYG RSPDEWSKLS SWFVGNRIYC
460 470 480 490 500
PNMTWMIQVP RIYDVFRSKN FLPHFGKMLE NIFLPVFEAT INPQTHPDLS
510 520 530 540 550
VFLKHITGFD SVDDESKHSG HMFSSKSPKP EEWTMENNPS YTYYAYYMYA
560 570 580 590 600
NIMVLNCLRK ERGMNTFLFR PHCGEAGALT HLMTAFMIAD NISHGLNLKK
610 620 630 640 650
SPVLQYLFFL AQIPIAMSPL SNNSLFLEYA KNPFLDFLQK GLMISLSTDD
660 670 680 690 700
PMQFHFTKEP LMEEYAIAAQ VFKLSTCDMC EVARNSVLQC GISHEEKAKF
710 720 730 740
LGNNYLEEGP VGNDIRRTNV AQIRMAYRYE TWCYELNLIA EGLKSTE
Length:747
Mass (Da):86,432
Last modified:July 1, 1989 - v1
Checksum:iC8928B67F2DD9478
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02811 mRNA Translation: AAB54086.1
M58688 mRNA Translation: AAA40726.1
PIRiA27366
RefSeqiNP_620231.1, NM_138876.1
UniGeneiRn.9794

Genome annotation databases

EnsembliENSRNOT00000025248; ENSRNOP00000025248; ENSRNOG00000018656
GeneIDi25028
KEGGirno:25028

Similar proteinsi

Entry informationi

Entry nameiAMPD1_RAT
AccessioniPrimary (citable) accession number: P10759
Secondary accession number(s): P78501, Q6LDJ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: May 23, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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