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Protein

Interleukin-1 beta

Gene

Il1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells.By similarity

Miscellaneous

IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei172Important for interaction with integrinBy similarity1
Sitei180Important for interaction with integrinBy similarity1
Sitei182Important for interaction with integrinBy similarity1
Sitei191Important for interaction with integrinBy similarity1
Sitei205Important for interaction with integrinBy similarity1

GO - Molecular functioni

  • cytokine activity Source: MGI
  • integrin binding Source: UniProtKB
  • interleukin-1 receptor binding Source: GO_Central
  • protein domain specific binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionCytokine, Mitogen, Pyrogen
Biological processInflammatory response

Enzyme and pathway databases

ReactomeiR-MMU-448706 Interleukin-1 processing
R-MMU-5660668 CLEC7A/inflammasome pathway
R-MMU-9020702 Interleukin-1 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 beta
Short name:
IL-1 beta
Gene namesi
Name:Il1b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:96543 Il1b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Lysosome, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000153111 – 1171 PublicationAdd BLAST117
ChainiPRO_0000015312118 – 269Interleukin-1 betaAdd BLAST152

Proteomic databases

PaxDbiP10749
PRIDEiP10749
TopDownProteomicsiP10749

PTM databases

iPTMnetiP10749
PhosphoSitePlusiP10749

Miscellaneous databases

PMAP-CutDBiP10749

Expressioni

Tissue specificityi

Expressed in activated macrophages (at protein level).3 Publications

Inductioni

By LPS.3 Publications

Gene expression databases

BgeeiENSMUSG00000027398 Expressed in 85 organ(s), highest expression level in blood
CleanExiMM_IL1B
GenevisibleiP10749 MM

Interactioni

Subunit structurei

Monomer. Interacts with MEFV. Interacts with integrins ITGAV:ITGBV and ITGA5:ITGB1; integrin-binding is required for IL1B signaling.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200624, 6 interactors
IntActiP10749, 1 interactor
STRINGi10090.ENSMUSP00000028881

Structurei

Secondary structure

1269
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP10749
SMRiP10749
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP10749

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-1 family.Curated

Phylogenomic databases

eggNOGiENOG410IGSZ Eukaryota
ENOG410XU2E LUCA
GeneTreeiENSGT00510000048687
HOGENOMiHOG000246399
HOVERGENiHBG007328
InParanoidiP10749
KOiK04519
OMAiPELTSEM
OrthoDBiEOG091G0GR9
PhylomeDBiP10749
TreeFamiTF300203

Family and domain databases

InterProiView protein in InterPro
IPR003296 IL-1_beta
IPR020877 IL-1_CS
IPR000975 IL-1_fam
IPR003502 IL-1_propep
IPR008996 IL1/FGF
PANTHERiPTHR44849 PTHR44849, 1 hit
PfamiView protein in Pfam
PF00340 IL1, 1 hit
PF02394 IL1_propep, 1 hit
PRINTSiPR00264 INTERLEUKIN1
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00253 INTERLEUKIN_1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P10749-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATVPELNCE MPPFDSDEND LFFEVDGPQK MKGCFQTFDL GCPDESIQLQ
60 70 80 90 100
ISQQHINKSF RQAVSLIVAV EKLWQLPVSF PWTFQDEDMS TFFSFIFEEE
110 120 130 140 150
PILCDSWDDD DNLLVCDVPI RQLHYRLRDE QQKSLVLSDP YELKALHLNG
160 170 180 190 200
QNINQQVIFS MSFVQGEPSN DKIPVALGLK GKNLYLSCVM KDGTPTLQLE
210 220 230 240 250
SVDPKQYPKK KMEKRFVFNK IEVKSKVEFE SAEFPNWYIS TSQAEHKPVF
260
LGNNSGQDII DFTMESVSS
Length:269
Mass (Da):30,931
Last modified:July 1, 1989 - v1
Checksum:i734FA17B02ED87EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15131 mRNA Translation: AAA39276.1
X04964 Genomic DNA Translation: CAA28637.1
AY902319 Genomic DNA Translation: AAX90604.1
CH466519 Genomic DNA Translation: EDL28238.1
BC011437 mRNA Translation: AAH11437.1
CCDSiCCDS16726.1
PIRiI55969
RefSeqiNP_032387.1, NM_008361.4
UniGeneiMm.222830

Genome annotation databases

EnsembliENSMUST00000028881; ENSMUSP00000028881; ENSMUSG00000027398
GeneIDi16176
KEGGimmu:16176
UCSCiuc008mht.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15131 mRNA Translation: AAA39276.1
X04964 Genomic DNA Translation: CAA28637.1
AY902319 Genomic DNA Translation: AAX90604.1
CH466519 Genomic DNA Translation: EDL28238.1
BC011437 mRNA Translation: AAH11437.1
CCDSiCCDS16726.1
PIRiI55969
RefSeqiNP_032387.1, NM_008361.4
UniGeneiMm.222830

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MIBX-ray2.84A118-269[»]
8I1BX-ray2.40A118-269[»]
ProteinModelPortaliP10749
SMRiP10749
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200624, 6 interactors
IntActiP10749, 1 interactor
STRINGi10090.ENSMUSP00000028881

PTM databases

iPTMnetiP10749
PhosphoSitePlusiP10749

Proteomic databases

PaxDbiP10749
PRIDEiP10749
TopDownProteomicsiP10749

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028881; ENSMUSP00000028881; ENSMUSG00000027398
GeneIDi16176
KEGGimmu:16176
UCSCiuc008mht.1 mouse

Organism-specific databases

CTDi3553
MGIiMGI:96543 Il1b

Phylogenomic databases

eggNOGiENOG410IGSZ Eukaryota
ENOG410XU2E LUCA
GeneTreeiENSGT00510000048687
HOGENOMiHOG000246399
HOVERGENiHBG007328
InParanoidiP10749
KOiK04519
OMAiPELTSEM
OrthoDBiEOG091G0GR9
PhylomeDBiP10749
TreeFamiTF300203

Enzyme and pathway databases

ReactomeiR-MMU-448706 Interleukin-1 processing
R-MMU-5660668 CLEC7A/inflammasome pathway
R-MMU-9020702 Interleukin-1 signaling

Miscellaneous databases

EvolutionaryTraceiP10749
PMAP-CutDBiP10749
PROiPR:P10749
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027398 Expressed in 85 organ(s), highest expression level in blood
CleanExiMM_IL1B
GenevisibleiP10749 MM

Family and domain databases

InterProiView protein in InterPro
IPR003296 IL-1_beta
IPR020877 IL-1_CS
IPR000975 IL-1_fam
IPR003502 IL-1_propep
IPR008996 IL1/FGF
PANTHERiPTHR44849 PTHR44849, 1 hit
PfamiView protein in Pfam
PF00340 IL1, 1 hit
PF02394 IL1_propep, 1 hit
PRINTSiPR00264 INTERLEUKIN1
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00253 INTERLEUKIN_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIL1B_MOUSE
AccessioniPrimary (citable) accession number: P10749
Secondary accession number(s): Q2M4J6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: July 1, 1989
Last modified: November 7, 2018
This is version 183 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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