UniProtKB - P10754 (ZFP13_MOUSE)
Protein
Zinc finger protein 13
Gene
Zfp13
Organism
Mus musculus (Mouse)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 266 – 288 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 294 – 316 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 322 – 344 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 350 – 372 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 378 – 400 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 406 – 428 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 434 – 456 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 462 – 484 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: NTNU_SB
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II regulatory region sequence-specific DNA binding Source: NTNU_SB
GO - Biological processi
- negative regulation of transcription by RNA polymerase II Source: NTNU_SB
- positive regulation of hydrogen peroxide biosynthetic process Source: MGI
- positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-212436 Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 13Short name: Zfp-13 Alternative name(s): Zinc finger protein Krox-8 |
Gene namesi | Name:Zfp13 Synonyms:Krox-8, Zfp-13 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:99159 Zfp13 |
Subcellular locationi
Nucleus
- Nucleus Curated
Mitochondrion
- mitochondrion Source: GOC
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047284 | 1 – 512 | Zinc finger protein 13Add BLAST | 512 |
Proteomic databases
PaxDbi | P10754 |
PRIDEi | P10754 |
PTM databases
iPTMneti | P10754 |
PhosphoSitePlusi | P10754 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000062012 Expressed in 123 organ(s), highest expression level in ear vesicle |
ExpressionAtlasi | P10754 baseline and differential |
Genevisiblei | P10754 MM |
Structurei
3D structure databases
ProteinModelPortali | P10754 |
SMRi | P10754 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 124 – 196 | KRABPROSITE-ProRule annotationAdd BLAST | 73 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 266 – 288 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 294 – 316 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 322 – 344 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 350 – 372 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 378 – 400 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 406 – 428 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 434 – 456 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 462 – 484 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721 Eukaryota COG5048 LUCA |
GeneTreei | ENSGT00940000161865 |
HOGENOMi | HOG000234617 |
HOVERGENi | HBG018163 |
InParanoidi | P10754 |
KOi | K09228 |
OMAi | GDEKEWR |
OrthoDBi | 1318335at2759 |
PhylomeDBi | P10754 |
TreeFami | TF338003 |
Family and domain databases
CDDi | cd07765 KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909 KRAB IPR036051 KRAB_dom_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type |
Pfami | View protein in Pfam PF01352 KRAB, 1 hit PF00096 zf-C2H2, 8 hits |
SMARTi | View protein in SMART SM00349 KRAB, 1 hit SM00355 ZnF_C2H2, 8 hits |
SUPFAMi | SSF109640 SSF109640, 1 hit SSF57667 SSF57667, 5 hits |
PROSITEi | View protein in PROSITE PS50805 KRAB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 8 hits PS50157 ZINC_FINGER_C2H2_2, 8 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: P10754-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MSADSQSIAA TENEEKSHEV PGNVQHCGDM LSGQEETVPL GTSQESTHIK
60 70 80 90 100
AEPEEPHSEG ASREDRTPGT QRWMSPCPGP KDKGPFLPGG VVPSPWTPVL
110 120 130 140 150
SRGGRTRERK MAAALLTAWS QMPVTFEDVA LYLSQEEWGR LDHTQQNFYR
160 170 180 190 200
DVLQGKNGLA LGAVEMGKVV PALAVATLED TKSIRTRARW APGEDPKCGQ
210 220 230 240 250
HVASGPGTKL TRDTGKAGQL KPAPSESRPL KTPEDSGPEK PSEGEEALKS
260 270 280 290 300
GEEGLVPDGD TGKKTYKCEQ CGKGFSWHSH LVTHRRTHTG EKPYTCTDCG
310 320 330 340 350
KRFGRSSHLI QHQIIHTGEK PYTCPSCWKS FSHHSTLIQH QRIHTGEKPY
360 370 380 390 400
VCDRCAKRFT RRSDLVTHQG THTGAKPHKC PICSKCFTQS SALVTHQRTH
410 420 430 440 450
TGVKPYPCPE CGKCFSQRSN LIAHNRTHTG EKPYHCLDCG KSFSHSSHLT
460 470 480 490 500
AHQRTHRGVR PYSCPLCGKS FSRRSNLHRH EKIHTTGPKA LAMLMLGAAA
510
AGALTAPPPA ST
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A2I3BQW3 | A0A2I3BQW3_MOUSE | Zinc finger protein 13 | Zfp13 | 118 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 400 – 401 | HT → PH (PubMed:2452975).Curated | 2 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_016902 | 84 – 90 | Missing in isoform 2. 1 Publication | 7 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK030240 mRNA Translation: BAC26860.1 BC052082 mRNA Translation: AAH52082.1 M19440 Genomic DNA Translation: AAA39388.1 |
CCDSi | CCDS28450.1 [P10754-2] |
PIRi | E29942 |
RefSeqi | NP_035877.1, NM_011747.2 [P10754-2] XP_006524272.1, XM_006524209.3 XP_006524273.1, XM_006524210.3 [P10754-1] XP_006524274.1, XM_006524211.3 [P10754-2] |
UniGenei | Mm.40326 |
Genome annotation databases
Ensembli | ENSMUST00000057029; ENSMUSP00000054595; ENSMUSG00000062012 [P10754-2] ENSMUST00000115516; ENSMUSP00000111178; ENSMUSG00000062012 [P10754-1] |
GeneIDi | 22654 |
KEGGi | mmu:22654 |
UCSCi | uc008ash.2 mouse [P10754-1] uc008asi.1 mouse [P10754-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK030240 mRNA Translation: BAC26860.1 BC052082 mRNA Translation: AAH52082.1 M19440 Genomic DNA Translation: AAA39388.1 |
CCDSi | CCDS28450.1 [P10754-2] |
PIRi | E29942 |
RefSeqi | NP_035877.1, NM_011747.2 [P10754-2] XP_006524272.1, XM_006524209.3 XP_006524273.1, XM_006524210.3 [P10754-1] XP_006524274.1, XM_006524211.3 [P10754-2] |
UniGenei | Mm.40326 |
3D structure databases
ProteinModelPortali | P10754 |
SMRi | P10754 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000054595 |
PTM databases
iPTMneti | P10754 |
PhosphoSitePlusi | P10754 |
Proteomic databases
PaxDbi | P10754 |
PRIDEi | P10754 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENSMUST00000057029; ENSMUSP00000054595; ENSMUSG00000062012 [P10754-2] ENSMUST00000115516; ENSMUSP00000111178; ENSMUSG00000062012 [P10754-1] |
GeneIDi | 22654 |
KEGGi | mmu:22654 |
UCSCi | uc008ash.2 mouse [P10754-1] uc008asi.1 mouse [P10754-2] |
Organism-specific databases
CTDi | 22654 |
MGIi | MGI:99159 Zfp13 |
Phylogenomic databases
eggNOGi | KOG1721 Eukaryota COG5048 LUCA |
GeneTreei | ENSGT00940000161865 |
HOGENOMi | HOG000234617 |
HOVERGENi | HBG018163 |
InParanoidi | P10754 |
KOi | K09228 |
OMAi | GDEKEWR |
OrthoDBi | 1318335at2759 |
PhylomeDBi | P10754 |
TreeFami | TF338003 |
Enzyme and pathway databases
Reactomei | R-MMU-212436 Generic Transcription Pathway |
Miscellaneous databases
PROi | PR:P10754 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000062012 Expressed in 123 organ(s), highest expression level in ear vesicle |
ExpressionAtlasi | P10754 baseline and differential |
Genevisiblei | P10754 MM |
Family and domain databases
CDDi | cd07765 KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909 KRAB IPR036051 KRAB_dom_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type |
Pfami | View protein in Pfam PF01352 KRAB, 1 hit PF00096 zf-C2H2, 8 hits |
SMARTi | View protein in SMART SM00349 KRAB, 1 hit SM00355 ZnF_C2H2, 8 hits |
SUPFAMi | SSF109640 SSF109640, 1 hit SSF57667 SSF57667, 5 hits |
PROSITEi | View protein in PROSITE PS50805 KRAB, 1 hit PS00028 ZINC_FINGER_C2H2_1, 8 hits PS50157 ZINC_FINGER_C2H2_2, 8 hits |
ProtoNeti | Search... |
Entry informationi
Entry namei | ZFP13_MOUSE | |
Accessioni | P10754Primary (citable) accession number: P10754 Secondary accession number(s): Q80WS0, Q8CDD0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | January 10, 2006 | |
Last modified: | February 13, 2019 | |
This is version 159 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot