Zfp14

Functionⁱ

May be involved in transcriptional regulation.

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	140 – 162	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	168 – 190	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	196 – 218	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	224 – 246	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	252 – 274	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	280 – 302	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	308 – 330	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	336 – 358	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	364 – 386	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	392 – 414	C2H2-type 10PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	420 – 442	C2H2-type 11PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	448 – 470	C2H2-type 12PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	476 – 498	C2H2-type 13PROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

blastocyst hatching
Source: MGI
Inferred from mutant phenotypeⁱ
- 27869233
regulation of transcription, DNA-templated Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-MMU-212436 Generic Transcription Pathway

Reactomeⁱ

R-MMU-212436 Generic Transcription Pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein 14 Short name: Zfp-14 Alternative name(s): Zinc finger protein Krox-9
Gene namesⁱ	Name:Zfp14 Synonyms:Kiaa1559, Krox-9, Zfp-14
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 7

Organism-specific databases

MGIⁱ	MGI:99160 Zfp14

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047286	1 – 501	Zinc finger protein 14Add BLAST		501

Proteomic databases

EPDⁱ	P10755
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P10755
PaxDbⁱ	P10755
PRIDEⁱ	P10755

PTM databases

iPTMnetⁱ	P10755
PhosphoSitePlusⁱ	P10755

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000053985 Expressed in 167 organ(s), highest expression level in substantia nigra
CleanExⁱ	MM_ZFP14
Genevisibleⁱ	P10755 MM

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000076960

STRINGⁱ

10090.ENSMUSP00000076960

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P10755
SMRⁱ	P10755
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	8 – 80	KRABPROSITE-ProRule annotationAdd BLAST		73

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	140 – 162	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	168 – 190	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	196 – 218	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	224 – 246	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	252 – 274	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	280 – 302	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	308 – 330	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	336 – 358	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	364 – 386	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	392 – 414	C2H2-type 10PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	420 – 442	C2H2-type 11PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	448 – 470	C2H2-type 12PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	476 – 498	C2H2-type 13PROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00840000129704
HOGENOMⁱ	HOG000234617
HOVERGENⁱ	HBG018163
InParanoidⁱ	P10755
KEGG Orthology (KO) More...KOⁱ	K09228
OMAⁱ	YQIVHNG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02KC
PhylomeDBⁱ	P10755
TreeFamⁱ	TF341817

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd07765 KRAB_A-box, 1 hit
InterProⁱ	View protein in InterPro IPR001909 KRAB IPR036051 KRAB_dom_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01352 KRAB, 1 hit PF00096 zf-C2H2, 12 hits
SMARTⁱ	View protein in SMART SM00349 KRAB, 1 hit SM00355 ZnF_C2H2, 13 hits
SUPFAMⁱ	SSF109640 SSF109640, 1 hit SSF57667 SSF57667, 7 hits
PROSITEⁱ	View protein in PROSITE PS50805 KRAB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 13 hits PS50157 ZINC_FINGER_C2H2_2, 13 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

P10755-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MALAQGLVTF GDVAVDFSQE EWEFLDPAQK NLYRDVMWET YSNFISLDLE 
        60         70         80         90        100
SRFKTDTSSS DKGICEVYSL QWELIEKIKN LSPQGSGLSD DQECKHKTGL 
       110        120        130        140        150
QKEPQEGYFG QLKITSEKVT YEKHSFLSEY QRVQNGEKFY ECKECRKTFI 
       160        170        180        190        200
RRSTLSQHLR IHTGEKPYKC KECGQPFRQR AHLIRHHKLH TGEKPYECKD 
       210        220        230        240        250
CGKAFTVLQE LTQHQRLHTG EKPYECKECG KAFRVHQQLA RHQRIHTGEK 
       260        270        280        290        300
PYECKECGKT FRQCTHLTRH QRLHTSEKLY ECKECGKAFV CGPDLRVHQK 
       310        320        330        340        350
IHFGEKPYAC KDCGKSFRIC QQLTVHQSIH TGEKPYECKE CGKTFRLRQQ 
       360        370        380        390        400
LVRHQRIHTH ERPYECLECW KTFSSYSQLI SHQSIHVGER PYECEECGKA 
       410        420        430        440        450
FRLLSQLTQH QSIHTGEKPY ECQECRKPFR LLSQLTQHRS IHTGEKPYEC 
       460        470        480        490        500
KDCGKAFRLY SFLSQHQRIH TGEKPYKCKE CKKAFRQHSH LTQHQKIHSG 

T

Length:501

Mass (Da):59,060

Last modified:January 10, 2006 - v2

Checksum:ⁱDAD07022035A22F5

GO

Sequence cautionⁱ

The sequence BAD90454 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	136	G → E in BAD90454 (Ref. 2) Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK028663 mRNA Translation: BAC26053.1 AK032214 mRNA Translation: BAC27763.1 AK220404 mRNA Translation: BAD90454.1 Different initiation. BC066057 mRNA Translation: AAH66057.1 M20758 Genomic DNA Translation: AAA39389.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS39875.1
PIRⁱ	F29942
NCBI Reference Sequences More...RefSeqⁱ	NP_035878.1, NM_011748.2 NP_848848.1, NM_178733.5 XP_006540012.1, XM_006539949.3 XP_017177726.1, XM_017322237.1
UniGeneⁱ	Mm.347644

Genome annotation databases

Ensemblⁱ	ENSMUST00000077787; ENSMUSP00000076960; ENSMUSG00000053985 ENSMUST00000207072; ENSMUSP00000146913; ENSMUSG00000053985 ENSMUST00000207873; ENSMUSP00000146824; ENSMUSG00000053985
GeneIDⁱ	243906
KEGGⁱ	mmu:243906
UCSC genome browser More...UCSCⁱ	uc009gcw.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P10755	Uncharacterized protein		MOUSE		457	UniRef100_P10755

Protein	Similar proteins		Species	Score	Length	Source
P10755	Uncharacterized protein		MOUSE		457	UniRef90_P10755
Zinc finger protein 82		RAT		501
LOC499124 protein		RAT		501
Zinc finger protein 82		RAT		470
UPI0003D0B8BF		RAT		512

Protein	Similar proteins		Species	Score	Length	Source
P10755	Zinc finger protein 140		HUMAN		457	UniRef50_P52738
ZNF140 isoform 3 (Fragment)		PANTR		87
Uncharacterized protein		NOMLE		462
Uncharacterized protein		Cebus capucinus imitator		460
Uncharacterized protein		CERAT		460
+291

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK028663 mRNA Translation: BAC26053.1 AK032214 mRNA Translation: BAC27763.1 AK220404 mRNA Translation: BAD90454.1 Different initiation. BC066057 mRNA Translation: AAH66057.1 M20758 Genomic DNA Translation: AAA39389.1
CCDSⁱ	CCDS39875.1
PIRⁱ	F29942
RefSeqⁱ	NP_035878.1, NM_011748.2 NP_848848.1, NM_178733.5 XP_006540012.1, XM_006539949.3 XP_017177726.1, XM_017322237.1
UniGeneⁱ	Mm.347644

3D structure databases

ProteinModelPortalⁱ	P10755
SMRⁱ	P10755
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000076960

STRINGⁱ

10090.ENSMUSP00000076960

PTM databases

iPTMnetⁱ	P10755
PhosphoSitePlusⁱ	P10755

Proteomic databases

EPDⁱ	P10755
MaxQBⁱ	P10755
PaxDbⁱ	P10755
PRIDEⁱ	P10755

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000077787; ENSMUSP00000076960; ENSMUSG00000053985 ENSMUST00000207072; ENSMUSP00000146913; ENSMUSG00000053985 ENSMUST00000207873; ENSMUSP00000146824; ENSMUSG00000053985
GeneIDⁱ	243906
KEGGⁱ	mmu:243906
UCSCⁱ	uc009gcw.1 mouse

Organism-specific databases

CTDⁱ	57677
MGIⁱ	MGI:99160 Zfp14
Rougeⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00840000129704
HOGENOMⁱ	HOG000234617
HOVERGENⁱ	HBG018163
InParanoidⁱ	P10755
KOⁱ	K09228
OMAⁱ	YQIVHNG
OrthoDBⁱ	EOG091G02KC
PhylomeDBⁱ	P10755
TreeFamⁱ	TF341817

Enzyme and pathway databases

Reactomeⁱ	R-MMU-212436 Generic Transcription Pathway

Reactomeⁱ

R-MMU-212436 Generic Transcription Pathway

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P10755
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000053985 Expressed in 167 organ(s), highest expression level in substantia nigra
CleanExⁱ	MM_ZFP14
Genevisibleⁱ	P10755 MM

Family and domain databases

CDDⁱ	cd07765 KRAB_A-box, 1 hit
InterProⁱ	View protein in InterPro IPR001909 KRAB IPR036051 KRAB_dom_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF01352 KRAB, 1 hit PF00096 zf-C2H2, 12 hits
SMARTⁱ	View protein in SMART SM00349 KRAB, 1 hit SM00355 ZnF_C2H2, 13 hits
SUPFAMⁱ	SSF109640 SSF109640, 1 hit SSF57667 SSF57667, 7 hits
PROSITEⁱ	View protein in PROSITE PS50805 KRAB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 13 hits PS50157 ZINC_FINGER_C2H2_2, 13 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZFP14_MOUSE
Accessionⁱ	P10755Primary (citable) accession number: P10755 Secondary accession number(s): Q5DTW6, Q8BFZ5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
	Last sequence update:	January 10, 2006
	Last modified:	November 7, 2018
	This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P10755 (ZFP14_MOUSE)

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Zinc finger protein 14

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ