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UniProtKB - P10746 (HEM4_HUMAN)
Protein
Uroporphyrinogen-III synthase
Gene
UROS
Organism
Homo sapiens (Human)
Status
Functioni
Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme).
Caution
Variant Ala-62 was originally reported to result in no detectable enzyme activity (PubMed:1737856), as measured in recombinant crude lysate extracts. Further experiments with the purified enzyme have shown that this variant does not affect activity (PubMed:11689424).2 Publications
Catalytic activityi
- EC:4.2.1.751 Publication
: protoporphyrin-IX biosynthesis Pathwayi
This protein is involved in step 3 of the subpathway that synthesizes coproporphyrinogen-III from 5-aminolevulinate. This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.View all proteins of this organism that are known to be involved in the subpathway that synthesizes coproporphyrinogen-III from 5-aminolevulinate, the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.
GO - Molecular functioni
- folic acid binding Source: Ensembl
- uroporphyrinogen-III synthase activity Source: UniProtKB
GO - Biological processi
- cellular response to amine stimulus Source: Ensembl
- cellular response to arsenic-containing substance Source: Ensembl
- heme biosynthetic process Source: UniProtKB
- protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
- response to antibiotic Source: Ensembl
- response to platinum ion Source: Ensembl
- uroporphyrinogen III biosynthetic process Source: UniProtKB
Keywordsi
Molecular function | Lyase |
Biological process | Heme biosynthesis, Porphyrin biosynthesis |
Enzyme and pathway databases
BRENDAi | 4.2.1.75, 2681 |
PathwayCommonsi | P10746 |
Reactomei | R-HSA-189451, Heme biosynthesis |
SignaLinki | P10746 |
UniPathwayi | UPA00251;UER00320 |
Names & Taxonomyi
Protein namesi | Recommended name: Uroporphyrinogen-III synthase (EC:4.2.1.75)Short name: UROIIIS Short name: UROS Alternative name(s): Hydroxymethylbilane hydrolyase [cyclizing] Uroporphyrinogen-III cosynthase |
Gene namesi | Name:UROS |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12592, UROS |
MIMi | 606938, gene |
neXtProti | NX_P10746 |
VEuPathDBi | HostDB:ENSG00000188690 |
Pathology & Biotechi
Involvement in diseasei
Congenital erythropoietic porphyria (CEP)14 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionPorphyrias are inherited defects in the biosynthesis of heme, resulting in the accumulation and increased excretion of porphyrins or porphyrin precursors. They are classified as erythropoietic or hepatic, depending on whether the enzyme deficiency occurs in red blood cells or in the liver. The manifestations of CEP are heterogeneous, ranging from nonimmune hydrops fetalis due to severe hemolytic anemia in utero to milder, later onset forms, which have only skin lesions due to cutaneous photosensitivity in adult life. The deficiency in UROS activity results in the non-enzymatic conversion of hydroxymethylbilane (HMB) into the uroporphyrinogen-I isomer.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_021615 | 3 | V → F in CEP; no residual activity. 1 PublicationCorresponds to variant dbSNP:rs773301339Ensembl. | 1 | |
Natural variantiVAR_003674 | 4 | L → F in CEP. 1 PublicationCorresponds to variant dbSNP:rs121908015EnsemblClinVar. | 1 | |
Natural variantiVAR_003675 | 19 | Y → C in CEP. 1 Publication | 1 | |
Natural variantiVAR_021616 | 47 | S → P in CEP; severe cutaneous lesions; less than 3% wild-type activity. 1 PublicationCorresponds to variant dbSNP:rs397515527EnsemblClinVar. | 1 | |
Natural variantiVAR_003676 | 53 | P → L in CEP; severe phenotype; no detectable activity. 1 PublicationCorresponds to variant dbSNP:rs121908013EnsemblClinVar. | 1 | |
Natural variantiVAR_003677 | 62 | T → A in CEP; does not affect enzymatic activity. 2 PublicationsCorresponds to variant dbSNP:rs28941775EnsemblClinVar. | 1 | |
Natural variantiVAR_003678 | 66 | A → V in CEP; mild phenotype; residual activity. 1 PublicationCorresponds to variant dbSNP:rs28941774EnsemblClinVar. | 1 | |
Natural variantiVAR_021617 | 69 | A → T in CEP; less than 2% wild-type activity. 1 Publication | 1 | |
Natural variantiVAR_003679 | 73 | C → R in CEP; frequent mutation in Western countries; severe phenotype; no detectable activity. 5 PublicationsCorresponds to variant dbSNP:rs121908012EnsemblClinVar. | 1 | |
Natural variantiVAR_003680 | 82 | V → F in CEP; mild phenotype; high residual activity. 1 PublicationCorresponds to variant dbSNP:rs121908016EnsemblClinVar. | 1 | |
Natural variantiVAR_003681 | 99 | V → A in CEP. 1 Publication | 1 | |
Natural variantiVAR_003682 | 104 | A → V in CEP; residual activity. 1 PublicationCorresponds to variant dbSNP:rs397515528EnsemblClinVar. | 1 | |
Natural variantiVAR_021618 | 129 | I → T in CEP; no residual activity. 1 Publication | 1 | |
Natural variantiVAR_013558 | 188 | G → R in CEP; less than 5% wild-type activity. 1 PublicationCorresponds to variant dbSNP:rs121908017EnsemblClinVar. | 1 | |
Natural variantiVAR_021619 | 188 | G → W in CEP; mild phenotype; less than 2% wild-type activity. 1 PublicationCorresponds to variant dbSNP:rs121908017EnsemblClinVar. | 1 | |
Natural variantiVAR_021620 | 210 – 211 | EL → HIQSQAQSQAQDN in CEP. 1 Publication | 2 | |
Natural variantiVAR_003683 | 212 | S → P in CEP; no residual activity. 1 PublicationCorresponds to variant dbSNP:rs139388833Ensembl. | 1 | |
Natural variantiVAR_021621 | 219 | I → S in CEP; moderately-severe phenotype; less than 2% wild-type activity. 1 PublicationCorresponds to variant dbSNP:rs767029901Ensembl. | 1 | |
Natural variantiVAR_003684 | 225 | G → S in CEP. 1 PublicationCorresponds to variant dbSNP:rs121908020EnsemblClinVar. | 1 | |
Natural variantiVAR_003685 | 228 | T → M in CEP; no detectable activity. 3 PublicationsCorresponds to variant dbSNP:rs121908014EnsemblClinVar. | 1 | |
Natural variantiVAR_067318 | 237 | L → P in CEP. 1 PublicationCorresponds to variant dbSNP:rs777433697Ensembl. | 1 | |
Natural variantiVAR_066247 | 248 | P → Q in CEP. 1 PublicationCorresponds to variant dbSNP:rs121908021EnsemblClinVar. | 1 |
Severe congenital erythropoietic porphyria is associated with non-immune hydrops fetalis, a generalized edema of the fetus with fluid accumulation in the body cavities due to non-immune causes. Non-immune hydrops fetalis is not a diagnosis in itself but a symptom, a feature of many genetic disorders, and the end-stage of a wide variety of disorders.
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 63 | S → A: Does not affect enzymatic activity. 1 Publication | 1 | |
Mutagenesisi | 65 | R → A: Slightly affects enzymatic activity. 1 Publication | 1 | |
Mutagenesisi | 103 | T → A: Slightly affects enzymatic activity. 1 Publication | 1 | |
Mutagenesisi | 127 | E → A: Does not affect enzymatic activity. 1 Publication | 1 | |
Mutagenesisi | 168 | Y → F: Impairs enzymatic activity. 1 Publication | 1 | |
Mutagenesisi | 197 | S → A: Does not affect enzymatic activity. 1 Publication | 1 | |
Mutagenesisi | 220 | K → A: Does not affect enzymatic activity. 1 Publication | 1 | |
Mutagenesisi | 227 | T → A: Does not affect enzymatic activity. 1 Publication | 1 | |
Mutagenesisi | 228 | T → A: Impairs enzymatic activity. 1 Publication | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 7390 |
GeneReviewsi | UROS |
MalaCardsi | UROS |
MIMi | 263700, phenotype |
OpenTargetsi | ENSG00000188690 |
Orphaneti | 79277, Congenital erythropoietic porphyria |
PharmGKBi | PA37222 |
Miscellaneous databases
Pharosi | P10746, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4433 |
Genetic variation databases
BioMutai | UROS |
DMDMi | 122849 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000135251 | 1 – 265 | Uroporphyrinogen-III synthaseAdd BLAST | 265 |
Proteomic databases
EPDi | P10746 |
jPOSTi | P10746 |
MassIVEi | P10746 |
MaxQBi | P10746 |
PaxDbi | P10746 |
PeptideAtlasi | P10746 |
PRIDEi | P10746 |
ProteomicsDBi | 52644 |
PTM databases
iPTMneti | P10746 |
PhosphoSitePlusi | P10746 |
Expressioni
Tissue specificityi
Ubiquitous.1 Publication
Gene expression databases
Bgeei | ENSG00000188690, Expressed in caudate nucleus and 232 other tissues |
ExpressionAtlasi | P10746, baseline and differential |
Genevisiblei | P10746, HS |
Organism-specific databases
HPAi | ENSG00000188690, Low tissue specificity |
Interactioni
Subunit structurei
Monomer.
1 PublicationProtein-protein interaction databases
BioGRIDi | 113236, 18 interactors |
IntActi | P10746, 7 interactors |
STRINGi | 9606.ENSP00000357787 |
Miscellaneous databases
RNActi | P10746, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P10746 |
BMRBi | P10746 |
SMRi | P10746 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P10746 |
Family & Domainsi
Sequence similaritiesi
Belongs to the uroporphyrinogen-III synthase family.Curated
Phylogenomic databases
eggNOGi | KOG4132, Eukaryota |
GeneTreei | ENSGT00390000009853 |
HOGENOMi | CLU_051874_1_1_1 |
InParanoidi | P10746 |
OMAi | VNCAQQY |
OrthoDBi | 1557657at2759 |
PhylomeDBi | P10746 |
TreeFami | TF324092 |
Family and domain databases
CDDi | cd06578, HemD, 1 hit |
Gene3Di | 3.40.50.10090, 2 hits |
InterProi | View protein in InterPro IPR036108, 4pyrrol_syn_uPrphyn_synt_sf IPR003754, 4pyrrol_synth_uPrphyn_synth IPR039793, UROS/Hem4 |
PANTHERi | PTHR12390, PTHR12390, 1 hit |
Pfami | View protein in Pfam PF02602, HEM4, 1 hit |
SUPFAMi | SSF69618, SSF69618, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 14 potential isoforms that are computationally mapped.Show allAlign All
P10746-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKVLLLKDAK EDDCGQDPYI RELGLYGLEA TLIPVLSFEF LSLPSFSEKL
60 70 80 90 100
SHPEDYGGLI FTSPRAVEAA ELCLEQNNKT EVWERSLKEK WNAKSVYVVG
110 120 130 140 150
NATASLVSKI GLDTEGETCG NAEKLAEYIC SRESSALPLL FPCGNLKREI
160 170 180 190 200
LPKALKDKGI AMESITVYQT VAHPGIQGNL NSYYSQQGVP ASITFFSPSG
210 220 230 240 250
LTYSLKHIQE LSGDNIDQIK FAAIGPTTAR ALAAQGLPVS CTAESPTPQA
260
LATGIRKALQ PHGCC
Computationally mapped potential isoform sequencesi
There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5T3L8 | Q5T3L8_HUMAN | Uroporphyrinogen-III synthase | UROS hCG_1727047 | 139 | Annotation score: | ||
Q5T3L7 | Q5T3L7_HUMAN | Uroporphyrinogen-III synthase | UROS | 133 | Annotation score: | ||
Q5T3L9 | Q5T3L9_HUMAN | Uroporphyrinogen-III synthase | UROS | 185 | Annotation score: | ||
A0A3B3ISM6 | A0A3B3ISM6_HUMAN | Uroporphyrinogen-III synthase | UROS | 292 | Annotation score: | ||
A0A3B3ITJ2 | A0A3B3ITJ2_HUMAN | Uroporphyrinogen-III synthase | UROS | 265 | Annotation score: | ||
A0A087X021 | A0A087X021_HUMAN | Uroporphyrinogen-III synthase | UROS | 122 | Annotation score: | ||
A0A087WUV7 | A0A087WUV7_HUMAN | Uroporphyrinogen-III synthase | UROS | 110 | Annotation score: | ||
A0A3B3ISL9 | A0A3B3ISL9_HUMAN | Uroporphyrinogen-III synthase | UROS | 160 | Annotation score: | ||
A0A3B3IS76 | A0A3B3IS76_HUMAN | Uroporphyrinogen-III synthase | UROS | 151 | Annotation score: | ||
A0A3B3ISX6 | A0A3B3ISX6_HUMAN | Uroporphyrinogen-III synthase | UROS | 137 | Annotation score: | ||
There are more potential isoformsShow all |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_021615 | 3 | V → F in CEP; no residual activity. 1 PublicationCorresponds to variant dbSNP:rs773301339Ensembl. | 1 | |
Natural variantiVAR_003674 | 4 | L → F in CEP. 1 PublicationCorresponds to variant dbSNP:rs121908015EnsemblClinVar. | 1 | |
Natural variantiVAR_003675 | 19 | Y → C in CEP. 1 Publication | 1 | |
Natural variantiVAR_021616 | 47 | S → P in CEP; severe cutaneous lesions; less than 3% wild-type activity. 1 PublicationCorresponds to variant dbSNP:rs397515527EnsemblClinVar. | 1 | |
Natural variantiVAR_003676 | 53 | P → L in CEP; severe phenotype; no detectable activity. 1 PublicationCorresponds to variant dbSNP:rs121908013EnsemblClinVar. | 1 | |
Natural variantiVAR_003677 | 62 | T → A in CEP; does not affect enzymatic activity. 2 PublicationsCorresponds to variant dbSNP:rs28941775EnsemblClinVar. | 1 | |
Natural variantiVAR_003678 | 66 | A → V in CEP; mild phenotype; residual activity. 1 PublicationCorresponds to variant dbSNP:rs28941774EnsemblClinVar. | 1 | |
Natural variantiVAR_021617 | 69 | A → T in CEP; less than 2% wild-type activity. 1 Publication | 1 | |
Natural variantiVAR_003679 | 73 | C → R in CEP; frequent mutation in Western countries; severe phenotype; no detectable activity. 5 PublicationsCorresponds to variant dbSNP:rs121908012EnsemblClinVar. | 1 | |
Natural variantiVAR_003680 | 82 | V → F in CEP; mild phenotype; high residual activity. 1 PublicationCorresponds to variant dbSNP:rs121908016EnsemblClinVar. | 1 | |
Natural variantiVAR_003681 | 99 | V → A in CEP. 1 Publication | 1 | |
Natural variantiVAR_003682 | 104 | A → V in CEP; residual activity. 1 PublicationCorresponds to variant dbSNP:rs397515528EnsemblClinVar. | 1 | |
Natural variantiVAR_049345 | 124 | K → R. Corresponds to variant dbSNP:rs17153561Ensembl. | 1 | |
Natural variantiVAR_021618 | 129 | I → T in CEP; no residual activity. 1 Publication | 1 | |
Natural variantiVAR_049346 | 171 | V → G. Corresponds to variant dbSNP:rs17173752EnsemblClinVar. | 1 | |
Natural variantiVAR_013558 | 188 | G → R in CEP; less than 5% wild-type activity. 1 PublicationCorresponds to variant dbSNP:rs121908017EnsemblClinVar. | 1 | |
Natural variantiVAR_021619 | 188 | G → W in CEP; mild phenotype; less than 2% wild-type activity. 1 PublicationCorresponds to variant dbSNP:rs121908017EnsemblClinVar. | 1 | |
Natural variantiVAR_021620 | 210 – 211 | EL → HIQSQAQSQAQDN in CEP. 1 Publication | 2 | |
Natural variantiVAR_003683 | 212 | S → P in CEP; no residual activity. 1 PublicationCorresponds to variant dbSNP:rs139388833Ensembl. | 1 | |
Natural variantiVAR_021621 | 219 | I → S in CEP; moderately-severe phenotype; less than 2% wild-type activity. 1 PublicationCorresponds to variant dbSNP:rs767029901Ensembl. | 1 | |
Natural variantiVAR_003684 | 225 | G → S in CEP. 1 PublicationCorresponds to variant dbSNP:rs121908020EnsemblClinVar. | 1 | |
Natural variantiVAR_003685 | 228 | T → M in CEP; no detectable activity. 3 PublicationsCorresponds to variant dbSNP:rs121908014EnsemblClinVar. | 1 | |
Natural variantiVAR_067318 | 237 | L → P in CEP. 1 PublicationCorresponds to variant dbSNP:rs777433697Ensembl. | 1 | |
Natural variantiVAR_066247 | 248 | P → Q in CEP. 1 PublicationCorresponds to variant dbSNP:rs121908021EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03824 mRNA Translation: AAA60273.1 AF230665 mRNA Translation: AAG36795.1 AH010036 Genomic DNA Translation: AAG36794.1 AK314896 mRNA Translation: BAG37410.1 AL360176 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW49221.1 CH471066 Genomic DNA Translation: EAW49222.1 BC002573 mRNA Translation: AAH02573.1 |
CCDSi | CCDS7648.1 |
PIRi | A40483 |
RefSeqi | NP_000366.1, NM_000375.2 |
Genome annotation databases
Ensembli | ENST00000368786.5; ENSP00000357775.1; ENSG00000188690.15 ENST00000368797.10; ENSP00000357787.4; ENSG00000188690.15 |
GeneIDi | 7390 |
KEGGi | hsa:7390 |
MANE-Selecti | ENST00000368797.10; ENSP00000357787.4; NM_000375.3; NP_000366.1 |
UCSCi | uc001liw.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03824 mRNA Translation: AAA60273.1 AF230665 mRNA Translation: AAG36795.1 AH010036 Genomic DNA Translation: AAG36794.1 AK314896 mRNA Translation: BAG37410.1 AL360176 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW49221.1 CH471066 Genomic DNA Translation: EAW49222.1 BC002573 mRNA Translation: AAH02573.1 |
CCDSi | CCDS7648.1 |
PIRi | A40483 |
RefSeqi | NP_000366.1, NM_000375.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1JR2 | X-ray | 1.84 | A/B | 1-265 | [»] | |
AlphaFoldDBi | P10746 | |||||
BMRBi | P10746 | |||||
SMRi | P10746 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 113236, 18 interactors |
IntActi | P10746, 7 interactors |
STRINGi | 9606.ENSP00000357787 |
Chemistry databases
ChEMBLi | CHEMBL4433 |
PTM databases
iPTMneti | P10746 |
PhosphoSitePlusi | P10746 |
Genetic variation databases
BioMutai | UROS |
DMDMi | 122849 |
Proteomic databases
EPDi | P10746 |
jPOSTi | P10746 |
MassIVEi | P10746 |
MaxQBi | P10746 |
PaxDbi | P10746 |
PeptideAtlasi | P10746 |
PRIDEi | P10746 |
ProteomicsDBi | 52644 |
Protocols and materials databases
Antibodypediai | 32416, 98 antibodies from 21 providers |
DNASUi | 7390 |
Genome annotation databases
Ensembli | ENST00000368786.5; ENSP00000357775.1; ENSG00000188690.15 ENST00000368797.10; ENSP00000357787.4; ENSG00000188690.15 |
GeneIDi | 7390 |
KEGGi | hsa:7390 |
MANE-Selecti | ENST00000368797.10; ENSP00000357787.4; NM_000375.3; NP_000366.1 |
UCSCi | uc001liw.5, human |
Organism-specific databases
CTDi | 7390 |
DisGeNETi | 7390 |
GeneCardsi | UROS |
GeneReviewsi | UROS |
HGNCi | HGNC:12592, UROS |
HPAi | ENSG00000188690, Low tissue specificity |
MalaCardsi | UROS |
MIMi | 263700, phenotype 606938, gene |
neXtProti | NX_P10746 |
OpenTargetsi | ENSG00000188690 |
Orphaneti | 79277, Congenital erythropoietic porphyria |
PharmGKBi | PA37222 |
VEuPathDBi | HostDB:ENSG00000188690 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4132, Eukaryota |
GeneTreei | ENSGT00390000009853 |
HOGENOMi | CLU_051874_1_1_1 |
InParanoidi | P10746 |
OMAi | VNCAQQY |
OrthoDBi | 1557657at2759 |
PhylomeDBi | P10746 |
TreeFami | TF324092 |
Enzyme and pathway databases
UniPathwayi | UPA00251;UER00320 |
BRENDAi | 4.2.1.75, 2681 |
PathwayCommonsi | P10746 |
Reactomei | R-HSA-189451, Heme biosynthesis |
SignaLinki | P10746 |
Miscellaneous databases
BioGRID-ORCSi | 7390, 82 hits in 1078 CRISPR screens |
EvolutionaryTracei | P10746 |
GenomeRNAii | 7390 |
Pharosi | P10746, Tbio |
PROi | PR:P10746 |
RNActi | P10746, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000188690, Expressed in caudate nucleus and 232 other tissues |
ExpressionAtlasi | P10746, baseline and differential |
Genevisiblei | P10746, HS |
Family and domain databases
CDDi | cd06578, HemD, 1 hit |
Gene3Di | 3.40.50.10090, 2 hits |
InterProi | View protein in InterPro IPR036108, 4pyrrol_syn_uPrphyn_synt_sf IPR003754, 4pyrrol_synth_uPrphyn_synth IPR039793, UROS/Hem4 |
PANTHERi | PTHR12390, PTHR12390, 1 hit |
Pfami | View protein in Pfam PF02602, HEM4, 1 hit |
SUPFAMi | SSF69618, SSF69618, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HEM4_HUMAN | |
Accessioni | P10746Primary (citable) accession number: P10746 Secondary accession number(s): B2RC13, D3DRF7, Q9H2T1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 1, 1989 |
Last sequence update: | July 1, 1989 | |
Last modified: | May 25, 2022 | |
This is version 199 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families