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Protein

Zinc finger protein 14

Gene

Zfp14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri140 – 162C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri168 – 190C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri196 – 218C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri224 – 246C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri252 – 274C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 302C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri308 – 330C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri336 – 358C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri364 – 386C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 414C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri420 – 442C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri448 – 470C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri476 – 498C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • blastocyst hatching Source: MGI
  • regulation of transcription, DNA-templated Source: InterPro

Keywordsi

Molecular functionDNA-binding
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 14
Short name:
Zfp-14
Alternative name(s):
Zinc finger protein Krox-9
Gene namesi
Name:Zfp14
Synonyms:Kiaa1559, Krox-9, Zfp-14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:99160 Zfp14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000472861 – 501Zinc finger protein 14Add BLAST501

Proteomic databases

EPDiP10755
MaxQBiP10755
PaxDbiP10755
PRIDEiP10755

PTM databases

iPTMnetiP10755
PhosphoSitePlusiP10755

Expressioni

Gene expression databases

BgeeiENSMUSG00000053985 Expressed in 167 organ(s), highest expression level in substantia nigra
CleanExiMM_ZFP14
GenevisibleiP10755 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076960

Structurei

3D structure databases

ProteinModelPortaliP10755
SMRiP10755
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 80KRABPROSITE-ProRule annotationAdd BLAST73

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri140 – 162C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri168 – 190C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri196 – 218C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri224 – 246C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri252 – 274C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 302C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri308 – 330C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri336 – 358C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri364 – 386C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 414C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri420 – 442C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri448 – 470C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri476 – 498C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00840000129704
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiP10755
KOiK09228
OMAiYQIVHNG
OrthoDBiEOG091G02KC
PhylomeDBiP10755
TreeFamiTF341817

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 12 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 13 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

Sequencei

Sequence statusi: Complete.

P10755-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALAQGLVTF GDVAVDFSQE EWEFLDPAQK NLYRDVMWET YSNFISLDLE
60 70 80 90 100
SRFKTDTSSS DKGICEVYSL QWELIEKIKN LSPQGSGLSD DQECKHKTGL
110 120 130 140 150
QKEPQEGYFG QLKITSEKVT YEKHSFLSEY QRVQNGEKFY ECKECRKTFI
160 170 180 190 200
RRSTLSQHLR IHTGEKPYKC KECGQPFRQR AHLIRHHKLH TGEKPYECKD
210 220 230 240 250
CGKAFTVLQE LTQHQRLHTG EKPYECKECG KAFRVHQQLA RHQRIHTGEK
260 270 280 290 300
PYECKECGKT FRQCTHLTRH QRLHTSEKLY ECKECGKAFV CGPDLRVHQK
310 320 330 340 350
IHFGEKPYAC KDCGKSFRIC QQLTVHQSIH TGEKPYECKE CGKTFRLRQQ
360 370 380 390 400
LVRHQRIHTH ERPYECLECW KTFSSYSQLI SHQSIHVGER PYECEECGKA
410 420 430 440 450
FRLLSQLTQH QSIHTGEKPY ECQECRKPFR LLSQLTQHRS IHTGEKPYEC
460 470 480 490 500
KDCGKAFRLY SFLSQHQRIH TGEKPYKCKE CKKAFRQHSH LTQHQKIHSG

T
Length:501
Mass (Da):59,060
Last modified:January 10, 2006 - v2
Checksum:iDAD07022035A22F5
GO

Sequence cautioni

The sequence BAD90454 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti136G → E in BAD90454 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028663 mRNA Translation: BAC26053.1
AK032214 mRNA Translation: BAC27763.1
AK220404 mRNA Translation: BAD90454.1 Different initiation.
BC066057 mRNA Translation: AAH66057.1
M20758 Genomic DNA Translation: AAA39389.1
CCDSiCCDS39875.1
PIRiF29942
RefSeqiNP_035878.1, NM_011748.2
NP_848848.1, NM_178733.5
XP_006540012.1, XM_006539949.3
XP_017177726.1, XM_017322237.1
UniGeneiMm.347644

Genome annotation databases

EnsembliENSMUST00000077787; ENSMUSP00000076960; ENSMUSG00000053985
ENSMUST00000207072; ENSMUSP00000146913; ENSMUSG00000053985
ENSMUST00000207873; ENSMUSP00000146824; ENSMUSG00000053985
GeneIDi243906
KEGGimmu:243906
UCSCiuc009gcw.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028663 mRNA Translation: BAC26053.1
AK032214 mRNA Translation: BAC27763.1
AK220404 mRNA Translation: BAD90454.1 Different initiation.
BC066057 mRNA Translation: AAH66057.1
M20758 Genomic DNA Translation: AAA39389.1
CCDSiCCDS39875.1
PIRiF29942
RefSeqiNP_035878.1, NM_011748.2
NP_848848.1, NM_178733.5
XP_006540012.1, XM_006539949.3
XP_017177726.1, XM_017322237.1
UniGeneiMm.347644

3D structure databases

ProteinModelPortaliP10755
SMRiP10755
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076960

PTM databases

iPTMnetiP10755
PhosphoSitePlusiP10755

Proteomic databases

EPDiP10755
MaxQBiP10755
PaxDbiP10755
PRIDEiP10755

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000077787; ENSMUSP00000076960; ENSMUSG00000053985
ENSMUST00000207072; ENSMUSP00000146913; ENSMUSG00000053985
ENSMUST00000207873; ENSMUSP00000146824; ENSMUSG00000053985
GeneIDi243906
KEGGimmu:243906
UCSCiuc009gcw.1 mouse

Organism-specific databases

CTDi57677
MGIiMGI:99160 Zfp14
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00840000129704
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiP10755
KOiK09228
OMAiYQIVHNG
OrthoDBiEOG091G02KC
PhylomeDBiP10755
TreeFamiTF341817

Enzyme and pathway databases

ReactomeiR-MMU-212436 Generic Transcription Pathway

Miscellaneous databases

PROiPR:P10755
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000053985 Expressed in 167 organ(s), highest expression level in substantia nigra
CleanExiMM_ZFP14
GenevisibleiP10755 MM

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 12 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 13 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZFP14_MOUSE
AccessioniPrimary (citable) accession number: P10755
Secondary accession number(s): Q5DTW6, Q8BFZ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: January 10, 2006
Last modified: November 7, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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