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UniProtKB - P10755 (ZFP14_MOUSE)
Protein
Zinc finger protein 14
Gene
Zfp14
Organism
Mus musculus (Mouse)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 140 – 162 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 168 – 190 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 196 – 218 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 224 – 246 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 252 – 274 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 280 – 302 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 308 – 330 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 336 – 358 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 364 – 386 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 392 – 414 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 420 – 442 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 448 – 470 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 476 – 498 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- blastocyst hatching Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 14Short name: Zfp-14 Alternative name(s): Zinc finger protein Krox-9 |
Gene namesi | Name:Zfp14 Synonyms:Kiaa1559, Krox-9, Zfp-14 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:99160, Zfp14 |
VEuPathDBi | HostDB:ENSMUSG00000053985 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047286 | 1 – 501 | Zinc finger protein 14Add BLAST | 501 |
Proteomic databases
EPDi | P10755 |
MaxQBi | P10755 |
PaxDbi | P10755 |
PRIDEi | P10755 |
PTM databases
iPTMneti | P10755 |
PhosphoSitePlusi | P10755 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000053985, Expressed in cortical plate and 202 other tissues |
Genevisiblei | P10755, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000076960 |
Miscellaneous databases
RNActi | P10755, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 8 – 80 | KRABPROSITE-ProRule annotationAdd BLAST | 73 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 140 – 162 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 168 – 190 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 196 – 218 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 224 – 246 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 252 – 274 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 280 – 302 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 308 – 330 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 336 – 358 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 364 – 386 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 392 – 414 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 420 – 442 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 448 – 470 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 476 – 498 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162016 |
HOGENOMi | CLU_002678_0_9_1 |
InParanoidi | P10755 |
OMAi | YECVECW |
OrthoDBi | 1318335at2759 |
PhylomeDBi | P10755 |
TreeFami | TF341817 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 12 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 13 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 13 hits PS50157, ZINC_FINGER_C2H2_2, 13 hits |
i Sequence
Sequence statusi: Complete.
P10755-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALAQGLVTF GDVAVDFSQE EWEFLDPAQK NLYRDVMWET YSNFISLDLE
60 70 80 90 100
SRFKTDTSSS DKGICEVYSL QWELIEKIKN LSPQGSGLSD DQECKHKTGL
110 120 130 140 150
QKEPQEGYFG QLKITSEKVT YEKHSFLSEY QRVQNGEKFY ECKECRKTFI
160 170 180 190 200
RRSTLSQHLR IHTGEKPYKC KECGQPFRQR AHLIRHHKLH TGEKPYECKD
210 220 230 240 250
CGKAFTVLQE LTQHQRLHTG EKPYECKECG KAFRVHQQLA RHQRIHTGEK
260 270 280 290 300
PYECKECGKT FRQCTHLTRH QRLHTSEKLY ECKECGKAFV CGPDLRVHQK
310 320 330 340 350
IHFGEKPYAC KDCGKSFRIC QQLTVHQSIH TGEKPYECKE CGKTFRLRQQ
360 370 380 390 400
LVRHQRIHTH ERPYECLECW KTFSSYSQLI SHQSIHVGER PYECEECGKA
410 420 430 440 450
FRLLSQLTQH QSIHTGEKPY ECQECRKPFR LLSQLTQHRS IHTGEKPYEC
460 470 480 490 500
KDCGKAFRLY SFLSQHQRIH TGEKPYKCKE CKKAFRQHSH LTQHQKIHSG
T
Sequence cautioni
The sequence BAD90454 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 136 | G → E in BAD90454 (Ref. 2) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK028663 mRNA Translation: BAC26053.1 AK032214 mRNA Translation: BAC27763.1 AK220404 mRNA Translation: BAD90454.1 Different initiation. BC066057 mRNA Translation: AAH66057.1 M20758 Genomic DNA Translation: AAA39389.1 |
CCDSi | CCDS39875.1 |
PIRi | F29942 |
RefSeqi | NP_035878.1, NM_011748.2 NP_848848.1, NM_178733.5 XP_006540012.1, XM_006539949.3 XP_017177726.1, XM_017322237.1 |
Genome annotation databases
Ensembli | ENSMUST00000077787; ENSMUSP00000076960; ENSMUSG00000053985 ENSMUST00000207072; ENSMUSP00000146913; ENSMUSG00000053985 ENSMUST00000207873; ENSMUSP00000146824; ENSMUSG00000053985 |
GeneIDi | 243906 |
KEGGi | mmu:243906 |
UCSCi | uc009gcw.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK028663 mRNA Translation: BAC26053.1 AK032214 mRNA Translation: BAC27763.1 AK220404 mRNA Translation: BAD90454.1 Different initiation. BC066057 mRNA Translation: AAH66057.1 M20758 Genomic DNA Translation: AAA39389.1 |
CCDSi | CCDS39875.1 |
PIRi | F29942 |
RefSeqi | NP_035878.1, NM_011748.2 NP_848848.1, NM_178733.5 XP_006540012.1, XM_006539949.3 XP_017177726.1, XM_017322237.1 |
3D structure databases
AlphaFoldDBi | P10755 |
SMRi | P10755 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000076960 |
PTM databases
iPTMneti | P10755 |
PhosphoSitePlusi | P10755 |
Proteomic databases
EPDi | P10755 |
MaxQBi | P10755 |
PaxDbi | P10755 |
PRIDEi | P10755 |
Protocols and materials databases
Antibodypediai | 29750, 89 antibodies from 17 providers |
DNASUi | 243906 |
Genome annotation databases
Ensembli | ENSMUST00000077787; ENSMUSP00000076960; ENSMUSG00000053985 ENSMUST00000207072; ENSMUSP00000146913; ENSMUSG00000053985 ENSMUST00000207873; ENSMUSP00000146824; ENSMUSG00000053985 |
GeneIDi | 243906 |
KEGGi | mmu:243906 |
UCSCi | uc009gcw.1, mouse |
Organism-specific databases
CTDi | 57677 |
MGIi | MGI:99160, Zfp14 |
VEuPathDBi | HostDB:ENSMUSG00000053985 |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162016 |
HOGENOMi | CLU_002678_0_9_1 |
InParanoidi | P10755 |
OMAi | YECVECW |
OrthoDBi | 1318335at2759 |
PhylomeDBi | P10755 |
TreeFami | TF341817 |
Enzyme and pathway databases
Reactomei | R-MMU-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 243906, 2 hits in 72 CRISPR screens |
ChiTaRSi | Zfp14, mouse |
PROi | PR:P10755 |
RNActi | P10755, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000053985, Expressed in cortical plate and 202 other tissues |
Genevisiblei | P10755, MM |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 12 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 13 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 13 hits PS50157, ZINC_FINGER_C2H2_2, 13 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZFP14_MOUSE | |
Accessioni | P10755Primary (citable) accession number: P10755 Secondary accession number(s): Q5DTW6, Q8BFZ5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | January 10, 2006 | |
Last modified: | May 25, 2022 | |
This is version 167 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families